Clinical trials: Toxemia
Sepsis, Sepsis Mrsa
Reducing Empiric VAncomycin Use in Pediatric Suspected Sepsis
The goal of this quasi-experimental interventional study is to determine the effectiveness of a multifaceted stewardship intervention in reducing overall vancomycin use in five tertiary care Pediatric Intensive Care Units (PICU).
- Conditions
- Sepsis, Sepsis Mrsa, Sepsis Bacteremia, Antimicrobial - Induced Nephropathy
- Trial name
- REVAMP (NCT05975671)
- Testing
- Multifaceted de-implementation strategy to reduce vancomycin overuse
- Where
- 4 sites in United States
- Volunteers
- 52,500 people
- Sponsor
- Children's Hospital of Philadelphia
Ventilator Acquired Pneumonia, Catheter Related Bloodstream Infection
Effect of Use of Probiotics on Systemic Infection in Critically Ill Patients: a Double Blind, Randomized, Placebo-controlled Trial
The primary goal of this study is to assess the benefit of probiotics in preventing or minimizing of various type of systemic infection in critically ill adult patients.
- Conditions
- Ventilator Acquired Pneumonia, Catheter Related Bloodstream Infection, Urinary Tract Infection, Diarrhea
- Trial name
- NCT07164781
- Testing
- Bacillus clausii, Sugar tablets
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Benha University
Respiratory Infections in Old Age, Bacteremia
Infectious Diseases in Aged Population
The increasing number of persons >65 years of age form a special population at risk for nosocomial and other health care-associated infections.
- Trial name
- AEQUI (NCT04825132)
- Testing
- Geriatric assessment tools
- Where
- 22 sites in France, Italy and 1 more
- Volunteers
- 521 people
- Sponsor
- University Hospital, Grenoble
Systemic Infection
Efficacy and Safety of a Protocol Using C-reactive Protein to Guide Antibiotic Therapy
The growing resistance of microorganisms to antimicrobials is a major threat to public health nowadays. Reducing the consumption of antibiotics is one of the main strategies to control this issue.
- Trial name
- NCT05841875
- Testing
- C reactive protein algorithm
- Where
- Brazil
- Volunteers
- 110 people
- Sponsor
- Federal University of Minas Gerais
Pre-Eclampsia, Intrauterine Growth Restriction
PEPPI Study: Identification of Women at Risk for Placental Dysfunction
The main purpose of this study is to evaluate Fetal Medicine Foundation's pre-eclampsia risk calculator using maternal characteristics, first trimester serum placental growth factor (PlGF) and mean arterial pressure (MAP) in a…
- Conditions
- Pre-Eclampsia, Intrauterine Growth Restriction, Polycystic Ovary Syndrome, Iron-deficiency
- Trial name
- NCT06115122
- Testing
- Pre-eclampsia screening program
- Where
- Finland
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Oulu University Hospital
Sepsis, Septic Shock
Multicenter Symphony IL-6 Monitoring Sepsis ICU Study
The primary objective of this study is to establish an IL-6 concentration cutoff and optimal time point(s) for using Symphony IL-6 that predict 28-day mortality in patients who are admitted or are intended to be admitted to the…
- Trial name
- SYMON (NCT06181604)
- Where
- 7 sites in United States
- Volunteers
- 143 people
- Sponsor
- Bluejay Diagnostics, Inc.
Hypertensive Disorder of Pregnancy, Vitamin D Deficiency
Vitamin D Deficiency With Selected Vitamin D Receptor Gene Polymorphism in Gestational Hypertension
This study aim to look into the prevalence of Vitamin D deficiency among Malaysian pregnant women and its associated risk factors.
- Trial name
- NCT05659173
- Testing
- Blood taking
- Where
- Malaysia
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Universiti Putra Malaysia
Acute Kidney Injury, Septic Shock
Prognostic Value Serum Concentration of Indoxyl Sulfate During Acute Kidney Injury in Septic Shock Patients.
The development of acute kidney injury (AKI) during septic shock is frequent and is associated with a high mortality rate. The reason of this increased mortality despite the use of renal replacement therapy is still unknown.
- Conditions
- Acute Kidney Injury, Septic Shock, Uremic; Toxemia, Mortality
- Trial name
- TOX-AKI (NCT03920982)
- Testing
- Determination of the blood concentration of indoxyl sulfate (IS)
- Where
- France
- Volunteers
- 114 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Magnesium Sulfate, Pregnancy; Pre-Eclampsia
The Effect of Magnesium Use in Reversal of Neuromuscular Block With Sugammadex
Magnesium therapy used for seizure prophylaxis in patients with preeclampsia. Magnesium has been shown to prolong the effect of nondepolarizing neuromuscular blocking agents (NMBA) and neostigmine used to reverse the effect of…
- Conditions
- Magnesium Sulfate, Pregnancy; Pre-Eclampsia, Neuromuscular Blockade
- Trial name
- NCT05558969
- Testing
- pregnant women taking magnesium
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Eskisehir Osmangazi University
Acute Kidney Injury, Uremic; Toxemia
Prognostic Role of the Uremic Toxin Indoxyl Sulfate on Vascular and Cardiac Functions During Acute Kidney Injury
Acute kidney injury (AKI) is a frequent disease in conventional hospital departments and in intensive care units. It's associated with a high risk to develop chronic kidney disease (CKD), even after a single small AKI episode.
- Conditions
- Acute Kidney Injury, Uremic; Toxemia, Vascular Dysfunction, Cardiac Dysfunction
- Trial name
- VASC-AKI (NCT05659589)
- Testing
- blood sample
- Where
- France
- Volunteers
- 105 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Omphalitis, Septicaemia
Efficacy of Umbilical Cord Cleansing With a Single Application of 4% Chlorhexidine for the Prevention of Newborn Infections in Uganda: a Randomized Controlled Trial
Background: Nearly all the yearly 3.3 million neonatal deaths occur in low and middle income countries. Infections, including those affecting the umbilical cord (omphalitis) are a significant factor in approximately a third of…
- Trial name
- NCT02606565
- Testing
- Intervention arm: 4% chlorhexidine
- Where
- Uganda
- Volunteers
- 4,760 people, healthy volunteers welcome
- Sponsor
- Makerere University
Severe Illness, Septicaemia
Early Versus Late BCG Vaccination in HIV-1 Exposed Infants in Uganda in Uganda
BCG vaccination may have non-specific effects (NSE) i.e., additional benefits on childhood morbidity and mortality that are separate the vaccine's effect on the incidence of disseminated tuberculosis.
- Conditions
- Severe Illness, Septicaemia, Diarrhoea, Lower Respiratory Infection
- Trial name
- NCT02606526
- Testing
- BCG at birth, Control arm: Delayed BCG
- Where
- Uganda
- Volunteers
- 4,500 people, healthy volunteers welcome
- Sponsor
- Makerere University
Haematological Malignancy, Febrile Neutropenia
Effect of the BioFire FilmArray (BCID2) for the Rapid Detection of Bloodstream Infection in Haematologic Patients With Febrile Neutropenia
The goal of this observational study is to assess if the molecular diagnostic tool BioFire FilmArray BCID2 is more useful for the microbiological diagnosis of bloodstream infections in hematological patients with febrile…
- Conditions
- Haematological Malignancy, Febrile Neutropenia, Blood Stream Infection
- Trial name
- ONFIRE (NCT06787326)
- Where
- Spain
- Volunteers
- 228 people
- Sponsor
- Hospital Universitari de Bellvitge
Primary Hyperaldosteronism, Hypertensive Disorder of Pregnancy
HyperAldosteronism in Pregnancy Predicted Impacts (H.A.P.P.I. Trial)
Primary hyperaldosteronism confers a higher risk of cardiovascular complications compared to essential hypertension. Preliminary data is controversial in regards of excessive maternal fetal and neonatal excessive risks in…
- Trial name
- NCT05636995
- Testing
- Aldosterone/Renin Ratio
- Where
- 2 sites in Canada
- Volunteers
- 200 people
- Sponsor
- Université de Sherbrooke
Hypertensive Disorder of Pregnancy
Remote BP Monitoring in the PP Period
The purpose of this study is to trial remote patient monitoring (RPM) in the postpartum hypertensive population in a randomized control design, with an aim to increase the number of blood pressure measurements taken during the…
- Trial name
- NCT03728790
- Testing
- Remote Patient Monitoring
- Where
- United States
- Volunteers
- 213 people
- Sponsor
- Columbia University
Sepsis, Bloodstream Infection
Process Mapping and Data Collection to Inform a Computer Simulation Model of Hospitalised Patients With Bloodstream Infection, Sepsis and Systemic Infection
The goal of this study is to create a computer simulation of patients with bloodstream infection to understand how changes in healthcare policies and resources affect patient treatment.
- Conditions
- Sepsis, Bloodstream Infection, Bacteraemia
- Trial name
- CSM-BSI (NCT06271031)
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Sepsis, Systemic Infection
CRP,CRP/Alb Ratio, N/L Ratio in Predictors of Both Systemic Infection and Survival in Patient With Sepsis in Assiut University Hospitals
the goal of this study is to asses the value of biomarker (CRP, CRP/Alb ratio, N/L ratio) in predictor of the outcome in normotensive patients with sepsis.
- Trial name
- NCT06586372
- Volunteers
- 100 people
- Sponsor
- Assiut University
Uremic; Toxemia
A Comparison of Protein-bound and Large Molecular Weight Uremic Toxin Removals With Novel Super High-flux Dialyzer Between Hemodialysis and High Volume Online HDF Modalities
The goal of this prospective, randomized, crossover study is to study about using super high-flux dialyzer in the chronic hemodialysis patients.
- Trial name
- NCT06567483
- Testing
- ELISIO21HX
- Where
- Thailand
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Albumin, Dialysis
Functionality of Albumin in the Context of Hemodialysis
Hemodialysis treatment enables patients with end-stage chronic kidney disease to survive. At the same time, however, this treatment also increases cardiovascular mortality, in particular due to a chronically increased level of…
- Conditions
- Albumin, Dialysis, Redox State, Uremic; Toxemia
- Trial name
- FACED (NCT06561191)
- Testing
- Hemodialysis mode, dialyzer type
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Universität Duisburg-Essen
Preeclampsia, Preeclampsia Severe
Nudge to Drive Transitions of Care
Hypertensive disorders of pregnancy (HDP) are stress tests which may identify women at high risk of future cardiovascular disease (CVD), the leading cause of death among women.
- Conditions
- Preeclampsia, Preeclampsia Severe, Gestational Hypertension, Hypertensive Disorder of Pregnancy
- Trial name
- REMIND (NCT04660032)
- Testing
- Nudge
- Where
- United States
- Volunteers
- 224 people
- Sponsor
- University of Pennsylvania