Clinical trials: Tourette's Disorder, open to volunteers
Tourette Syndrome in Children
Exploring the Role of Neuroactive Steroids in Tourette Syndrome
Tourette syndrome (TS) is a disabling neurodevelopmental disorder characterized by motor and phonic tics. The studies proposed in this application will explore the endocrine mechanisms underlying two of the least well-understood…
- Trial name
- NS in TS (NCT05281445)
- Testing
- Tic suppression task
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Utah
Tourette Syndrome, Chronic Tic Disorder
Internet-based Behavior Therapy for Adults With Tourette Syndrome
This study protocol outlines a parallel-group, randomized controlled trial (RCT) designed to evaluate the effectiveness of Internet-delivered behavior therapy (BT) based on exposure with response prevention (ERP) for adults with…
- Trial name
- TICNET (NCT06271083)
- Testing
- Exposure with response prevention, Brief psychoeducation with general psychological support
- Where
- Sweden
- Volunteers
- 110 people
- Sponsor
- Karolinska Institutet
Tourette Syndrome, Tic Disorders
Trajectories of Change in Tourette Syndrome
This K23 Career Development Award is designed to provide the training needed for the PI to achieve her long-term career goal of conducting independent, programmatic intervention research in developmental populations.
- Trial name
- NCT06679790
- Testing
- Comprehensive Behavioral Intervention for Tics
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Minnesota
Tourette Syndrome in Adolescence
Neurofeedback From the Supplementary Motor Area for Tourette Syndrome
This is a clinical trial where adolescents aged 10-16 years old with Tourette Syndrome (or chronic tic disorder) are randomized to receive either real-time functional magnetic resonance imaging (fMRI) neurofeedback targeting the…
- Trial name
- NCT05558566
- Testing
- Neurofeedback from the SMA, Neurofeedback from control region
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Yale University
Post-Acute COVID-19 Syndrome, ME/CFS
Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research
The unhide® Project is a non-interventional, longitudinal research study designed to establish a secure data repository of demographic, health, and lifestyle information from individuals with brain inflammation and related…
- Conditions
- Post-Acute COVID-19 Syndrome, ME/CFS, Rheumatic Arthritis, Juvenile Rheumatoid Arthritis (JRA)
- Trial name
- NCT04806620
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Brain Inflammation Collaborative
Tourette Syndrome
Multimodal Electrophysiological Study of Cortico-subcortical Biomarkers of Tics in Tourette Syndrome
Tourette syndrome (TS) is a complex neurodevelopmental disorder characterized by the occurrence of involuntary movements (motor tics) and vocalizations (phonic tics).
- Trial name
- BioTic (NCT06909656)
- Testing
- Multimodal electrophysiological recordings
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Bordeaux
Tourette Syndrome
Transcranial Ultrasound Stimulation for Tourette Syndrome
This is a phase 1 clinical trial investigating the use of low-energy Transcranial Ultrasound Stimulation (TUS) to treat Tourette Syndrome (TS). Objectives and Background.
- Trial name
- TUS-TS (NCT07699783)
- Testing
- Focused ultrasound stimulation
- Volunteers
- 20 people
- Sponsor
- University of Calgary
Tourette Syndrome, Deep Brain Stimulation
Multitarget Stereotactic Electrophysiological Recording and Stimulation for Tourette Syndrome
The goal of this clinical trial is to investigate the neural mechanisms underlying Tourette syndrome (TS) and see if personalized deep brain stimulation (DBS) can help reduce tics in TS patients and improve related issues like…
- Trial name
- MASTERS-TS (NCT06889480)
- Testing
- New Target DBS, CM-DBS
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Beijing Tiantan Hospital
Tourette Syndrome in Children
The Findings of Magnetic Resonance Imaging in Subtypes of Tics-related Disorders
The findings of resting-state functional magnetic resonance imaging and diffusion spectrum imaging in subtypes of tics-related disorders
- Trial name
- NCT05566496
- Testing
- Brain MRI
- Where
- Taiwan
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Tourette Syndrome
Sensory Symptoms in Tourette Syndrome
Patients with tics will be asked to complete a series of validated questionnaires (in electronic and/or paper format) regarding symptoms and conditions often associated with Tourette syndrome, including premonitory urges, sensory…
- Trial name
- SenST (NCT03851484)
- Where
- 2 sites in United States
- Volunteers
- 214 people
- Sponsor
- Vanderbilt University Medical Center
Tourette Syndrome
Effect of RNS in Treatment-refractory Tourette's Syndrome
The study is to investigate the effect of personalized responsive neurostimulation (RNS) therapy guided by stereoelectroencephalography (SEEG) in patients with treatment-resistant Tourette's Syndrome (TR-TS).
- Trial name
- NCT06785532
- Testing
- Responsive Neurostimulation (RNS)
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Xuanwu Hospital, Beijing
Tourette Syndrome
Observational Database on Deep Brain Stimulation in Tourette Syndrome
Within an ongoing deep brain stimulation (DBS) program for Tourette syndrome (TS) at the Department of Neurology, Pitié-Salpêtrière Hospital, Paris/France, the investigator team plans to evaluate patients pre-operatively and then…
- Trial name
- POSTSTIC (NCT04449068)
- Testing
- Neurological and neuropsychological Follow-up after deep brain stimulation, EEG recordings
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
OCD, Tic Disorders
Objective Characterizatoion of Repetitive Behaviors
Introduction: Repetitive behaviors (RB) constitute a broad range of symptoms across different psychiatric/neurologic disorders. The most famous are stereotypies (found in autism), compulsions (found in…
- Conditions
- OCD, Tic Disorders, Gilles de la Tourette Syndrome
- Trial name
- NCT06050369
- Testing
- EEG, MRI
- Where
- 3 sites in France
- Volunteers
- 50 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Neurodevelopmental Disorders, Autism
Sertraline vs. Placebo in the Treatment of Anxiety in Children and AdoLescents With NeurodevelopMental Disorders
There are currently no approved medications for the treatment of anxiety in children and youth with neurodevelopmental disorders (NDDs), both common and rare.
- Conditions
- Neurodevelopmental Disorders, Autism, Autism Spectrum Disorder, Fragile X Syndrome
- Trial name
- CALM (NCT06081348)
- Testing
- Sertraline
- Where
- 7 sites in Canada
- Volunteers
- 130 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
Tourette Syndrome, Tic Disorder
Sensorimotor and Psychosocial Trajectories in Adolescents With Tic Disorder
Individuals with tic disorders have lower quality of life, sensory and movement difficulties, and poorer mental, social, and physical health compared to the general population.
- Trial name
- NCT06576726
- Testing
- This study involves no intervention.
- Where
- United States
- Volunteers
- 351 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Tourette's Syndrome
Exploring DBS Efficacy in Treatment-refractory Tourette's Syndrome
The primary purpose of this study is to investigate the effect of deep brain stimulation (DBS) in patients with Treatment-refractory Tourette's syndrome (TR-TS) implantation targeting the Antero-medial globus pallidus interna…
- Trial name
- NCT06361004
- Testing
- Deep Brain Stimulation (DBS)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xuanwu Hospital, Beijing
Neurodevelopmental Outcomes, ADHD - Attention Deficit Disorder With Hyperactivity
Where Wild Things Grow: Nature- and Activity-based Group Interventions for Neurodivergent Children and Youth
The goal of this action research project is to develop and implement nature- and activity-based group interventions across health care, school and leisure settings in Southern Norway.
- Conditions
- Neurodevelopmental Outcomes, ADHD - Attention Deficit Disorder With Hyperactivity, Autism, Tourette Syndrome
- Trial name
- NCT07203469
- Testing
- Universal approach, Selective approach, Outdoor therapy
- Where
- 2 sites in Norway
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Sorlandet Hospital HF
Tourette Disorder
Serotonin Control of Impulsivity in Tourette Disorder
Tourette disorder (TD) is a neurodevelopmental disorder characterized by motor and vocal tics. It is often associated with multiple psychiatric comorbidities involving a high degree of impulsivity such as obsessive-compulsive…
- Trial name
- ARITEP (NCT05942716)
- Testing
- Administration of a PET radiotracer
- Where
- 2 sites in France
- Volunteers
- 25 people
- Sponsor
- Hospices Civils de Lyon
Tourette Syndrome, Tourette's Disorder
Remote Delivery of a Mindfulness-based Intervention for Tics
This research study is being done to compare a mindfulness-based intervention for tics (MBIT) to psychoeducation with relaxation and supportive therapy (PRST) for individuals with Tourette's syndrome or Persistent Tic Disorders…
- Conditions
- Tourette Syndrome, Tourette's Disorder, Chronic Motor Tic Disorder, Chronic Vocal Tic Disorder
- Trial name
- MBIT (NCT06408662)
- Testing
- mindfulness-based intervention for tics (MBIT), psychoeducation with relaxation and supportive therapy (PRST)
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Johns Hopkins University
Tourette Syndrome, Tic Disorders
Evaluating and Promoting Resilience in Adolescents With Tourette Syndrome
This study adapts and tests PRISM (Promoting Resilience in Stress Management), a short skills-based program that teaches resilience, for teens ages 12-18 with Tourette syndrome or persistent tic disorder.
- Conditions
- Tourette Syndrome, Tic Disorders, Persistent (Chronic) Motor or Vocal Tic Disorder
- Trial name
- PRISM-TS (NCT07905898)
- Testing
- PRISM Intervention, Usual care intervention
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Wake Forest University Health Sciences