Clinical trials: Total Mesorectal Excision
Rectal Cancer
Short-term Outcomes of Transanal Total Mesorectal Excision With Structured Training Curriculums in China
Transanal total mesorectal excision (TaTME) is an alternative for mid-low rectal cancer. In China, this procedure has been performed in high-volume centers with structured training curriculums.
- Trial name
- NCT05108753
- Testing
- Procedure/Surgery
- Where
- 2 sites in China
- Volunteers
- 175 people
- Sponsor
- Shanghai Minimally Invasive Surgery Center
Genito Urinary Function Evaluation
Genito Urinary Function With High or Low Inferior Mesenteric Artery Ligation in Laparoscopic Anterior Rectal Resection
The aim of this study is to compare the incidence of genito-urinary function depression and anastomotic leak in Laparoscopic Anterior Rectal Resection (LAR) with Total Mesorectal Excision with Ligation if the Inferior Mesenteric…
- Trial name
- NCT02153801
- Testing
- During the surgical procedure of Laparoscopic Low Anterior Resection with Total mesorectal Excision .
- Where
- Italy
- Volunteers
- 212 people
- Sponsor
- Niguarda Hospital
Colon Cancer
Comparison of Limb Size of Transverse Coloplasty Pouch
The aim of the study is the comparison of pouch function with two different sizes of limb of transverse coloplasty pouch after rectal resection and total mesorectal excision.
- Trial name
- NCT01071824
- Testing
- Transverse coloplasty pouch (Long limb), Transverse coloplasty pouch (Short limb)
- Where
- Switzerland
- Volunteers
- 52 people
- Sponsor
- Kantonsspital Liestal
Rectal Cancer
Preoperative Chemoradiotherapy and Transanal Endoscopic Microsurgery Versus Total Mesorectal Excision in T2-T3s N0, M0 Rectal Cancer
The standard treatment of rectal adenocarcinoma is total mesorectal excision (TME). The technique involves a low anterior rectal or colo-anal resection, very often associated with a protective stoma or abdominal-perineal…
- Trial name
- NCT01308190
- Testing
- Capecitabine (Xeloda), 50.4 Gy, Transanal Endoscopic Microsurgery
- Where
- Spain
- Volunteers
- 173 people
- Sponsor
- Corporacion Parc Tauli
Rectal Cancer
Open or Laparoscopic Mesolectal Excision in Low Rectum Cancer
To compare the open approach and the laparoscopic-assisted approach of dissection of lateral lymph nodes in low advanced rectal cancer patients with clinically suspected nodal metastases in terms of safety, technical feasibility…
- Trial name
- NCT04561830
- Testing
- laparoscopic-assited excision of mesorectum with pelvic lymph nodes excision
- Volunteers
- 60 people
- Sponsor
- Zagazig University
Adenocarcinoma of the Rectum
Can we Save the Rectum by Watchful Waiting or TransAnal Surgery Following (Chemo)Radiotherapy Versus Total Mesorectal Excision for Early REctal Cancer?
Bowel cancer is the second most common tumour with 41 000 new cases diagnosed annually in the UK, 447 000 across Europe and 1.36 million worldwide; of which one third are located in the rectum.
- Trial name
- STAR-TREC (NCT02945566)
- Testing
- Standard TME surgery, Long course concurrent chemoradiation with capecitabine and radiotherapy, Short course radiotherapy
- Where
- 5 sites in Belgium, Denmark and 3 more
- Volunteers
- 380 people
- Sponsor
- University of Birmingham
Rectal Cancer
The Evaluation of the Safety and the Efficacy of Transanal Total Mesorectal Excision
The purpose of this study is evaluation of the safety and the efficacy of transanal total mesorectal excision.
- Trial name
- NCT01938027
- Testing
- Transanal total mesorectal excision
- Where
- South Korea
- Volunteers
- 12 people
- Sponsor
- National Cancer Center, Korea
Colorectal Cancer
Eval. of Safety and Effectiveness of the FMwand Ferromagnetic Surgical System During Total Mesorectal Excision Surgery
The objective of the clinical trial is to determine the suitability of the FMwand Ferromagnetic Surgical System for Total Mesorectal Excision Surgery.
- Trial name
- NCT02423174
- Testing
- Total Mesorectal Excision, FMwand Surgical System
- Sponsor
- Domain Surgical, Inc.
Rectal Cancer
Multicenter Validation of the PREDICT Score
Even after adequate TME with grade III mesorectal grading, local recurrence remains a possible event. Several studies investigated different parameters and assessed their predictive power in regards to local recurrence after TME.
- Trial name
- NCT05078515
- Testing
- PREDICT score
- Where
- Egypt
- Volunteers
- 262 people
- Sponsor
- Mansoura University
Low Rectal Cancer
Outcomes of TAMIS-Total Mesorectal Excision Versus Transanal Loco-regional Excision for T2 Low Rectal Cancer
Cases with stage T2 N0 low rectal cancer will undergo either Transanal minimally invasive total mesorectal excision or transanal minimally invasive locoregional resection.
- Trial name
- TAMIS (NCT02488577)
- Testing
- Transanal minimally invasive total mesorectal excision, transanal minimally invasive locoregional resection
- Volunteers
- 50 people
- Sponsor
- Osama Mohammad Ali ElDamshety
Rectal Cancer
Trial Evaluating 3-year Disease Free Survival in Patients With Locally Advanced Rectal Cancer Treated With Chemoradiation Plus Induction or Consolidation Chemotherapy and Total Mesorectal Excision or Non-operative Management
The study is designed to test the hypothesis that patients with Locally advanced rectal cancer ( LARC) treated with Total neoadjuvant therapy (TNT) and Total mesorectal excision (TME) or Non-operative management (NOM) will have…
- Trial name
- NCT02008656
- Testing
- Oxaliplatin (OXAL), 5-Fluorouracil (5-FU), Leucovorin
- Where
- 26 sites in United States
- Volunteers
- 358 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Rectal Cancer Patients
Single-port Robotic Transanal Total Mesorectal Excision
This is a phase 2a clinical trial based on the IDEAL framework to evaluate the safety, feasibility and clinical efficacy of single-port robotic transanal total mesorectal excision (SPr-taTME )surgery.
- Trial name
- NCT06591572
- Testing
- Single-port robotic transanal total mesorectal excision
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Rectal Cancer
Intraoperative Monitoring of the Pelvic Autonomic Nerves
One of the major problems of rectal cancer surgery is pelvic autonomic nerve damage, which is the main cause of urogenital dysfunction influencing postoperative quality of life.
- Trial name
- NEUROS (NCT01585727)
- Testing
- TME, Neuromonitoring
- Where
- Germany
- Volunteers
- 188 people
- Sponsor
- Johannes Gutenberg University Mainz
Rectal Cancer, Abdominoperineal Resection
Abdominoperineal Extra-Elevators Rectal Resection for Cancer: Prone Position vs. Supine Position
Prospective multicenter randomized controlled trial comparing the prone vs. the supine position of the perineal time of the Miles operation in patients with advanced rectal cancer.
- Trial name
- APPRO (NCT02163785)
- Testing
- Abdominoperineal extra-elevators rectal resection for low lying rectal cancer
- Where
- 19 sites in Spain
- Volunteers
- 280 people
- Sponsor
- Hospital Universitario La Fe
Rectal Cancer, Total Mesorectal Excision
Timing Evaluation of Stoma Closure (TIMES). Early vs Late Closure of Stoma After Rectal Cancer Surgery.
The purpose of this study is to asses the safety and efficacy of early stoma closure (2-3 weeks after total mesorectal excision) vs late closure (16-24 weeks after mesorectal excision).
- Conditions
- Rectal Cancer, Total Mesorectal Excision, Ileostomy - Stoma, Ileostomy; Complications
- Trial name
- TIMES (NCT05284864)
- Testing
- Stoma closure
- Where
- 9 sites in Spain
- Volunteers
- 150 people
- Sponsor
- Hospital Universitario La Fe
Rectal Cancer Stage II, Rectal Cancer Stage III
Optimal Surgery and MRI Based Radiochemotherapy in Rectal Carcinoma
The objective of the study is to provide proof that a MRI based preoperative radiochemotherapy in patients with locally advanced rectal carcinoma allows limiting RCT to high risk patients without increase of locoregional…
- Trial name
- OCUM (NCT01325649)
- Testing
- total mesorectal excision / long course radiochemotherapy, long course 5-FU bases radiochemotherapy
- Where
- Germany
- Volunteers
- 1,051 people
- Sponsor
- Johannes Gutenberg University Mainz
Rectal Cancer
Selective sPlenic flExure Mobilization for Low colorEctal Anastomosis After D3 lYmph Node Dissection (Speedy Trial)
In the Low Anterior Resection of rectum for cancer, the section level of IMA and the need of SFM is still debated. The aim of this study is to explore the different impacts of high and low ligation with peeling off vascular…
- Trial name
- SpeeDy (NCT03895255)
- Testing
- Paraaortic lymph node dissection, IMA high ligation, TME, routine splenic flexure mobilization, Paraaortic lymph node dissection, IMA low ligation, TME, selective splenic flexure mobilization
- Where
- Russia
- Volunteers
- 142 people
- Sponsor
- Russian Society of Colorectal Surgeons
Chemotherapy Effect, Rectal Cancer
Salvage Chemotherapy Versus Total Mesorectal Resection for Local Resection Rectal Cancer Patients
Whether to perform radical TME or salvage chemoradiotherapy after local resection of intermediate-risk T1 rectal cancer is still controversial.
- Trial name
- NCT06043999
- Testing
- Radical total mesorectal excision, Salavge Adjuvant Chemoradiotherapy
- Where
- China
- Volunteers
- 392 people
- Sponsor
- Sun Yat-sen University
Rectal Cancer
Minimally Invasive Sphincter Sparing Total Mesorectal Excision for Ultra-low Rectal Cancer After Initial Chemo-radiotherapy (MISS-TRICR).
A prospective study is planned for management of low rectal cancer with the aim of sphincter preservation and improving the oncological outcome of the patients, through comparing of both approaches minimally invasive techniques…
- Trial name
- MISS-TRICR (NCT02488707)
- Testing
- laparoscopic intersphincteric resection (LISR group), Transanal minimally invasive Total mesorectal excision (TAMIS group)
- Where
- Egypt
- Volunteers
- 250 people
- Sponsor
- Mansoura University
Rectal Cancer, Surgery
Transanal Transection and Single-stapled Anastomosis (TTSS) in Rectal Cancer Patients
The Transanal Transection and Single-Stapled anastomosis (TTSS) technique may be a valid alternative to traditional double-stapled anastomosis for low rectal cancer surgery.
- Trial name
- TTSS-REC (NCT06314646)
- Testing
- Transanal Transection and Single-Stapled anastomosis (TTSS), Double-stapled Total Mesorectal Excision (TME)
- Where
- Italy
- Volunteers
- 472 people
- Sponsor
- Istituto Clinico Humanitas