Clinical trials: Total Mesorectal Excision
Rectal Neoplasms
Effective Study of Preoperative Short-course Radiotherapy for the Advanced Resectable Rectal Cancer
The local recurrence of rectal cancer is one of the main problem that fail the treatment. The preoperative neoadjuvant (chemo)radiotherapy has been confirmed to reduce the local recurrence rate,especially in the advanced rectal…
- Trial name
- NCT01437514
- Testing
- preoperative short-course radiotherapy
- Where
- 4 sites in China
- Volunteers
- 410 people
- Sponsor
- West China Hospital
Chemotherapy Effect, Rectal Cancer
Salvage Chemotherapy Versus Total Mesorectal Resection for Local Resection Rectal Cancer Patients
Whether to perform radical TME or salvage chemoradiotherapy after local resection of intermediate-risk T1 rectal cancer is still controversial.
- Trial name
- NCT06043999
- Testing
- Radical total mesorectal excision, Salavge Adjuvant Chemoradiotherapy
- Where
- China
- Volunteers
- 392 people
- Sponsor
- Sun Yat-sen University
Rectal Cancer, Rectum Neoplasm
Local Excision for Organ Preservation in Early REctal Cancer With No Adjuvant Treatment
Rectal cancer is one of the most frequent malignant tumors nowadays. There are several possible treatment options including chemotherapy, radiotherapy and surgery.
- Trial name
- LORENA (NCT05927584)
- Testing
- Transanal local excision
- Where
- Spain
- Volunteers
- 145 people
- Sponsor
- Fundación de Investigación Biomédica - Hospital Universitario de La Princesa
Rectal Cancer
Physical Exercise for Colorectal Cancer Patients After Transanal Total Mesorectal Excision
Fecal incontinence is common in patients with rectal cancer after surgery. Previous studies showed that pelvic floor muscle and external sphincter muscle training after stoma closure could improve the severity of incontinence and…
- Trial name
- NCT03120104
- Testing
- pelvic floor muscle exercise before stoma closure, pelvic floor muscle exercise after stoma closure
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- Taipei Medical University WanFang Hospital
Total Mesorectal Excision, Laparoscopic
Laparoscopic Extraperitoneal Total Mesorectal Excision (LE-TME): A New Feasible Technical Approach.
The study involves the use of Retroperitoneal plane for TME for rectal anterior resection. Through a pilot prospective study, LR-TME will be assessed as one arm study.
- Trial name
- LE-TME (NCT02455752)
- Testing
- LE-TME
- Where
- Egypt
- Volunteers
- 5 people
- Sponsor
- Mansoura University
Rectal Cancer
Transanal Total Mesorectal Excision for Rectal Cancer on Anal Physiology + Fecal Incontinence
Low Anterior Resection (LAR) surgery can be done using various techniques. The traditional technique for performing the surgery is through one or multiple incision(s) in the muscular wall of the abdomen.
- Trial name
- NCT03283540
- Testing
- TaTME, TME
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Case Comprehensive Cancer Center
Rectal Neoplasms Malignant
A Study on the Efficacy of a Novel Approach to Achieving Laparoscopic Distal Rectal Transection for Rectal Cancers
The wide application of ISR and DST has greatly improved the anal preservation rate for low rectal cancers, but the technical difficulty has also been obviously increased because of the limited pelvic space.
- Trial name
- NCT05067413
- Testing
- Transanterior obturator nerve gateway approach, Total mesorectal excision approach
- Where
- 4 sites in China
- Volunteers
- 200 people
- Sponsor
- Peking University First Hospital
Rectal Neoplasms
Robotic Assisted Transanal Total Mesorectal Excision Surgery for Rectal Cancer in Low Site
To investigates the feasibility, practicability, safety and subjective as well as functional outcome of Robotic transanal total mesentery excision for rectal cancer in low site.
- Trial name
- NCT03422835
- Testing
- R-TME, R-TaTME
- Volunteers
- 50 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Rectal Cancer, Ileostomy; Functional Disturbance
Trial Evaluating the Tailored Versus the Systematic Use of Defunctioning Stoma After Total Mesorectal Excision for Rectal Cancer (GRECCAR17)
GRECCAR 17 will be the first prospective and randomized trial to assess a tailored policy in the use of defunctioning stoma after TME according to the personalized risk of anastomotic leakage.
- Trial name
- GRECCAR17 (NCT05233787)
- Testing
- Tailored use of defunctioning stoma after TME, Systematic use of defunctioning stoma
- Where
- 28 sites in France
- Volunteers
- 212 people
- Sponsor
- University Hospital, Bordeaux
Cancer, Rectum
Optimization of Preoperative Treatment in Locally Advanced Rectal Cancer
The purpose of this study is to compare effectiveness of short-term radiotherapy with neoadjuvant chemotherapy(TNT group) with preoperative long-term chemoradiotherapy(CRT group) in locally advanced rectal cancer.
- Trial name
- STELLAR (NCT02533271)
- Testing
- Short-course radiotherapy with neoadjuvant chemotherapy, Long-term chemoradiotherapy
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Chinese Academy of Medical Sciences
Rectal Cancer
"Impact of Pelvic Floor Prehabilitation Using Biofeedback on the Severity of the Low Anterior Resection Syndrome in Patients Undergoing a Total Mesorectal Excision for Rectal Cancer"
There is currently no specific treatment and only few measures to prevent the low anterior resection syndrome (LARS). The LARS often results in a severe alteration of quality of life.
- Trial name
- CONTICARE (NCT03876561)
- Testing
- Pelvic floor prehabilitation
- Where
- 6 sites in France
- Volunteers
- 120 people
- Sponsor
- Nantes University Hospital
Rectal Cancer, Abdominoperineal Resection
Abdominoperineal Extra-Elevators Rectal Resection for Cancer: Prone Position vs. Supine Position
Prospective multicenter randomized controlled trial comparing the prone vs. the supine position of the perineal time of the Miles operation in patients with advanced rectal cancer.
- Trial name
- APPRO (NCT02163785)
- Testing
- Abdominoperineal extra-elevators rectal resection for low lying rectal cancer
- Where
- 19 sites in Spain
- Volunteers
- 280 people
- Sponsor
- Hospital Universitario La Fe
Colorectal Cancer
Oxaliplatin, Capecitabine, and Radiation Therapy With or Without Cetuximab in Treating Patients Undergoing Surgery for High-Risk Rectal Cancer
RATIONALE: Drugs used in chemotherapy, such as oxaliplatin and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- EXPERT-C (NCT00383695)
- Testing
- cetuximab, capecitabine, oxaliplatin
- Where
- 13 sites in Spain, Sweden and 1 more
- Volunteers
- 164 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Rectal Cancer
PROSPECTIVE CONTROLLED AND RANDOMIZED STUDY OF THE GENITOURINARY FUNCTION AFTER RECTAL CANCER SURGERY IN RELATION TO THE DISSECTION OF THE INFERIOR MESENTERIC VESSELS
Purpose: The "Total Mesorectal Excision" (TME) is the standard surgical technique for the treatment of rectal cancer. Up to 50% of sexual dysfunction is described after TME and up to 30% of urinary dysfunction.
- Trial name
- NCT03520088
- Testing
- Inferior mesenteric Vein dissection, Inferior mesenteric Artery dissection
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Corporacion Parc Tauli
Rectum Cancer
Bacteriological Differences Between Transanal and Laparoscopic Total Mesorectal Excision for Rectal Cancer.
The primary purpose of this study is to compare the differences of bacteriological in rectal cancer patients undergoing laparoscopic or transanal endoscopy radical resection.
- Trial name
- NCT05201872
- Where
- China
- Volunteers
- 216 people
- Sponsor
- Yanhong Deng
Rectal Cancer
Multi-Technology Integrated Total Mesorectal Excision Versus Conventional Total Mesorectal Excision for the Treatment of Middle and Distal Rectal Cancer.
A multicenter, prospective, randomized, controlled clinical trial of multi-technology integration total mesorectal excision (MTI-TME) versus conventional total mesorectal excision (C-TME) for the treatment of middle and distal…
- Trial name
- NCT06613399
- Testing
- MTI-TME, C-TME
- Volunteers
- 324 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Single-Port Colorectal Surgeries
A Real-World Study to Evaluate the Clinical Performance and Safety of da Vinci SP Surgical System for Single-Port Colorectal Surgeries（SPiM-RWS-CR）
A real-world study to evaluate the clinical performance and safety of da Vinci SP Surgical System ("SP single-port robot" for short) for single-port robot-assisted colorectal surgeries in the real world, providing a real world…
- Trial name
- NCT06141421
- Testing
- procedure
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Ruijin Hospital
Rectal Cancer
Lateral Lymph Node Dissection After Neoadjuvant Chemo-radiation in Advanced Low Rectal Cancer
Lateral lymph nodes (LLD) metastasis is a major cause of local recurrence for advanced rectal cancer. As for the treatment strategies on LLN metastasis, there are huge controversies on whether lateral pelvic lymph nodes…
- Trial name
- NCT02614157
- Testing
- LLND, labeled line
- Where
- China
- Volunteers
- 51 people
- Sponsor
- West China Hospital
Rectal Adenocarcinoma, LARS - Low Anterior Resection Syndrome
ProLARS Trial: Prospective Longitudinal Follow-up of Low Anterior Resection Syndrome (LARS) and COREFO Score After Rectum Surgery in Patients Undergoing Upfront Surgery or Different Neo-adjuvant Treatment Regimens
OBJECTIVE Low anterior resection syndrome (LARS) is a term for functional bowel complaints occurring after low anterior resection.
- Conditions
- Rectal Adenocarcinoma, LARS - Low Anterior Resection Syndrome, Rectal Resection, Low Anterior Resection
- Trial name
- ProLARS (NCT07339904)
- Testing
- Questionnaire
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- University Hospital, Antwerp
Rectal Neoplasms
Neo-Adjuvant FOLFOX for Rectal Carcinoma
A Phase II open- labeled, prospective study to determine the efficacy of pre-operative chemotherapy with six cycles of modified FOLFOX 6 followed by total mesorectal excision (TME) followed by an additional six cycles of FOLFOX…
- Trial name
- NCT00832299
- Testing
- FOLFOX, total mesorectal excision (TME)
- Where
- 2 sites in United States
- Volunteers
- 2 people
- Sponsor
- Beth Israel Medical Center