Clinical trials: Total Knee Replacements
Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee
Testing Implementation of Total Joint Replacement Rehabilitation Quality Indicator Toolkits
The goal of this feasibility study is to test the procedures for implementing quality indicator toolkits for hip and knee replacement rehabilitation in clinical settings.
- Trial name
- NCT06208553
- Testing
- QI toolkit implementation
- Where
- Canada
- Volunteers
- 135 people
- Sponsor
- University of British Columbia
Arthroplasty
Knee Joint Icing and Knee-extension Strength
With this study the investigators wish to (1) investigate the acute effect of knee joint icing on knee-extension strength shortly after total knee arthroplasty (TKA); and (2) investigate the acute effect of knee joint icing on…
- Trial name
- IS (NCT01249612)
- Testing
- Thermotherapy
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Hvidovre University Hospital
Knee Osteoarthritis, Total Knee Arthroplasty
In Vivo Kinematics for Subjects With Smith & Nephew Journey II BCS TKA, Journey II CR TKA, Or Journey II XR TKA
The objective of this study is to determine and compare the in vivo kinematics and vibroarthrography (VAG) signals for subjects implanted with Journey II Bi-Cruciate Stabilized (BCS), CR (Cruciate Retaining), and Bi-Cruciate…
- Conditions
- Knee Osteoarthritis, Total Knee Arthroplasty, Knee
- Trial name
- NCT04612036
- Testing
- Journey II Bi-Cruciate Stabilized TKA, Journey II Cruciate Retaining TKA, Journey II Bi-Cruciate Retaining TKA
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- The University of Tennessee, Knoxville
Knee Pain Chronic, Rheumatoid Arthritis
Cemented vs Cementless Persona Keel RCT
The main objective of this study is to evaluate the safety, performance, and clinical benefits of the Persona Keel cementless and cemented knee.
- Conditions
- Knee Pain Chronic, Rheumatoid Arthritis, Osteoarthritis, Traumatic Arthritis
- Trial name
- NCT05630053
- Testing
- Cementless Persona Knee System, Cemented Persona Knee System
- Where
- 7 sites in United States
- Volunteers
- 300 people
- Sponsor
- Zimmer Biomet
Venous Thromboembolism
Comparative Study of Prophylactic Agent for Venous Thromboembolism After Total Knee Arthroplasty
The purpose of this study is to compare the efficacy of two prophylactic agent(aspirin 300mg/day and rivaroxaban 10mg/day) for venous thromboembolism after total knee arthroplasty.
- Trial name
- NCT02271399
- Testing
- acetylsalicylic acid, rivaroxaban
- Where
- South Korea
- Volunteers
- 156 people
- Sponsor
- Hanyang University Seoul Hospital
Postoperative Pain
A Phase 3 Study to Evaluate the Safety and Efficacy of SKY0402 in Subjects Undergoing Total Knee Arthroplasty
The primary objective is to demonstrate that SKY0402 is superior when compared to bupivacaine HCl in the management of postoperative pain for patients undergoing total knee arthroplasty.
- Trial name
- TKA (NCT00745290)
- Testing
- Bupivacaine HCl, SKY0402
- Where
- 19 sites in United States
- Volunteers
- 245 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Knee Osteoarthritis \(OA\)
Motor Sparing Techniques, Genicular Nerve Radiofrequency Ablation Has Emerged As a Viable Alternative to Conservative Therapy and Total Knee Arthroplasty
There has recently been considerable interest in the role of radiofrequency ablation (RFA) of the genicular nerves for KOA. In the majority of previous studies, ablation was done via a radiofrequency technique using either…
- Trial name
- NCT06594003
- Testing
- Radiofrequency
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Arthropathy of Knee Joint
Regional Prophylactic Vancomycin With Restricted Tourniquet Time in Primary Total Knee Replacement
The purpose of this study is to determine whether or not giving a lower dose of antibiotics (Vancomycin) in the area where it is needed (the knee joint) is more effective at obtaining adequate tissue levels of the antibiotic than…
- Trial name
- NCT03506347
- Testing
- Vancomycin
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Mayo Clinic
Knee Osteoarthritis
Comparison of Postoperative Pain Score Between Perioperative Intravenous Ketamine and Placebo in Patients Undergoing Unilateral Total Knee Arthroplasty Under General Anesthesia
The goal of this clinical trial is to compare postoperative pain score between perioperative intravenous ketamine and placebo in patients undergoing unilateral total knee arthroplasty under general anesthesia.
- Trial name
- NCT06267638
- Testing
- Ketamine group
- Where
- Thailand
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Thailand
Spinal Anesthesia
The Bupivacaine Dose Sparing Effect of Intrathecal Epinephrine
Intrathecal epinephrine has been known to increase the duration of spinal anesthesia, or increase the quality of anesthesia. However, there is still a controversy, and the mechanism of epinephrine is recently suggested as a…
- Trial name
- NCT01261078
- Testing
- epinephrine 25, Epinephrine 50, epinephrine 100
- Where
- South Korea
- Volunteers
- 75 people
- Sponsor
- Seoul Medical Center
Arthritis Knee
Trial to Compare Femoral Nerve Block With Local Anaesthetic Injection for Post-operative Pain After Knee Replacement.
Pain after a knee replacement can impair recovery and use of the new knee. Having an injection to numb the femoral nerve is known to give good pain relief after the operation but may lead to slower mobilisation as it also…
- Trial name
- LIFT (NCT02288923)
- Testing
- Femoral nerve block, Local Infiltration Analgesia, Sub arachnoid analgesia
- Where
- United Kingdom
- Volunteers
- 199 people
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
Osteoarthritis, Knee, Obesity
Effect Of The Use Of Navigation In The Alignment Obtained When Performing A Total Knee Arthroplasty In Obese Patients
NAOBE is a randomized, open and prospective clinical trial that evaluates the accuracy to achieve an adequate mechanical axis of the lower extremity in obese patients after total knee replacement.
- Conditions
- Osteoarthritis, Knee, Obesity, Arthropathy of Knee
- Trial name
- NCT03865524
- Testing
- Total knee arthroplasty implanted with GPS navigation system, Total knee arthroplasty implanted with standard guides.
- Where
- 2 sites in Spain
- Volunteers
- 159 people
- Sponsor
- Pedro-José Torrijos-Garrido
Total Knee Arthroplasty, Older Adults
Movement Pattern Biofeedback Training After Total Knee Arthroplasty
This research study explores the effects of movement pattern training using real-time biofeedback insoles after total knee arthroplasty.
- Trial name
- MOVE (NCT03325062)
- Testing
- Control, Experimental: MOVE
- Where
- United States
- Volunteers
- 138 people
- Sponsor
- University of Colorado, Denver
Total Knee Arthroplasty
Clinical Utility and Gait Analysis of NextAR System AUS
This study titled "Does Personalised Soft Tissue Balance Data Improve Outcomes in Patients Undergoing Medially Stabilised Arthroplasty? A Prospective, Randomised Study Investigating the Clinical Utility of the NextAR navigation…
- Trial name
- NCT05863741
- Testing
- Implantation of GMK Sphere with conventional instrumentation, Implantation of GMK Sphere using the NextAR guidance system
- Where
- Australia
- Volunteers
- 100 people
- Sponsor
- Medacta International SA
Osteoarthritis
A Retrospective Study of the iTotal CR Knee Replacement System
This study involves retrospective collection of data regarding the first approximately 100 iTotal Knee Replacement System surgeries and their short term outcomes at a small set of centers throughout the US.
- Trial name
- NCT01564654
- Testing
- iTotal KRS
- Where
- 4 sites in United States
- Volunteers
- 89 people
- Sponsor
- Restor3D
Pain Management, Function
Evaluation of Post Hospital Administration of Celecoxib Following Minimally Invasive Knee Replacement Surgery
This study will evaluate the benefits of continuing celecoxib through six weeks of total knee arthroplasty recovery. This is a randomized, double blind study with a group of approximately 130 primary total knee patients.
- Conditions
- Pain Management, Function, Minimally Invasive Total Knee Arthroplasty, Celecoxib
- Trial name
- NCT00474773
- Testing
- Celecoxib
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- St. Louis Joint Replacement Institute
Knee Osteoarthritis
Cost Effectiveness of Prolotherapy Injections Prior to Total Knee Arthroplasty
This study compared the cost effectiveness of two-stage algorithm (prolotherapy injections (PrT) combined with rehabilitation protocol (RP) prior to total knee arthroplasty (TKA)) and one-stage algorithm (TKA) in the management…
- Trial name
- NCT03758183
- Testing
- total knee arthroplasty
- Where
- Turkey (Türkiye)
- Volunteers
- 197 people
- Sponsor
- Tokat State Hospital
Knee Osteoarthritis, Rehabilitation
Preoperative Rehabilitation in Greek Patients Undergoing Total Knee Arthroplasty
Purpose: The purpose of this study was to investigate the efficacy of a 6-week supervised high-intensity preoperative training program on muscle strength, functional performance and patient-reported outcomes in patients…
- Trial name
- NCT04911205
- Testing
- Preoperative training program
- Volunteers
- 88 people
- Sponsor
- National and Kapodistrian University of Athens
Knee Osteoarthritis, Total Knee Arthroplasty
Effect of Hemovac Drain Removal on Early Outcomes After Total Knee Arthroplasty
This study aims to evaluate whether the timing of Hemovac drain removal affects early clinical outcomes after primary total knee arthroplasty (TKA).
- Trial name
- NCT07342894
- Where
- Turkey (Türkiye)
- Volunteers
- 207 people
- Sponsor
- Ankara City Hospital Bilkent
Rehabilitation, Telerehabilitation
Does Rehabilitation After Total Hip Or Knee Arthroplasty Work (DRAW2)
Overall frame: The overall or "parent" DRAW-project is a large-scale project run in Denmark that aims to provide substantial level 1A evidence-data related to the question: Does rehabilitation after total hip and knee…
- Conditions
- Rehabilitation, Telerehabilitation, Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee
- Trial name
- DRAW2 (NCT04960241)
- Testing
- Homebased telerehabilitation, Homebased rehabilitation, No physical rehabilitation
- Where
- Denmark
- Volunteers
- 169 people
- Sponsor
- Troels Mark Christensen