Clinical trials: Total Knee Replacement
Arthroplasty, Replacement, Knee, Pain, Postoperative
Pharmacogenomics Information in Enhancing Post-operative Total Joint Replacement Pain Management: a Pilot Study
The objective of this study is to see how pain management and its outcomes are effected when pharmacogenomic testing is used to determine patient specific pain medication and dosing.
- Trial name
- NCT02711592
- Testing
- Genetic Panel for Analgesics
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- TriHealth Inc.
Nerve Block, Regional Anaesthesia
A Comparative Study of Combined Adductor Canal and Interspace Between Popliteal Artery and Knee Capsule Versus Combined Adductor Canal and Genicular Nerve in Total Knee Arthroplasty
The aim of this study is to investigate the effectiveness of combined adductor canal block (ACB) with interspace between popliteal artery and the knee capsule (IPACK) versus combined ACB with genicular nerve block (GNB) for…
- Trial name
- NCT06864663
- Testing
- nerve block with bupivacaine 0.25%
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Ain Shams University
Osteoarthritis
Prediction of Outcomes Following Total Knee Replacement
This is an observational study (not a treatment study) of pain and physical functioning after total knee replacement. The study includes 5 visits, 1 before surgery and 4 after surgery.
- Trial name
- POKR (NCT01370421)
- Where
- United States
- Volunteers
- 248 people
- Sponsor
- Brigham and Women's Hospital
Total Knee Arthroplasty
Phase Ⅱ Study of Adductor Canal Block With HR18034 for Postsurgical Pain Management
Phase Ⅱ, randomized, double-blind, comparator-controlled study to evaluate the efficacy, safety and pharmacokinetics of single injection adductor canal block with HR18034 for postoperative pain management compared with…
- Trial name
- NCT05561309
- Testing
- HR18034;Ropivacaine Hydrochloride Injection
- Where
- China
- Volunteers
- 89 people
- Sponsor
- Shanghai Hengrui Pharmaceutical Co., Ltd.
Sleep Quality Post-TKA, Postoperative Knee Function
Doxepin Alone or Combined With Ramelteon Versus Placebo for Improving Sleep Quality After Primary Total Knee Arthroplasty
Many patients experience poor sleep during recovery after total knee arthroplasty (TKA). Disturbed sleep can last weeks to months and may worsen pain, slow healing, and reduce overall quality of life.
- Conditions
- Sleep Quality Post-TKA, Postoperative Knee Function, Quality of Life After Primary TKA
- Trial name
- NCT07598734
- Testing
- Doxepin 6 mg, Ramelteon 8 mg
- Where
- United States
- Volunteers
- 129 people
- Sponsor
- University of Washington
Knee Osteoarthritis
Influence of Knee Alignment and Pelvis Rotation on Accuracy of Radiograph Measurements Before Total Knee Arthroplasty
The aim of this study is to determine the accuracy of long leg standing X-rays with respect to coronal alignment of the knee.
- Trial name
- NCT05277883
- Testing
- CT scan
- Where
- Slovenia
- Volunteers
- 112 people
- Sponsor
- Valdoltra Orthopedic Hospital
Post-Operative Pain, Total Knee Arthroplasty
The Benefits Of Cryoablation In Patients Undergoing Total Knee Arthroplasty
The purpose of this study is to evaluate the efficacy of cryoablation use on patient-reported outcomes (PROMs) and opioid consumption following total knee arthroplasty.
- Trial name
- NCT06991231
- Testing
- Total knee arthroplasty (TKA), Cryoablation
- Where
- United States
- Volunteers
- 215 people
- Sponsor
- NYU Langone Health
Osteoarthritis
Comparing Surgery Versus Standard Physical Therapy in Treating People With a Meniscal Tear and Osteoarthritis
There are two cartilage structures, called menisci, in each knee joint. A torn meniscus can be caused by a traumatic injury or aging-related degeneration.
- Trial name
- NCT00597012
- Testing
- Arthroscopic partial menisectomy, Standard physical therapy, Postoperative rehabilitative physical therapy
- Where
- 7 sites in United States
- Volunteers
- 351 people
- Sponsor
- Brigham and Women's Hospital
Postoperative Pain, Inflammation
Steroids in Total Knee Arthroplasty
The purpose of this study is to evaluate if the use of two small doses of intravenous (IV) steroids around the time of knee replacement surgery decrease a patient's pain or use of pain medication.
- Conditions
- Postoperative Pain, Inflammation, Osteoarthritis
- Trial name
- NCT02219581
- Testing
- Dexamethasone 10 mg, Dexamethasone 20 mg, Standard multimodal pain management regimen
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Thomas L Bradbury
Total Knee Replacement
Action Observation in Knee Replacement
Postoperative rehabilitation is required for a successful outcome following total knee arthroplasty. Traditionally rehabilitative programs aim to increase range of motion, to strengthen quadriceps, to restore normal gait, and to…
- Trial name
- NCT02707419
- Testing
- Experimental group, Control group, Conventional physiotherapy
- Where
- Italy
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Arthroplasty, Replacement, Knee
Scorpio Posterior Stabilised (PS) vs Scorpio NRG ("Energize") PS - Total Knee Arthroplasty
Single-centre, prospective, randomized comparative study to compare the maximum flexion and Chair Raise achievement ratios of the Scorpio PS and and the Scorpio NRG PS. Documentation of all complications.
- Trial name
- ScorpioNRGPS (NCT02520531)
- Testing
- Scorpio PS (posterior stable), Scorpio NRG PS
- Where
- Netherlands
- Volunteers
- 84 people
- Sponsor
- Stryker Orthopaedics
Osteoarthritis, Degenerative Joint Disease
The Study of Physical Activity Rewards After Knee Surgery
The objectives of this research are to conduct a proof of concept randomized controlled trial with 200 patients undergoing primary total knee replacement (TKR) at Brigham and Women's Hospital (BWH).
- Trial name
- SPARKS (NCT01970631)
- Testing
- Motivational Interviewing (MI), Financial Incentives
- Where
- United States
- Volunteers
- 202 people
- Sponsor
- Brigham and Women's Hospital
Total Knee Arthroplasty
Conventional vs. Sensor Guided Soft Tissue Balancing in TKA RCT
To ensure a successful outcome after total knee replacement (TKR) soft tissue balance and proper implant position are very important during the surgical procedure.
- Trial name
- NCT02976428
- Testing
- Sensor Guided Soft Tissue Balancing, Standard Soft Tissue Balancing
- Where
- Canada
- Volunteers
- 184 people
- Sponsor
- Hamilton Health Sciences Corporation
Total Knee Arthroplasty
NexGen Gender Fixed Bearing Knee Versus NexGen Legacy Knee Posterior Stabilized (LPS) - Flex Fixed Bearing Knee: A Study Comparing Two Different Knee Prostheses
The purpose of this trial is to study potential differences between two prostheses, including: "feel of prosthesis" (i.e., how natural does the prosthesis feel), range of motion (ROM), pain perception for each prosthesis…
- Trial name
- NCT00901329
- Testing
- NexGen Gender Fixed Bearing Knee prosthesis, NexGen LPS-Flex Fixed Bearing Knee prosthesis
- Where
- 2 sites in Denmark
- Volunteers
- 24 people
- Sponsor
- Hvidovre University Hospital
Total Knee Arthroplasty
Effect of Ambulatory Continuous Femoral Nerve Blocks on Readiness-for-Discharge Following Total Knee Replacement
To determine if following total knee replacement, putting local anesthetic-or numbing medication-for five days through a tiny tube next to the nerves that go to the knee will decrease the time that patients need to spend in the…
- Trial name
- NCT00419276
- Testing
- Ambulatory continuous femoral nerve block for 100 hours
- Where
- 4 sites in United States, Canada
- Volunteers
- 81 people
- Sponsor
- University of California, San Diego
Knee Osteoarthritis
Interactive Virtual Telerehabilitation After Total Knee Arthroplasty
The purpose of this clinical trial is to compare the effectiveness of a new interactive virtual telerehabilitation (IVT) system with the conventional program in the rehabilitation of patients after total knee arthroplasty.
- Trial name
- REHABITIC (NCT01604174)
- Testing
- Interactive Virtual Telerehabilitation (IVT), Standard care rehabilitation
- Where
- Spain
- Volunteers
- 140 people
- Sponsor
- Parc de Salut Mar
Total Knee Arthroplasty, Rehabilitation
Knee Arthroplasty Rehabilitation Outcomes Study
The objective of the KAROS study is to compare rehabilitation outcomes between 3 proposed protocols and a current standard of care protocol for the purpose of identifying better practice for outpatient rehabilitation among…
- Trial name
- KAROS (NCT02426190)
- Testing
- Anti-gravity treadmill, PENS - neuro-muscular stimulation, Anti-gravity treadmill & PENS - neuro-muscular stimulation
- Where
- United States
- Volunteers
- 386 people
- Sponsor
- MedStar National Rehabilitation Network
Total Knee Arthroplasty, Infection
Tissue Adhaesive in Wound Closure Following Primary Total Knee Arthroplasty
The study's primary objective is to compare the following parameters between wound closure following primary TKA with and without supplement tissue adhesive (Leukosan®):
- Conditions
- Total Knee Arthroplasty, Infection, Arthroplasty Complications
- Trial name
- NCT03289247
- Testing
- tissue adhesive (Leukosan®)
- Volunteers
- 30 people
- Sponsor
- Hvidovre University Hospital
Osteoarthritis
Effect of Cutting Blades for Total Knee Arthroplasty on Implant Migration
There have been considerable efforts to control rising health care costs. One of the more recent developments is the practice of reprocessing single use medical devices.
- Trial name
- NCT01772589
- Testing
- New saw blade, Reprocessed saw blade
- Where
- Canada
- Sponsor
- Glen Richardson
Osteoarthritis, Osteoarthritis, Hip
Incorporating Wearable Technology for Enhanced Rehabilitation Monitoring After Hip and Knee Replacement
This study focuses on the impact of osteoarthritis (OA), a leading cause of disability among older adults, with the hip and knee joints being particularly affected.
- Trial name
- MOVEUP-WT (NCT06157190)
- Testing
- Unsupervised monitoring
- Where
- Belgium
- Volunteers
- 1,144 people
- Sponsor
- PXL University College