Clinical trials: Total Knee Replacement
- Condition Total Knee Replacement
- Funder type Industry (pharma, biotech, devices)
- Accepts healthy volunteers yes
Osteoarthritis, Traumatic Arthritis
Prospective Multicenter Post Approval Study of the LPS-Flex Mobile Bearing Knee
The purpose of the study is to assess the long-term performance of the NexGen LPS-Flex Mobile Bearing Knee in the treatment of patients with severe knee pain or degenerative knee disease.
- Conditions
- Osteoarthritis, Traumatic Arthritis, Avascular Necrosis of the Femoral Condyle, Moderate Varus
- Trial name
- NCT00854295
- Testing
- NexGen LPS-Flex Mobile Bearing Knee
- Where
- 3 sites in United States
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- Zimmer Biomet
Knee Osteoarthritis, Knee Pain Chronic
Kinematic Alignment vs Mechanical Alignment for Total Knee Arthroplasty
This is a prospective, randomized, single-blinded, multi-center trial comparing Kinematic Alignment vs Mechanical Alignment in TKA patients using patient reported outcomes, clinical and functional performance tests and…
- Trial name
- KA vs MA (NCT05461638)
- Testing
- Mechanical Alignment and Unrestricted Kinematic Alignment using Medacta GMK Sphere with MyKnee Custom guides, Mechanical Alignment and Restricted Kinematic Alignment using Medacta GMK Sphere with custom cutting guides
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medacta USA
Osteoarthritis
Bilateral Total Knee Arthroplasty vs Unicompartment Arthroplasty Retrospective and Clinical Outcome Study
To determine if there is a patient satisfaction preference of Total Knee Arthroplasty (TKA) vs Unicompartmental Knee Arthroplasty (UKA) in patients with bilateral knee osteoarthritis who underwent a primary TKA one side and a…
- Trial name
- NCT02583113
- Testing
- Total and Unicompartment Knee Replacement
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medacta USA
Total Knee Replacement
Long Term Foundation Knee Study
The purpose of this study is to obtain long-term (10+ yrs) clinical and patient outcomes data on patients who received the cruciate-retaining Foundation Knee system during or prior to the year 2000.
- Trial name
- NCT01274546
- Testing
- cruciate-retaining Foundation Knee system
- Where
- 2 sites in United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Encore Medical, L.P.
Total Knee Arthroplasty
Treatment With Iovera° for Total Knee Arthroplasty (TKA) Post-Operative Pain
This study is designed to investigate whether iovera° treatment prior to TKA decreases cumulative participant opioid use over the course of 6 weeks following TKA while maintaining similar levels of pain relief.
- Trial name
- NCT03327220
- Testing
- iovera°
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Pacira Pharmaceuticals, Inc
Osteoarthritis, Knee
Study of the KinexConnect Telerehabilitation System (KCTRS)
A randomized, single-blind study comparing telerehabilitation at home with continuous passive motion (CPM) and a tablet-based patient engagement application (KinexConnect) versus traditional outpatient physical therapy (PT)…
- Trial name
- KCTRS (NCT04191798)
- Testing
- Telerehabilitation using the KinexConnect system for rehabilitation after TKA., Traditional outpatient PT for rehabilitation after TKA.
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kinex Medical Company, LLC
Pain, Postoperative
An Open-Label Functionality, Safety and Efficacy Study in Patients Undergoing Elective Unilateral Knee Replacement
This study is being performed to evaluate the functionality of a device (Sufentanil NanoTab® PCA System) that has been developed for use by patients to self-administer the ARX-F01 pain medication (Sufentanil NanoTab 15 mcg) for…
- Trial name
- NCT00859313
- Testing
- Sufentanil NanoTab PCA System/15 mcg
- Where
- 3 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Talphera, Inc
Osteoarthritis
Gait and Functional Improvement in Total Knee Arthroplasty With the Use of Verasense for Soft Tissue Balancing
The primary objectives of this study are to understand the effects of soft-tissue balancing on Gait, function and rehabilitation potential after sensor-assisted Total Knee Arthroplasty and correlate Intra-operative subjective…
- Trial name
- NCT02290119
- Testing
- Sensor-assisted TKR (Verasense), Control - Without the use of Verasense
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Orthosensor, Inc.
Arthritis of the Knee
A Randomized, Study to Evaluate the Iovera° Device in Treating Pain Associated With Total Knee Arthroplasty
This study will evaluate the iovera° device in treating pain associated with total knee arthroplasty (TKA). This study will also assess if overall pain medication is reduced following TKA and will investigate the relationship…
- Trial name
- NCT02284113
- Testing
- iovera°
- Where
- 8 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Pacira Pharmaceuticals, Inc
Osteoarthritis
Medacta GMK Sphere® Multicenter Post-Market Outcomes Study
This study is to average Forgotten Knee Score (FJS) of those patients receiving the Medacta GMK Sphere® knee at the two and five year time points.
- Trial name
- NCT02501733
- Testing
- Medacta GMK Sphere® Medial Knee Prosthesis
- Where
- 5 sites in United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Medacta USA
Total Knee Arthroplasty
CT Assessment of Minimally Invasive Surgery and Computer Assisted Navigation in Total Knee Arthroplasty
The functional flexion axis of the knee can be established by computer-assisted intra-operative data, through range of motion techniques, not specific landmarks such as epicondyles.
- Trial name
- NCT00409266
- Testing
- Computer assisted navigation
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Stryker Instruments
Osteoarthritis of the Knee
Total Knee Arthroplasty Functional Outcomes Study Research Design
The purpose of this study is to obtain patient oriented and clinically oriented physical function outcomes both pre-operatively and post-operatively in patients receiving a total knee arthroplasty.
- Trial name
- NCT02228538
- Testing
- Total knee arthroplasty patients
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Restor3D
Osteoarthritis, Knee
JOURNEY™ II CR Total Knee System
The purpose of this study is to evaluate the safety and effectiveness of the JOURNEY™ II CR Total Knee System in subjects with degenerative joint disease (DJD) requiring primary total knee replacement.
- Trial name
- NCT02440672
- Testing
- JOURNEY™ II CR Total Knee System (J II CR TKS)
- Where
- 9 sites in United States, Spain and 1 more
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Smith & Nephew, Inc.
Joint Disease
Gait and Functional Outcomes Study Following Total Knee Arthroplasty With Medial-pivot or Posterior-stabilized Implants
MicroPort Orthopedics (MPO) is conducting this study to build upon the results of a previous study which showed the Medial Pivot (MP) system required lower quadriceps activation than subjects implanted with a Posterior stabilized…
- Trial name
- GOLD (NCT02589197)
- Testing
- Group 1 (Medial-Pivot), Group 2 (Posterior-Stabilized)
- Where
- 2 sites in Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- MicroPort Orthopedics Inc.
Knee Arthroplasty, Total
Evaluation of Navigation-Assisted TKA Using Mechanical vs. Restricted Kinematic Alignment
The purpose of this study is to evaluate both clinical measures and PROMs in patients undergoing total knee arthroplasty (TKA) using restricted inverse kinematic alignment (iKA) compared to mechanical alignment (MA), both using…
- Trial name
- NCT05516381
- Testing
- Optetrak Logic CR Knee System
- Where
- Spain
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Exactech
Osteoarthritis
Fixed Bearing Versus Mobile Bearing Patient Satisfaction and Clinical Outcome Study
The purpose of this study is to determine if there is a patient satisfaction preference of Fixed Bearing versus Mobile Bearing Unicompartmental Knee Arthroplasty (UKA) in patients who are at a minimum two years post operative.
- Trial name
- NCT02633085
- Testing
- Fixed Bearing or Mobile Bearing UKA
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medacta USA
Osteoarthritis
Single-use Efficiency Instruments With Patient Specific Technique (MyKnee®) Versus Traditional Metal Instruments With Conventional Surgical Technique
To compare economic factors and the rate of adverse events between two types of instrumentation used for total knee replacement: Single-use Efficiency Instruments with Patient Specific Technique (MyKnee®) Traditional Metal…
- Trial name
- NCT03148379
- Testing
- Customized patient instruments, Traditional Metal Instruments
- Where
- 5 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Medacta USA
Osteoarthritis, Knee
A Study of the Construct Validity of Community Walking Speed Data Collected Remotely With the Canary canturioTM te Tibial Extension
The purpose of this study is to determine the construct validity of the Canary Tibial Extension's measure of self-selected community walking speed.
- Trial name
- NCT05539326
- Testing
- Performance Clinical Outcome Test
- Where
- 6 sites in United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Canary Medical
Arthroplasty, Knee Replacement, Wound Healing
Zip® Surgical Skin Closure Device vs. Staples for Skin Closure in Subjects Having Undergone Bilateral Knee Arthroplasty
Study designed to compare the Zip Surgical Skin Closure device vs. conventional staples for wound closure following bi lateral knee replacement surgery.
- Trial name
- NCT02460172
- Testing
- Zip Surgical Skin Closure, Steel Staples
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- ZipLine Medical Inc.
Osteoarthritis of Knee, Edema
Microcurrent Stimulation Reduces Post-Operative Swelling and Healing Time Following Knee Replacement Surgery
The purpose of this study is to determine if patients undergoing a total knee arthroplasty (TKA) experience a clinically significant reduction in healing time when treated post operatively with a specific form of micro and…
- Conditions
- Osteoarthritis of Knee, Edema, Wounds and Injuries
- Trial name
- NCT02623660
- Testing
- ODIN1, Standard Care, Diagnostic Device Testing
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Bioelectric Research Corporation