Clinical trials: Total Blood Loss
Osteoarthritis
Study Comparing Peri-articular Injection of Bupivacaine With and Without Epinephrine
This study involves research. The purpose of this research is to formally investigate the hemostatic efficacy of epinephrine to minimize blood loss after total joint arthroplasty.
- Trial name
- NCT00737139
- Testing
- Peri-articular injection of marcaine/epinephrine, Peri-articular injection of marcaine alone
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Hemorrhage Postoperative, Anterior Cruciate Ligament Rupture
Oral Administration of Tranexamic Acid in Anterior Cruciate Ligament Surgery Reduce Postoperative Haemarthrosis
To find superiority relationship between oral and intravenous administration of tranexamic acid on peroperative and postoperative blood loss, haemarthrosis prevalence and improvement functional prognosis in anterior cruciate…
- Conditions
- Hemorrhage Postoperative, Anterior Cruciate Ligament Rupture, Arthroscopy, Total Blood Loss
- Trial name
- NCT04855877
- Testing
- Oral tablet
- Where
- Belgium
- Volunteers
- 104 people
- Sponsor
- University of Liege
Bleeding, Transfusion Related Complication
Use of Transexamic Acid in Hip Replacement
Studies have shown that tranexamic acid reduces blood loss and transfusion need in patients undergoing total hip arthroplasty. However, no to date, no study has been large enough to determine definitively whether the drug is safe…
- Trial name
- NCT02587845
- Testing
- Tranexamic Acid (IV), Tranexamic Acid (Topical)
- Where
- South Korea
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Blood Loss
Blood Loss Between Surgical Blade and Unipolar Electrocautery in TKA
Using of surgical blade may have less blood loss than unipolar electrocautery in Total Knee Arthroplasty (TKA).
- Trial name
- TKA (NCT02108327)
- Testing
- surgical blade, electrocautery
- Where
- Thailand
- Volunteers
- 80 people
- Sponsor
- Thammasat University
Arthroplasty, Replacement, Knee
The Combined Efficacy of Evicel and Tranexamic Acid on Total Knee Arthroplasty
Total knee arthroplasty is a surgical procedure that involves a significant amount of blood loss and it has always been the surgeons' goal to try to minimize blood loss.
- Trial name
- NCT02553122
- Testing
- Evicel, tourniquet
- Sponsor
- Montefiore Medical Center
Blood Loss
Intravenous Versus Topical Administration of Low Dose Epinephrine Plus Combined Administration of Intravenous and Topical Tranexamic Acid (TXA)for Primary Total Knee Arthroplasty
The purpose of this study is to compare the blood loss of intravenous and topical administration of low dose epinephrine plus combined administration of intravenous and topical tranexamic acid for primary total knee arthroplasty.
- Trial name
- NCT02860221
- Testing
- Tranexamic acid (TXA), Epinephrine
- Where
- China
- Volunteers
- 210 people
- Sponsor
- Southwest Hospital, China
Anticoagulant Antagonist Toxicity
Strategies for Protamine Dosing After Anticoagulation in Cardiovascular Surgery
In cardiovascular surgery, patients are anticoagulated with heparin during cardiopulmonary bypass, subsequently, anticoagulation is reversed with protamine to reduce bleeding due to residual heparin-induced coagulopathy, which…
- Trial name
- SEPARATION (NCT04628884)
- Testing
- Conventional dose, Dosing according residual heparin
- Where
- Colombia
- Volunteers
- 136 people
- Sponsor
- Fundación Clínica Shaio
Intraoperative Blood Loss
Rectal Misoprostol in Women Undergoing Total Abdominal Hysterectomy for Intraoperative Blood Loss Reduction
Comparing of the intraoperative blood loss between group rectal misoprostol group and control group
- Trial name
- NCT05862428
- Testing
- Rectal misoprostol
- Where
- Thailand
- Volunteers
- 56 people
- Sponsor
- Queen Savang Vadhana Memorial Hospital, Thailand
Blood Loss After Primary Total Joint Arthroplasty, Need for Blood Transfusion After Total Joint Arthroplasty
Oral vs. Intravenous TXA Study Proposal: TJA
Purpose: Examine oral and intravenous Tranexamic Acid (TXA) to determine whether or not the different routes of drug administration are equivalent in terms of post-operative reduction in hemoglobin, number of transfusions, and…
- Trial name
- NCT02233101
- Testing
- Oral Tranexamic Acid, Intravenous Tranexamic Acid
- Where
- United States
- Volunteers
- 167 people
- Sponsor
- Rush University Medical Center
Blood Loss, Surgical
Suction Drainage in the Management of Peri-operative Bleeding in Total and Unicomcompartmental Knee Arthroplasty
Although, suction drainage is routinely used in orthopedic clinical practice, there are still no precise guidelines on its use in total joint arthroplasty, particularly in total as well as unicompartmental knee arthroplasty.
- Trial name
- NCT04508101
- Volunteers
- 153 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Infection, Bleeding
Effects of Microcrystalline Titanium Dioxide With Covalently Linked Monovalent Silver Ions on Complications After Total Hysterectomy
Total hysterectomy is one of the most performed surgical procedures in the world and it is associated with post-operative complications.
- Conditions
- Infection, Bleeding, Complication, Postoperative
- Trial name
- ISTIAB-1 (NCT03789799)
- Testing
- TIAB: microcrystalline titanium dioxide with covalently linked monovalent silver ions
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Università degli Studi dell'Insubria
Avascular Necrosis of Hip
THRA_hematologic Variables
Total hip replacement arthroplasty is a surgery having intra- and postoperative substantial blood loss. The investigators will investigate the relationship between the various hematologic variables and postoperative bleeding…
- Trial name
- NCT01521858
- Where
- South Korea
- Volunteers
- 73 people
- Sponsor
- Seoul National University Bundang Hospital
Osteoarthritis of Knee
Temporary Clamping of Drains Combined With Tranexamic Acid Reduce Blood Loss After TKA: A Prospective RCT
Total knee arthroplasty (TKA) may be associated with significant blood loss, and transfusion carries substantial risk of immunologic reaction and disease transmission.
- Trial name
- NCT01449552
- Testing
- Tranexamic acid, Drain clamping, Drain clamping and tranexamic acid
- Volunteers
- 240 people
- Sponsor
- Mahidol University
Thromboembolic Events, Post-operative Bleeding
Frequency of Vascular Events With Short-term Thromboprophylaxis in Fast-track Hip and Knee-arthroplasty.
There are many different views regarding ideal duration and type of thromboprophylaxis after hip or knee surgery. An important factor in Fast-track surgery is early mobilization, which in itself is thought to prevent clotting.
- Trial name
- FETA (NCT01557725)
- Where
- 6 sites in Denmark
- Volunteers
- 4,924 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Hip Arthroplasty Replacement
Changes in Perioperative Blood Volume and Fluid Distribution in Patients Undergoing Primary Total Hip Replacement.
Clinical assessment of bleeding and calculation of perioperative blood loss do not provide an accurate estimate of blood volume.
- Trial name
- NCT06888908
- Where
- Denmark
- Volunteers
- 25 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Hip Replacement, Postoperative Hemorrhage
Topical Application of Tranexamic Acid Reduces Postoperative Blood Loss in Total Hip Arthroplasty
Tranexamic acid has been shown to reduce postoperative blood losses and transfusion requirements in a number of types of surgery.
- Trial name
- NCT01260818
- Testing
- Tranexamic Acid, normal saline
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine
Hepatocellular Carcinoma
Total Hemihepatic Vascular Exclusion in Hepatectomy in Hepatocellular Carcinoma Treatment
Total hemihepatic vascular exclusion(THHVE),completely isolates the right or left hemiliver ipsilateral to the lesion that requires resection from the systemic circulation,has the advantage of preventing backflow hemorrhage or…
- Trial name
- NCT00827047
- Testing
- Total hemihepatic vascular exclusion, Hemihepatic vascular Clamping, Pringle's Maneuver
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Eastern Hepatobiliary Surgery Hospital
Arthritis
Prospective Evaluation of Vitagel for Reduction in Blood Loss and Pain Following Unilateral Total Knee Arthroplasty
Vitagel® is an FDA approved class III medical device. It is a surgical hemostat, which has been shown to control bleeding during orthopaedic, cardiac, hepatic, and general surgical procedures.
- Trial name
- NCT01027286
- Testing
- Vitagel
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- The Cleveland Clinic
Osteoarthritis
Evaluation of Short-term Effects of Tourniquet Use in Different Ways During Total Knee Arthroplasty
To study the short-term effects of tourniquet use in different ways in total knee arthroplasty,60 patients were randomly divided into 2 groups (30 cases/group): group A using the tourniquet throughout the operation, and group B…
- Trial name
- NCT02102581
- Testing
- short time tourniquet
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking Union Medical College Hospital
Blood Loss, Surgical
Tranexamic Acid for Total Knee Arthroscopy
The purpose of this investigation is to determine the most effective regimen of administration of tranexamic acid to improve clinical outcome among patients undergoing total knee arthroplasty.
- Trial name
- NCT04443920
- Testing
- Tranexamic acid (TXA)
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- The Miriam Hospital