Clinical trials: Topical Anesthesia
Pain
Topical Anesthesia in Small Gauge Vitrectomy
The use of topical anesthetics is a non invasive option avoiding local or general anesthesia in small gauge vitrectomy without causing intolerable pain
- Trial name
- Anesthesia (NCT01022879)
- Testing
- vitrectomy
- Volunteers
- 30 people
- Sponsor
- Asociación para Evitar la Ceguera en México
Atrial Fibrillation
Effects of Topical Local Anesthesia of Pulmonary Vein Combined With Vagus Nerve Block on the Incidence of Atrial Fibrillation After Thoracic Surgery
This study intends to explore a new therapy to reduce the incidence of atrial fibrillation in thoracic patient who receive video-assisted thoracoscopic lobectomy .The results of the study are to assess the effects of this new…
- Trial name
- NCT03919786
- Testing
- topical local anesthesia of pulmonary vein combined with vagus nerve block
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Han Yuan
Cataract
Clinical Outcomes of Sedation in Cataract Surgery Performed Under Topical Anesthesia
This study aims to evaluate the clinical outcomes of different sedation strategies in patients undergoing cataract surgery performed under topical anesthesia.
- Trial name
- SADCAT (NCT07347886)
- Testing
- Normal Saline, Midalozam, Fentanyl (IV)
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Istanbul University - Cerrahpasa
Anesthesia, Local
Soft Mist Nasal Administration Device for Topical Anaesthesia of the Nasal Cavity
Rationale: Effective and fast topical anesthesia of the nasal mucosa is of paramount importance for nasal instrumentation like nasal fiberoptic procedures, awake nasal fiberoptic intubation and placement of nasogastric tubes.
- Trial name
- NCT06205680
- Testing
- NAA for topical anaesthesia of the nasal cavity
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Ophthalmology, Cataract Surgery Anesthesia
An Extension Test of Whether to Use Oral Anti-anxiety Drugs (Alprazolam) When Patients Choose Second Eye Cataract Surgery After Unblinding, and Analyze Their Anxiety, Satisfaction and Pain Satisfaction
Phacoemulsification is one of the most used surgical methods for cataract surgery today, and the surgeries are under the anesthetic and sedative to make it comfortable and safe for patients.
- Conditions
- Ophthalmology, Cataract Surgery Anesthesia, Oral Anxiolytic, Satisfaction Survey
- Trial name
- NCT06874452
- Testing
- Alprazolam (Xanax)
- Where
- Taiwan
- Volunteers
- 250 people
- Sponsor
- National Taiwan University Hospital
Local Anesthetics, Ultrasound Guidance
Duplex Guided Application of Local Anesthetic Before Femoral Artery Catheterization
The aim of this study is to evaluate the optimization of local anesthetic effect with duplex ultrasound-guided injection of lidocaine before femoral artery puncture during diagnostic or therapeutic interventional procedures.
- Conditions
- Local Anesthetics, Ultrasound Guidance, Catheterization
- Trial name
- NCT00903825
- Testing
- Ultrasound guided injection of femoral local anesthetic (lidocaine), Injection of femoral local anesthetic (lidocaine) with manual palpation
- Where
- Greece
- Volunteers
- 200 people
- Sponsor
- University of Patras
Postoperative Pain
Topical Ketamine Versus Caudal Ketamine for Postoperative Analgesia in Children Undergoing Inguinal Herniotomy
To find alternatives to caudal analgesia that could be more safe and effective and to demonstrate the analgesic efficacy of topical ketamine.
- Trial name
- TKversusCK (NCT02462174)
- Testing
- Ketamine, Bupivacaine
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Assiut University
Lumbar Puncture, Topical Analgesia
Jet Injection of 1% Buffered Lidocaine Versus Topical EMLA for Local Anesthesia Before Lumbar Puncture in Children
The purpose of this study is to evaluate the effectiveness of a needle-free jet-injection system with 1% buffered lidocaine for local anesthesia for lumbar punctures compared to a topical anesthetic agent.
- Trial name
- JTIP (NCT01628874)
- Testing
- J-Tip, EMLA, Lidocaine
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Esophagogastroduodenoscopy
Usefulness of Lidocaine as Topical Pharyngeal Anaesthesia in Esophagogastroduodenoscopy Under Sedation With Propofol
The purpose of this study is to determine the efficacy of application of the anaesthesia topical pharyngeal with lidocaine in esophagogastroduodenoscopy under propofol´s sedation, in therms of dosage and side effect´s reduction…
- Trial name
- NCT01489891
- Testing
- Lidocaine
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario Infanta Cristina
Conscious Sedation
Dexmedetomidine and Pregabalin for Conscious Sedation During Cataract Surgery
Although topical anesthesia by eye drops for cataract surgery is a non-invasive technique but it may provide insufficient anesthesia which requires the intraoperative use of additional topical local anesthetics and raises the…
- Trial name
- NCT03735368
- Testing
- Dexmedetomidine Injection, Pregabalin Oral Capsule, topical anesthesia
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Abd-Elazeem Abd-Elhameed Elbakry
Airway Complication of Anesthesia
Role of Airway Topicalization in Awake Fiberoptic Intubation
Airway management is an integral part of general anesthesia. Difficult airway management may lead to various adverse events such as airway trauma, up to cardiopulmonary arrest.
- Trial name
- NCT06720220
- Testing
- Dexmedetomidine Hydrochloride, Nebulization, Atomization
- Where
- Egypt
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Retinopathy of Prematurity
Incidence of Hypoxia During Intravitreal Anti-VEGF (Vascular Endothelial Growth Factor) Injections for Retinopathy of Prematurity (ROP) Under Topical Anesthesia
Purpose: To evaluate the incidence and severity of hypoxia and address a genuine evidence gap focusing on intraprocedural hypoxia during bedside intravitreal ranibizumab injection for retinopathy of prematurity (ROP), an area…
- Trial name
- NCT07701759
- Testing
- ranibizumab
- Where
- Saudi Arabia
- Volunteers
- 74 people
- Sponsor
- Minia University
Dental Trauma, Local Anesthesia
Clinical Efficiency of Xanthan Hydrogels Containing Local Anesthetics Encapsulated in Nanostructured Lipid Carries
In a crossover, randomized, placebo-controlled, double-blind study, 40 volunteers will receive the following formulations: hydrogels containing LAs (local anesthetic) - lidocaine and prilocaine (both at 2.5%) encapsulated in CLN…
- Conditions
- Dental Trauma, Local Anesthesia, Oral Cavity Disease
- Trial name
- NCT05912335
- Testing
- Topical anesthetic
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Pain
Topical Local Anaesthesia and Cooling During Capsaicin 8% Patch Application
Aim of the study is to demonstrate superiority of a continuous cooling of the skin over topical EMLA or placebo in reducing the burning pain during the application of capsaicin 8% patch ("Qutenza").
- Trial name
- LACCA (NCT01523951)
- Where
- Austria
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Dental Anxiety, Dental Fear
The Effect of Rubber Dam on Objective and Subjective Parameters of Stress During Dental Treatment in Children
Although rubber dam application provides many advantages, several pediatric dentists avoid using it, arguing that it may increase stress for young patients.
- Conditions
- Dental Anxiety, Dental Fear, Rubberdam, Anesthesia, Dental
- Trial name
- NCT06779448
- Testing
- Evaluation of objective and subjective stress parameters caused by local anesthesia during treatments, Evaluation of objective and subjective stress parameters caused by topical anesthesia during treatments, Evaluation of objective and subjective stress parameters caused by the application of rubber dam during treatments in the patient and dentist
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University
Wounds, Local Anesthesia
To Evaluate Reduction of Pain in Wounds Treatment Previously Applying Lidocaine Topical Solution vs Placebo
The purpose of this study is to evaluate if applying a lidocaine topical solution before wounds treatment decreases the pain of the procedure in comparison with placebo solution.
- Trial name
- NCT02584335
- Testing
- Lidocaine solution ("A"), Saline solution ("B")
- Where
- Spain
- Volunteers
- 7 people
- Sponsor
- Hospital Universitari de Bellvitge
Cataract Surgery
Music Listening for Cataract Surgery
The purpose of the study is to assess the effect of music therapy on anxiety and hypertension during cataract surgery procedures performed under topical anaesthesia.
- Trial name
- MUSICATOP (NCT02892825)
- Testing
- Music, No Music
- Where
- France
- Volunteers
- 313 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Throat Disorder
Pretreatment to Reduce Pain and Discomfort During Fiberoptic Nasal Pharyngoscopy and Laryngoscopy
Fiberoptic laryngoscopy (FOL) is one of the most common procedure done in an Ear Nose Throat (ENT) clinic. Topical anesthesia or decongestant or both have been used to improve patient comfort level during the procedure.
- Trial name
- NCT03620513
- Testing
- Decongestant (oxymetazoline 0.05%), Anesthesia (Lidocaine 15%), Decongestants and Anesthesia (oxymetazoline and lidocaine)
- Where
- Nepal
- Volunteers
- 160 people
- Sponsor
- Lumbini Medical College
Anesthesia, Local
Lidocaine Administration Using STAR Particles
This study is being done to answer the question: Do STAR particles (tiny pieces of ceramic with small spikes) help numbing gel (a gel that helps you feel less pain) work more quickly to provide local anesthesia or numbing in a…
- Trial name
- NCT06034340
- Testing
- LET Gel after STAR Particle Application (Right or Left Arm), LET Gel Application without STAR Particle Application (Contralateral Arm)
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Emory University
Topical Anesthesia
Impact of Topical Pharyngeal Anesthetics on Discharge of the Patients When Used in Conjunction With Propofol Sedation in Routine EGD's
To find out if the administration of the local pharyngeal anesthetic, lidocaine, in conjunction with Propofol during elective Esophagogastroduodenoscopy (EGD) is useful, safe and impacts the time of discharge of patient compared…
- Trial name
- NCT02507440
- Testing
- Lidocaine, Propofol
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Bassett Healthcare