Clinical trials: Tooth Decay
Caries, Dental
Efficacy of Licorice on Reducing Salivary Streptococcus Mutans Versus Chlorohexidine in Caries Risk Patients
To compare the effect of a natural herbal licorice containing preventive measure alternative to chlorohexidine preventive measure to decrease the effect of streptococcus mutans.
- Trial name
- NCT03590977
- Testing
- licorice extract mouthwash, chlorohexidine mouthwash
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Cairo University
Caries,Dental
Correlation Between Caries Experience in Primary Molars and First Permanent Molars
A cross- sectional observational study which will investigate whether data of past caries experience of the primary molars of 6-9 years old children can serve as an indicator for caries development in first permanent molars.as…
- Trial name
- NCT03671200
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Caries, Tooth Demineralization
"Comparison of the Effects of Resin Infiltrant, Fluoride Varnish, and the Combined Application of Resin Infiltrant and Fluoride Varnish on Primary Molars in the Treatment of Proximal Non-Cavitated Carious Lesions in Children."
Purpose: This randomized controlled clinical trial aimed to compare the effectiveness of fluoride varnish, resin infiltrant, and their combination in treating superficial proximal carious lesions in primary molars of children…
- Conditions
- Dental Caries, Tooth Demineralization, Pediatric Dentistry, Molar, Deciduous
- Trial name
- NCT07112963
- Testing
- Fluoride Varnish
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Sacide Duman
Dental Caries, Teeth Loss
The Effect of Bitewing Radiography on Outcomes and Costs of Treating Caries in Permanent Teeth
Dentists commonly use bitewing radiographs (dental X-rays) together with a visual-tactile (clinical) examination to detect cavities between the back teeth.
- Conditions
- Dental Caries, Teeth Loss, Necrosis of Pulp, Irreversible Pulpitis
- Trial name
- BROCC (NCT07882693)
- Testing
- Visual-tactile caries examination, Visual-tactile caries examination and bilateral bitewing radiography
- Where
- Finland
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Jukka Leinonen
Malnutrition, Child
Chronic Malnutrition and Oral Health Status in Children Aged One to Five Years
Malnutrition is a public health problem that can exert a negative impact on the general and oral health of children. The aim of the present study was to evaluate the effect of chronic malnutrition on the oral health of children…
- Trial name
- NCT03529500
- Testing
- Caries detection - dmtf index, Saliva flow rate, Saliva Buffering Capacity
- Where
- Brazil
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Molar Incisor Hypomineralisation, Enamel Breakdown
Correlation Between Colour of Defect and Enamel Breakdown in First Permanent Molars With Molar Incisor Hypomineralisation (MIH)
Cheese molars (MIH) can be recognized not only by their colour abnormalities but also by the enamel breakdown. Clinical management of those teeth may become challenging by the chronic hypersensitivity, that makes various steps…
- Conditions
- Molar Incisor Hypomineralisation, Enamel Breakdown, Colour of Defect
- Trial name
- MIH (NCT07727200)
- Where
- Switzerland
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Basel
Dental Caries
Evaluation of Anti-biofilm Effects of Ferumoxytol (Feraheme) Using an in Situ Biofilm Demineralization Model
To evaluate the effects of a clinically approved and commercially available iron oxide formulation Ferumoxytol (Feraheme®) to control cariogenic biofilms and enamel demineralization.
- Trial name
- NCT03678012
- Testing
- Ferumoxytol/Hydrogen peroxide, Hydrogen Peroxide, Water
- Where
- 2 sites in United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Dental Caries
Comparative Evaluation of Effectiveness of Hall Technique and Resin Modified Glass Ionomer Cement in Controlling Occlusoproximal Caries in Primary Molars in Children
•To investigate clinical and radiographic outcomes of Hall Technique and conventional restorative care using RMGIC in occulusoproximal carious lesions of primary molars in children.
- Trial name
- NCT04355000
- Testing
- Hall technique, RMGIC restoration
- Where
- India
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Dental Caries
DPBRN Longitudinal Study of Questionable Occlusal Caries Lesions
The purpose of this study will allow us to observe and follow the subjects' treatment from DPBRN Prevalence of Questionable Occlusal Caries Lesions Study over a 24 month period.
- Trial name
- NCT01309971
- Where
- 7 sites in United States, Denmark
- Volunteers
- 2,624 people, healthy volunteers welcome
- Sponsor
- Dental Practice-Based Research Network
Dental Anxiety, Child Development
Relationship Between Children's Colour Preferences and Their Dental Anxiety
The objective of this study was to examine the relationship between children's color preferences and their dental anxiety. It aims to answer are: 1.
- Trial name
- NCT06484998
- Testing
- Dental anxiety level and child's compomer colors selection
- Where
- Turkey (Türkiye)
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- Bulent Ecevit University
Smoking, Obesity
TEACH: Technology Evaluation to Address Child Health
The proposed study is a pre- /post-implementation study in a pediatric practice with a control practice designed to test the feasibility and effectiveness of an electronic screening and service delivery tool for three modifiable…
- Conditions
- Smoking, Obesity, Dental Caries
- Trial name
- TEACH (NCT02912000)
- Testing
- TEACH intervention
- Where
- United States
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Dental Caries
Two Years Survival Rate of Class II ART Restorations in Primary Molars Using Two Ways to Avoid Saliva Contamination
AIM: To evaluate influence of two methods to avoid saliva contamination on the survival rate of atraumatic restorations in primary molars.
- Trial name
- NCT01924611
- Testing
- Atraumatic Restorative Technique using cotton rolls, Atraumatic Restorative Technique
- Where
- Brazil
- Volunteers
- 232 people
- Sponsor
- Federal University of Paraíba
Dental Caries
Evaluation of the Salivary-free Amino Acids Levels (Glycine , Proline , Lysine , and Alanine ) With Caries Activity
This study will be aimed to investigated the correlation between levels of salivary amino acids (glycine , proline , lysine , alanine ) in the saliva of healthy children with and without active carious lesions and to estimate the…
- Trial name
- NCT06953557
- Testing
- To compare the effect of salivary glycine , proline , lysine and alanine concentration between participants with high caries activity and participants with negative caries activity
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Al-Mustansiriyah University
Dental Caries
Masticatory Performance in Mixed Dentition Children Before and After Dental Treatment
This prospective clinical study aimed to evaluate the effects of dental treatment on masticatory performance and food preferences in children during the mixed dentition period.
- Trial name
- NCT07271901
- Testing
- Dental Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- TC Erciyes University
Salivary Calcium
Salivary Calcium in Post-menopausal Women and Prevalence of Dental Caries
Different phases of a woman's life are puberty, menses, pregnancy, and menopause. Menopause is one of the normal developmental stages in a woman's life, marks the permanent cessation of menstruation.
- Trial name
- NCT05205057
- Testing
- Saliva
- Where
- India
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ajman University
Caries, Dental
Clinical Performance of an Alkasite-based Restorative Material
The evolution of restorative dental materials and technology has enabled the use of tooth-colored restorative materials in dental restorations, with all dentists hoping for the presence of materials that combine biocompatible…
- Trial name
- NCT06317857
- Testing
- Centio Forte
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Caries
Post-Approval Clinical Study to Evaluate the Calcivis Caries Activity Imaging System
This is a prospective, multi-centre, post-approval clinical study to assess the safety and the performance of the Calcivis Caries Activity Imaging System in aiding the identification of active caries lesions on the occlusal…
- Trial name
- NCT02098304
- Testing
- Calcivis Caries Activity Imaging System
- Where
- 3 sites in United Kingdom
- Volunteers
- 42 people
- Sponsor
- Calcivis Ltd
Dental Caries
Supervised Toothbrushing and Oral Health Education in Primary Schools in Saudi Arabia
The goal of this pilot study is to assess the feasibility of implementing school-based oral health programmes including supervised toothbrushing and oral health education.
- Trial name
- NCT07091578
- Testing
- Supervised toothbrushing, Oral Health Education
- Where
- Saudi Arabia
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- Fatimah Alshehri
Orthodontics, White Spot Lesions [Initial Caries] on Smooth Surface of Tooth
Orthodontic Treatment on Oral Microbiota and Salivary Proteins
Study on the changes in oral microbiota during orthodontic treatment in patients aged 8-18 years. Orthodontic patients treated at Stomatology Hospital of Xi'an Jiaotong University from March 2025 to March 2027 will be recruited.
- Conditions
- Orthodontics, White Spot Lesions [Initial Caries] on Smooth Surface of Tooth, Caries, Dental
- Trial name
- NCT06824493
- Testing
- no interventions, No Intervention: Observational Cohort
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Xi'an Jiaotong University
Dental Caries, Dental Anxiety
Er:YAG Laser Therapy in Combination With Behaviour Management Technique in Reducing Anxiety Among Paediatric Patients
The aim of the study is to assess the efficacy of a modified version of the behaviour management technique Latent inhibition in combination with Er:YAG laser for achieving reduction of dental anxiety in paediatric dental…
- Conditions
- Dental Caries, Dental Anxiety, Behavior
- Trial name
- NCT04924452
- Testing
- Laser conditioning and Sealant application, Sealant application, Er:YAG laser therapy
- Where
- Bulgaria
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Plovdiv Medical University