Clinical trials: Tooth Caries
Dental Caries
A Clinical Study to Assess an Experimental Dentifrice in an Experimental Model of Early Stage Caries
The aim of this study is to evaluate the relative efficacy of an experimental dentifrice containing 1150 parts per million (ppm) fluoride (as sodium fluoride [NaF]) to remineralize early stage caries type lesions in an in situ…
- Trial name
- NCT06949072
- Testing
- Test Dentifrice, Reference Dentifrice, Negative Control Dentifrice
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- HALEON
Tooth; Lesion, White Spot Lesions
Remineralisation of White Spot Lesions by Elmex® gelée in Post-orthodontic Patients
The aim of this study is to monitor the effect of intraoral topical high fluoride application on the development of white spot lesions (WSL) after orthodontic treatment with multibracket appliances and to compare it to a placebo.
- Trial name
- NCT01329731
- Testing
- elmex® gelée
- Where
- Germany
- Volunteers
- 48 people
- Sponsor
- Gaba International AG
Dental Caries
Clinical Evaluation of 3M™ ESPE™ Adper™ Scotchbond™ SE Self-Etch Adhesive in Class I and Class II Restorations in Adults
The purpose of this study is to evaluate the performance of a new dental adhesive system in the restoration of Class I and Class II cavities in adult teeth.
- Trial name
- NCT00658138
- Testing
- 3M ESPE Adper Scotchbond SE, 3M ESPE Adper Scotchbond 1XT
- Where
- Italy
- Volunteers
- 61 people
- Sponsor
- Solventum US LLC
Dental Caries in Children
Multi-Media Parent-based Intervention to Promote Dental Hygiene Among Young Children: BeReady2Smile
This application, BeReady2Smile, will promote dental health behavioral parenting strategies among parents by incorporating a behavioral program for their children.
- Trial name
- BR2S (NCT03637309)
- Testing
- BeReady2Smile Video and App
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Oregon Research Behavioral Intervention Strategies, Inc.
Dental Caries
Clinical Evaluation of Three Dental Adhesive Systems in Class V Restorations
The purpose of this study is to compare the clinical performance of three dental adhesive systems used to bond Class V cavity fillings in adult teeth.
- Trial name
- NCT00643461
- Testing
- Adhesive A, Adhesive B, Adhesive C
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Solventum US LLC
Dental Caries
Safety Evaluation of Advantage Anti-Caries Varnish
The purpose of the study is to confirm the safety of Advantage Anti-Caries Varnish.
- Trial name
- NCT02645617
- Testing
- Varnish
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Advantage Dental Services, LLC
Dental Restoration, Permanent, Dental Restorations
Clinical Investigation Measuring the Long Term Clinical Performance and Safety of Biodentine™ XP in Patients Treated for Coronal Restorative or Endodontic Dental Indications.
The aim of this present study is to collect additional data for the post-marketing follow-up of Biodentine™ XP and measure long-term (up to 10 years) performance and safety of the biomaterial in all its indications.
- Conditions
- Dental Restoration, Permanent, Dental Restorations, Endodontic Treatment
- Trial name
- BIOD XP (NCT06955429)
- Testing
- Dental restorative or endodontic treatment requiring Biodentine XP use
- Where
- 8 sites in Belgium, France
- Volunteers
- 275 people
- Sponsor
- Septodont
Dental Caries
Everybody Brush: A Community-wide Toothpaste Distribution Campaign
Dental caries (tooth decay) is a disease with significant public health implications afflicting low-income children, with marked rural disparities in disease prevalence and treatment.
- Trial name
- NCT02327507
- Testing
- Toothpaste & Telephone Support
- Where
- United States
- Volunteers
- 21,731 people
- Sponsor
- Advantage Dental Services, LLC
Dental Caries, Unsatisfactory or Defective Restoration of Tooth
Clinical Evaluation of a Bulk Fill Resin Composite
The purpose of this clinical trial is to measure the clinical outcomes of Tetric PowerFill Class I and II restorations cured in 3 seconds with the Bluephase PowerCure curing unit.
- Trial name
- NCT04686422
- Testing
- Tetric PowerFill
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Ivoclar Vivadent AG
Dental Plaque, Pus Collection
Regular Antibacterial Photodynamic Therapy on Oral Hygiene in Elderly Residents
Around 40 people will participate in the study. The study participants will be recruited from service homes in the City of Helsinki. The subjects will be randomized into two groups.
- Conditions
- Dental Plaque, Pus Collection, Oral Disease, Dryness Oral
- Trial name
- NCT05853679
- Testing
- Lumoral Treatment, Standard oral hygiene instructions according to the Finnish Dental Association
- Where
- Finland
- Volunteers
- 31 people
- Sponsor
- Koite Health Oy
Dental Plaque, Behavior
The Impact of a 21day School Brushing Intervention on the Knowledge, Behaviour and Oral Health of School Children
In this study we aim to study the effectiveness of a specially designed 21 day Brush Day and Night programme for school children aged 6-9 which aims to establish the habit of twice a day toothbrushing for oral health.
- Conditions
- Dental Plaque, Behavior, Behavior, Health
- Trial name
- NCT04001296
- Testing
- 21 day Brush Day and Night school programme
- Where
- 2 sites in Indonesia, Nigeria
- Volunteers
- 2,020 people, healthy volunteers welcome
- Sponsor
- Unilever R&D
Dental Caries
Intraoral Appliance (IOA) Model Evaluating the Efficacy of a Whitening Toothpaste
This single-center, randomized, double-blind, three-period crossover in situ study evaluated the enamel remineralization potential and fluoride bioavailability of three dentifrices-one fluoride-free negative control, one positive…
- Trial name
- NCT07419685
- Testing
- Negative Control Toothpaste, Active Comparator, Test Toothpaste
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Church & Dwight Company, Inc.
Dental Caries
Phase 2, Safety & Microbiology Study of C16G2 in Multiple Oral Gel &/or Mouth Rinse Doses to Healthy Adults
The focus of the study is to evaluate the safety of multiple study drug administrations and the study drug selectively reducing or eliminating a specific bacteria in the mouth.
- Trial name
- NCT02044081
- Testing
- C16G2 Rinse, C16G2 Gel
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Armata Pharmaceuticals, Inc.
Dental Caries
Evaluation of Oral Hygiene Products in an In Situ Caries Model
The study will evaluate and compare the potential anti-caries efficacy of a test regimen: placebo (fluoride free) toothpaste (twice daily use) plus fluoride mouthwash (once daily use), in comparison with brushing with a placebo…
- Trial name
- NCT02399163
- Testing
- Fluoride free toothpaste, Fluoride toothpaste, Fluoride mouthwash
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dental Caries
Phase 2, Open-Label Study for Safety, Microbiology and PK of Single or Multiple Oral C16G2 Gel Doses
Part A: Open-label, multiple arm, safety, microbiology and pharmacokinetic (PK) study in healthy adult male and female subjects 18-75 years of age. All subjects will be assessed for safety and microbiology parameters.
- Trial name
- NCT02254993
- Testing
- C16G2
- Where
- 2 sites in United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Armata Pharmaceuticals, Inc.
Caries Active, Caries Root
Surface Caries Feature Study
Dental caries (dental cavity) is very common and can impact oral health and oral health-related quality of life. Dental caries is when the tooth surfaces break down, and if left untreated, can cause tooth pain.
- Conditions
- Caries Active, Caries Root, Caries,Dental, Caries; Initial
- Trial name
- NCT07048444
- Testing
- N/A as observational study
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- 3Shape A/S
Dental Caries
Sequential PVP-I and FV
This prospective cohort study in children will determine if: topical povidone iodine 10% followed by topical fluoride varnish is superior to placebo iodine followed two different varnishes alone to prevent tooth decay (dental…
- Trial name
- NCT07683910
- Testing
- fluoride varnish, 2.5%, topical fluoride, 2.1%, Povidone Iodine Topical
- Volunteers
- 393 people, healthy volunteers welcome
- Sponsor
- Advantage Silver Dental Arrest, LLC
Dental Caries Class I, Dental Caries Class II
Clinical Study of Filtek™ Bulk Fill Posterior Restorative in Class I and II Restorations
Purpose of the Study:This study was to evaluate the 1 week, 1 year safety and effectiveness of dental composite resin (Filtek™ Bulk Fill Posterior Restorative) in restoring Class I and II dental cavities in posterior teeth.
- Trial name
- NCT03764059
- Testing
- Filtek™ Bulk Fill Posterior Restorative, Filtek™ Z350XT Universal Restorative
- Where
- 3 sites in China
- Volunteers
- 240 people
- Sponsor
- 3M
Tooth Loss, Dentin Caries
PMCF Study on The Performance and Safety of ON DENT® PMMA Discs/Blocks and Resin Products for Temporary Restorations
This prospective, single-center, interventional post-market clinical follow-up (PMCF) study aims to evaluate the clinical performance and safety of temporary crown and bridge restorations fabricated using CE-marked ON DENT™…
- Conditions
- Tooth Loss, Dentin Caries, Tooth Fractures
- Trial name
- NCT07632443
- Testing
- Temporary Fixed Prosthesis (Tempo-CAD Monocolor PMMA), Temporary Fixed Prosthesis (Tempo-CAD Monocolor SHT PMMA), Temporary Fixed Prosthesis (Tempo-CAD Multicolor SHT PMMA)
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- On Dent Tibbi Malzeme Dis Protez Ith. ve Ihr. San. Ltd. Sti.
Dental Caries
A Clinical Trial to Assess the Safety and the Anti-caries Efficacy of COL 101 (Arginine) Non-fluoride Dentifrices in Comparison With 0.24% Sodium Fluoride (1100 Ppm F) Dentifrice Control in 10 to 14-year-old Children
The objective of this study is to assess the safety and to evaluate the anti-caries efficacy of COL101 (arginine) non-fluoride dentifrices compared to a 0.24% sodium fluoride dentifrice in 10-14 year-old children over a one year…
- Trial name
- NCT04750902
- Testing
- 0.24% Sodium Fluoride Dentifrice, 1.5% Arginine Dentifrice, 4.0% Arginine Dentifrice
- Where
- 9 sites in United States, Puerto Rico
- Volunteers
- 2,025 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive