Clinical trials: Tonsillar Disorder
Tonsil Disease, Pain Management
Analgesic Effects of Intranasal Diclofenac Sodium, Ibuprofen, and Paracetamol in Pediatric Tonsillectomy Cases
This study aims to evaluate the efficacy and safety of intranasal Diclofenac Sodium, intranasal Ibuprofen, and intranasal Paracetamol for pain control following tonsillectomy in pediatric patients.
- Conditions
- Tonsil Disease, Pain Management, Intranasal Drug Administration
- Trial name
- NCT06731556
- Testing
- Intravenous paracetamol, Intranasal Paracetamol, Intranasal Diclofenac Sodium
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Bezmialem Vakif University
Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
Ipilimumab, Nivolumab, and Radiation Therapy in Treating Patients With HPV Positive Advanced Oropharyngeal Squamous Cell Carcinoma
This phase II trial studies the side effects and best dose of ipilimumab, nivolumab, and radiation therapy and how well they work in treating patients with advanced human papillomavirus (HPV) positive oropharyngeal squamous cell…
- Conditions
- Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Human Papillomavirus Positive Oropharyngeal Squamous Cell Carcinoma, Oropharyngeal Basaloid Carcinoma
- Trial name
- NCT03799445
- Testing
- Intensity-Modulated Radiation Therapy, Ipilimumab, Nivolumab
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- M.D. Anderson Cancer Center
Head and Neck Carcinoma, Adenoid Cystic Carcinoma
VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma
This is a multicenter, open-label, Phase 1/2 study of orally administered VMD-928 monotherapy and in combination with pembrolizumab in adult subjects with advanced solid tumors or lymphoma that have progressed or are non…
- Conditions
- Head and Neck Carcinoma, Adenoid Cystic Carcinoma, Lung Cancer, Non-Small Cell Lung Cancer
- Trial name
- NCT03556228
- Testing
- VMD-928 100 mg Tablet, VMD-928 Tablet and Pembrolizumab (200 mg)
- Where
- 15 sites in United States, Puerto Rico
- Volunteers
- 242 people
- Sponsor
- VM Oncology, LLC
Tonsil Cancer
Photon Therapy Versus Proton Therapy in Early Tonsil Cancer.
In this trial, patients with early squamous cell carcinoma of the tonsil with clinical stage T1-2 (p16-positive or p16-negative) N0-1 (p16-positive)/N0-N2b (p16-negative) according to American Joint Committee on Cancer (AJCC) 8th…
- Trial name
- ARTSCAN V (NCT03829033)
- Testing
- Radiotherapy
- Where
- 12 sites in Sweden
- Volunteers
- 100 people
- Sponsor
- Lund University Hospital
Squamous Cell Carcinoma of Oropharynx, HPV Positive Cancer
ctHPVDNA in HPV Positive Squamous Cell Carcinoma of the Oropharynx
This study is a prospective phase II trial, designed to assess the efficacy and feasibility of adjuvant treatment deintensification guided by ctHPVDNA levels for patients with HPV+OPSCC who undergo transoral surgery and neck…
- Conditions
- Squamous Cell Carcinoma of Oropharynx, HPV Positive Cancer, Throat Cancer, Tonsil Cancer
- Trial name
- NCT06915038
- Testing
- NavDx, Adjuvant Radiation 30 Gray, Adjuvant Radiation 40 Gray
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- Indiana University
HER2-positive Breast Cancer, HER2 Gene Mutation
Study of A166 in Patients With Relapsed/Refractory Cancers Expressing HER2 Antigen or Having Amplified HER2 Gene
Open-label, Phase I-II, first-in-human (FIH) study for A166 monotherapy in HER2-expressing or amplified patients who progressed on or did not respond to available standard therapies.
- Conditions
- HER2-positive Breast Cancer, HER2 Gene Mutation, HER-2 Gene Amplification, HER2 Positive Gastric Cancer
- Trial name
- NCT03602079
- Testing
- A166
- Where
- 10 sites in United States
- Volunteers
- 49 people
- Sponsor
- Klus Pharma Inc.
Obstructive Sleep Apnea Syndrome in Children
ATT Compared With ATE in OSAS Children
Non-inferiority hypothesis; adenotonsillotomy is equally good as adenotonsillectomy in treating obstructive sleep apnea syndrome (OSAS) in children after one, three and ten years.
- Trial name
- RCT ATE/ATT (NCT01676181)
- Testing
- Adenotonsillectomy, Adenotonsillotomy
- Where
- Sweden
- Volunteers
- 79 people
- Sponsor
- Karolinska University Hospital
Tonsillar Disorder
Modality of Pain Management in Ambulatory Tonsillectomy Surgery in Adults
No SFORL recommendation for adult ambulatory tonsillectomy. This study would allow the establishment of an ambulatory management during an adult tonsillectomy.
- Trial name
- DACAA (NCT04853173)
- Testing
- Assess pain management modalities in adult outpatient tonsillectomy surgery
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Pulmonary Diseases, Tonsillar Hypertrophy
The Influence of Feeding Position on Pulmonary Morbidity in Young Children
Supine feeding position is associated with serous otitis media. The hypothesis is that supine feeding is associated with recurrent otitis media, tonsillar and adenoid hypertrophy and recurrent pneumonia secondary to recurrent…
- Conditions
- Pulmonary Diseases, Tonsillar Hypertrophy, Otitis Media, Dental Caries
- Trial name
- NCT00248391
- Testing
- upright feeding
- Where
- Israel
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Gonorrhea, Infection, Bacterial
Penetration of the Innovative Antibiotic Gepotidacin Into Prostate and Tonsillar Tissue
Gepotidacin is a new antibiotic that may potentially be used to treat prostatic infections and pharyngeal gonorrhoea. To date, no data exists on gepotidacin pharmacokinetics in those tissues.
- Trial name
- AB-Direct (NCT04484740)
- Testing
- Gepotidacin
- Where
- 4 sites in Austria, France
- Volunteers
- 53 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Adenoid Hypertrophy, Tonsillar Hypertrophy
Evaluation of the Effects of Adenoidectomy and Adenotonsillectomy on Voice in Children
This prospective study aims to evaluate the effects of adenoidectomy and adenotonsillectomy on voice and speech functions in children.
- Conditions
- Adenoid Hypertrophy, Tonsillar Hypertrophy, Voice Disorders in Children
- Trial name
- NCT07399041
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Malignant Neoplasms of Lip Oral Cavity and Pharynx, Oropharyngeal Cancer
Trial of Magnetic Resonance Imaging Guided Radiotherapy Dose Adaptation in Human Papilloma Virus Positive Oropharyngeal Cancer
The goal of this clinical research study is to compare the use of MRI simulations to plan different doses of intensity modulated radiotherapy (IMRT) to the standard IMRT dose in patients with low risk human papilloma virus…
- Trial name
- NCT03224000
- Testing
- Modified Barium Swallow (MBS), Swallowing Questionnaire, Symptom Questionnaire
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- M.D. Anderson Cancer Center
Cancer of Head and Neck, Adenopathy
Interest of Bilateral Basic Tongue Mucosectomy Assisted by Robot or Laser in Combination with Tonsillectomy in the Assessment of Prevalent Cervical Lymphadenopathy
We are proposing a randomized phase II study to assess the benefit of bilateral robot-assisted or laser basal tongue mucosectomy in combination with tonsillectomy in the assessment of prevalent cervical lymphadenopathy
- Trial name
- RoboCUP (NCT04767048)
- Testing
- bilateral mucosectomy + tonsillectomy, tonsillectomy
- Where
- 5 sites in France
- Volunteers
- 72 people
- Sponsor
- Centre Francois Baclesse
Tonsil Disease, Surgical Wound
Effect of Pre-operative Oral Hydration on Post-operative Pain and Nausea in Adults Undergoing Tonsillectomy
Tonsillectomy is commonly described as one of the most painful procedures that an adult can undergo. This study's aim is to evaluate if pre-operative oral hydration has an impact in reducing post-operative pain, nausea and…
- Conditions
- Tonsil Disease, Surgical Wound, Pain, Postoperative
- Trial name
- NCT05507918
- Testing
- Oral water and clear liquids
- Sponsor
- Corewell Health East
Tonsillar Hypertrophy, Tonsillitis
Comparison of Bizact With Electroscissor for Tonsillectomy
In a randomized, partly double-blind prospective setup we want to compare traditional adult electro-scissor tonsillectomy With ultrasound Technology, Bizact.
- Trial name
- NCT03854279
- Testing
- tonsillar dissection
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Oslo University Hospital
Upper Respiratory Infection, Acute Otitis Media
Lactobacillus Rhamnosus GG in the Middle Ear and Adenoid Tonsil
The purpose of this study is to evaluate the effect of oral administration of probiotic Lactobacillus rhamnosus GG in middle ear and adenoid tonsil.
- Trial name
- NCT02110732
- Testing
- Lactobacillus rhamnosus GG
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Chronic Tonsillitis, Tonsillar Hypertrophy, Tonsillitis
Comparing Two Agents Used to Stop Bleeding During Tonsil Removal Surgery: Adrenaline Versus Hydrogen Peroxide
The goal of this quasi-experimental study is to compare the effectiveness of topical adrenaline and 3% hydrogen peroxide for controlling bleeding (hemostasis) during tonsil removal surgery in patients aged 5 to 18 years.
- Conditions
- Chronic Tonsillitis, Tonsillar Hypertrophy, Tonsillitis, Tonsillectomy
- Trial name
- NCT07675278
- Testing
- Adrenaline, Hydrogen Peroxide
- Where
- Pakistan
- Volunteers
- 64 people
- Sponsor
- Rawalpindi Medical College
Tonsillitis
Children Recovering From Tonsil Surgery
Children recovering from tonsil surgery following day surgery Tonsil surgery - self-care and treatment - the TONIST-study The main objective of this study is to evaluate the effect and experience of acupuncture, acupressure…
- Trial name
- TONIST (NCT03292068)
- Testing
- Acupuncture, acupressure, Timbal diet, Extended telephone counseling
- Where
- Sweden
- Volunteers
- 576 people, healthy volunteers welcome
- Sponsor
- Lund University
Oropharynx Squamous Cell Carcinoma, Oropharynx Cancer
Circulating Biomarkers in Oropharyngeal Cancers
The goal of this observational longitudinal study is to learn about circulating tumor Human Papilloma Virus-DNA (ctHPV-DNA) as a biomarker for HPV positive oropharyngeal cancer and cancer of unknown primary of the head and neck.
- Conditions
- Oropharynx Squamous Cell Carcinoma, Oropharynx Cancer, Tonsillar Cancer, Base of the Tongue Carcinoma
- Trial name
- CIRCOS (NCT05904327)
- Where
- Sweden
- Volunteers
- 130 people
- Sponsor
- Region Örebro County
Obstructive Sleep Apnea, Tonsillar Hypertrophy
Tonsillectomy vs. Tonsillotomy in Adults With Obstructive Sleep Apnea
The primary purpose of this randomized controlled trial s to investigate whether surgical reduction of palatine tonsils (tonsillotomy) is a superior treatment compared to complete surgical removal of palatine tonsils…
- Trial name
- NCT06376383
- Testing
- Tonsillectomy, Tonsillotomy
- Volunteers
- 464 people
- Sponsor
- University of Aarhus