Clinical trials: Tonsil Cancer
Human Papillomavirus Positive Oropharyngeal Squamous Cell Carcinoma, Oropharynx Cancer
New Modalities for Detection of Oropharyngeal Cancer
Background: The incidence of human papilloma virus-driven oropharyngeal cancer (HPV-OPC), a type of head and neck cancer, is rapidly increasing within the US. Currently, there are no screening methods for early detection.
- Conditions
- Human Papillomavirus Positive Oropharyngeal Squamous Cell Carcinoma, Oropharynx Cancer, Base of Tongue Carcinoma, Tonsil Cancer
- Trial name
- NCT03226613
- Testing
- Transcervical Oropharyngeal Ultrasound, Oral Rinse Collection, Blood Draw
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Vanderbilt University Medical Center
Cancer of Head and Neck, Adenopathy
Interest of Bilateral Basic Tongue Mucosectomy Assisted by Robot or Laser in Combination with Tonsillectomy in the Assessment of Prevalent Cervical Lymphadenopathy
We are proposing a randomized phase II study to assess the benefit of bilateral robot-assisted or laser basal tongue mucosectomy in combination with tonsillectomy in the assessment of prevalent cervical lymphadenopathy
- Trial name
- RoboCUP (NCT04767048)
- Testing
- bilateral mucosectomy + tonsillectomy, tonsillectomy
- Where
- 5 sites in France
- Volunteers
- 72 people
- Sponsor
- Centre Francois Baclesse
Oropharynx Cancer, Tonsil Cancer
Surgeon-performed Outpatient Transoral and Transcervical Ultrasound of the Oropharynx
The purpose of the study is to compare the sensitivity and specificity of transoral ultrasound, transcervical ultrasound, Magnetic Resonance Imaging (MRI) and Positron Emission Tomography-Computerized Tomography (PET-CT) in terms…
- Conditions
- Oropharynx Cancer, Tonsil Cancer, Base of the Tongue Tumor, Tonsil Hypertrophy
- Trial name
- SPOT-US (NCT05696314)
- Testing
- Transoral Ultrasound, Transcervical Ultrasound
- Where
- 3 sites in Denmark
- Volunteers
- 201 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Tonsil Cancer
Photon Therapy Versus Proton Therapy in Early Tonsil Cancer.
In this trial, patients with early squamous cell carcinoma of the tonsil with clinical stage T1-2 (p16-positive or p16-negative) N0-1 (p16-positive)/N0-N2b (p16-negative) according to American Joint Committee on Cancer (AJCC) 8th…
- Trial name
- ARTSCAN V (NCT03829033)
- Testing
- Radiotherapy
- Where
- 12 sites in Sweden
- Volunteers
- 100 people
- Sponsor
- Lund University Hospital
Tonsil Neoplasm, Oropharynx Neoplasm
Buccal Fat for Transoral Robotic Lateral Oropharyngectomy Defects to and Postoperative Pain
The goal of this randomized clinical trial is to determine the pain intensity during rest and swallowing in patients undergoing transoral robotic surgery for tonsil lesions with and without buccal fat reconstruction.
- Conditions
- Tonsil Neoplasm, Oropharynx Neoplasm, Transoral Robotic Surgery
- Trial name
- BOLT (NCT06965738)
- Testing
- Buccal fat reconstruction, No buccal fat reconstruction
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University Health Network, Toronto
Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
Ipilimumab, Nivolumab, and Radiation Therapy in Treating Patients With HPV Positive Advanced Oropharyngeal Squamous Cell Carcinoma
This phase II trial studies the side effects and best dose of ipilimumab, nivolumab, and radiation therapy and how well they work in treating patients with advanced human papillomavirus (HPV) positive oropharyngeal squamous cell…
- Conditions
- Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Human Papillomavirus Positive Oropharyngeal Squamous Cell Carcinoma, Oropharyngeal Basaloid Carcinoma
- Trial name
- NCT03799445
- Testing
- Intensity-Modulated Radiation Therapy, Ipilimumab, Nivolumab
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- M.D. Anderson Cancer Center
Oropharynx Squamous Cell Carcinoma, Oropharynx Cancer
Circulating Biomarkers in Oropharyngeal Cancers
The goal of this observational longitudinal study is to learn about circulating tumor Human Papilloma Virus-DNA (ctHPV-DNA) as a biomarker for HPV positive oropharyngeal cancer and cancer of unknown primary of the head and neck.
- Conditions
- Oropharynx Squamous Cell Carcinoma, Oropharynx Cancer, Tonsillar Cancer, Base of the Tongue Carcinoma
- Trial name
- CIRCOS (NCT05904327)
- Where
- Sweden
- Volunteers
- 130 people
- Sponsor
- Region Örebro County
Head and Neck Carcinoma, Malignant Parotid Gland Neoplasm
Customized 3D Printed Oral Stents During Head and Neck Radiotherapy
This clinical trial studies the effect of customized 3 dimensional (3D) printed oral tents on patients with head and neck cancer who are receiving radiotherapy.
- Conditions
- Head and Neck Carcinoma, Malignant Parotid Gland Neoplasm, Maxillary Sinus Carcinoma, Nasal Cavity Carcinoma
- Trial name
- NCT04870762
- Testing
- Best Practice, Medical Device Usage and Evaluation
- Where
- 7 sites in United States
- Volunteers
- 88 people
- Sponsor
- M.D. Anderson Cancer Center