Clinical trials: Tobacco Abstinence
Nicotine Dependence
Effects of Varenicline on Brain Activity During Nicotine Abstinence
This project aims to define mechanisms through which varenicline might be an effective smoking cessation medication.
- Trial name
- NCT00602927
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Nicotine Dependence, Nicotine Addiction
Effectiveness of N-Acetylcysteine (NAC) in Motivational Enhancement Therapy for Nicotine Addiction
The goal of this clinical trial is to determine the effectiveness of the combination of n-acetylcysteine and motivational enhancement therapy on laboratory improvement in the form of changes in blood nicotine, radiological…
- Trial name
- NCT05903014
- Testing
- n-acetylcysteine, Motivational Enhancement Therapy
- Where
- Indonesia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Smoking Cessation
A Second Study of NicVAX/Placebo as an Aid for Smoking Cessation
The purpose of this study is to evaluate NicVAX as an aid to smoking cessation for long term abstinence.
- Trial name
- NCT01102114
- Testing
- NicVAX Vaccine
- Where
- 25 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Nabi Biopharmaceuticals
Smoking Cessation
Smoking Cessation in Hospitalized Smokers
When smokers are hospitalized they quit smoking, either voluntarily or involuntarily. Most of them, however, go back to smoking soon after discharge.
- Trial name
- NCT01289275
- Testing
- Nicotine Patches, Telephone Counseling, Brief Hospital Counseling
- Where
- 6 sites in United States
- Volunteers
- 1,270 people
- Sponsor
- University of California, San Diego
Smoking Cessation
Telephone Counseling and the Distribution of Nicotine Patches to Smokers
The primary purpose of this study is to determine the effects of distributing free nicotine replacement therapy (NRT) to tobacco quitline callers directly. Specifically, this study aims to: 1.
- Trial name
- NCT00851357
- Testing
- Nicotine Patch, Telephone Counseling, Self-Help Materials
- Where
- United States
- Volunteers
- 4,200 people
- Sponsor
- University of California, San Diego
Nicotine Addiction, Smoking Cessation
Evaluation of a Smoking Cessation Program for Long-Term Abstinence
This observational study evaluates a structured smoking cessation program delivered via weekly group sessions. The primary objective is to assess participant-reported smoking abstinence following completion of the program and at…
- Trial name
- ESCaPe (NCT06746025)
- Testing
- Quit Center cessation program
- Where
- United States
- Volunteers
- 371 people
- Sponsor
- Quit Center LLC
Tobacco Use Disorder, Homelessness
Abstinence Reinforcement Therapy (ART) for Homeless Veteran Smokers
The goal of this research study is to examine the effects of a treatment for helping homeless veterans who smoke to stop smoking. Participants in the study will be assigned to one of two study groups.
- Trial name
- NCT02245308
- Testing
- Nicotine Patches, mobile contingency management (mCM), Smoking cessation counseling
- Where
- United States
- Volunteers
- 133 people
- Sponsor
- VA Office of Research and Development
Smoking
Reduced Exposure Study in Smokers Using the Tobacco Heating System 2.2 (THS 2.2) for 5 Days in a Confinement Setting
The overall goal of the study is to evaluate if the ad libitum use of the Tobacco Heating System 2.2 (THS 2.2) for 5 consecutive days by adult Japanese healthy smokers affects the levels of biomarkers of exposure for selected…
- Trial name
- NCT01970982
- Testing
- Tobacco Heating System (THS 2.2), Smoking abstinence (SA), Conventional cigarette (CC)
- Where
- Japan
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Nicotine Dependence
Pilot Study of Tolcapone in Smokers
The goals of this within-subject pilot study are: (1) assess the feasibility and safety of administering the Catechol-O-Methyl-Transferase (COMT) inhibitor, tolcapone, to smokers, and (2) explore whether tolcapone may reduce…
- Trial name
- NCT01202955
- Testing
- Tolcapone
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Pennsylvania
Tobacco Use Disorder
Smokers' Health Project: Self-Determination and Maintaining Tobacco Abstinence
These two studies will examine the role of autonomous motivation in maintained adherence. The first study will determine whether smokers are still abstinent from tobacco 32 months after starting in a previous project (Smoker's…
- Trial name
- SHP (NCT00178685)
- Testing
- Self-determination Intervention for Tobacco Dependence
- Where
- United States
- Volunteers
- 837 people
- Sponsor
- University of Rochester
Tobacco Use Disorder
Abstinence Reinforcement Therapy for Veterans Who Smoke Tobacco and Are Experiencing Homelessness
Seventy to eighty percent of Veterans experiencing homelessness (VEH) smoke, which is four times the rate of the U.S. population and 2.5 times higher than among impoverished Americans.
- Trial name
- New HART (NCT07714200)
- Testing
- Cognitive Behavioral Therapy for Smoking Cessation, Nicotine Replacement Therapy, Bupropion
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- VA Office of Research and Development
Tobacco Use Disorder
Effect of Ramelteon on Smoking Abstinence
This is a randomized, double-blind, placebo-controlled crossover study to test whether a medication called ramelteon (Brand Name: Remeron) will help smokers quit and whether it reduces sleep problems that smokers experience…
- Trial name
- RAP (NCT02560324)
- Testing
- Ramelteon
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- University of Pennsylvania
Smoking, Smoking Cessation
Preventing Relapse Following Involuntary Smoking Abstinence
The prevalence of tobacco use in the military is too high. This study is designed to take advantage of the 8.5 weeks of forced tobacco cessation during Basic Military Training and develop effective interventions to prevent…
- Trial name
- AFV (NCT01374724)
- Testing
- Tobacco Use Ban, Tailored Pamphlet, Informational Pamphlet
- Where
- 2 sites in United States
- Volunteers
- 23,000 people, healthy volunteers welcome
- Sponsor
- University of Tennessee
Smoking, Tobacco
A Multi-Site Study to Assess the Effect of Availability of a Heated Tobacco Product on Smoking Abstinence Among Current Primary Cigarette Smokers
The goal of this study is to evaluate the rate of end of study complete cigarette reduction in health adult consumers of cigarettes when given access to a heated tobacco product (HTP).
- Trial name
- NCT07710820
- Testing
- 31237616, 31237617, 31237571
- Where
- 9 sites in United States
- Volunteers
- 1,060 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Tobacco Dependence, Cessation of Smoking
Effectiveness of an E-mail Tracking Intervention Among the Continued Abstinence of Tobacco Consumption
Objectives. To evaluate the effectiveness and cost effectiveness of clinical practice guide based intervention with two face-to-face visits and e-mail tracking compared to brief advice to obtain continued smoking abstinence at 6…
- Trial name
- TABATIC (NCT01494246)
- Testing
- electronic mail
- Where
- Spain
- Volunteers
- 1,064 people, healthy volunteers welcome
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Nicotine Withdrawal, Tobacco Abstinence
Effects of Transcranial Direct Current Stimulation on Tobacco Withdrawal Symptoms
We hypothesize that transcranial direct current stimulation will reduce tobacco withdrawal symptoms of tobacco dependent smokers abstinent from smoking for more than 10 hours.
- Trial name
- tDCSsmokers (NCT01567982)
- Testing
- tDCS, prefrontal cortex and parietal cortex
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yale University
Tobacco Use Disorder
Maintaining Abstinence in Chronic Cigarette Smokers - 1
The purpose of this study is to evaluate the extended pharmacological and psychological treatment for chronic cigarette smokers.
- Trial name
- NCT00087880
- Testing
- Bupropion and NRT
- Where
- United States
- Volunteers
- 407 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cigarette Smoking, Tobacco Use
Gabapentin for Smoking Cessation
Gabapentin is an anti-epileptic agent that has shown preliminary evidence of efficacy for improving symptoms of cocaine and alcohol withdrawal in pilot studies.
- Trial name
- NCT00578552
- Testing
- Gabapentin - 1800 mg/day, Gabapentin - 2700 mg/day
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Schizophrenia, Tobacco Use Disorder
Varenicline Effects In Schizophrenic Smokers
This is an open label pre-post study of the effects of clinical treatment with varenicline on 1) decreasing smoking in schizophrenic patients, 2) improving selected cognitive measures in schizophrenic patients, and 3)…
- Conditions
- Schizophrenia, Tobacco Use Disorder, Nicotine Dependance
- Trial name
- NCT00548470
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Nathan Kline Institute for Psychiatric Research
Smoking Cessation
Not Quite Ready to Quit
In our communications with the public, the investigators will call this the Not Quite Ready to Quit Smoking Study. One new method to increase quit attempts is to have smokers reduce their cigs/day.
- Trial name
- NCT01866722
- Testing
- Usual care, Reduction, 5Rs
- Where
- United States
- Volunteers
- 560 people
- Sponsor
- University of Vermont