Clinical trials: Tobacco Abstinence
Smoking Cessation
Physiological, Cognitive and Cerebral Activity Changes as a Function of Cigarette Smoking (With or Without Nicotine) and Tobacco Abstinence
Background: Denicotinized cigarettes are similar to commercial cigarettes but contain and deliver virtually no nicotine. Denicotinized cigarettes are used as a control condition in smoking research, as a substitute treatment for…
- Trial name
- NCT01034384
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Inflammation, Oxidative Stress
Reduction of Exposure, Inflammation, and Oxidative Stress Following at Least 2 Years of Switching to THS Use Compared to Cigarette Smoking
This is a cross-sectional 3-group study with subjects enrolled and matched by region (Asia, Europe), age, sex, and average daily product consumption over the last 2 years as self-reported.
- Conditions
- Inflammation, Oxidative Stress, Smoking, Smoking Abstinence
- Trial name
- NCT05385055
- Testing
- THS use, Cigarette smoking, Smoking abstinence
- Where
- 37 sites in Bulgaria, Czechia and 4 more
- Volunteers
- 974 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Smoking, Tobacco
A Study to Determine the Effects of ENDS Flavor Availability on Abstinence Within Smokers
The overall purpose of this study will be to assess primary combustible cigarette users' abstinence from smoking their usual brand of combustible cigarettes at the end of the study, when provided with an electronic nicotine…
- Trial name
- NCT07598136
- Testing
- P2613422, P2611222, P2615522
- Where
- 7 sites in United States
- Volunteers
- 1,280 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Smoking
Reduced Exposure Study Using THS 2.2 Menthol With 5 Days in a Confinement Setting Followed by 86 Days in an Ambulatory Setting
Evaluate if the ad libitum use of the THS 2.2 Menthol (mTHS), a candidate Modified Risk Tobacco Product, for 5 days in confinement, and after 86 days in an ambulatory setting, by apparently adult healthy smokers results in a…
- Trial name
- NCT01989156
- Testing
- THS 2.2 Menthol (mTHS 2.2), Menthol Conventional Cigarette (mCC), Smoking Abstinence (SA)
- Where
- 2 sites in United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Smoking
Reduced Exposure Study in Smokers Using THS 2.2 With 5 Days in a Confinement Setting.
The overall goal of the study is to evaluate if the ad libitum use of the Tobacco Heating System 2.2 (THS 2.2) for 5 days by adult healthy smokers results in a reduction in the levels of biomarkers of exposure (BoExp) for…
- Trial name
- NCT01959932
- Testing
- Tobacco Heating System (THS 2.2), Smoking abstinence (SA), Conventional cigarette (CC)
- Where
- Poland
- Volunteers
- 169 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Smoking, Smoking Cessation
BRP1802 Smoking Abstinence Study
A single-center study designed to evaluate changes in short-term biomarkers of potential harm (BoPH) in healthy adult cigarette smokers of two age groups (Group A: 24-34 years; Group B: 35-60 years) during 14 days of smoking…
- Conditions
- Smoking, Smoking Cessation, Tobacco Use
- Trial name
- NCT04979013
- Testing
- Smoking Abstinence
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Cigarette Smoking
Internet-based Group Contingency Management to Promote Smoking Abstinence
The purpose of the study is to develop and test an Internet-based group contingency management program designed to promote smoking cessation.
- Trial name
- NCT01181661
- Testing
- Full Group Contingency, Mixed Group Contingency
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- National Development and Research Institutes, Inc.
Smoking Cessation
Smokers' Quitline for Asian Language Speakers
The study tested the effects of telephone counseling for smokers from three Asian language speaking groups: Chinese, Korean, and Vietnamese.
- Trial name
- NCT01248832
- Testing
- Telephone Counseling, Self-Help Materials
- Where
- United States
- Volunteers
- 2,277 people
- Sponsor
- University of California, San Diego
Smoking, Tobacco Abstinence
Texting to Promote Tobacco Abstinence in Emergency Department Smokers: A Pilot Study
This is a pilot study to test the feasibility of conducting a text based smoking cessation trial with Emergency Department patients who are smokers.
- Trial name
- NCT02081144
- Testing
- Smokefree TXT Program, nicotine replacement patches, Nicotine Replacement Gum
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Yale University
Smoking
Web and Phone Intervention to Maintain Postpartum Tobacco Abstinence
This study seeks to develop and test a Web-based tobacco relapse prevention program targeting postpartum women who quit smoking for pregnancy.
- Trial name
- StayQuit (NCT01864954)
- Testing
- Web+phone
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Oregon Research Institute
Smoking Cessation, Nicotine Addiction
Factors Sustaining Tobacco Abstinence in Cancer Patients Treated With Radio-chemotherapy or Radiotherapy
The TABAC STOP ORL POUMON study aims to evaluate the factors influencing long-term smoking cessation in patients with head and neck cancer (HNC) or lung cancer undergoing radiotherapy or chemoradiotherapy.
- Conditions
- Smoking Cessation, Nicotine Addiction, Nicotine Dependence, Smoking
- Trial name
- TABAC STOP ORL (NCT06910566)
- Testing
- Chemoradiotherapy or radiotherapy alone
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Oscar Lambret
Smoking, Nicotine
Impact of Daridorexant on Sleep, Daytime Alertness, and Smoking
Tobacco use is the leading cause of preventable death in the U.S., with 480,000 deaths per year and 7.7 million deaths globally.
- Conditions
- Smoking, Nicotine, Tobacco, Addiction
- Trial name
- NCT07328594
- Testing
- Daridorexant 50 mg
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Legacy Health System
Smoking Cessation
12-Month Efficacy of Exercise and Cytisinicline for Tobacco Abstinence
Current scientific evidence demonstrates the relationship between good physical fitness and a lower incidence of certain chronic diseases, including smoking, as well as the effectiveness of cytisinicline.
- Trial name
- MEDSEC-CTA12 (NCT06579846)
- Testing
- Cytisinicline and exercise, Cytisinicline
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Maimónides Biomedical Research Institute of Córdoba
Nicotine Dependence
Tobacco Use in Opioid Agonist Treated Pregnant Women
The primary objective of the proposed study is to evaluate the efficacy of tobacco abstinence-contingent voucher incentives versus non-tobacco abstinence-contingent incentives for reducing or eliminating tobacco use during…
- Trial name
- ROSE (NCT00497068)
- Testing
- tobacco abstinent contingent, non-contingent, control
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- Johns Hopkins University
Smoking Cessation, Tobacco Use Disorder
A Randomized Trial of Internet Access to Nicotine Patches
People who smoke cigarettes have an increased risk of developing emphysema, heart disease, and certain types of cancer. This study will evaluate the effectiveness of providing free nicotine patches from an online smoking…
- Trial name
- iQS (NCT00534404)
- Testing
- Nicotine patches, Telephone counseling, iQuit Smoking website
- Where
- United States
- Volunteers
- 2,485 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Smoking Cessation, Smoking Abstinence
Breathe 2 Project 3: Comprehensive Chronic Care
This study will evaluate Comprehensive Chronic Care (CCC), a healthcare treatment approach designed to increase smoking treatment engagement and abstinence among primary care patients who smoke.
- Trial name
- NCT05382221
- Testing
- Comprehensive Chronic Care, Standard Care
- Where
- 2 sites in United States
- Volunteers
- 979 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Tobacco Use Cessation
Mobile Media-Rich Interactive Guideline System (MMRIGS) Pilot Study
The goal of this research study is to learn about 2 different interactive methods that are designed to help people with HIV/AIDS stop smoking.
- Trial name
- NCT02302859
- Testing
- Nicotine Patch, Questionnaires, Pamphlet
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Tobacco Dependence
S-Adenosyl-L-Methionine (SAMe) for Smoking Abstinence
Cigarette smoking is of great public health importance and is the single most important preventable cause of morbidity, mortality and excess health care costs in the United States.
- Trial name
- NCT00722124
- Testing
- S-Adenosyl-L-Methionine
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Tobacco Use Cessation
Quit IT: Preliminary Testing of a Web-based, 3D Coping Skills Game to Increase Quitting Self-Efficacy for Maintaining Smoking Abstinence Following Hospitalization
The purpose of this study is to develop and test a web-based game called Quit It that is designed to help smokers who have quit smoking cope with any smoking urges they may have.
- Trial name
- NCT02099097
- Testing
- web-based video game (Quit IT), Questionnaires, Salvia sample
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Tobacco Use
Early Tobacco Abstinence - 5
This proposal will conduct a prospective examination of the clinical course (intensity, content and duration) of tobacco (nicotine) abstinence effects in male and female smokers who are either heavy/light alcohol drinkers…
- Trial name
- NCT00224965
- Testing
- Behavior Therapy
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- National Institute on Drug Abuse (NIDA)