Clinical trials: To Assess Cardiovascular Function
Subclinical Atherosclerotic Cardiovascular Disease, Neurocognitive Decline
MISTIC Study: Atherosclerosis, Neurocognition & Cardiovascular Signaling
The MISTIC study is a non-profit, cross-sectional clinical research project aimed at investigating the relationship between atherosclerosis and both cardiovascular and cognitive function in adult populations.
- Trial name
- MISTIC (NCT07520643)
- Testing
- Peripheral Vascular Imaging, Coro-CT, Neurocognitive Assesment
- Where
- Italy
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Coronary Artery Disease, Heart Diseases
Angiography-Derived Quantitative Functional Assessment Versus Pressure-Derived FFR and IMR: The FAIR Study
Coronary angiography-derived FFR assessment (AngioQFA) is a novel technique for physiological lesion assessment based on 3-dimensional (3D) quantitative coronary angiography (QCA) and virtual hyperemic flow derived from contrast…
- Conditions
- Coronary Artery Disease, Heart Diseases, Cardiovascular Diseases, Arteriosclerosis
- Trial name
- NCT06039748
- Testing
- AngioQFA
- Where
- 5 sites in China
- Volunteers
- 330 people
- Sponsor
- Shenzhen Raysight Intelligent Medical Technology Co., Ltd.
Healthy
Trial to Assess the Effects of Different Trans-fatty Acids on Endothelial Function in Humans
The aim of the study is to compare a diet rich in trans fatty acids (TFA) from ruminant sources with a diet rich in TFA from hydrogenated vegetable oils (PHVO) in regard to their effects on cardiovascular risk markers…
- Trial name
- NCT00933322
- Testing
- diet enriched with industrial trans fatty acids, diet enriched with ruminant trans fatty acids, diet without any trans fatty acids
- Where
- Switzerland
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Heart Failure, Congestive
Rosuvastatin Impact on Ventricular Remodelling Lipids and Cytokines
The purpose of this study is to assess the effect of rosuvastatin (up-titrated to a dose of 40mg/day) compared to placebo on cardiac remodelling, estimated by change in left ventricular ejection fraction on radionuclide…
- Trial name
- NCT00240292
- Testing
- Rosuvastatin
- Where
- 13 sites in Australia
- Volunteers
- 160 people
- Sponsor
- AstraZeneca
Heart Failure, Congestive
PROTECT-2: A Study of the Selective A1 Adenosine Receptor Antagonist KW-3902 for Patients Hospitalized With Acute HF and Volume Overload to Assess Treatment Effect on Congestion and Renal Function
The study is being conducted to examine whether KW-3902IV will result in greater improvement in signs and symptoms of heart failure, with less treatment failure than standard therapy, when it is added to IV loop diuretics in…
- Trial name
- NCT00354458
- Testing
- rolofylline
- Volunteers
- 1,102 people
- Sponsor
- NovaCardia, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Heart Failure
A Phase II Trial to Assess Hemodynamic Effects of Istaroxime in Pts With Worsening HF and Reduced LV Systolic Function
The purpose of this study is to determine the minimum effective dose of Istaroxime, in patients requiring hospitalization for deterioration of chronic heart failure and left ventricular systolic dysfunction.
- Trial name
- HORIZON-HF (NCT00616161)
- Testing
- Istaroxime
- Volunteers
- 120 people
- Sponsor
- sigma-tau i.f.r. S.p.A.
Tricuspid Regurgitation, Right Ventricular Dilatation
Pharmacological Reduction of Right Ventricular Enlargement
Functional tricuspid regurgitation (TR) has been regarded as a secondary phenomenon of heart failure (HF), mitral valve (MV) disease or atrial fibrillation.
- Trial name
- PROVE (NCT04345796)
- Testing
- Carvedilol+Empagliflozin, Carvedilol, Empagliflozin
- Where
- 3 sites in South Korea
- Volunteers
- 56 people
- Sponsor
- Asan Medical Center
Cardiac Arrest, Brain Injuries
Functional MRI to Assess Brain Damage in Cardiac Arrest Patients
This is a single-center, observational study. Patients after successful cardiopulmonary resuscitation (CPR) will be transferred to the emergency intensive care unit for further standardized management.
- Trial name
- NCT05966389
- Testing
- No interventions
- Where
- China
- Volunteers
- 31 people
- Sponsor
- Capital Medical University
Heart Failure
Hemodynamic Testing Strategies to Assess Pulmonary Hypertension in Heart Failure
The goal of this observational study is to learn about heart function and high lung blood pressure in patients with heart failure.
- Trial name
- NCT05672719
- Testing
- Right Heart Catheterization
- Where
- Canada
- Volunteers
- 74 people
- Sponsor
- Mount Sinai Hospital, Canada
Parkinson Disease, Autonomic Dysfunction
Parkinson's Autonomic Responses to Treadmill Walking
This study will compare examine autonomic and cardiovascular responses to peak exercise testing in Parkinson's disease patients in varying stages of the disease, and healthy, age-matched participants.
- Trial name
- NCT03156400
- Testing
- Exercise Stress Test
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Miami
Acute Coronary Syndrome
Ticagrelor Monotherapy Compared to Aspirin Monotherapy in Patients With History of ACS
Antiplatelet agents are cornerstones for management of ischemic heart disease. For patients suffering from acute coronary syndrome (heart attack), treatment with aspirin and ticagrelor are typically given for one year after index…
- Trial name
- FMD_ACS (NCT03881943)
- Testing
- Ticagrelor 60 mg, Aspirin 100 MG Oral Tablet, Enteric Coated
- Where
- China
- Volunteers
- 200 people
- Sponsor
- The University of Hong Kong
Ischemia-reperfusion Injury, Kidney Transplant; Complications
A Trial to Assess Efficacy and Safety of ex Vivo Allograft Admin of iCM012 Solution 2 mg/ml to Improve Its Function in Recipients of DCD Kidneys
Randomized (1:1), placebo controlled, double blind efficacy trial. 200 patients will be followed up for 12 months post transplantation.
- Trial name
- NCT06582485
- Testing
- iCM012 solution 2 mg/mL
- Volunteers
- 200 people
- Sponsor
- iCoat Medical AB
Pulmonary Hypertension
Targeting Right Ventricle in Pulmonary Hypertension Gilead
This study is looking to see if giving ranolazine to subjects on stable pulmonary hypertension therapies but with right ventricular dysfunction (RVEF <45%) will improve their health by improving right ventricular (RV) function.
- Trial name
- NCT02829034
- Testing
- Ranolazine
- Where
- 3 sites in United States
- Volunteers
- 22 people
- Sponsor
- University of Pennsylvania
Heart Failure, Congestive
PROTECT-1: A Study of the Selective A1 Adenosine Receptor Antagonist KW-3902 for Patients Hospitalized With Acute HF and Volume Overload to Assess Treatment Effect on Congestion and Renal Function
The study is being conducted to examine whether KW-3902IV will result in greater improvement in signs and symptoms of heart failure, with less treatment failure than standard therapy, when it is added to IV loop diuretics in…
- Trial name
- NCT00328692
- Testing
- rolofylline
- Volunteers
- 932 people
- Sponsor
- NovaCardia, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Metabolic Syndrome, Predisposition to Cardiovascular Disease
Analysis of the Postprandial Effects of a Vegetable Protein Mixture Rich in Arginine, Cysteine and Leucine on Endothelial Dysfunction and Inflammation at Low Noise in Elderly People With Cardiometabolic Risk
By 2050, the expanding world population will consume two-thirds more animal protein than it consumes today. The increase in chronic diseases associated with the generalization of these consumption patterns tend to understand the…
- Trial name
- P-PROBS CM (NCT04923555)
- Testing
- Vegetable proteins (VP) rich in leucine, cystein, arginine, Animal proteins (AP), No protein (T)
- Where
- France
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Stroke
Penumbra Imaging Collaborative Study (PICS)
The primary aim of this study are to gather data on the "real world" experience of the Penumbra System and to determine if there is a correlate between the imaging-defined size of the ischemic penumbra at admission and patient…
- Trial name
- PICS (NCT00785161)
- Testing
- Penumbra System
- Where
- United States
- Volunteers
- 289 people
- Sponsor
- Penumbra Inc.
Acute Ischemic Stroke
A Safety and Efficacy Study of Intravenous (IV) Elezanumab Assessing Change in Neurologic Function in Adult Participants With Acute Ischemic Stroke
Stroke is one of the leading causes death and major functional disability worldwide. Treatment options for acute stroke are limited with many patients having residual neurologic impairment.
- Trial name
- EAISE (NCT04309474)
- Testing
- Elezanumab
- Where
- 42 sites in United States, Australia and 4 more
- Volunteers
- 121 people
- Sponsor
- AbbVie
Aortic Aneurysm, Abdominal
Cortisol Response to Adrenocorticotrophin (ACTH) in Acute Stress
Cortisol deficiency is diagnosed by the adrenocorticotrophin (ACTH) stimulation test. This test measures cortisol levels in the blood before and after giving an injection of ACTH.
- Trial name
- CRAAS (NCT00493389)
- Testing
- Adrenocorticotrophic hormone
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- University of Ottawa
Coronary Disease, Heart Diseases
Myocardial Contrast Echocardiography (MCE) to Check for Living and Working Heart Muscle
Coronary artery disease (CAD) can cause poor blood flow and supply to the heart muscle. It can result in irreversible damage to the heart muscle and poor function.
- Trial name
- NCT00001891
- Testing
- Myocardial contrast echocardiography, Dobutamine echocardiography
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Obesity, Overweight
Study of the Effect of Moxonidine and Diet on Sympathetic Functions in Young Adults With Obesity
The prevalence of obesity is increasing rapidly among adults and has more than doubled in the past 10 years. The metabolic syndrome (MS) is often associated with obesity.
- Trial name
- NCT01180231
- Testing
- Moxonidine (Physiotens), Dietary intervention
- Where
- 2 sites in Australia
- Volunteers
- 77 people
- Sponsor
- Baker Heart and Diabetes Institute