Clinical trials: Tissue Repair
Diabetic Foot Ulcer (DFU), Venous Leg Ulcer (VLU)
Evaluation of the Safety and Efficacy of Dehydrated Human Placenta Tissue (dHPT) for Wound Healing
The retrospective trial is observational, intended to stand alone, complement and integrate data collected in ongoing clinical studies to aid in establishing payor coverage in the United States (U.S.) for Cellution Biologics…
- Conditions
- Diabetic Foot Ulcer (DFU), Venous Leg Ulcer (VLU), Pressure Ulcer (PU)
- Trial name
- RETRO-PLAST (NCT07375160)
- Testing
- dHPT, AIC
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Cellution Biologics
Inguinal Hernia, Pain
SEMPERFLO* Pain Management System in Inguinal Hernia Repair
This study will compare the clinical performance of the SEMPERFLO* Pain Management System with another commercial pain relief system using 0.5% bupivacaine following unilateral, open, inguinal hernia repair procedures. *Trademark
- Trial name
- NCT00423241
- Testing
- SEMPERFLO Pain Management System, ON-Q PainBuster Post-Op Pain Relief System
- Where
- 6 sites in United States
- Volunteers
- 7 people
- Sponsor
- Ethicon, Inc.
Intrapartum Hemorrhage
Exteriorization Versus Non-exteriorization of the Uterus During Repair of Uterine Incision in a Repeated Cesarean Section
Cesarean section is one of the most frequently performed major operations worldwide. It accounts for between 1% and 70% of deliveries depending on the facilities or country assessed.
- Trial name
- NCT03009994
- Testing
- Repair of uterine incision, Exteriorization of the uterus, Non exteriorization of the uterus
- Where
- Egypt
- Volunteers
- 1,024 people
- Sponsor
- Assiut University
Gingival Recession
Platelet Rich Fibrin in the Treatment of Palatal Wounds
In this study it will be investigated the usefulness of Platelet-Rich Fibrin (PRF) on in the epithelialized connective tissue graft palatal donor site healing acceleration and in the patient's morbidity reduction.
- Trial name
- NCT02438046
- Testing
- Palatal wound bandage
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- G. d'Annunzio University
Inguinal Hernia,Laparoscopy,Extra-peritoneal
A Comparative Study on Trans-umbilical Single-port Laparoscopic Extra-peritoneal Approach Versus Conventional Repair for Inguinal Hernia in Children
Inguinal hernia is a common disease in children. Treatment of this disease by laparoscopic high ligation of the hernia sac has been accepted by domestic and foreign scholars.
- Trial name
- NCT02960529
- Testing
- extra-peritoneal high ligation of hernia, intraabdominal high ligation of hernia
- Where
- China
- Volunteers
- 300 people
- Sponsor
- zebing Zheng
Cleft Palate Repair
Double Blind Randomized Study Into the Efficacy of Codeine Phosphate Analgesia After Cleft Palate Repair in Infants
This study examines the analgesic efficacy of codeine phosphate. It is compared to placebo in infants receiving morphine after surgery. Codeine may be effective enough to make morphine unnecessary.
- Trial name
- NCT00386269
- Testing
- Codeine Phosphate Analgesia
- Where
- United Kingdom
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Institute of Child Health
Shoulder Instability, Shoulder Dislocation or Subluxation
Multifactorial Approach Training for Anterior Shoulder Instability in Patients Undergoing Arthroscopic Bankart Repair
This study will compare functional outcomes after an arthroscopic Bankart repair between patients that underwent conventional arthroscopic Bankart repair rehabilitation, following the American Society of Shoulder and Elbow…
- Conditions
- Shoulder Instability, Shoulder Dislocation or Subluxation, Fear of Movement, Kinesiophobia
- Trial name
- MATASI (NCT06157229)
- Testing
- MAT, CABRR
- Volunteers
- 100 people
- Sponsor
- Spaarne Gasthuis
Mitral Regurgitation, Mitral Valve Disease
Multicenter Post-Market Observational Registry of the NeoChord Artificial Chordae Delivery System
The objective of this study is to evaluate the 5-year outcomes of participants with degenerative mitral valve disease treated with the NeoChord Artificial Chordae System, Model DS1000 in a post-market setting.
- Conditions
- Mitral Regurgitation, Mitral Valve Disease, Mitral Valve Insufficiency, Mitral Valve Prolapse
- Trial name
- AcChord (NCT04190602)
- Testing
- NeoChord Artificial Chordae Delivery System, Model DS1000
- Where
- 5 sites in Germany, Greece and 1 more
- Volunteers
- 500 people
- Sponsor
- NeoChord
Articular Cartilage Damage
NeoCart Phase 2 Clinical Trial
The objective of this study is to gather additional information regarding the performance of NeoCart to fill articular cartilage defects in the knee.
- Trial name
- NCT00548119
- Testing
- NeoCart, microfracture
- Where
- 6 sites in United States
- Volunteers
- 30 people
- Sponsor
- Histogenics Corporation
Diabetic Foot Ulcer (DFU)
Evaluating the Efficacy of FoundationDRS Solo in Addition to Standard of Care for the Treatment of Non-healing Diabetic Foot Ulcers
The goal of this clinical trial is to learn if using FoundationDRS Solo improves healing of chronic, non-healing foot ulcers in diabetic patients.
- Trial name
- NCT07290673
- Testing
- FoundationDRS Solo, Standard of Care
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Samaritan Biologics
Mitral Valve Insufficiency, Coronary Stenosis
Impact of Mitral Regurgitation on Coronary Haemodynamics and Instantaneous Effect of Transcatheter Mitral Valve Repair
In the present study, the investigators aim to use the in-vivo Transcatheter Mitral Valve Repair (TMVR) model to determine how Mitral Regurgitation (MR) affects coronary hemodynamics in patients affected with severe MR and…
- Conditions
- Mitral Valve Insufficiency, Coronary Stenosis, Mitral Regurgitation, Coronary Artery Disease
- Trial name
- MitraFLOW (NCT04245956)
- Testing
- Measure of hemodynamic indices in a stenosed coronary artery using a pressure wire
- Where
- Switzerland
- Volunteers
- 1 people
- Sponsor
- University Hospital, Geneva
Chronic Tympanic Membrane Perforation
In-office Repair of Chronic Tympanic Membrane Perforations
The goal of this clinical trial is to compare the application of fibroblast growth factor 2 (FGF2) with normal saline for the healing of chronic tympanic membrane (TM) perforations. This is an extension of a prior study.
- Trial name
- NCT06448039
- Testing
- Fibroblast Growth Factor 2, Saline control
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- D. Bradley Welling, MD, PhD
Anterior Prolapse Surgery Using the Transobturator Repair by Vaginal Plastron
Transobturator Repair by Vaginal Plastron
The autologous vaginal route consists of repairing the genital prolapse through the vagina using the patient's tissues without a prosthesis. Vaginal prostheses are actually currently prohibited in France [1, 2].
- Trial name
- CYSPTO (NCT05741567)
- Testing
- correction of anterior prolapse
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Hospices Civils de Lyon
Necrotic Primary Molars
3Mixtatin Versus Modified 3Mix-MP in Lesion Sterilization and Tissue Repair for Treatment of Necrotic Primary Molars
This randomized clinical study aims to assess the clinical and radiographic success rate of the 3Mixtatin versus the 3Mix in LSTR in necrotic primary molars.
- Trial name
- LSTR (NCT05677945)
- Testing
- 3Mixtatin paste: Simvastatin mixed with modified triple antibiotic, 3Mix: Modified triple antibiotic mix in propylene glycol
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Functional Mitral Regurgitation
The JensClip Transcatheter Valve Repair System for Treating Functional Mitral Regurgitation
To evaluate the efficacy and safety of the JensClip transcatheter valve repair system for patients with moderate-severe or greater (MR ≥ 3+) functional mitral regurgitation (FMR) who have received adequate treatment but are still…
- Trial name
- NCT05931900
- Testing
- moderate-severe or greater (MR ≥ 3+) functional mitral regurgitation (FMR) patients
- Where
- China
- Volunteers
- 129 people
- Sponsor
- Jenscare Scientific
Aorta Dissection, Aorta Aneurysm
Hybrid Operation in Thoracic Aortic Dissection
The purpose of this study is to investigate the short to mid term efficacy and safety of different hybrid operations who had complex aortic lesions, such as ascending aortic/arch aneurysm, pseudo-aneurysm, Stanford Type A…
- Trial name
- NCT01500395
- Testing
- Hybrid operation
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Xijing Hospital
Cesarean Wound Repair
Extra - Abdominal Versus Intra - Abdominal Repair of the Uterine Incision at Cesarean Section
To evaluate the effects of extra-abdominal repair of the uterine incision compared to intra-abdominal repair, and to study is there superiority of one technique over the other in terms of primary outcomes - operative( up to 4…
- Trial name
- EKAM (NCT02373501)
- Testing
- Intra-abdominal repair, Extra-abdominal repair
- Where
- Israel
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Pectus Excavatum, Chest Deformities
SPSIPB Versus SAPB for Postoperative Analgesia After Minimally Invasive Repair of Pectus Excavatum
This prospective observational cohort study will compare postoperative analgesic outcomes in patients undergoing minimally invasive repair of pectus excavatum.
- Trial name
- NCT07697222
- Testing
- Postoperative Analgesia Protocol, Bispectral Index Monitoring, Serratus Posterior Superior Intercostal Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Marmara University
Colorectal Cancer Metastatic, Colon Cancer
Immunotherapy With Y90-RadioEmbolization for Metastatic Colorectal Cancer
This clinical trial will be conducted as a single-center, open-label, Phase I/2 trial to evaluate the feasibility and safety of Yttrium-90 radioembolization (Y90-RE) in combination with a fixed dose of of immunotherapy…
- Conditions
- Colorectal Cancer Metastatic, Colon Cancer, Metastatic Colorectal Cancer, Rectal Cancer
- Trial name
- iRE-C (NCT04108481)
- Testing
- Durvalumab, Yttrium-90 RadioEmbolization
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Iowa
Mitral Valve Insufficiency, Heart Failure
Carillon Mitral Contour System® for Reducing Functional Mitral Regurgitation
The objective of this prospective, multi-center, randomized, double-blind trial is to assess the safety and efficacy of the Carillon Mitral Contour System in treating functional mitral regurgitation (FMR) associated with heart…
- Trial name
- REDUCE FMR (NCT02325830)
- Testing
- Carillon Mitral Contour System
- Where
- 31 sites in Australia, Czechia and 6 more
- Volunteers
- 163 people
- Sponsor
- Cardiac Dimensions Pty Ltd