Clinical trials: Tic, Motor
Obsessive Compulsive Disorder, Healthy
Cortical Excitability in Obsessive-Compulsive and Related Disorders
This study will use transcranial magnetic stimulation (TMS) to study the function of the cerebral cortex (outer layer of the brain) in people with obsessive compulsive disorder (OCD) and related disorders.
- Trial name
- NCT00029068
- Where
- United States
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Tourette's Syndrome, Attention Deficit Hyperactivity Disorder
Study of Clonidine on Sleep Architecture in Children With Tourette's Syndrome (TS) and Comorbid ADHD
In the present study, we examine the question "Will day-time aggression in children improve when their night-time sleep is treated with pharmacological intervention (i.e.
- Trial name
- NCT00152750
- Testing
- APO-clonidine
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Chronic Motor or Vocal Tic Disorder, Tourette's Disorder
Aripiprazole in Children and Adolescents With Chronic Tic Disorder or Tourette's Disorder
The purpose of this trial is to demonstrate the efficacy and safety of aripiprazole in children and adolescents aged 6~18 years with chronic tic disorders or Tourette's disorder
- Trial name
- NCT00706589
- Testing
- aripiprazole
- Where
- 6 sites in South Korea
- Volunteers
- 61 people
- Sponsor
- Korea Otsuka Pharmaceutical Co., Ltd.
Tic Disorder, Tourette Syndrome
Role of the Sensory Experience in Generating Motor Tics in Tourette Syndrome
This study will investigate the sensation that many people with Tourette syndrome (TS) experience before they have a motor tic. It will also test whether blocking the sensation causes the tic to stop.
- Trial name
- NCT00755339
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Tourette Syndrome, Chronic Motor Tic Disorder
A Study to Evaluate the Effects of ABX-1431 on Patients With Tourette Syndrome
The study will investigate the effects and the safety of a single-dose of ABX-1431 HCl on tics and other symptoms of Tourette Syndrome. During part 1 (periods 1 and 2) each patient will receive study drug once and placebo once.
- Trial name
- NCT03058562
- Testing
- ABX-1431
- Where
- Germany
- Volunteers
- 23 people
- Sponsor
- Abide Therapeutics
Tourette Syndrome, Tic Disorders
Median Nerve Stimulation Pilot
Results from the University of Nottingham suggested that rhythmic median nerve stimulation (MNS) improves tic symptoms in Tourette syndrome (TS).
- Conditions
- Tourette Syndrome, Tic Disorders, Tic Disorder, Chronic Motor or Vocal
- Trial name
- MNS (NCT04731714)
- Testing
- Rhythmic median nerve stimulation, Arrhythmic median nerve stimulation
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Washington University School of Medicine
Tourette Syndrome, Tic Disorders
Cognitive Behavior Therapy and Habit Reversal Training for the Treatment of Chronic Tic Disorders in Children
This study will determine the effectiveness of cognitive behavior therapy (CBT) with habit reversal training (HRT) in treating chronic tic disorders (CTDs) in children and adolescents.
- Trial name
- CBIT (NCT00218777)
- Testing
- Comprehensive Behavioral Intervention for Tics
- Where
- 3 sites in United States
- Volunteers
- 120 people
- Sponsor
- Tourette Association of America
Tourette Syndrome, Motor Tic Disorder
Study of ABX-1431 in Adult Patients With Tourette Syndrome or Chronic Motor Tic Disorder
Two-part study consisting of a double-blind, randomized, placebo-controlled, study at two target dose levels (Part 1) and an open-label, non-randomized study (Part 2) to determine the efficacy of ABX-1431 in treating adult…
- Trial name
- NCT03625453
- Testing
- ABX-1431
- Where
- 8 sites in Germany, Poland and 1 more
- Volunteers
- 50 people
- Sponsor
- Abide Therapeutics
Tourette Syndrome, Tic Disorders
Brain Dynamics Involved in Generating Tics and Controlling Voluntary Movement
This study will use electroencephalography (EEG) and electromyography (EMG) to examine how the brain generates tics and controls voluntary movement in patients with Tourette's syndrome and chronic motor tic disorder.
- Trial name
- NCT00056420
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Communication Disorder, Healthy
Central Mechanisms in Speech Motor Control Studied With H215O PET
Positron Emission Tomography (PET) is a technique used to investigate the functional activity of the brain. The PET technique allows doctors to study the normal biochemical and metabolic processes of the central nervous system of…
- Conditions
- Communication Disorder, Healthy, Stuttering, Tourette Syndrome
- Trial name
- NCT00001308
- Where
- United States
- Volunteers
- 1,163 people, healthy volunteers welcome
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)
Chronic Pain, Chronic Pain Syndrome
Outcomes Mandate National Integration With Cannabis as Medicine
This will be a multistate, multicenter clinical study to determine the efficacy and safety of medical cannabis for a wide variety of chronic medical conditions.
- Conditions
- Chronic Pain, Chronic Pain Syndrome, Chronic Pain Due to Injury, Chronic Pain Due to Trauma
- Trial name
- OMNI-Can (NCT03944447)
- Testing
- Cannabis, Medical, RYAH-Medtech Inhaler
- Where
- 17 sites in United States
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- OMNI Medical Services, LLC
Tourette Syndrome, Persistent Tic Disorder
Activity in Tourette Syndrome
Tics are brief repetitive movements or vocalizations. Gilles de la Tourette's syndrome (TS) is a disorder characterized by recurrent motor and vocal tics. Tourette syndrome and tic disorders affect up to 8% of children.
- Trial name
- NCT02153463
- Testing
- Physical Activity Counselling
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- Children's Hospital of Eastern Ontario
Tourette's Syndrome, Tourette's Disorder
Psychosocial Intervention for Young Children With Chronic Tics
Analysis of data from the recently completed NIH Child Comprehensive Behavioral Intervention for Tics (CBIT) study found a manualized behavioral treatment approach strongly superior to psychoeducation/supportive therapy for…
- Conditions
- Tourette's Syndrome, Tourette's Disorder, Tourette's Disease, Tourette Disorder
- Trial name
- CBIT JR (NCT03042507)
- Testing
- Comprehensive Behavioral Intervention for Tics (CBIT)
- Volunteers
- 15 people
- Sponsor
- Weill Medical College of Cornell University
Tourette Syndrome, Tic Disorder
Sensorimotor and Psychosocial Trajectories in Adolescents With Tic Disorder
Individuals with tic disorders have lower quality of life, sensory and movement difficulties, and poorer mental, social, and physical health compared to the general population.
- Trial name
- NCT06576726
- Testing
- This study involves no intervention.
- Where
- United States
- Volunteers
- 351 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Tourette Syndrome, Chronic Tic Disorder
Neurofeedback for Tourette Syndrome
The aim of this study is to train patients with tic disorders to control activity in a region of their brain that has been associated with the urge to tic.
- Trial name
- NCT01702077
- Testing
- Neurofeedback
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Yale University
Tourette Syndrome
Safety, Tolerability, Pharmacokinetic, and Efficacy Study of AZD5213 in Adolescents With Tourette's Disorder
This is a two-part, randomized, multi-center, blinded study in adolescents with Tourette's Disorder. There will be an up to 21-day screening period in which subject eligibility will be determined.
- Trial name
- NCT01904773
- Where
- 7 sites in United States
- Volunteers
- 29 people
- Sponsor
- AstraZeneca
Parkinson's Disease, Tourette's Syndrome
Physiological Investigations of Movement Disorders
Background: Previous studies have given researchers information on how the brain controls movement, how people learn to make fine, skilled movements, and why some people have movement disorders.
- Conditions
- Parkinson's Disease, Tourette's Syndrome, Tic Disorders, Dystonia
- Trial name
- NCT01019343
- Testing
- Transcranial Direct Current Stimulation (tDCS), Eye-tracking Device, Pulsed vibrator
- Where
- United States
- Volunteers
- 1,273 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Tourette's Syndrome, Motor Tic Disorder
Safety Study of Galantamine in Tic Disorders
The purpose of this study is to determine the safety, tolerability and efficacy of galantamine in tic disorders. The impact of galantamine on commonly associated behaviors (i.e. attention, obsessions, etc.) will also be examined.
- Conditions
- Tourette's Syndrome, Motor Tic Disorder, Vocal Tic Disorder
- Trial name
- NCT00226824
- Testing
- galantamine
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Parkinson's Disease and Movement Disorders Center
Tourette's Disorder, Persistent (Chronic) Motor or Vocal Tic Disorder
Internet-delivered Behaviour Therapy for Children and Adolescents With Tourette's Disorder
The purpose of this trial is to evaluate the clinical efficacy, 12-month durability, and cost-effectiveness of BIP TIC - a therapist-guided and parent-guided internet-delivered behavioural intervention for children and…
- Trial name
- NCT03916055
- Testing
- Exposure and response prevention (ERP), Education on tics
- Where
- Sweden
- Volunteers
- 221 people
- Sponsor
- Karolinska Institutet
Motor Activity, Motor Tic Disorders
The Sense of Agency
The ability to recognize of being the actors of the behaviour and its consequences, the so-called "Sense of Agency" (SoA), is a crucial component of self-awareness.
- Trial name
- SOA (NCT03361332)
- Testing
- Behavioral and fMRI
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio