Clinical trials: Tibial Fractures, open to volunteers
Fractures, Bone
Continuous Passive Motion Following Fixation of Pelvic and Knee Fractures
The investigators will directly compare the visual analog scale scores and narcotic pain medication requirements in the patients who have continuous passive motion (CPM) versus those who do not during the course of the hospital…
- Trial name
- NCT04389749
- Testing
- CPM
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Cincinnati
Tibial Shaft Fracture, Intramedullary Nail
RCT - Suprapatellar Approach Versus Lateral Parapatellar Approach in Tibial Shaft Fracture
This study aims to compare 2 surgical techniques for tibial shaft nailing (suprapatellar approach vs extra-articular lateral parapatellar approach). following peri-operative and postoperative outcomes
- Trial name
- ELPP (NCT07657559)
- Testing
- suprapatellar approach, extra-articular lateral parapatellar approach
- Volunteers
- 40 people
- Sponsor
- Queen Savang Vadhana Memorial Hospital, Thailand
Tibial Plateau Fractures
Genicular Nerve Block After Open Reduction Internal Fixation of Tibial Plateau
The investigators are conducting this research study to find better ways of treating pain following knee surgery. There is a standard (accepted) approach, which involves injection of numbing medication into the area around the…
- Trial name
- NCT06639503
- Testing
- Bupivacain
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of Chicago
Tibial Plateau Fractures
Posterior Column Fractures of Tibial Plateau
The goal of this observational study is to learn about the long-term effects of internal fixation methods in patients with posterior column fractures of tibial plateau according to three column concept.
- Trial name
- NCT06931366
- Testing
- Open reduction and internal fixation
- Where
- Egypt
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Assiut University
Tibial Fracture
Blood Flow Restriction Therapy to Optimize Muscle Size and Strength in Recovery From Lower Limb Fractures
This study will assess the feasibility and effectiveness of blood flow restriction therapy in patients with tibia fractures (or lower leg bone).
- Trial name
- BOOST (NCT07103252)
- Testing
- Blood Flow Restriction Therapy
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of British Columbia
Calcaneus Fracture
Posterior Tibial Nerve PRF for Painful Calcaneal Fracture
Patients who underwent pulsed radiofrequency (PRF) treatment of the posterior tibial nerve under ultrasound guidance, which is routinely performed in our clinic for severe heel pain following a calcaneal fracture, were evaluated…
- Trial name
- NCT06888804
- Testing
- ultrasound-guided posterior tibial nerve pulsed radiofrequency, Control Group
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Diskapi Teaching and Research Hospital
Tibial Fracture
Criteria-Based Rehabilitation After Tibial Fracture Fixation: A Randomized Controlled Trial
This randomized controlled trial will evaluate the effectiveness of a criteria-based progressive loading and functional rehabilitation program compared with usual physiotherapy in adults following surgical fixation of traumatic…
- Trial name
- NCT07810478
- Testing
- Criteria-Based Progressive Loading and Functional Rehabilitation Program
- Where
- Palestinian Territories
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Tibial Plateau Fractures
Local Anesthetic for Plateau Fractures
Subjects may receive an injection at the end of the surgery to fix their broken leg that may reduce their pain and hospital stay
- Trial name
- NCT06474949
- Testing
- Bupivacaine injection, Saline
- Volunteers
- 100 people
- Sponsor
- University of Washington
Tibial Shaft Fracture, Tibial Plateau Fracture
Gene Expression in Lower Extremity Acute Traumatic Compartment Syndrome
The purpose of this study is to evaluate both genotypic differences and differences in local gene expression in individuals who develop acute traumatic compartment syndrome relative to control patients with at-risk lower…
- Trial name
- NCT05521958
- Testing
- Acute injury without compartment syndrome, Acute injury with compartment syndrome, Exertional compartment syndrome
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Utah
Fracture of Tibia, Wound Heal
Incisional Negative Pressure Wound Therapy to Reduce Infection and Complications in High-Risk Fractures
This is a multi-center, pragmatic, parallel arm randomized controlled trial (RCT) of 352 patients with high-risk open or closed tibial plateau fracture, high-risk open or closed tibial pilon fracture, or open tibial shaft…
- Conditions
- Fracture of Tibia, Wound Heal, Infected Wound, Wound Complication
- Trial name
- iVAC (NCT06337292)
- Testing
- Incisional Negative Pressure Wound Therapy (NPWT)
- Where
- 6 sites in United States
- Volunteers
- 352 people
- Sponsor
- Major Extremity Trauma Research Consortium
Fracture Femur, Fracture Tibia
Oral Supplementation With a Formulation Based on Cetylated Fatty Acids for Post-fracture Long Bone Healing
This clinical study aims to evaluate the potential benefits of a formulation based on Cetylated Fatty Acids in improving fracture healing of long bones in the lower limbs.
- Trial name
- CETIULTRA-BONE (NCT07299851)
- Testing
- CFA-based food supplement
- Where
- 6 sites in Belgium
- Volunteers
- 100 people
- Sponsor
- Pharmanutra S.p.a.
Tibial Fracture, Femoral Fracture
Magnesium-Titanium Hybrid Intramedullary Nail System For Long Bone Fractures
This is a prospective, multicenter, randomized, controlled, non-inferiority clinical trial designed to evaluate the safety and effectiveness of the magnesium-titanium hybrid intramedullary nail system compared with the marketed…
- Conditions
- Tibial Fracture, Femoral Fracture, Humeral Fracture
- Trial name
- NCT07569575
- Testing
- Magnesium-Titanium Hybrid Intramedullary Nail System, Commercially Locked Metallic Intramedullary Nail
- Where
- 5 sites in China
- Volunteers
- 160 people
- Sponsor
- HuaMg Perfection Med Tech (Suzhou) Co., Ltd.
Tibial Fracture
Tibial IMN Vs. Tibial Micromotion IMN
Our null hypothesis is that micromotion tibial intramedullary fixation (IMFN) does not impact union or complication rates when compared to standard of care treatment with non-micromotion tibial nail fixation.
- Trial name
- NCT06976801
- Testing
- Intramedullary tibial Nail, Intermedullary nail
- Where
- United States
- Volunteers
- 372 people
- Sponsor
- University of Chicago
Femur Shaft Fracture, Tibia Fractures
Assessing Bone Fracture Healing Effect of Almonds
Femur and tibia shaft fractures are common after trauma with a burden of 5% and 20% respectively. Clinicians recommend costly bone strengthening drugs/supplements while treating bone fractures.
- Conditions
- Femur Shaft Fracture, Tibia Fractures, Vitamin D, Sweet Almonds
- Trial name
- AFHEA (NCT07153302)
- Testing
- Prunus dulcis (sweet almonds)
- Where
- Pakistan
- Volunteers
- 136 people
- Sponsor
- Aga Khan University Hospital, Pakistan
Open tíbia Fracture
Antibiotic Cement Bead Pouch Versus Negative Pressure Wound Therapy
The Beads vs Vac trial is a multi-centre randomized controlled trial of 312 participants with a severe open tibia fracture requiring multiple irrigation and debridement surgeries.
- Trial name
- BeadsvsVac (NCT05615844)
- Testing
- Antibiotic Cement Bead Pouch, Negative Pressure Wound Therapy
- Where
- 35 sites in United States, Canada
- Volunteers
- 312 people
- Sponsor
- University of Maryland, Baltimore
Tibial Fractures, Epiphyseal Fracture
Study of Prognostic Factors of the Distal Epiphysis of the Tibia Fracture Prognosis
Background: Epiphysis of distal end of tibia fracture is quite common in children epiphysis injury, because of the complex damage mechanism and often leads to growth retardation and joint deformity, the patient's physical and…
- Trial name
- NCT02723825
- Testing
- Closed reduction, Open reduction
- Volunteers
- 200 people
- Sponsor
- Foshan Hospital of Traditional Chinese Medicine
Tibia Fracture, Humerus Fracture
A Case Series: TRUMATCH Graft Cage for Segmental Long Bone Defects
This project consists of a prospective case design. Study candidates will include all patients ages 18 and over who were evaluated at UCSD and found to have a critical-sized humerus, femur, or tibia segmental defect that would be…
- Conditions
- Tibia Fracture, Humerus Fracture, Femoral Fracture, Long Bone Segmental Defect
- Trial name
- NCT05668182
- Testing
- TRUMATCH Graft Cage
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of California, San Diego
Fracture Open Tibia
Gentamicin Open Tibia Study
Local application of antibiotics directly to the traumatic wound is a promising treatment for the prevention of infection after open tibia fractures, which are a significant source of disease burden globally, particularly in…
- Trial name
- GO-Tibia (NCT05157126)
- Testing
- Gentamicin, normal Saline
- Where
- Tanzania
- Volunteers
- 890 people
- Sponsor
- University of California, San Francisco
Fracture Healing, Treatment Duration
Smart Crutch Tips for Guided Weight-Bearing in Patients Recovering From Extra-Articular Distal Tibia Fractures
The goal of this clinical trial is to learn whether personalized weight-bearing prescriptions using Smart Crutch Tips™ can improve recovery after surgery for extra-articular distal tibia fractures.
- Conditions
- Fracture Healing, Treatment Duration, Distal Tibia Fracture
- Trial name
- NCT07138066
- Testing
- Smart Crutch Tips™, Finite Element Analysis (FEA), Iterative walking
- Where
- 18 sites in Ukraine
- Volunteers
- 30 people
- Sponsor
- Comeback Mobility Inc
Femoral Shaft Fracture, Tibial Shaft Fractures
Rehabilitation After Lower Extremity Nailing Trial
The goal of this clinical trial is to learn if outpatient physical therapy (PT) results in differing functional outcomes compared to a self-guided home exercise program (HEP) in tibial or femoral nail patients.
- Trial name
- ReLENT (NCT07783568)
- Testing
- Formal Physical Therapy (PT), Home Exercise Program (HEP)
- Volunteers
- 80 people
- Sponsor
- University of Chicago