Clinical trials: Tibial Fractures, open to volunteers
Distal Tibial Fracture, Tibial Fractures
Robot-Assisted Closed Reduction and Internal Fixation for Extra-Articular Distal Tibial Fractures
This study aims to evaluate the clinical efficacy and safety of an intelligent fracture reduction robot system in treating extra-articular distal tibial fractures.
- Trial name
- NCT07733271
- Testing
- Robot-assisted closed reduction, Traditional surgeon-led reduction
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Beijing Jishuitan Hospital
Tibia Fractures, Trauma (Including Fractures)
Assessment of the Feasibility of Using a Preoperative Surgical Fracture Analysis Tool
This study aims to evaluate a preoperative fracture analysis tool that uses 3D visualization and biomechanical modeling to assist surgeons in planning screw and plate fixation for complex tibial plateau fractures.
- Conditions
- Tibia Fractures, Trauma (Including Fractures), Surgical Planning
- Trial name
- NCT07193524
- Testing
- 3D Fracture Analysis Tool
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Brigham and Women's Hospital
Fragility Ankle Fractures and Complex Distal Tibial Fractures
Tibio-talo-calcaneal Fusion by Hindfoot Nail Versus Open Reduction and Internal Fixation in Treatment of Complex Fractures Distal Tibial and Fragility Ankle Fractures in Elderly
Tibiotalar calcaneal fusion by hindfoot nail Vs open reduction and internal fixation in treatment of complex distal tibial fractures and ankle fragility ankle fractures in elderly
- Trial name
- NCT06709365
- Testing
- Tibiotalar calcaneal fusion by hindfoot
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Sohag University
Tibial Fractures
Comparison of Healing Measures Tibial Fractures Following Standard Intramedullary Nailing or Micromotion Tibial Intramedullary Nailing
The primary purpose of this study is to perform a high-quality randomized control trial comparing intramedullary tibial nail fixation with standard design nails to a micromotion tibial nail device, to evaluate the rates of union…
- Trial name
- NCT06679049
- Testing
- micromotion intramedullary nail cohort, standard intramedullary nail cohort
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Alabama at Birmingham
Open Tibia Fracture, Open Dislocation of Ankle
Accelerated Flap Coverage Versus Standard Timing in the Treatment of Severe Lower Extremity Musculoskeletal Injuries
The goal of this randomized controlled trial is to determine if accelerated flap coverage compared to standard flap coverage timing leads to improved infection-related complications in patients with open fractures and/or…
- Conditions
- Open Tibia Fracture, Open Dislocation of Ankle, Extremity Fracture Lower, Extremity Injuries Lower
- Trial name
- FLAP ATTACK (NCT07828613)
- Testing
- Accelerated Flap Coverage Surgery, Standard of Care Flap Timing
- Where
- 31 sites in United States
- Volunteers
- 356 people
- Sponsor
- Johns Hopkins University
Calcaneus Fracture
Posterior Tibial Nerve PRF for Painful Calcaneal Fracture
Patients who underwent pulsed radiofrequency (PRF) treatment of the posterior tibial nerve under ultrasound guidance, which is routinely performed in our clinic for severe heel pain following a calcaneal fracture, were evaluated…
- Trial name
- NCT06888804
- Testing
- ultrasound-guided posterior tibial nerve pulsed radiofrequency, Control Group
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Diskapi Teaching and Research Hospital
Femur Fracture, Tibia Fracture
Outpatient Floor Pedal Bike Utilization
The goals of this clinical trial are: to test the feasibility of identifying patients and getting patients the floor pedal bikes, to test how well floor pedal bikes help patients with lower body injuries heal, and to test methods…
- Conditions
- Femur Fracture, Tibia Fracture, Ankle Injuries
- Trial name
- NCT06586190
- Testing
- Floor Pedal Bike with Guided Instructions for Home
- Volunteers
- 20 people
- Sponsor
- Wake Forest University Health Sciences
Tibial Fracture
Blood Flow Restriction Therapy to Optimize Muscle Size and Strength in Recovery From Lower Limb Fractures
This study will assess the feasibility and effectiveness of blood flow restriction therapy in patients with tibia fractures (or lower leg bone).
- Trial name
- BOOST (NCT07103252)
- Testing
- Blood Flow Restriction Therapy
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of British Columbia
Orthopedic Disorder, Trauma Injury
X-BS Ortho Bone Graft Study
Randomised investigation of the osteoconductive performance and safety of CE-marked FDBS bone graft (GraftR3®), with contextual reference to CE-marked IBS (MBCP® Putty), in the filling of orthopaedic bone defects.
- Conditions
- Orthopedic Disorder, Trauma Injury, Extremity Injury
- Trial name
- NCT06326827
- Testing
- FDBS (GraftR3®), IBS (MBCP® Putty)
- Volunteers
- 200 people
- Sponsor
- Advanced Medical Solutions Ltd.
PCL - Posterior Cruciate Ligament Deficiency, Posterior Cruciate Ligament Tear
Multicenter Clinical Study on Robotic-Assisted Surgical Management of Posterior Cruciate Ligament Tibial Avulsion Fractures
The primary objective of this clinical trial is to evaluate the efficacy of robotic-assisted surgery in the management of posterior cruciate ligament (PCL) avulsion fractures involving the tibial insertion site of the cruciate…
- Conditions
- PCL - Posterior Cruciate Ligament Deficiency, Posterior Cruciate Ligament Tear, PCL - Posterior Cruciate Ligament Rupture
- Trial name
- NCT07575256
- Testing
- Surgical robot-assisted arthroscopic surgery, Open reduction and internal fixation surgery
- Where
- China
- Volunteers
- 22 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Tibial Plateau Fractures
Posterior Column Fractures of Tibial Plateau
The goal of this observational study is to learn about the long-term effects of internal fixation methods in patients with posterior column fractures of tibial plateau according to three column concept.
- Trial name
- NCT06931366
- Testing
- Open reduction and internal fixation
- Where
- Egypt
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Assiut University
Open tíbia Fracture, Osteomyelitis Tibia
Intramedullary Calcium Sulfate Antibiotic Depot
The goal of this randomized clinical trial is to study the best treatment for open lower leg fractures to prevent infection. The main questions it aims to answer is if treating tibia fracture patients with a calcium sulfate…
- Conditions
- Open tíbia Fracture, Osteomyelitis Tibia, Tibial Fractures
- Trial name
- NCT05766670
- Testing
- Vancomycin Hydrochloride, Gentamicin, Standard Intramedullary Nail
- Where
- 12 sites in United States
- Volunteers
- 242 people
- Sponsor
- Wake Forest University Health Sciences
Distal Tibial Fracture, Tibial Fracture
Elastic Nailing With Kirschner Wires Versus Plate Fixation for Distal Tibial Fractures in Adolescents
This prospective randomized controlled trial will compare two surgical methods for treating distal tibial metaphyseal-diaphyseal junction fractures in adolescents aged 10 to 16 years.
- Conditions
- Distal Tibial Fracture, Tibial Fracture, Fracture Fixation, Intramedullary, Fracture Fixation, Internal
- Trial name
- NCT07783529
- Testing
- Elastic Stable Intramedullary Nailing Supplemented by Kirschner Wires, Plate fixation
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Sohag University
Congenital Pseudarthrosis of Tibia
A Study to Assess How Effective and Safe NVD003 is for Treating Patients With Congenital Pseudarthrosis of the Tibia.
The purpose of this study is to assess the efficacy and safety of NVD003 in pediatric participants with unilateral Congenital Pseudarthrosis of the Tibia (CPT) compared with iliac crest bone graft (ICBG) at 12 months post graft…
- Trial name
- NCT07112443
- Testing
- NVD003, Iliac Crest Bone Graft
- Where
- 7 sites in United States, Belgium and 2 more
- Volunteers
- 12 people
- Sponsor
- Novadip Biosciences
Tibial Fracture
Criteria-Based Rehabilitation After Tibial Fracture Fixation: A Randomized Controlled Trial
This randomized controlled trial will evaluate the effectiveness of a criteria-based progressive loading and functional rehabilitation program compared with usual physiotherapy in adults following surgical fixation of traumatic…
- Trial name
- NCT07810478
- Testing
- Criteria-Based Progressive Loading and Functional Rehabilitation Program
- Where
- Palestinian Territories
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Proximal Tibia Fracture, Tibial Shaft Fracture
MY01 Pressure Monitoring in Adolescent Tibia Fractures
The goal of this clinical trial is to learn more about anterior leg compartment pressures in adolescents who have sustained tibia fractures.
- Conditions
- Proximal Tibia Fracture, Tibial Shaft Fracture, Acute Compartment Syndrome
- Trial name
- NCT07674043
- Testing
- Continuous Compartmental Pressure Monitor
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Boston Children's Hospital
Tibial Fracture, Femoral Fracture
Magnesium-Titanium Hybrid Intramedullary Nail System For Long Bone Fractures
This is a prospective, multicenter, randomized, controlled, non-inferiority clinical trial designed to evaluate the safety and effectiveness of the magnesium-titanium hybrid intramedullary nail system compared with the marketed…
- Conditions
- Tibial Fracture, Femoral Fracture, Humeral Fracture
- Trial name
- NCT07569575
- Testing
- Magnesium-Titanium Hybrid Intramedullary Nail System, Commercially Locked Metallic Intramedullary Nail
- Where
- 5 sites in China
- Volunteers
- 160 people
- Sponsor
- HuaMg Perfection Med Tech (Suzhou) Co., Ltd.
Compartment Syndromes
Can Near-Infrared Spectroscopy (NIRS) or Intramuscular Glucose Levels Detect Impaired Leg Compartment' Perfusion?
Near infrared spectroscopy (NIRS), a technique that relies on differential absorption of infrared light to provide relative estimation of tissue oxygenation, has been successfully used to monitor perfusion of various tissues…
- Trial name
- NIRS (NCT06512870)
- Testing
- Near infrared spectroscopy (NIRS)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Florida
Smoking, Tibia Fracture
Effect of Tobacco Heating System (THS) on Closed Lower Limb Fracture Healing
The goal of this clinical trial is to investigate the role of switching from cigarette smoking (CS) to tobacco heat system (THS) on the clinical outcome of closed lower limb (tibia and femur) fractures from smokers' orthopedic…
- Trial name
- NCT05859451
- Testing
- Tobacco Heating System (THS), Smoking abstinence
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- University Hospital Tuebingen
Fracture Open Tibia
Gentamicin Open Tibia Study
Local application of antibiotics directly to the traumatic wound is a promising treatment for the prevention of infection after open tibia fractures, which are a significant source of disease burden globally, particularly in…
- Trial name
- GO-Tibia (NCT05157126)
- Testing
- Gentamicin, normal Saline
- Where
- Tanzania
- Volunteers
- 890 people
- Sponsor
- University of California, San Francisco