Clinical trials: Tibial Fracture
Femoral Fracture, Tibial Fractures
Rehabilitation Strategies to Improve Outcomes For Patients With a Lower Extremity Fracture
The purpose of this study is to evaluate speed high intensity interval training (HIIT) walking program following an orthopedic trauma.
- Trial name
- RIFLE (NCT05274022)
- Testing
- Standard of Care Physical Therapy Program, Speed Walking Intervention
- Where
- 2 sites in United States
- Volunteers
- 66 people
- Sponsor
- Brian W. Noehren
Fracture Femur, Fracture Tibia
Oral Supplementation With a Formulation Based on Cetylated Fatty Acids for Post-fracture Long Bone Healing
This clinical study aims to evaluate the potential benefits of a formulation based on Cetylated Fatty Acids in improving fracture healing of long bones in the lower limbs.
- Trial name
- CETIULTRA-BONE (NCT07299851)
- Testing
- CFA-based food supplement
- Where
- 6 sites in Belgium
- Volunteers
- 100 people
- Sponsor
- Pharmanutra S.p.a.
Tibial Plateau Fractures
EFFECT OF EARLY WEIGHT BEARING AND ACTIVE KNEE EXERCISES IN TREATMENT OF TIBIAL PLATEAU FRACTURES
This study will answer the following research questions: Are there any significant differences between combination of early active knee ROM exercises and weight bearing versus early passive ROM with delayed weight bearing on pain…
- Trial name
- NCT07251699
- Testing
- Early active exercises will be applied from the first day by the participation of the patient with the assistance of the physiotherapist
- Where
- Egypt
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Cairo University
Tibial Fractures, Fracture Infection
Zimmer® Natural Nail® (ZNN) Bactiguard Tibia Post-Market Clinical Follow-up Study
Primary objective of this study is to compare fracture related infection (FRI) rates of ZNN Bactiguard Tibia to conventional uncoated titanium-alloy nails 12 months after tibia fracture fixation.
- Trial name
- NCT05022485
- Testing
- ZNN Bactiguard tibia
- Where
- 16 sites in Austria, France and 6 more
- Volunteers
- 500 people
- Sponsor
- Zimmer Biomet
Tibial Fractures, Lower Extremity Fracture
Blood Flow Restriction Training in Patients With Lower Extremity Fractures
This study will look at the effect of using a blood flow restriction device during low load strengthening exercises on patients with tibial shaft fractures, compared to patients performing exercise without the device.
- Trial name
- NCT06496035
- Testing
- Blood Flow Restriction with low load exercise, Therapeutic Exercise
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Denver Health and Hospital Authority
Tibial Plateau Fractures
Blood Flow Restriction Therapy Improves Tibial Plateau Fracture Recovery
The goal of this clinical trial is to investigates the effectiveness of physical therapy augmented with blood flow restriction (BFR) therapy relative to standard physical therapy in patients after an open reduction and internal…
- Trial name
- NCT06589115
- Testing
- Blood Flow Restriction Cuff, Physical Therapy
- Where
- United States
- Sponsor
- Medical College of Wisconsin
Tibia Fractures, Trauma (Including Fractures)
Assessment of the Feasibility of Using a Preoperative Surgical Fracture Analysis Tool
This study aims to evaluate a preoperative fracture analysis tool that uses 3D visualization and biomechanical modeling to assist surgeons in planning screw and plate fixation for complex tibial plateau fractures.
- Conditions
- Tibia Fractures, Trauma (Including Fractures), Surgical Planning
- Trial name
- NCT07193524
- Testing
- 3D Fracture Analysis Tool
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Brigham and Women's Hospital
Tibia Fracture
OIF/β-TCP in Patients With Open Tibial Fractures in Need of Bone Grafting
A prospective, randomized, evaluator-blinded, controlled study for subjects with open tibial fractures classified as Gustilo type II, IIIA or IIIB (see Appendix 1) who will receive bone graft implantation for the potential of…
- Trial name
- NCT04960722
- Testing
- OIF/β-TCP
- Where
- Taiwan
- Volunteers
- 35 people
- Sponsor
- BioGend Therapeutics Co.Ltd
Acute Compartment Syndrome, Fracture, Bone
Evaluation of the Diagnostic and Therapeutic Value of Tissue Ultrafiltration in Patients at Risk of Acute Compartment Syndrome (ACS)
The goal of this clinical trial is to learn if tissue ultrafiltration (TUF) catheters can reduce intramuscular pressure and prevent acute compartment syndrome (ACS) in adults ages 18-60 with severe proximal tibia or tibial shaft…
- Conditions
- Acute Compartment Syndrome, Fracture, Bone, Tibial Fractures
- Trial name
- NCT05889559
- Testing
- Tissue Ultrafiltration Catheters
- Where
- 4 sites in United States
- Volunteers
- 60 people
- Sponsor
- Major Extremity Trauma Research Consortium
Tibial Fracture, Fracture of the Tibia Type AO/OTA 42
Fracture-Related Outcome Study for Operatively Treated Tibia Shaft Fractures
Approximately 1000 patients presenting with tibial shaft fractures (AO type 42) will be enrolled prospectively in this registry.
- Trial name
- FROST (NCT03598530)
- Testing
- Surgery
- Where
- 15 sites in United States, Belgium and 7 more
- Volunteers
- 1,000 people
- Sponsor
- AO Clinical Investigation and Publishing Documentation
Tibial Fracture
Blood Flow Restriction Therapy to Optimize Muscle Size and Strength in Recovery From Lower Limb Fractures
This study will assess the feasibility and effectiveness of blood flow restriction therapy in patients with tibia fractures (or lower leg bone).
- Trial name
- BOOST (NCT07103252)
- Testing
- Blood Flow Restriction Therapy
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of British Columbia
Tibial Plateau Fracture
TPF Machine Learning Algorithms
To adopt a machine learning technique to decide whether operative or non-operative treatment will result in the best patient-outcome.
- Trial name
- NCT04983316
- Where
- Belgium
- Volunteers
- 70 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Tibial Plateau Fracture, Tibial Plateau Fractures
Epidemiology of Tibial Plateau Fractures in a Tertiary Care Center: A Retrospective Cross Sectional Study
A retrospective cross-sectional study was conducted following approval from the institutional review board. Patients who presented to our center over a four-year period, from July 1 2015 to June 30 2019, were included in the…
- Trial name
- NCT07081165
- Volunteers
- 137 people
- Sponsor
- National Trauma Center
Tibial Fractures, Pain
Effect of NSAIDs on Union, Opioid Utilization and Pain Management for Tibia Fractures: A Pragmatic, Randomized Controlled Trial
Two arm, pragmatic, randomized controlled multicenter Phase III noninferiority trial evaluating the efficacy of standard pain management without NSAIDs (Group 1) vs.
- Trial name
- NSAID (NCT07006675)
- Testing
- 600 mg Ibuprofen
- Where
- 14 sites in United States, Canada
- Volunteers
- 1,000 people
- Sponsor
- Major Extremity Trauma Research Consortium
Toddler's Fracture
Toddlers Fractures - Cast Versus Removable Boot
A toddler's fracture is a fracture that occurs in the lower leg, oven the shin, of children 9 months to four years of age. It usually happens when a young child twists the leg while running or jumping.
- Trial name
- NCT03971448
- Testing
- LPWB, AKWC
- Where
- Canada
- Volunteers
- 129 people
- Sponsor
- The Hospital for Sick Children
Tibial Plateau Fractures
Posterior Column Fractures of Tibial Plateau
The goal of this observational study is to learn about the long-term effects of internal fixation methods in patients with posterior column fractures of tibial plateau according to three column concept.
- Trial name
- NCT06931366
- Testing
- Open reduction and internal fixation
- Where
- Egypt
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Assiut University
Femur Fracture, Tibial Fractures
Distal Targeter vs Free-hand
This study is a randomized controlled trial comparing the use of two different surgical techniques--free-hand versus distal targeting jig-based for distal interlock screw--placement and their effects on total operative time and…
- Conditions
- Femur Fracture, Tibial Fractures, Nonunion of Fracture, Nonunion of Fracture of Tibia
- Trial name
- NCT05613257
- Testing
- Distal targeting jig, Free-hand/perfect circles technique
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Cedars-Sinai Medical Center
Tibial Plateau Fracture
Clinical Efficacy of Open Reduction and Suture Bridge Fixation for PCL Tibial Avulsion Fractures
Abstract Background: Posterior cruciate ligament (PCL) tibial avulsion fractures significantly impair knee function; however, optimal surgical fixation approaches are not agreed upon.
- Trial name
- fracture (NCT06918171)
- Testing
- Clinical Efficacy of Open Reduction and Anchor Suture Bridge Fixation
- Where
- China
- Volunteers
- 17 people
- Sponsor
- Second Affiliated Hospital of Soochow University
Femoral Shaft Fracture, Tibial Shaft Fracture
MAGIK for Femoral/Tibial Shaft Fractures
The purpose of this phase 2 randomized control trial will be to evaluate the effect of glucose-insulin-potassium (GIK) therapy in the setting of lower extremity trauma to reduce short- and long-term muscle damage, acute…
- Trial name
- MAGIK (NCT05627479)
- Testing
- GIK solution, Isotonic Normal Saline Solution
- Where
- United States
- Sponsor
- NYU Langone Health
Femur Fracture, Tibial Fractures
Postoperative Pain Management in Patients Undergoing Intramedullary Nail Fixation After Tibia and Femoral Fractures
The purpose of this trial is to determine whether oral acetaminophen and intravenous ketorolac are viable alternatives to opioid medication regimens for the pain management of patients with tibial and femoral shaft fractures…
- Trial name
- NCT04761302
- Testing
- Intravenous ketorolac and oral acetaminophen, Intravenous morphine and oral oxycodone
- Where
- Puerto Rico
- Volunteers
- 167 people, healthy volunteers welcome
- Sponsor
- University of Puerto Rico