Clinical trials: Thrombus
Venous Thrombosis Deep (Limbs), Post Thrombotic Syndrome
EXERT: Exercise Physiology After Thrombosis
Deep vein thrombosis (DVT) can cause long-term scarring and narrowing of veins. When there is extensive damage to the veins in the legs, groin or abdomen it can affect the way that blood is able to flow back up to the heart.
- Trial name
- NCT05296499
- Testing
- Cardiopulmonary exercise test (CPET), Exercise cardiac MRI, 6 minute walk test
- Where
- United Kingdom
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Retinal Vein Occlusions
Single Site, Masked, Randomized, Controlled Study to Assess Efficacy of Osurdex as Adjunct to Avastin Compared With Avastin Alone in the Treatment of Patients With Macular Edema Due to Central or Branch Retinal Vein Occlusion
Comparative study to see if treating with Osurdex in addition to Avastin in patients with retinal vein occlusions helps increased visual acuity outcomes
- Trial name
- NCT01085734
- Testing
- Avastin, Osurdex
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Maturi, Raj K., M.D., P.C.
Healthy
Trial to Assess the Effects of Different Trans-fatty Acids on Endothelial Function in Humans
The aim of the study is to compare a diet rich in trans fatty acids (TFA) from ruminant sources with a diet rich in TFA from hydrogenated vegetable oils (PHVO) in regard to their effects on cardiovascular risk markers…
- Trial name
- NCT00933322
- Testing
- diet enriched with industrial trans fatty acids, diet enriched with ruminant trans fatty acids, diet without any trans fatty acids
- Where
- Switzerland
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
End-Stage Renal Disease
A Pharmacokinetics, Pharmacodynamics and Safety Study of Single Dose of Rivaroxaban in Participants With End-Stage Renal Disease (ESRD) on Maintenance Hemodialysis
The purpose of this study is to assess the pharmacokinetics (the study of the way a drug enters and leaves the blood and tissues over time) and pharmacodynamics (the way a drug may change body function) of a single 15-milligram…
- Trial name
- NCT02289703
- Testing
- Rivaroxaban 15 mg
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Insulin Resistance, Cardiovascular Disease
Depot-medroxyprogesterone Acetate (DMPA) Contraceptive Method and Metabolism
Objective: The purpose of this study is to determine the etiology of the weight increase in Depot-medroxyprogesterone Acetate (DMPA) users.
- Conditions
- Insulin Resistance, Cardiovascular Disease, Bone Loss, Eating Disorders
- Trial name
- DMPA (NCT01527526)
- Where
- Brazil
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Menopause
Hormone Estradiol Replacement Therapy Additional Herbals
The purpose of this study is to determine whether Hormone Replacement Therapy (HRT), safety studies are combined with herbal (garlic oil, rutin, and nattokinase) to reduce estrogen side effects.
- Trial name
- WH (NCT02618148)
- Testing
- ESTROGEN HERBALS 21, ESTROGEN HERBALS 28
- Where
- Vietnam
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Trieu, Nguyen Thi, M.D.
Deep Venous Thrombosis
Doppler Ultrasound Imaging of Plastic Surgery Patients for DVT Detection
This prospective controlled study examines the use of Doppler ultrasound as a means to screen elective plastic surgery patients for the presence of deep venous blood clots both before and after surgery.
- Trial name
- NCT02123550
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Swanson Center
Other Acute Illnesses Presenting to the Hospital, Heart Failure
Evaluation of Implementation of a National Point-of-Care Ultrasound Training Program
This VA QUERI Partnered Evaluation Initiative will evaluate the impact of an immersive Point-of-care Ultrasound (POCUS) Training Course on provider skill acquisition and retention; the frequency of POCUS use by trained providers…
- Conditions
- Other Acute Illnesses Presenting to the Hospital, Heart Failure, Pneumonia, Deep Venous Thrombosis
- Trial name
- NCT03296280
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Deep Venous Thromboses, Deep Venous Thrombosis of Left Leg
Point of Care Ultrasound For The Diagnosis Of Deep Venous Thrombosis And Its Effect On Length Of Hospital Stay
This is a Clinical Trial on the use of Point Of Care Ultrasound for the diagnosis of deep venous thrombosis (DVT) and its effect on length of hospital stay.
- Conditions
- Deep Venous Thromboses, Deep Venous Thrombosis of Left Leg, Deep Venous Thrombosis of Right Leg, Deep Venous Thrombosis Proximal
- Trial name
- NCT03038893
- Testing
- Point Of Care Ultrasound (PODUS), Echo Doppler Ultrasound (EDUS)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Vascular Function, Atherothrombosis
Comparison of Vascular Function in Emergency Service Professionals
Emergency Service Professionals have an increased risk of death from heart attacks when compared to the general public. All the emergency professions share similar responsibilities such as emergency call-outs and shift work.
- Trial name
- FIRECOP (NCT01813032)
- Testing
- Forearm Vascular Study, Badimon Chamber
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Atrial Fibrillation
Blinded Randomized Controlled Trial of Artificial Intelligence Guided Detection of Intracardiac Thrombus
To determine whether an integrated AI decision support can save time and improve the accuracy of detection of intracardiac thrombus, the investigators are conducting a blinded, randomized controlled study of AI-guided detection…
- Trial name
- NCT06206187
- Testing
- Automated detection of the intracardiac thrombus through deep learning, Electrophysiologist judgment of the intracardiac thrombus
- Where
- China
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Shanghai Chest Hospital
Heart Disease
The Effect of a Retrofit Particle Trap on the Vascular Effects of Diesel Exhaust Inhalation
The purpose of this study is to determine whether a retrofit particle trap can reduce the adverse vascular responses to diesel exhaust inhalation
- Trial name
- NCT00745446
- Testing
- Forearm Venous Occlusion Plethysmography
- Where
- Sweden
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Brain Injuries, Pulmonary Embolism
Improving the Stewardship of Diagnostic Imaging Resources in Alberta Emergency Departments
Utilization of diagnostic imaging in the Emergency Department has increased dramatically over the past two decades, driven by an increased availability of advanced imaging, legal pressures to exclude serious diagnoses in low-risk…
- Trial name
- NCT02410941
- Testing
- Clinical decision support
- Where
- 16 sites in Canada
- Volunteers
- 52,058 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Venous Thrombosis
A Comparison of Neuromuscular Electrical Stimulation and Intermittent Pneumatic Compression in Terms of Lower Limb Blood Flow
Deep Vein Thrombosis (DVT) is a life threatening condition and a serious concern among hospitalized patients, with death occurring in approximately 6% of cases.
- Trial name
- NCT01886612
- Testing
- Duo-STIM neuromuscular electrical stimulator, AV Impulse System Model 6000
- Where
- Ireland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National University of Ireland, Galway, Ireland
Healthy, Intravenous Catheterization
Effect of Flexible Catheter Materials on Catheter Angle and Blood Vessel Irritation
Peripheral intravenous catheters (PIVCs; commonly known as "cannulas") are very small tubes made out of rubber-like materials which are inserted into patients' arms using a needle to allow easy access to veins.
- Conditions
- Healthy, Intravenous Catheterization, Oedema, Thrombosis
- Trial name
- FLEXIT (NCT06927141)
- Testing
- Bilateral Peripheral Intravenous Catheterisation
- Where
- Australia
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Griffith University
Glanzmann Thrombasthenia
The Genetics and Functional Basis of Inherited Platelet, White Blood Cell, Red Blood Cell, and Blood Clotting Disorders.
Blood contains red blood cells, white blood cells, and platelets, as well as a fluid portion termed plasma. We primarily study blood platelets, but sometimes we also analyze the blood of patients with red blood cell disorders…
- Trial name
- NCT00230165
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
Deep Venous Thrombosis of Deep Femoral Vein
Venous Thrombosis Prevention and Sleep Quality: A Comparison of the Kendall and the Recovery Health MAC Systems
Venous thromboembolism is prevalent, associated with a high degree of morbidity and mortality, and largely preventable. External mechanical compression is a standard of care for prevention, but compliance with traditional…
- Trial name
- NCT06042686
- Testing
- RF Health MAC Device
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Amherst
Venous Thrombosis, Venous Insufficiency
Evaluating the Relationship Between Blood Clotting Disorders, Inflammation, and Obesity in Individuals With Venous Disorders and Post-Thrombotic Syndrome
Venous thrombosis is the development of a blood clot in a vein. Post-thrombotic syndrome (PTS) is a painful condition that can develop following a venous thrombosis in one of the deep veins of the leg.
- Trial name
- NCT00395265
- Where
- United States
- Volunteers
- 2,211 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Thrombosis, Menopause
Exercise Training and Thrombotic Risk in Post-menopausal Women
At menopausal transition, the risk of cardiovascular diseases increases. This is partly due to aging, but largely also the loss of estrogen, which has many positive effects on the circulation and protects against cardiovascular…
- Conditions
- Thrombosis, Menopause, Exercise Training, Vascular Dilation
- Trial name
- TIME (NCT04596501)
- Testing
- Early and late postmenopausal women
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Periodontoclasia, Gingiva; Injury
Use of Injectable-platelet-rich-fibrin (I-PRF) to Thicken Gingival Phenotype
The main objective of this study is to investigate whether the for individuals with thin gingival thickness who are susceptible to gingival recession, the investigators will use i-PRF with microneedle to increase gingival…
- Conditions
- Periodontoclasia, Gingiva; Injury, Condition, Blood Clot
- Trial name
- NCT03274674
- Testing
- I-PRF
- Where
- Turkey (Türkiye)
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University