Clinical trials: Thrombin
Burns
Autologous Platelets Concentrate and Autologous Thrombin for the Treatment of Deep Burn Trauma
Deep skin burn injuries, especially extensive deep burns or/and deep burns extending on the face, hands, feet, genitalia and perineum, remain one of the most challenging therapeutic problems.
- Trial name
- NCT01383187
- Testing
- DE graft and PRP concentrate, DE graft
- Where
- Czechia
- Volunteers
- 30 people
- Sponsor
- University Hospital Ostrava
Sepsis, Disseminated Intravascular Coagulation
Thrombin Generation and Thromboelastography in Non-overt DIC
Sepsis is the 13th most common cause of death in the United States, causing approximately 210,000 deaths per year. Once DIC has developed, irreversible organ injury has already occurred and the mortality rate is 70%.
- Trial name
- NCT00299949
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- The University of Texas Health Science Center, Houston
Bleeding, Surgery
Trial of PCC Versus FFP in Patients Undergoing Heart Surgery
The PROPHESY trial is a single centre pilot trial investigating Fresh Frozen Plasma (FFP) or Prothrombin Complex Concentrate (PCC) treatment for patients who are bleeding during cardiac surgery, and who are NOT receiving a…
- Conditions
- Bleeding, Surgery, Transfusion
- Trial name
- PROPHESY (NCT03715348)
- Testing
- Prothrombin Complex Concentrate (PCC), Fresh Frozen Plasma
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Queen Mary University of London
Targeted Temperature Management, Cardiac Arrest
The Impact of Targeted Temperature Management Duration on Thrombin Function in Cardiac Arrest Patients
This study will be a single-center, prospective, randomized controlled trial with an estimated sample size of 64 patients. Eligible patients will be randomly assigned in a 1:1 ratio to receive TTM for either 24 hours or 72 hours.
- Conditions
- Targeted Temperature Management, Cardiac Arrest, Thrombin Function, Treatment Duration
- Trial name
- ITTC (NCT06543849)
- Testing
- Target Temperature Management Treatment
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Tang Ziren
Type 2 Diabetes Mellitus, Hypercholesterolemia
Atorvastatin, Aspirin, Oxidative Stress, Coagulation and Platelet Activation Indexes
Primary and secondary prevention trials with statins, as well as with antiplatelet, clearly demonstrated that these drugs are able to reduce cardiovascular events.
- Trial name
- NCT01322711
- Testing
- Atorvastatin
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Roma La Sapienza
Gastrointestinal Bleeding
Management of Gastrointestinal Bleeding Under Direct Oral Anticoagulants
Gastrointestinal bleeding (GIB) is a common emergency in hepatology and gastroenterology, with an overall mortality rate ranging from 5% to 10% depending on the study.
- Trial name
- HEMOD-AOD (NCT07333144)
- Where
- France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Strasbourg, France
End Stage Renal Disease, Thrombosis
Safety and Efficacy Study of AB002 (E-WE Thrombin) in End Stage Renal Disease Patients on Chronic Hemodialysis
This study evaluates the safety and efficacy of AB002 (E-WE thrombin) in patients with end stage renal disease on chronic hemodialysis. Two dose levels will be evaluated in two cohorts.
- Trial name
- NCT03963895
- Testing
- AB002 Dose 1, AB002 Dose 2
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Aronora, Inc.
Prothrombin Complex Factor Deficiency
Efficacy and Safety of Prothromplex Total (Prothrombin Complex Concentrate) in Oral Anticoagulant Reversal
The purpose of the study is to assess the efficacy and safety of Prothromplex Total as a treatment for the immediate reversal of oral anticoagulant therapy with vitamin K antagonists in patients with acquired deficiency of…
- Trial name
- NCT01159210
- Testing
- Prothrombin complex concentrate (coagulation factors IX, II, VII and X in combination)
- Where
- 6 sites in Austria, Hungary
- Volunteers
- 61 people
- Sponsor
- Baxalta now part of Shire
Anticoagulation, Anticoagulation Reversal
Assessment of Coagulation Factor Levels in Left Ventricular Device (LVAD )Patients Following Temporary Warfarin Reversal With Four Factor Prothrombin Complex Concentrate (4F-PCC)
Prospective assessment of vitamin K dependent coagulation factor levels after temporary warfarin reversal in participants with left ventricular assist devices (LAVD).
- Trial name
- KVAD (NCT03473132)
- Testing
- four factor prothrombin complex concentrate
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Brigham and Women's Hospital
Venous Thromboembolism, Cancer
Prediction of Venous Thrombosis During chemotherapy-the PINPOINT Study
Cancer patients are at higher risk of getting a blood clot (known as venous thromboembolism (VTE)) especially during chemotherapy and some patients are more at risk than others.
- Trial name
- PINPOINT (NCT07196020)
- Where
- 3 sites in Ireland
- Volunteers
- 380 people
- Sponsor
- University of Dublin, Trinity College
Device-detected Atrial Fibrillation, Subclinical Atrial Fibrillation
Blood Clotting Markers and Heart Ultrasound in People With Device-Detected Atrial Fibrillation
The purpose of this observational study is to investigate whether blood tests related to blood clotting are associated with established clinical stroke risk scores, the total amount of device-detected atrial fibrillation recorded…
- Conditions
- Device-detected Atrial Fibrillation, Subclinical Atrial Fibrillation, Atrial High Rate Episodes
- Trial name
- DDAF-HEV (NCT07713615)
- Where
- Denmark
- Volunteers
- 222 people
- Sponsor
- Andreas Sjøholm-Christensen
Clotting Disorders
Study to Determine the Accuracy of Prothrombin Time of Warfarinised Blood
The purpose of this study is to measure prothrombin time (PT) expressed in International Normalised Ratio (INR) units in persons receiving coumadin (warfarin) treatment on an experimental device and a commercially available…
- Trial name
- NCT01375725
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Universal Biosensors Pty Ltd
Shock, Hemorrhagic
Early Administration of Prothrombin Concentrate Complex in Patients With Acute Hemorrhage Following Severe Trauma
Acute traumatic coagulopathy (ATC) is common in severe trauma patients (around 25 to 30% of patients with severe trauma) and is associated with increased mortality.
- Trial name
- PROCOAG (NCT03218722)
- Testing
- Pro-Thrombin Concentrate Complex, NaCl 0.9%
- Where
- 12 sites in France
- Volunteers
- 350 people
- Sponsor
- University Hospital, Grenoble
Fibrin Blood Clot, Pregnancy
Pregnancy and Fibrin Clot Properties
1. The structure of fibrin clot and thrombin generation may vary between trimesters of pregnancy. 2. Unfavorably altered fibrin clot properties along with enhanced thrombin generation may lead to the development of complications…
- Conditions
- Fibrin Blood Clot, Pregnancy, Pregnancy Complicated by Cardiovascular Disorders as Postpartum Condition, Delivered During Previous Episode
- Trial name
- NCT07275476
- Testing
- analysis of fibrin clot properties and thrombin generation
- Where
- Poland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Jagiellonian University
Cardiac Surgery
Interruptions in the Coagulationsystem in Relation With Cardiac Surgery - A Study Comparing Two Heparinization Strategies During On-pump Cardiac Surgery
The purpose of this study is to find the heparinization method, which 1. affect the heparin-protaminsulfate ratio in the best way to achieve haemostasis 2.
- Trial name
- NCT01462968
- Testing
- Activated clotting time versus blood-heparin concentration
- Where
- Denmark
- Sponsor
- Aalborg University Hospital
Beta Thalassemia Major Anemia
Thrombin Generation in Beta-thalassemia Major
This study aims to evaluate the persistence of a hypercoagulable state in chronically-transfused patients with beta thalassemia major, by using the thrombin generation test (performed in whole blood and plasma).
- Trial name
- TG-THAL (NCT04962984)
- Testing
- blood sampling
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Sterility, Female, Reproductive Technology, Assisted
Prothrombotic Biomarkers and Ovarian Stimulation
The aim of this study is to assess the impact of different protocols used for ovarian stimulation during in vitro fertilization procedures (IVF) on prothrombotic biomarkers (blood coagulation markers associated with…
- Trial name
- HEMOSTIM (NCT04188444)
- Testing
- Blood test
- Where
- 2 sites in Switzerland
- Volunteers
- 65 people
- Sponsor
- University Hospital, Geneva
Hemophilia A
Version Testing of EnzySystem Version A for Hemophilia A
Background of the study: To measure blood clotting, blood is taken from a vein. This blood is processed in the laboratory and then tested.
- Trial name
- NCT06273865
- Testing
- Several assays
- Where
- 2 sites in Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Intracranial Hemorrhages
International Normalized Ratio (INR) Normalization in Coumadin Associated Intracerebral Haemorrhage
Intracerebral haemorrhage (ICH) is the most feared complication in patients on vitamin K antagonists (VKA). VKA related ICH occurs 8-10 times more frequently and the mortality is 2 times higher than in non-anticoagulated…
- Trial name
- INCH (NCT00928915)
- Testing
- Prothrombin complex concentrate (PCC); fresh frozen plasma (FFP)
- Where
- Germany
- Volunteers
- 54 people
- Sponsor
- Heidelberg University
Postpartum Haemorrhage
PCC and Fibrinogen Compared With FFP in PPH
The purpose of the study is to find out if the regimen of prothrombin complex concentrate (PCC) together with fibrinogen concentrate is as efficient as fresh frozen plasma (FFP) (plus fibrinogen if needed) during the early stages…
- Trial name
- NCT01910675
- Testing
- PCC, FFP
- Where
- Finland
- Sponsor
- Helsinki University Central Hospital