Clinical trials: Thoracic Tumor
Breast Cancer, Lung Cancer
Study for the Multidimensional Analyses of Resistance and Toxicity to Immune- and Targeted-therapies.
Novel treatment modalities like targeted therapies and Immune checkpoint inhibitors have revolutionised the therapeutic landscape in oncology and hematology, significantly improving outcomes even in clinical contexts in which…
- Conditions
- Breast Cancer, Lung Cancer, Melanoma, Head and Neck Cancer
- Trial name
- POSITive (NCT06321640)
- Testing
- Cohort A: primarily operable disease, candidate to adjuvant, Cohort B: locally advanced disease, Cohort C: metastatic disease
- Where
- Italy
- Volunteers
- 265 people, healthy volunteers welcome
- Sponsor
- European Institute of Oncology
Lung Cancer
Early Detection of Lung Cancer in a High-Risk Population Defined by PFT, Biomarkers, and CT Scanning
Lung cancer is the number one cancer killer in Kentucky and has a very high incidence within the 5th Congressional District of Kentucky (110.8 cases per 100,000 in period 1996-2000).
- Trial name
- NCT00596310
- Testing
- CT
- Where
- 4 sites in United States
- Volunteers
- 531 people, healthy volunteers welcome
- Sponsor
- Susanne Arnold
Mediastinal Tumor
Totally no Tube (TNT) Uniportal Video-assisted Thoracoscopic Surgery (VATS) VS Traditional Uniportal VATS for Mediastinal Tumor
TNT surgery is a new area of exploration and evolution in thoracic minimal invasive surgery. TNT Uniportal Video-assisted Thoracoscopic Surgery (VATS) has become popular during mediastinal tumors resection.
- Trial name
- NCT03537430
- Testing
- TNT uniportal VATS mediastinal tumor resection, Traditional uniportal VATS mediastinal tumor resection
- Where
- China
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Xueying Yang
Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia
Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection
This study collects blood and tissue samples from patients with cancer and without cancer to evaluate tests for early cancer detection.
- Conditions
- Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Ann Arbor Stage I Lymphoma, Ann Arbor Stage II Lymphoma
- Trial name
- NCT05334069
- Testing
- Questionnaire Administration, Biospecimen Collection
- Where
- 751 sites in United States
- Volunteers
- 2,900 people, healthy volunteers welcome
- Sponsor
- Alliance for Clinical Trials in Oncology
Non-Small Cell Lung Cancer
Clinical Trial to Evaluate the Safety and Effects of Ethnicity and Food on Pharmacokinetics of YH25448
Clinical trial is to evaluate the effect of ethnicity and food on the pharmacokinetics (how a drug is absorbed, metabolized, distributed and excreted; plasma drug concentration will be measured in this clinical trial) of YH25448…
- Trial name
- NCT03556436
- Testing
- YH25448 240mg
- Where
- South Korea
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Yuhan Corporation
Lung Non-Small Cell Carcinoma
Developing a Shared Decision Making Tool for Patients With Surgically Removed Non-small Cell Lung Cancer
This study observes conversations between non-small cell lung cancer patients and their doctors to support the development of a decision aid that can be used to inform discussions about treatment options for after surgery.
- Trial name
- NCT05416983
- Testing
- Discussion, Questionnaire Administration
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Inflammation, Smoking Cessation
Screening and Multiple Intervention on Lung Epidemics
This prospective randomized pilot trial will evaluate a multiple intervention program of prevention in lifelong smokers aiming at reduction of chronic inflammation status through treatment with low-dose acetylsalicylic acid…
- Conditions
- Inflammation, Smoking Cessation, Diet Modification, Physical Activity
- Trial name
- SMILE (NCT03654105)
- Testing
- Cytisine, Acetylsalicylic acid, Diet Modification and Physical Activity Increase
- Where
- Italy
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Breast Cancer, Risk Reduction
BC Risk Assessment Before Top Surgery
The population of transgender and gender-diverse (TGD) persons in Wisconsin and the U.S. is steadily increasing. As this population grows, the number of individuals seeking gender-affirming therapies, including gender-affirming…
- Trial name
- NCT06239766
- Testing
- Breast Cancer Risk Assessment
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Non Small Cell Lung Cancer, Chronic Obstructive Pulmonary Disease
Study of Use of CTC in NSCLC
The purpose of this study is to assess whether the detection of circulating tumor cells (CTC) could be used as a tool to earlier diagnose, more accurately predict treatment response / failure and predict overall survival in…
- Trial name
- NCT01990651
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Cardiovascular Diseases, Chronic Obstructive Pulmonary Diseases
The Efficacy and Safety of Electronic Cigarettes: a 5-year Follow-up Study
The main aim of this multicentric 5-year follow-up study is to evaluate for the first time the long-term efficacy and safety (in terms of smoking-related serious diseases requiring hospitalization) of e-cigarette smoking…
- Conditions
- Cardiovascular Diseases, Chronic Obstructive Pulmonary Diseases, Cancer of the Lung, Cancer of the Bladder
- Trial name
- NCT01785537
- Where
- Italy
- Volunteers
- 1,050 people, healthy volunteers welcome
- Sponsor
- Università degli Studi 'G. d'Annunzio' Chieti e Pescara
Lung Carcinoma
Educating Smokers About Lung Cancer Screening Using Tobacco Quitlines
This implementation study will examine the best ways to refer heavy smokers to information about lung cancer screening.
- Trial name
- NCT04595422
- Testing
- Educational Intervention, Questionnaire Administration, Survey Administration
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Breast Cancer, Colorectal Cancer
UMCC 003 Cancer-Related Protein Biomarkers in Blood and Tumor Tissue of Patients With Cancer
RATIONALE: Studying samples of blood and tumor tissue in the laboratory from patients with cancer and blood from healthy participants may help doctors learn more about changes that may occur in DNA and identify biomarkers related…
- Conditions
- Breast Cancer, Colorectal Cancer, Esophageal Cancer, Liver Cancer
- Trial name
- IRB 2000-294 (NCT00900094)
- Testing
- fluorescence in situ hybridization, polymerase chain reaction, protein expression analysis
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Michigan Rogel Cancer Center
Cardiovascular Abnormalities, Arterial Blood Pressure
Multicenter Study on Cardiovascular and Metabolic Complications in Patients With Biochemically Silent Pheochromocytomas and Paragangliomas
The aim of the study is to characterise the cardiovascular and metabolic complications pre- and post-surgery of patients with biochemically negative PPGL and to compare them with normal individuals and patients with secreting…
- Conditions
- Cardiovascular Abnormalities, Arterial Blood Pressure, Heart Rate, Congestive Heart Failure Chronic
- Trial name
- NCT07316075
- Where
- Greece
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Laikο General Hospital, Athens
Urinary Retention
Post-operative Urinary Retention (POUR) Following Thoracic Surgery
Inability to urinate a common complication that happens to many patients after a surgery, especially in men over 60 years of age who undergo surgery on their chest.
- Trial name
- POUR (NCT03609580)
- Testing
- Tamsulosin - 1 week, Tamsulosin - 3 days
- Where
- United States
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- Hackensack Meridian Health
Mesothelioma, Lung Cancer
Early Detection of Lung Cancer and Mesothelioma in Workers Exposed to Asbestos
This is a pilot study that aims to develop a lung cancer screening program for workers in British Columbia, Canada exposed to asbestos who are at risk of developing lung cancer/pleural mesothelioma.
- Trial name
- NCT01719068
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- British Columbia Cancer Agency
Caregiver, Head and Neck Carcinoma
Geriatric and Quality of Life Assessments in Older Patients With Non-metastatic or Metastatic Head and Neck or Lung Cancer Undergoing Surgery or Chemoradiation and Their Caregivers
This trial studies comprehensive geriatric and quality of life assessments in older patients with head and neck or lung cancer that has or has not spread to other parts of the body who are undergoing standard surgery or…
- Conditions
- Caregiver, Head and Neck Carcinoma, Lung Carcinoma, Metastatic Head and Neck Carcinoma
- Trial name
- NCT03902535
- Testing
- Comprehensive Geriatric Assessment, Quality-of-Life Assessment, Questionnaire Administration
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Malignant Female Reproductive System Neoplasm, Malignant Hepatobiliary Neoplasm
Acceptance and Commitment Therapy in Improving Well-Being in Patients With Stage III-IV Cancer and Their Partners
This pilot clinical trial studies how well acceptance and commitment therapy works in improving well-being in patients with stage III-IV cancer and their partners.
- Conditions
- Malignant Female Reproductive System Neoplasm, Malignant Hepatobiliary Neoplasm, Partner, Stage III Breast Cancer
- Trial name
- NCT03112668
- Testing
- Cognitive Behavior Therapy, Quality-of-Life Assessment, Questionnaire Administration
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Lung Cancer, PROM
Impact of COVID-19 on Lung Cancer Patients
During the COVID-19 pandemic, people's lives have changed dramatically. People with lung cancer who are shielding may have been particularly affected as they may be unable to carry out many of their normal daily activities, such…
- Conditions
- Lung Cancer, PROM, Covid19, Psychological
- Trial name
- NCT04538456
- Testing
- questionnaire and optional interview
- Where
- United Kingdom
- Volunteers
- 296 people, healthy volunteers welcome
- Sponsor
- The Christie NHS Foundation Trust
Lung Cancer (Diagnosis), Non-Small Cell Lung Cancer
Lung Cancer Screening in Population Who Had Never Smoked
Study design: prospective, single arm. Objectives: survey lung cancer detection rate of low-dose computed tomography (LDCT) screening in individuals who had never smoked.
- Conditions
- Lung Cancer (Diagnosis), Non-Small Cell Lung Cancer, Small Cell Carcinoma of Lung, Screening Strategy
- Trial name
- NCT07383454
- Testing
- Low dose computed tomography
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Chung Shan Medical University
COPD, Lung Cancer (NSCLC)
Tumors and Respiratory System Diseases Due to Air Pollution: New Biomarkers of Exposure and Effects
This study aims to examine the exposure to atmospheric pollutants in a group of non-smoking patients suffering from lung cancer, chronic obstructive pulmonary disease (COPD), and leukemia.
- Conditions
- COPD, Lung Cancer (NSCLC), Leukemia
- Trial name
- RECAP (NCT06800586)
- Where
- 3 sites in Italy
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna