Clinical trials: Thoracic Nerve Block
Pain
Paravertebral Analgesia Associated With Intravenous Morphine PCA After Thoracotomy
osteolateral thoracotomy is a painful surgical procedure.Thoracic epidural analgesia (TEA) is usually considered as the "gold standard" for postoperative thoracic analgesia.
- Trial name
- NCT00620490
- Testing
- ropivacaine, nacl 0,9%
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Strasbourg, France
Pain, Postoperative, Coronary Artery Disease
Pecto-Intercostal Fascial Block vs. Transversus Thoracic Muscle Plane Block in Cardiac Surgery
In patients undergoing open cardiac surgery, pain control is an essential part of the enhanced recovery process. The current study aimed to evaluate the analgesic efficacies of ultrasound-guided pecto-intercostal fascial block…
- Trial name
- NCT04791592
- Testing
- Single-injection, ultrasound-guided bilateral PIF block., Single-injection, ultrasound-guided bilateral TTMP block.
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Ondokuz Mayıs University
Non-Small Cell Lung Cancer (NSCLC), Microsatellite Instability-High (MSI-H)
Study of RP1 Monotherapy and RP1 in Combination With Nivolumab (IGNYTE)
The Phase 2 study is a multicenter, open-label study of RP1 to further investigate safety and to estimate the efficacy of RP1 at the RP2D in combination with nivolumab in patients with Stage IIIb-IV unresectable melanoma…
- Conditions
- Non-Small Cell Lung Cancer (NSCLC), Microsatellite Instability-High (MSI-H), Non-melanoma Skin Cancer (NMSC), Cutaneous Melanoma
- Trial name
- IGNYTE (NCT03767348)
- Testing
- RP1, nivolumab
- Where
- 51 sites in United States, France and 3 more
- Volunteers
- 340 people
- Sponsor
- Replimune, Inc.
Thoracic Diseases, Postoperative Pain
Minimally Invasive Thoracic Surgery Intercostal Nerve Block Trial
The Minimally Invasive Thoracic Surgery Intercostal Nerve Block Trial is a single center, double-blind, randomized, active-comparator controlled clinical trial to assess the analgesic efficacy of intercostal nerve block by…
- Conditions
- Thoracic Diseases, Postoperative Pain, Opioid Use
- Trial name
- NCT03508830
- Testing
- Liposomal bupivacaine, Bupivacaine Injection
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Post-operative Pain, Acute, Post-operative Pain
Postoperative Analgesia y After Uniportal Video-assisted Thoracoscopic Surgery
Ultrasound-guided erector spinae plane block (ESPB) is an interfascial blockade during thoracic anesthesia, first described by Forero in 2016, and is highlighted by technically feasibility and less complication rate.
- Conditions
- Post-operative Pain, Acute, Post-operative Pain, Thoracic Diseases, Post-Op Complication
- Trial name
- NCT05242328
- Testing
- Ultrasound-guided erector spinae plane block, surgical thoracoscopic intercostal nerve block
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Cheng-Kung University Hospital
Thoracoscopic Surgery, Nerve Block
Comparison of Analgesic Effect and Postoperative Recovery of SAPB Combined With ESPB and TPB After Thoracoscopic Surgery
After thoracoscopic surgery, patients still face moderate to severe pain. How to effectively control pain and promote postoperative recovery of patients is a challenging problem.
- Trial name
- NCT05538429
- Testing
- erector spinal plane combined with serratus anterior plane block
- Where
- China
- Volunteers
- 92 people
- Sponsor
- Zhangyi
Postoperative Pain Following Coronary Artery Bypass Grafting (CABG)
Combined SPSP and TTP Blocks for Postoperative Analgesia Post-CABG
The goal of this clinical trial is to learn if combining two ultrasound-guided nerve blocks - one for the front of the chest and one for the side of the chest - works better than standard pain medications alone to treat pain…
- Trial name
- PACT (NCT07658521)
- Testing
- Transversus Thoracic Plane Block, Transversus Thoracic Plane (TTP) Block, Conventional Systemic Analgesia
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Breast Cancer, Analgesia
U/S Guided Transversus Thoracic and Pectoral Nerve Block Versus Pectoral Nerve Block in MRM
Interfascial blocks score over regional anesthetic techniques such as Transversus Thoracic Plane Block and Pectoral Nerves (PECS) Block as they have no risk of sympathetic blockade, intrathecal or epidural spread, which may lead…
- Trial name
- NCT06371625
- Testing
- Transeversus Thoracic Plane Block (TTPB) and Pectoral Nerves (PECS) Block, Pectoral Nerves (PECS) Block
- Where
- 3 sites in Egypt
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Ahmed Mohamed Soliman
Thoracic Paravertebral Block, Video-assisted Thoracoscopic Surgery
Comparison of Thoracic Paravertebral Block and Pectoral Nerve Block
This study aims to compare the efficacy and safety of ultrasound-guidedPECS II block with TPVB for postoperative analgesia after VATS.
- Conditions
- Thoracic Paravertebral Block, Video-assisted Thoracoscopic Surgery, Postoperative Analgesia
- Trial name
- NCT04855994
- Testing
- paravertebral block, pectoral block
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Rib Fractures, Pain, Acute
Erector Spinae Plane (ESP) Versus Paravertebral Nerve (PVB) Blockade for Acute Unilateral Rib Fracture Pain
Continuous paravertebral analgesia and erector spinae plane blockade (ESP) are accepted techniques at University of Pittsburgh Medical Center (UPMC) for the management of thoracic pain following surgery and trauma.
- Conditions
- Rib Fractures, Pain, Acute, Thoracic Injuries, Neuropathic Pain
- Trial name
- NCT03540095
- Testing
- Erector Spinae Plane Block, Paravertebral Nerve Block
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Pittsburgh
Lung Diseases
ESPB Versus INB With PCIA in Video-assisted Thoracic Surgery
A randomized prospective trial to test the non-inferiority of erector spinae plane block (ESPB) in comparison with intercostal nerve block combined with patient-controlled intravenous analgesia in Thoracoscopic lung surgery
- Trial name
- NCT03682354
- Testing
- Intercostal Nerve Block with PCIA, Erector Spinae Plane Block (ESPB)
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Peking University Third Hospital
Thoracic Surgery, Glycemic Variability
Comparison of Liposomal Bupivacaine Paravertebral Nerve Block Versus Intercostal Nerve Block on Postoperative Glycemic Variability in Patients Undergoing Minimally Invasive Pulmonary Resection: A Randomized Controlled Non-Inferiority Trial
In this randomized controlled non-inferiority trial, we will test whether liposomal bupivacaine intercostal nerve block is non-inferior to paravertebral nerve block for the coefficient of variation (CV) of glucose during the 0…
- Trial name
- NCT07754916
- Testing
- Paravertebral nerve block, Intercostal nerve block
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Xiangya Hospital of Central South University
Thoracic Anesthesia, Postoperative Pain
Serratus Posterior Superior Intercostal Plane Block Versus Intrathecal Morphine in VATS
This study aims to compare the analgesic effects of the serratus posterior superior intercostal plane block and intrathecal morphine in patients undergoing video-assisted thoracoscopic surgery.
- Conditions
- Thoracic Anesthesia, Postoperative Pain, Video Assisted Thoracic Surgery (VATS)
- Trial name
- NCT07540104
- Testing
- Intrathecal Morphine, Serratus Posterior Superior Intercostal Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ondokuz Mayıs University
Pain
Effects and Dose Response of Dexamethasone on Intercostal Blocks With Bupivicaine in Post Thoracic Surgery Patients
Post-op analgesia is the most important part of early and safe patient recovery in thoracic surgery. This is for both humane and patient outcome reasons.
- Trial name
- NCT02936427
- Testing
- Dexamethasone
- Where
- Ireland
- Volunteers
- 60 people
- Sponsor
- University College Dublin
Robotic Lung Surgery
Bupivacaine/Epinephrine +Dexamethasone vs. Liposomal Bupivacaine
This study will assess analgesia after robotic lung surgery. Subjects will be randomized to receive wound infiltration and intercostal nerve block with either liposomal bupivacaine or bupivacaine/epinephrine + dexamethasone.
- Trial name
- NCT03906617
- Testing
- Intercostal nerve block and wound infiltration with liposomal bupivacaine, Intercostal nerve block and wound infiltration with bupivacaine/epinephrine + dexamethasone
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- The Cooper Health System
Analgesia, Postoperative Pain
Serratus Anterior Plane Block Versus Intercostal Nerve Block for Postoperative Analgesia
A prospective randomized controlled study was undertaken to compare the postoperative analgesic effect between ultrasound-guided serratus anterior plane block and intercostal nerve block after video-assisted thoracoscopic…
- Conditions
- Analgesia, Postoperative Pain, Lung Cancer
- Trial name
- NCT04250272
- Testing
- Thoracoscopic lobectomy
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Kyungpook National University Hospital
Oxycodone
Oxycodone in Combination With Parathoracic Nerve Block is Used for Postoperative Analgesia in Lung Cancer
In this study, the effect of oxycodone combined with ultrasound-guided paravertebral nerve block on the postoperative analgesic effect of thoracoscopic lung cancer was investigated, and the effect and reasonable dose of oxycodone…
- Trial name
- NCT05742256
- Testing
- Oxycodone 1mg/kg, Oxycodone 1.5mg/kg, Sufentanil
- Volunteers
- 159 people
- Sponsor
- Qianfoshan Hospital
Melanoma, Renal Cell Carcinoma (RCC)
PET Quantitative Assessments of Solid Tumor Response to Immune Checkpoint Blockade Therapy
This study aims to develop methods for quantitative imaging of solid tumors in patients who are receiving immunotherapies that have a delayed mechanism of action.
- Conditions
- Melanoma, Renal Cell Carcinoma (RCC), Non-small Cell Lung Cancer (NSCLC)
- Trial name
- NCT01666353
- Testing
- PET/CT imaging with [18F] 2-deoxy-2-(18F)fluoro-D-glucose (FDG)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Cancer
Study of RP2 Monotherapy and RP2 in Combination With Nivolumab in Patients With Solid Tumors
RP2-001-18 is a Phase 1, multicenter, open label, single agent dose escalation and combination treatment study of RP2 in adult subjects with advanced solid tumors, to determine the maximum tolerated dose (MTD) and recommended…
- Trial name
- NCT04336241
- Testing
- RP2, nivolumab
- Where
- 6 sites in Spain, United Kingdom
- Volunteers
- 36 people
- Sponsor
- Replimune, Inc.
Rib Fractures, Nerve Block
Erector Spinae Plane Block for Acute Pain Management in the Emergency Department
Rib fractures are a common cause of respiratory distress in trauma patients as poor pain control and subsequent hypoventilation commonly results in lung tissue collapse (atelectasis).
- Trial name
- NCT03590782
- Testing
- Erector Spinae Block
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University of Manitoba