Clinical trials: Thoracic, open to volunteers
Medical Education in Thoracic Ultrasound
Evidence Based Education in Thoracic Ultrasound
The goal of this cluster randomized controlled trial is to evaluate if a web-based thoracic ultrasound (TUS) training program can effectively educate users non-inferiorly to traditional classroom teaching in physicians and…
- Trial name
- NCT07846228
- Testing
- Web-based Thoracic Ultrasound Training, Class based Thoracic Ultrasound Training
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Thoracic Diseases
Artificial Intelligence Versus Anesthesiology Residents in Chest X-Ray Interpretation
This observational study will compare how accurately anesthesiology residents and an artificial intelligence system (hChestXR) identify abnormalities on chest X-rays.
- Trial name
- NCT07846553
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Çiğdem Ünal Kantekin
Thoracic Cancer
MINTER Trial: Metal Intervention aNd ThErapy With Radiotherapy In Thoracic Cancer Using Copper Donor Therapy: A Phase 2, Open-Label Study
This study is being done to test whether adding two drugs-disulfiram and copper gluconate-to radiation therapy can help overcome this resistance and improve treatment outcomes.
- Trial name
- NCT07843537
- Testing
- Disulfiram 250 mg, Copper Gluconate 2 mg, Radiation Therapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- M.D. Anderson Cancer Center
Respiratory Monitoring, Thoracic Surgery
AirGo™ Respiratory Monitoring in Lung Resection
Patients undergoing lung resection surgery may experience changes in respiratory function during the perioperative period. Current monitoring methods provide important clinical information but are often limited to specific time…
- Conditions
- Respiratory Monitoring, Thoracic Surgery, Lung Resection Surgery, Respiratory Function
- Trial name
- NCT07838025
- Testing
- AirGoTM system
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Non-Small Cell Lung Cancer (NSCLC), Colorectal Cancer
Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors
This study is to evaluate the safety, tolerability, and PK profiles of Elironrasib and Daraxonrasib as monotherapies and combination therapy in patients with KRAS G12C-mutated solid tumors.
- Conditions
- Non-Small Cell Lung Cancer (NSCLC), Colorectal Cancer, Pancreatic Ductal Adenocarcinoma
- Trial name
- NCT06128551
- Testing
- Elironrasib, Daraxonrasib
- Where
- 56 sites in United States, France and 5 more
- Volunteers
- 534 people
- Sponsor
- Revolution Medicines, Inc.
Lung Non-Small Cell Carcinoma, Thoracic Cancer
Qualitative Study on Detection & Tx of NSCLC in Pts w/ a History of Alcohol or SUD
This study will attempt to identify social facilitators and barriers to detection and treatment of non-small cell lung cancer in order to learn how a history of substance abuse or alcohol use impacts care for non-small cell lung…
- Trial name
- NCT07186699
- Testing
- Non-Interventional Study
- Where
- 2 sites in United States
- Volunteers
- 45 people
- Sponsor
- University of Southern California
Thoracic Hypomobility
Immediate Effects of Sustained Versus Oscillatory Mobilization in Patients With Thoracic Hypo-mobility
This randomized controlled trial compares two manual therapy interventions for adults with thoracic spine hypo mobility. Fifty-two participants are randomly allocated by coin toss to one of two equal groups (n = 26 each).
- Trial name
- NCT07834190
- Testing
- oscillatory mobilization, Sustained Mobilizations
- Where
- Pakistan
- Volunteers
- 52 people
- Sponsor
- Foundation University Islamabad
Thoracic Diseases, Lung Diseases
AI-Based Assessment of Chest Diseases on Chest X-ray Imaging Using DenseNet-121 and a CheXpert-Trained Model
Chest X-rays are widely used to detect thoracic and lung conditions, but reviewing high volumes of radiographs can lead to workload strain and variation between interpreters.
- Trial name
- NCT07834879
- Volunteers
- 100 people
- Sponsor
- Assiut University
Thoracic Outlet Syndrome
Motivational Interviewing in Thoracic Outlet Syndrome
The goal of this clinical trial is to learn if motivational interviewing (MI) works to improve symptoms in people with thoracic outlet syndrome (TOS).
- Trial name
- NCT07668206
- Testing
- Motivational Interviewing, Home Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Hacettepe University
Rib Fractures, Acute Pain
Comparison of Dexmedetomidine Versus Dexamethasone as Adjuvants to Bupivacaine in Ultrasound-Guided Erector Spinae Plane Block for Acute Pain Management in Patients With Traumatic Rib Fractures
Traumatic rib fractures cause severe chest wall pain that can impair normal breathing, coughing, and lung function. While systemic opioids are commonly used to treat traumatic pain, their side effects, such as sedation and…
- Conditions
- Rib Fractures, Acute Pain, Thoracic Trauma
- Trial name
- NCT07827157
- Testing
- Dexmedetomidine with Bupivacaine in ESPB, Dexamethasone with Bupivacaine in ESPB
- Volunteers
- 100 people
- Sponsor
- Assiut University
Chest Trauma
Thorax Trauma Severity Score in Chest Trauma: A Study in Iraq
This prospective observational study aims to evaluate the predictive utility of the Thorax Trauma Severity Score (TTSS) in determining morbidity and mortality in patients presenting with chest trauma at a tertiary hospital in…
- Trial name
- TTSS-Iraq (NCT06744959)
- Where
- Iraq
- Volunteers
- 166 people
- Sponsor
- Al-Nahrain University
Thoracic Neoplasms, Lung Diseases, Small Cell Lung Carcinoma
A Study of YL201 in Combination With Other Anti-Cancer Therapies in Patients With Advanced Solid Tumors
This is a phase Ib/II, multicenter, open-label study of YL201 combined with atezolizumab. The study will include 2 parts. Part 1 of the study is a dose escalation in participants with previously untreated ES-SCLC to determine the…
- Trial name
- NCT07407933
- Testing
- YL201, Atezolizumab
- Where
- 38 sites in United States, Belgium and 7 more
- Volunteers
- 118 people
- Sponsor
- MediLink Therapeutics (Suzhou) Co., Ltd.
Chest Wall Tumor, Breast Cancer
Pharmacologic Therapies to Mitigate Radiation- Associated Heart Disease
Radiation therapy is an essential treatment for tumors in the chest area, including breast, lung, esophageal, mediastinal cancers, and spine metastases.
- Conditions
- Chest Wall Tumor, Breast Cancer, Lung Cancer, Esophageal Cancer
- Trial name
- NCT07685938
- Testing
- Atorvastatin and Lisinopril
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Multiple Rib Fractures, Isolated Blunt Thoracic Trauma
GNRI and PNI for Predicting Short-Term Outcomes in Older Adults With Multiple Rib Fractures
This prospective observational cohort study will evaluate whether the Geriatric Nutritional Risk Index (GNRI) and Prognostic Nutritional Index (PNI) can predict short-term clinical outcomes in adults aged 65 years or older with…
- Trial name
- NCT07823712
- Where
- Turkey (Türkiye)
- Volunteers
- 294 people
- Sponsor
- Ankara Etlik City Hospital
Lung Cancer (Diagnosis), Liver Cancer, Adult
A Study Evaluating a New Radiation Treatment Workflow (NGDS)
The purpose of this research is to evaluate the "Next Generation Delivery System" (NGDS) and determine if this machine will be more efficient at delivering radiation in shorter treatment time and better patient tolerance, with…
- Conditions
- Lung Cancer (Diagnosis), Liver Cancer, Adult, Pancreatic Cancer, Thoracic Cancers
- Trial name
- SPEED (NCT07824583)
- Testing
- Next Generation Delivery System (NGDS)
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Varian, a Siemens Healthineers Company
Frailty, Thoracic Surgery
A Frailty-specific Prehabilitation Program for Mild to Moderately Frail Patients Undergoing Cardiac Surgeries/Procedures
The purpose of this study is to investigate the effects of the frailty-specific prehabilitation program on functional capacity, frailty, cardiac-specific functional status, serum albumin level, high-sensitivity C-reactive protein…
- Trial name
- NCT07824700
- Testing
- Frailty-specific prehabilitation program
- Where
- Hong Kong
- Volunteers
- 144 people
- Sponsor
- The University of Hong Kong
Gastrointestinal Cancer, Hematologic Cancer
SURGE: Supporting Utility and Representation in Genomics-based Cancer Trial Enrollment (Intervention)
SURGE aims to increase representation in clinical trial enrollment by addressing barriers to genomic testing, which is increasingly needed to assess precision clinical trial eligibility and access standard precision therapies.
- Conditions
- Gastrointestinal Cancer, Hematologic Cancer, Thoracic Cancer
- Trial name
- SURGE (NCT05375643)
- Testing
- SURGE
- Where
- 3 sites in United States
- Volunteers
- 210 people
- Sponsor
- Nadine Jackson, MD, MPH
Cancer, Thoracic Cancer
Fatigue and Molecular Mechanisms in Cancer Patients Receiving CCRT
Cancer-related fatigue (CRF) is a significant problem for cancer patients. This prospective, basic science, observational study will evaluate for changes in CRF associated with molecular characteristics prior to, during, and at…
- Conditions
- Cancer, Thoracic Cancer, Gynecologic Cancer, Head and Neck Cancer
- Trial name
- NCT06633224
- Testing
- Blood Specimen Collection, Stool Specimen Collection, Quality of Life (QOL) Questionnaires
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- University of California, San Francisco
Chest Trauma
Predictive Value of Chest Trauma Score , Revised Trauma Score , and Glasgow Coma Scale in Patients Presenting With Chest Trauma at Assiut University Emergency Unit.
Thoracic trauma is a critical clinical entity and a major global public health burden, representing the second most frequently occurring unintentional traumatic injury and the third most common cause of death-following head and…
- Trial name
- NCT07812038
- Volunteers
- 100 people
- Sponsor
- Assiut University
Non-Small Cell Lung Cancer (NSCLC), Rehabilitation
The Construction and Clinical Application of an Integrated Perioperative Management System for Lung Cancer Based on Wearable Devices and Intelligent Platforms
This study aims to develop and evaluate an integrated perioperative management system based on wearable devices and a digital rehabilitation platform for patients with non-small cell lung cancer (NSCLC) undergoing thoracic…
- Conditions
- Non-Small Cell Lung Cancer (NSCLC), Rehabilitation, Thoracic Surgery, Perioperative Management
- Trial name
- NCT07310056
- Testing
- Wearable-Based Digital Perioperative Rehabilitation System, Standard Perioperative Rehabilitation Guidance
- Where
- China
- Volunteers
- 126 people
- Sponsor
- West China Hospital