Clinical trials: Testosterone Deficiency
Aging, Testosterone Deficiency
The Efficacy of Fenugreek Supplementation on Men's Health
1. The problem: There is limited research on the use of herbal supplements in general, and fenugreek specifically, to improve male health, particularly to increase testosterone levels.
- Trial name
- NCT03528538
- Testing
- AlphaFen fenugreek 400 mg, AlphaFen fenugreek 500 mg
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Jacksonville University
Aqueous Tear Deficiency, Meibomian Gland Dysfunction of Bilateral Eyes (Disorder)
Eyelid Androgen Treatment in Dry Eye
The purpose of this research study is to evaluate the effectiveness and safety of applying androgen sex hormone (i.e., testosterone) gel on the eyelids in the treatment of dry eye patients.
- Trial name
- NCT06154200
- Testing
- Testosterone gel 4.5%, Vehicle gel
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Southern California College of Optometry at Marshall B. Ketchum University
Primary Hypogonadism, Hypogonadotropic Hypogonadism
Bioequivalence Study of Test and Reference Testosterone Topical Gel, 1.62% Metered Pump in Testosterone Deficient Adult Male Subjects Under Fasting Conditions
Bioequivalence study comparing the rate and extent of testosterone absorption for a test formulation versus the reference product.
- Trial name
- NCT02110368
- Testing
- Testosterone Topical Gel, 1.62% Metered Pump, AndroGel (testosterone gel) 1.62% Metered-Dose Pump
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Amneal Pharmaceuticals, LLC
Heart Failure
Benefit of the Treatment With Testosterone in Chronic Heart Failure Testosterone Deficiency Subjects
The purpose of this clinical trial is to determine whether intermittent administration of testosterone against placebo is associated with a reduction of mortality and heart failure hospitalizations at 1 year, in male patients…
- Trial name
- TIC (NCT01813201)
- Testing
- Testosterone undecanoate, Saline isotonic solution
- Where
- Spain
- Volunteers
- 14 people
- Sponsor
- Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia
HIV Infections, Cachexia
Phase II Randomized Study of Physiologic Testosterone Replacement in Premenopausal, HIV-Positive Women
OBJECTIVES: I. Determine whether physiologic testosterone replacement can increase fat-free mass, therefore contributing to weight maintenance, improved muscle function, and quality of life in HIV-infected women. II.
- Trial name
- NCT00004400
- Testing
- testosterone
- Where
- 3 sites in United States
- Volunteers
- 56 people
- Sponsor
- Charles Drew University of Medicine and Science
Hypogonadism, Benign Prostatic Hyperplasia
TRADE-Testosterone Replacement and Dutasteride Effectiveness
The purpose of this research study is to determine whether the combination of the male hormone testosterone [T] in gel form and the oral drug dutasteride [D], used to shrink large prostate glands can safely reduce the size of the…
- Trial name
- TRADE (NCT00194675)
- Testing
- Dutasteride, Testosterone gel
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Washington
Hypogonadism
Testosterone Treatment for Hypogonadal Men
Demonstrate efficacy and safety of Testosterone Gel 1.62% for the treatment of hypogonadal men
- Trial name
- NCT00433199
- Testing
- Testosterone (T) Gel 1.62%
- Volunteers
- 274 people
- Sponsor
- Abbott
Testosterone Deficiency, Hypogonadism, Male
Subcutaneous vs. Intramuscular Testosterone
In this randomized, cross-over study 20 subjects who are undergoing testosterone (T) therapy for the treatment of T deficiency will receive both subcutaneous testosterone therapy and intramuscular testosterone therapy.
- Trial name
- NCT03091348
- Testing
- Testosterone
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Men's Health Boston
Autonomic Neuropathy, Male Hypogonadism
Autonomic Manifestations of Testosterone Deficiency in Men
The primary goal of this pilot study is to investigate the association between testosterone deficiency and the presence of abnormalities in the function of the autonomic nervous system.
- Trial name
- NCT02715713
- Where
- United States
- Sponsor
- Texas Tech University Health Sciences Center
Muscle Weakness
Effect of PROGRESSive Training and Teststerone in Older Frail Men
In this scientific clinical investigation we will test whether testosterone and progressive resistance training can improve muscle strength and reduce the risk of falls in older men.
- Trial name
- PROGRESS (NCT02873559)
- Testing
- testosterone, Progressive muscle training
- Where
- 2 sites in Denmark
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Insulin Resistance, Type 2 Diabetes Mellitus
T-IR- Study to Understand the Effects of Testosterone and Estrogen on the Body's Response to the Hormone Insulin
The purpose of this research study is to understand the effects of testosterone and estrogen on the body's response to the hormone insulin.
- Conditions
- Insulin Resistance, Type 2 Diabetes Mellitus, Obesity, Androgen Deficiency
- Trial name
- T-IR (NCT01686828)
- Testing
- Acyline, Testosterone 1.62% gel, Letrozole
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Washington
Hypogonadism, Hypogonadism, Male
28-Day Study of Testosterone Co-administered With Dutasteride in Hypogonadal Men
The combination of testosterone and dutasteride is intended for use in hypogonadal men. This study will evaluate the effect of 28-day repeat dosing of this combination with varying BID doses of testosterone (T), in combination…
- Trial name
- NCT00398580
- Testing
- Nanomilled testosterone, Nanomilled dutasteride, commercially available dutasteride
- Where
- 7 sites in United States
- Volunteers
- 43 people
- Sponsor
- GlaxoSmithKline
COVID-19, Testosterone Deficiency
SARS-CoV-2, TESTOSTERONE AND MALE FRAGILITY
The hormonal environment (steroid, primarily) could have a very relevant pathophysiological role in association with SARS-CoV-2.
- Conditions
- COVID-19, Testosterone Deficiency, Infertility, Male
- Trial name
- PROTEGGIMI (NCT06177002)
- Testing
- Collection of biological data
- Where
- Italy
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Hypogonadism, Male, Secondary Hypogonadism
AIM-TEST: Microbiome-Targeted Nutrition for Functional Secondary Hypogonadism
AIM-TEST is a randomized, double-blind, placebo-controlled clinical trial evaluating whether an AI-guided, microbiome-targeted nutritional intervention can increase the body's own testosterone production in men aged 30-65 years…
- Trial name
- AIM-TEST (NCT07761546)
- Testing
- Fixed-Formula Microbiome-Targeted Oral Nutritional Supplement
- Where
- Turkey (Türkiye)
- Volunteers
- 112 people
- Sponsor
- Varol TUNALI
Spinal Cord Injury, Spinal Cord Injuries
Locomotor Training With Testosterone to Promote Bone and Muscle Health After Spinal Cord Injury
This pilot study will determine the feasibility of implementing a combinatory rehabilitation strategy involving testosterone replacement therapy (TRT) with locomotor training (LT; walking on a treadmill with assistance and…
- Conditions
- Spinal Cord Injury, Spinal Cord Injuries, Trauma, Nervous System, Wounds and Injury
- Trial name
- NCT04460872
- Testing
- Testosterone Enanthate, Locomotor Training
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- North Florida Foundation for Research and Education
Testosterone Deficiency
Metabolomics During Testosterone Therapy
One promising but understudied area in the field of testosterone (T) therapy is its effect on metabolism and the development of type II diabetes.
- Trial name
- NCT01963390
- Testing
- Testosterone Therapy
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Men's Health Boston
Frail Elderly Patients, Hypogonadal Males
Effect of Testosterone on Elderly Frail Men With Testosterone Deficiency
The purpose of this study is to increase the functional level of the elderly to thereby reduce fall risk, improve motor skills, and increase psychological well-being, as well as to assess whether the restoration of a normal…
- Conditions
- Frail Elderly Patients, Hypogonadal Males, Testosterone Replacement Therapy, Falls (Accidents) in Old Age
- Trial name
- NCT07512323
- Testing
- Nebido (Testosterone Undecanoate)
- Where
- Denmark
- Volunteers
- 96 people
- Sponsor
- Rune Skovgaard Rasmussen
Spinal Cord Injuries, Endothelial Dysfunction
Testosterone Deficiency and Endothelial Dysfunction After Spinal Cord Injury
Heart attacks and strokes are among the most common causes of premature death in individuals living with spinal cord injury (SCI) and appear to occur earlier in life.
- Conditions
- Spinal Cord Injuries, Endothelial Dysfunction, Testosterone Deficiency
- Trial name
- NCT07227740
- Testing
- Intra-arterial Infusion of Vasoactive Agents, Intra-arterial Vitamin C Infusion, Blood Sampling
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Craig Hospital
Metastatic Prostate Cancer
High Dose Testosterone for ATM, CDK12 or CHEK2 Altered Prostate Cancers
This study will determine whether the presence of DNA repair deficiency in the form of alterations in the genes ATM, CDK12 or CHEK2 predicts for a high likelihood of responding to the use of intermittent high dose testosterone.
- Trial name
- VA-BAT (NCT05011383)
- Testing
- High dose testosterone
- Where
- 17 sites in United States
- Volunteers
- 51 people
- Sponsor
- VA Office of Research and Development
Testosterone Deficiency
Patient Satisfaction After Switching to Oral Testosterone Undecanoate
The purpose of this research study is to evaluate patient satisfaction with an oral testosterone agent, Jatenzo, compared to other forms of testosterone therapy.
- Trial name
- NCT04983940
- Testing
- Jatenzo
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Miami