Clinical trials: Testosterone
Healthy
Effect of Antidepressants on Sex Hormone Levels and Sexual Functioning
This study will evaluate the effect of antidepressants on sex hormone levels in women and if the potential changes in sex hormone levels are related to sexual side effects.
- Trial name
- NCT00611975
- Testing
- Fluoxetine, Bupropion
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Healthy Males
HOP-3 Manipulation of the Intratesticular Hormonal Milieu With Exogenous Testosterone
The purpose of this investigational study is to determine how much male hormone, testosterone, is necessary to maintain sperm production in the testis.
- Trial name
- HOP-3 (NCT00839319)
- Testing
- Acyline, hCG (human chorionic gonadotropin), Testosterone gel
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University of Washington
Female Sexual Dysfunction, Anorgasmia
Clitoral Location in Relation to Sexual Function Using Pelvic Imaging
Women who are unable to achieve orgasm compared to women who have normal orgasmic function may have different clitoral anatomy and different hormone levels.
- Trial name
- NCT01195701
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- TriHealth Inc.
Andropause
The Testosterone Trials in Older Men
The Testosterone Trials are a multi-center set of trials involving 12 clinical sites geographically distributed across the United States.
- Trial name
- NCT00799617
- Testing
- AndroGel® (testosterone gel)
- Where
- 12 sites in United States
- Volunteers
- 790 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Healthy Participants
A Study of Effect of Deodorant and Axillary Hair on Testosterone Absorption in Healthy Participants
This study will evaluate the effect of deodorant and antiperspirant use and the presence of underarm hair on the absorption of testosterone.
- Trial name
- NCT01725451
- Testing
- Testosterone, Deodorant Spray, Deodorant and Antiperspirant Combination Spray
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Healthy Males
ITT4 Intratesticular Hormonal Milieu in Man (ITT4)
The purpose of this research study is to determine how much male hormone, testosterone, is necessary to maintain sperm production in the testis.
- Trial name
- ITT4 (NCT01215292)
- Testing
- Acyline, Testosterone gel, ketoconazole 400
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Washington
Hypogonadism, Male, Physical Activity
Strength Training as a Supplemental Therapy of Androgen Deficiency of the Aging Male
This study examines the effect of 12-week strength training program with and without testosterone replacement therapy (TRT) on body composition, physical function, selected biochemical markers of metabolic health, molecular…
- Conditions
- Hypogonadism, Male, Physical Activity, Testosterone Deficiency
- Trial name
- NCT03282682
- Testing
- Strength training
- Where
- Slovakia
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Comenius University
Healthy Men, Male Contraception
Study of Serum Testosterone and Nestorone in Females After Secondary Exposure to Nestorone ® (NES) + Testosterone (T) Combined Gel Applied to Shoulders and Upper Arms in Males
This is a two-center, open-label study conducted in healthy male and female volunteers at two academic research centers. The study will consist of three single applications of the Nestorone (NES) + testosterone (T) combined gel…
- Conditions
- Healthy Men, Male Contraception, Healthy Women, Product Transference
- Trial name
- CCN005B (NCT02994602)
- Testing
- Nestorone + Testosterone Combination Gel
- Where
- 2 sites in United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Kimberly Myer
Hypogonadism
Cycled Testosterone Replacement Study
The purpose of this study is to determine whether testosterone (male hormone) therapy is effective if administered in a cyclic fashion (periodic dosing) compared to continuous dosing in men aged 60 to 85 years.
- Trial name
- NCT00957528
- Testing
- Testosterone
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Type 2 Diabetic Male With Hypogonadotrophic Hypogonadism
Effect of Androgel on Atherogenesis in Type 2 Diabetic Males With Hypogonadotrophic Hypogonadism
The purpose of this study is to examine the effects of testosterone deficiency in men with diabetes on atherogenesis, inflammation, cardiovascular Risk factors And adiposity .
- Trial name
- NCT00467987
- Testing
- androgel
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University at Buffalo
Female Sexual Dysfunction
PK Study of Testosterone Nasal Gel (TBS-2) in Healthy Premenopausal Women
The purpose of this study was to assess the bioavailability of total testosterone through pharmacokinetic profiles obtained following (a) single administration of three doses of TBS-2 b) multiple administration TBS-2.
- Trial name
- NCT01364623
- Testing
- Low dose testosterone nasal gel, single dose, Medium dose testosterone nasal gel, single dose, High dose testosterone nasal gel, single dose
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Acerus Pharmaceuticals Corporation
Healthy
CEP-1 Hormonal Regulation of Circulating Endothelial Progenitor Cells and HDL-C in Men
The original purpose of this research study was to understand the effects of testosterone (T) and estrogen on stem cells in the blood.
- Trial name
- CEP-1 (NCT00729859)
- Testing
- Acyline, Acyline + Testosterone gel, Acyline + testosterone gel + anastrozole
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Washington
HIV, Prophylaxis
Pre-Exposure Prophylaxis (PrEP)- Gender Affirming Hormone Therapy (GAHT) Interactions in TGW
This is a research study to determine the best way to dose Truvada®, an oral medication licensed to be taken as Pre-Exposure Prophylaxis (PrEP) to prevent HIV infection, in transgender women who are also taking feminizing…
- Conditions
- HIV, Prophylaxis, Transgender
- Trial name
- NCT04760691
- Testing
- Truvada alone, Truvada plus Leuprolide 11.25mg intramuscular injection, Truvada plus Estradiol 1 mg
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Hypogonadism
CYP19A1 (Cytochrome P450 Family 19 Subfamily A Member 1) Gene and Pharmacogenetics of Response to Testosterone Therapy
Testosterone (T) replacement prevents bone loss and relieves symptoms associated with androgen deficiency in male patients with hypogonadism, but at the expense of an increase in prostate-related adverse events and in the…
- Trial name
- NCT01378299
- Testing
- Testosterone Cypionate
- Where
- 2 sites in United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Prostatic Neoplasms
The Effects of Castration on the Pharmacokinetics of Zolpidem After Single Dose Administration In Men With Prostate Cancer Undergoing Androgen Deprivation Therapy Compared to Normal Healthy Females
Background: Insomnia is associated with difficulty sleeping. The drug zolpidem is widely prescribed for insomnia. Women have reported worse effects from the drug than men.
- Trial name
- NCT03436745
- Testing
- Zolpidem, ECG
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Insulin Resistance, Type 2 Diabetes Mellitus
T-IR- Study to Understand the Effects of Testosterone and Estrogen on the Body's Response to the Hormone Insulin
The purpose of this research study is to understand the effects of testosterone and estrogen on the body's response to the hormone insulin.
- Conditions
- Insulin Resistance, Type 2 Diabetes Mellitus, Obesity, Androgen Deficiency
- Trial name
- T-IR (NCT01686828)
- Testing
- Acyline, Testosterone 1.62% gel, Letrozole
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Washington
Healthy Males, Male Contraceptive
Oral T7 Oral Testosterone in Man
The purpose of this study is to test how the body absorbs and processes new forms of oral testosterone. Information gained during the study may help develop better forms of testosterone therapy in the future.
- Trial name
- Oral T7 (NCT00842751)
- Testing
- First Intervention (7 days), First Washout (7 days), Second Intervention (7 days)
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Washington
Hypogonadism
Pharmacokinetic Study of Subcutaneous Testosterone Enanthate
Evaluation of pharmacokinetics of subcutaneous testosterone enanthate
- Trial name
- NCT02233751
- Testing
- Testosterone enanthate auto-injector
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Antares Pharma Inc.
Abuse of Anabolic Steroids
Intranasal Delivery of Testosterone and Its Effect on Doping Markers
Hypothesis: Intranasal administration of exogenous testosterone results in a characteristic profile during anti-doping testing, which is different than the profile seen when testosterone is administered into muscle, on skin or…
- Trial name
- Intranasal (NCT02611154)
- Testing
- Testosterone
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Utah
Healthy
ORAL T-8 Oral Testosterone for Male Hormonal Contraception
The purpose of this study is to test how the body absorbs a new form of oral testosterone (T). On Day 1 and Day 9 there are overnight stays in the General Clinical Research Center at the University of Washington to monitor blood…
- Trial name
- Oral T8 (NCT01167829)
- Testing
- Oral Testosterone, Acyline
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Washington