Clinical trials: Terminal Illness
Kidney Disease, End-Stage
PATH-03 Paraguay Feasibility Study
The goal of this study is to evaluate the safety and effectiveness of the ePATH system in the creation of an endovascular AVF (endoAVF) in patients who require or will soon require hemodialysis and are eligible for a fistula.
- Trial name
- NCT07034092
- Testing
- ePATH System will be used to create an endoAVF
- Where
- Paraguay
- Volunteers
- 20 people
- Sponsor
- Pathfinder Medical
End Stage Kidney Disease
Mapping Multidimensional Illness Trajectories of Patients With End-stage Kidney Disease
Patients with end-stage kidney disease (ESKD) must manage not only the demands of dialysis and comorbid conditions but also associated symptoms and acute life-threatening events that contribute to functional limitations and…
- Trial name
- NCT01530945
- Where
- United States
- Volunteers
- 227 people
- Sponsor
- University of North Carolina, Chapel Hill
Illness Terminal
Conscious Dying/Conscious Living: Ketamine-Assisted Psychotherapy
The Conscious Dying/Conscious Living study will investigate the effect of KAP (ketamine-assisted psychotherapy) on individuals with terminal illness at five separate geographic locations.
- Trial name
- KRF-EOL (NCT05214417)
- Testing
- Ketamine Injectable Solution, Naturalistic Control
- Volunteers
- 120 people
- Sponsor
- The Ketamine Research Foundation
Renal Disease, Chronic, Renal Disease, End-Stage
Non-invasive Testing for End-Stage Chronic Kidney Disease
This study evaluates the clinical performance of a non-invasive digital diagnostic test (KF4+, developed and manufactured by Gisens Biotech) for the measurement of urea and potassium in capillary blood in patients with end-stage…
- Conditions
- Renal Disease, Chronic, Renal Disease, End-Stage, Dialysis Patients, Urea in Blood; High
- Trial name
- NiTED (NCT07777523)
- Testing
- KF4+ Noninvasive Test
- Where
- Argentina
- Volunteers
- 55 people
- Sponsor
- Gisens Biotech
Neoplasms, Neurodegenerative Diseases
Evaluation of the Organization of Continuity of Care for Home Hospice Patients by Four Parisian Health Networks
In Paris, France, home hospice care for terminally ill patients is organized by four "palliative care networks". These networks are responsible for information sharing and coordination of all health care professionals working…
- Conditions
- Neoplasms, Neurodegenerative Diseases, Terminal Illness
- Trial name
- DICODOM (NCT03336489)
- Where
- 4 sites in France
- Volunteers
- 200 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Malignant Neoplasm, Leukemia, Lymphocytic, Chronic, B-Cell
Project to Improve Communication About Serious Illness - Pilot Study
This two-year pilot study will test whether a one-page "Jumpstart Form" will affect goals-of-care discussions in the hospital. This form will be provided to clinicians and will include patient-specific information about…
- Conditions
- Malignant Neoplasm, Leukemia, Lymphocytic, Chronic, B-Cell, Lung Disease Chronic, Congestive Heart Failure
- Trial name
- PICSI-P (NCT03746392)
- Testing
- Jumpstart Intervention
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- University of Washington
Error Disclosure, Diagnoses Disease
A Priori Diagnosis and Diagnostic Errors
This is a prospective randomized single-blind simulator-based trial. 156 4th year medical students were randomised to receive one of three different suspected diagnoses of a pre-treating physician (no diagnosis, myocardial…
- Conditions
- Error Disclosure, Diagnoses Disease, Simulation of Physical Illness
- Trial name
- NCT04659265
- Testing
- Suspected diagnosis of a pre-treating physician
- Where
- Switzerland
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Narrative Medicine, Chronic Disease
Impact of Early Implementation of Narrative Medicine Techniques on Patient Centered Attitudes of Medical Students
A qualitative study assessing the impact of early narrative medicine practice on Medical Honors Program (MHP) students' attitudes regarding patient-centered interactions, through interviewing patients with chronic or…
- Conditions
- Narrative Medicine, Chronic Disease, Terminal Illness, Cancer
- Trial name
- NCT03041571
- Testing
- Patient Provider Orientation Scale, Interview performed by MHP student
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
Terminal Illness, Xerostomia
A Randomized Controlled Trial Evaluating the Effectiveness of a Salvia-based Mouthwash in Palliative Care
This study examines the effectiveness of an herbal mouthwash made from salvia in maintaining good oral health among patients in palliative care.
- Trial name
- NCT02067572
- Testing
- Saline mouthwash, Salvia mouthwash
- Where
- Norway
- Volunteers
- 88 people
- Sponsor
- Lovisenberg Diakonale Hospital
Cancer, Congestive Heart Failure (CHF)
Outlook Quality of Life Intervention Study
The purpose of this study is to determine whether discussions of life story, forgiveness, and future goals improve quality of life for patients with serious illness.
- Conditions
- Cancer, Congestive Heart Failure (CHF), Chronic Obstructive Pulmonary Disease (COPD), End Stage Renal Disease (ESRD)
- Trial name
- NCT01044290
- Testing
- Life Completion, Attention Control
- Where
- United States
- Volunteers
- 221 people
- Sponsor
- VA Office of Research and Development
Terminal Illness
Family Talk Intervention in the Context of Specialised Palliative Home Care
This intervention study aims to evaluate a psychosocial family based intervention in clinical practice, the Family Talk Intervention (FTI), for families with dependent children affected by life-threatening/life-limiting illness…
- Trial name
- NCT05365919
- Testing
- Family Talk Intervention
- Where
- Sweden
- Volunteers
- 400 people
- Sponsor
- Ersta Sköndal University College
Multiple Chronic Conditions, End Stage Disease
Optimising Drug Therapy in Polymedicated Patients According to the Person-centered Care Model
Introduction: In recent years, multi-aging has increased by 25%. This is related to plutipatology, frailty, polymedications, elevated sanitary cost, low quality of life, adverse events and mortality.
- Trial name
- NCT04188470
- Testing
- person-centered care model
- Where
- 2 sites in Spain
- Volunteers
- 208 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Decision Making, Terminal Illness
Organ Donation and End-of-life Decisions
Variation in organ donation after brain death (DBD) per million population varies markedly between countries, within country regions, between and within intensive care units (ICU).
- Conditions
- Decision Making, Terminal Illness, Tissue and Organ Procurement
- Trial name
- NCT04131140
- Where
- Sweden
- Volunteers
- 12,072 people
- Sponsor
- Swedish Intensive Care Registry
Hemodialysis Access Failure, Kidney Disease, End-Stage
Low-Dose Apixaban Added to Standard Heparin Lock Versus Heparin Lock Alone to Prevent Tunneled Hemodialysis Catheters Dysfunction (APICATH-HD)
This randomized, single-center, PROBE trial evaluates whether adding low-dose apixaban (2.5 mg orally every 12 hours) to standard intraluminal heparin lock prolongs primary functional patency of tunneled hemodialysis catheters…
- Conditions
- Hemodialysis Access Failure, Kidney Disease, End-Stage, Hemodialysis Catheter
- Trial name
- APICATH-HD (NCT07404345)
- Testing
- Apixaban, Heparin sodium lock solution
- Where
- Mexico
- Volunteers
- 54 people
- Sponsor
- Hospital Civil de Guadalajara
Kidney Disease, End-Stage, Donor Specific Antibodies
Evaluation of Anti-rejection Drug, Tacrolimus, in African-Americans With Kidney Transplant
In spite of conventional immunosuppression with lymphocyte-depleting induction followed by tacrolimus- and mycophenolate-based regimens, African American (AA) renal transplant recipients experience higher rates of acute rejection…
- Conditions
- Kidney Disease, End-Stage, Donor Specific Antibodies, Acute Rejection of Renal Transplant
- Trial name
- NCT04665310
- Testing
- Envarsus XR
- Volunteers
- 46 people
- Sponsor
- The Methodist Hospital Research Institute
Critical Illness, Acute Kidney Injury
Sup-Icu RENal (SIREN)
Data show that episodes of bleeding may often be observed in critically ill patients with dialysis-dependent acute renal failure (ARF) on renal replacement therapy (RRT).
- Conditions
- Critical Illness, Acute Kidney Injury, End-stage Renal Disease, Renal Replacement Therapy
- Trial name
- SIREN (NCT02718261)
- Testing
- Pantoprazole
- Where
- 2 sites in Denmark, Switzerland
- Volunteers
- 3,350 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Febrile Illness Acute
Treatment of Febrile Infectious Disease Among Children in Hadera District Given the Final Diagnosis. Descriptive Study
Study goal - to describe pediatric patients with febrile disease that administered to the emergency department (ED) of hillel-yaffe hospital, according to arrival diagnosis, ED diagnosis, given therapy, and therapy concordance…
- Trial name
- NCT02313532
- Where
- Israel
- Volunteers
- 500 people
- Sponsor
- Hillel Yaffe Medical Center
End Stage Renal Disease
Effect of Expanded Dialysis on Patient Reported Symptoms Using LEVIL
Investigators know that many patients who are on dialysis suffer from the burden of unwanted symptoms, which can affect quality of life.
- Trial name
- NCT03640858
- Testing
- Theranova Dialyzer
- Where
- 2 sites in Canada
- Volunteers
- 82 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Critical Illness, Terminal Illness
Prevalence of Potentially Inappropriate Treatments
A multicenter point prevalence study in Turkish intensive care units.
- Conditions
- Critical Illness, Terminal Illness, Potentially Inappropriate Medication List
- Trial name
- INAPPT-ICU (NCT03520270)
- Where
- Turkey (Türkiye)
- Volunteers
- 1,128 people
- Sponsor
- Istanbul University
Delirium, Terminal Illness
Comparing Haloperidol and Olanzapine in Treating Terminal Delirium
As patients with terminal illness enter the dying phase, they may experience symptoms of restlessness, agitation, or cognitive disturbance, known as terminal delirium.
- Trial name
- HALOLAN (NCT04750395)
- Testing
- Haloperidol Solution, Olanzapine Tablets
- Where
- Singapore
- Volunteers
- 80 people
- Sponsor
- HCA Hospice Care