Clinical trials: Temporal Interference Stimulation
NMO Spectrum Disorder
Efficacy and Safety of Transcranial Temporal Interference Stimulation (tTIS) for Neuropathic Pain in Neuromyelitis Optica Spectrum Disorder (NMOSD)
This is an open-label, single-arm, single-center prospective pilot study to assess the efficacy and safety of transcranial temperol interference stimulation in patients with neuromyelitis optica spectrum disorder (NMOSD)…
- Trial name
- NCT07377305
- Testing
- 10Hz tTIS (2-4mA) Intervention
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Tang-Du Hospital
Mild Cognitive Impairment (MCI)
Non-invasive Deep Brain Stimulation to Enhance Motor Skill Acquisition in Individuals With Mild Cognitive Impairment
The goal of this study is to investigate the impact of non-invasive deep brain stimulation on motor skill acquisition in individuals with Mild Cognitive Impairment.
- Trial name
- NCT07092839
- Testing
- transcranial electric stimulation
- Where
- 2 sites in Switzerland
- Volunteers
- 15 people
- Sponsor
- Friedhelm Hummel
Major Depressive Disorder (MDD)
Efficacy and Safety of Transcranial Temporal Interference Stimulation for Depression
The goal of this clinical trial is to learn whether transcranial temporal interference stimulation (tTIS) can help treat major depressive disorder (MDD) in adults.
- Trial name
- NCT07612501
- Testing
- Active Transcranial Temporal Interference Stimulation Targeting Left ALIC, Active Transcranial Temporal Interference Stimulation Targeting Left sgACC
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Yonggui Yuan
Bipolar Depression
Efficacy and Safety Assessment of Temporal Interference Stimulation to Improve Bipolar Depression
The aim of this study was to explore the efficacy and safety of temporal interference stimulation to improve bipolar depression, as well as to explore the corresponding neuroimaging mechanisms using magnetic resonance and…
- Trial name
- NCT07021508
- Testing
- Temporal Interference Stimulation
- Where
- China
- Volunteers
- 160 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Adolescent, Depression - Major Depressive Disorder
Efficacy and Mechanism of Transcranial Temporal Interference Stimulation (tTIS) in the Treatment of Adolescent Depression
This trial is a single-center, single-blind, randomized, sham-stimulation controlled clinical trial. The primary objective of the trial is to detect the targeted effect of tTIS on the nucleus accumbens of adolescent depression…
- Trial name
- NCT06902064
- Testing
- Transcranial temporal interference stimulation
- Volunteers
- 30 people
- Sponsor
- Xijing Hospital
Essential Hypertension
Safety and Efficacy Evaluation of Non-invasive Temporal Interference Stimulation for Blood Pressure Modulation in Patients With Mild Essential Hypertension
The primary objective of this research is to study the efficacy and safety of temporal interference stimulation for blood pressure modulation in patients with mild essential hypertension.
- Trial name
- NCT07577323
- Testing
- Temporal Interference
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xuanwu Hospital, Beijing
Epilepsy
TIS for Drug Resistant TLE
Temporal interference (TI) stimulation is a new neuromodulation method. Compared with traditional neuromodulation therapy, TI has deep targeting and focusing, and it has been confirmed to modulate sleep, cognition, and movement…
- Trial name
- TITE-Effect (NCT07519018)
- Testing
- TI Stimulation
- Volunteers
- 30 people
- Sponsor
- Xijing Hospital
Parkinson Disease
STN-tTIS Modulates Parkinson Motor Symptoms With and Without Medications
The goal of this clinical trial is to evaluate the immediate effects of individualized 130 Hz STN-tTIS(Subthalamic Nucleus - transcranial Temporal Interference Stimulation)on motor symptoms in early-to-mid-stage PD patients…
- Trial name
- NCT06980935
- Testing
- NervioX-2400
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Ruijin Hospital
Nicotine Use Disorder, Substance Use Disorders
Temporal Interference Methods for Addiction Treatment
This clinical study is testing whether a new non-invasive brain stimulation method, called temporal interference (TI), can reduce nicotine cravings and usage in people who vape.
- Trial name
- NCT07210268
- Testing
- TI-NDBS
- Where
- 2 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Indiana University
Essential Tremor
Temporal Interference for Essential Tremor
This single-center prospective study aims to investigate the treatment efficacy of temporal interference (TI) in essential tremor patients aged 30-70.
- Trial name
- NCT07016425
- Testing
- Temporal Interference
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Liankun_Ren
Depression
Brain Stimulation and Decision-making
Decision-making is an important process that is frequently shown to be impaired in patients with depression. While a number of preclinical and clinical studies have identified key regions involved in this process, it remains…
- Trial name
- NCT04099056
- Testing
- Neurostimulation
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Emory University
Healthy Adult Participants
Overcoming the Barriers to Effective Transcranial Temporal Interference Stimulation in Humans
Transcranial temporal interference stimulation (TIS) is an emerging novel tool for non-invasive transcranial brain stimulation that holds the potential for focal and steerable neuromodulation, and the possibility to stimulate…
- Trial name
- NCT07593859
- Testing
- transcranial Temporal Interference Stimulation
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Northeastern University
Young Healthy Adults
Investigating the Mechanisms of Decision-Making Using Non-Invasive Brain Stimulation
This study aims to investigate which of two brain regions is important for which decision-making strategy. The investigators suppose that one brain region - the *striatum* - is important for repeatedly choosing objects that have…
- Trial name
- StimMaps_YH (NCT07749378)
- Testing
- Hippocampal intermittent-theta burst stimulation, Striatal intermittent-theta burst stimulation, High-frequency control stimulation with striatal electrode set-up
- Where
- Germany
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Wuerzburg University Hospital
Drug Resistant Epilepsy
Temporal Interference for Drug Resistant Epilepsy
This single-center prospective study aims to investigate the treatment efficacy of temporal interference (TI) in drug-resistant epilepsy patients aged 6-60.
- Trial name
- TIE (NCT06708143)
- Testing
- Temporal Interference
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Xuanwu Hospital, Beijing
Treatment-Resistant Depression
Early Identification of TRD and Construction and Clinical Validation of NTBS Precision Technology
The goal of this clinical trial is to learn about the characteristics, identify early and intervene effectively in time in Treatment-Resistant Depression.
- Trial name
- NCT05777876
- Testing
- non-invasive transcranial deep brain stimulation, Motor cortex stimulation, non-invasive transcranial deep brain stimulation with closed-loop
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Nicotine Use Disorder, Substance Use Disorders
Temporal Interference Neurostimulation and Addiction
This project aims to develop a line of research using new non-invasive neurostimulation technology to treat adults with opioid use disorders (OUDs).
- Trial name
- NCT04432064
- Testing
- Active TI-NDBS, tDCS
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Indiana University
Mild Cognitive Impairment (MCI)
Effects of Transcranial Temporal Interference Stimulation on Cognitive Function in Mild Cognitive Impairment
To explore the effects of transcranial temporal interference stimulation (tTIS) on cognitive function and dual-task walking performance, as well as its underlying neuroimaging mechanisms, in individuals with mild cognitive…
- Trial name
- TIS-MCI (NCT07519798)
- Testing
- Active Temporal Interference Stimulation (TIS)
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shanghai University of Sport
Autism Spectrum Disorder
Temporal Pole Transcranial Alternating Current Stimulation for Children With Autism Spectrum Disorder
The goal of this open-label randomized controlledl trial is to explore the safety and efficacy of conventional transcranial alternating current stimulation (tACS) and transcranial temporal interference stimulation (tTIS)…
- Trial name
- NCT07045584
- Testing
- Transcranial Alternating Current Stimulation, transcranial Temporal Interference Stimulation
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Fei Li
Chronic Insomnia
Transcranial Temporal Interference Stimulation (tTIS) for Chronic Insomnia
The purpose of this exploratory randomized controlled clinical trial is to evaluate the efficacy and safety of transcranial temporal interference stimulation (tTIS) in the treatment of chronic insomnia.
- Trial name
- NCT07755852
- Testing
- Active Transcranial Temporal Interference Stimulation (tTIS)-Experimental
- Volunteers
- 30 people
- Sponsor
- Ruijin Hospital