Clinical trials: Temporal Interference Stimulation
Visual Acuity
Temporal Interference Brain Stimulation
The primary aim of this study is to translate temporal interference (TI) stimulation methodology into humans and examine its safety, feasibility, steerability, and focality.
- Trial name
- TI (NCT03747601)
- Testing
- Temporal Interference (TI) Stimulation
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Post-traumatic Stress Disorder (PTSD)
The Efficacy and Safety of Temporal Interference Stimulation in the Treatment of Post-Traumatic Stress Disorder
This study aims to evaluate the efficacy and safety of Temporal Interference (TI) stimulation in treating patients with post-traumatic stress disorder (PTSD) and to explore its potential neural mechanisms using magnetic resonance…
- Trial name
- NCT07644338
- Testing
- TI stimulation device (nerviox-1000）
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Shanghai Mental Health Center
Stroke, Stroke Assessment
Non-Invasive Deep Brain Stimulation for Upper Limb Recovery After Stroke (NIMBUS)
NIMBUS is a clinical study evaluating a new, non-invasive brain stimulation treatment to improve arm and hand function in people with long-term effects of stroke.
- Trial name
- NIMBUS (NCT07792811)
- Testing
- Non-invasive transcranial Temporal Interference Stimulation (iTBS-tTIS Striatum), Concurrent Intensive Motor Rehabilitation
- Where
- Switzerland
- Volunteers
- 84 people
- Sponsor
- Friedhelm Hummel
Reward-guided Behaviour
Oscillations in Reward-guided Behavior
While people are reading, talking or playing computer games, their brain cells elicit electrical signals so they could perform these actions.
- Trial name
- NCT04761471
- Testing
- TI transcranial electrical stimulation
- Where
- Switzerland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Schizophrenia
Overnight Thalamic TES-TI to Modulate Sleep Spindles in Individuals With Schizophrenia Spectrum Disorders and Matched Healthy Controls
This study to find out whether a type of non-invasive electrical brain stimulation called transcranial electrical stimulation with temporal interference (TES-TI) can temporarily change brain activity during sleep-especially sleep…
- Trial name
- ONSETS (NCT07680114)
- Testing
- TES-TI
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Parkinson's Disease (PD)
STN-tTIS With Different Intervention Intervals Versus Standard Medical Treatment for Parkinson's Disease
The goal of this clinical trial is to compare the efficacy and safety of different Intervention Intervals of subthalamic nucleus-targeted transcranial temporal interference stimulation (STN-tTIS) in patients with Parkinson…
- Trial name
- NCT07774312
- Testing
- STN-tTIS Once Weekly, STN-tTIS Twice Weekly, STN-tTIS Five Times Weekly
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Ruijin Hospital
Parkinson Disease
Subthalamic Nucleus (STN)-Targeted Transcranial Temporal Interference Stimulation (TIS) for Parkinson's Disease: Efficacy and Safety From a Single-Center, Prospective, Double-Blind Randomized Controlled Trial
This is a single-center, prospective, double-blind, randomized controlled trial to evaluate the efficacy and safety of transcranial temporal interference stimulation targeting the subthalamic nucleus in patients with Parkinson's…
- Trial name
- TIS-STN-PD1 (NCT07361250)
- Testing
- NervioX-1000
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Tang Zhouping
Cognitive Flexibility, Emotional Regulation
The STRENGTHEN Study
This study uses two different types of interventions including electrical brain stimulation delivered during sleep, and brief, daily meditation training.
- Trial name
- NCT06267521
- Testing
- Healthy Minds Program, Stimulation in Lab, MRI Scanner
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Parkinson's Disease, Parkinsonian Syndromes
Temporal Interference Noninvasive Deep Brain Stimulation for Idiopathic Parkinson's Disease and Parkinsonian Syndromes: Effects and Target Exploration
This study aims to explore the therapeutic effects of noninvasive deep brain electrical stimulation using temporal interference principles (Temporal Interference Stimulation, TIS) on both motor and non-motor symptoms in patients…
- Trial name
- NCT07698236
- Testing
- AB Temporal Interference Stimulation, BA Temporal Interference Stimulation
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Ruijin Hospital
Narcolepsy Type 1
Temporal Interference Stimulation of Hypothalamus in Patients With Narcolepsy Type 1
Narcolepsy type 1 (NT1) is a chronic brain disorder caused by selective loss or dysfunction of orexin (hypocretin) neurons in the lateral hypothalamus, for which current pharmacological treatments offer limited efficacy.
- Trial name
- TINY (NCT07727239)
- Testing
- Active Temporal Interference Stimulation
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Xijing Hospital
Disorder of Consciousness, Minimally Conscious State
Temporal Interference Stimulation for Disorders of Consciousness
This study aims to investigate whether a new non-invasive brain stimulation technique, called temporal interference stimulation, can influence brain activity and potentially improve signs of consciousness in patients with severe…
- Conditions
- Disorder of Consciousness, Minimally Conscious State, Vegetative State, Unresponsive Wakefulness Syndrome
- Trial name
- NCT07874178
- Testing
- Temporal Interference
- Volunteers
- 4 people
- Sponsor
- Centre Hospitalier Universitaire de Liege
Mild Cognitive Impairment (MCI)
Temporal Interference Stimulation Combined With Tai Chi for Mild Cognitive Impairment
This study aims to evaluate whether individualized hippocampal transcranial temporal interference stimulation (tTIS) combined with Tai Chi training can improve cognitive function and dual-task performance in individuals with mild…
- Trial name
- NCT07799584
- Testing
- Active Transcranial Temporal Interference Stimulation, Tai Chi Training
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shanghai University of Sport
Mild Cognitive Impairment (MCI)
Hippocampal Temporal Interference Stimulation for Memory and Dual-Task Postural Control in Older Adults With Mild Cognitive Impairment
This trial aims to investigate whether a single session of 40 Hz hippocampal temporal interference stimulation can improve memory function and dual-task postural control among older adults with mild cognitive impairment (MCI).
- Trial name
- NCT07771036
- Testing
- Temporal Interference Stimulation
- Where
- China
- Volunteers
- 21 people
- Sponsor
- Shanghai University of Sport
Traumatic Brain Injury
Plasticity of Deep Brain Structures in Mild Cognitive Impairment and Healthy Aging
Acute and chronic cognitive impairment (TBI and MCI) is one of the most common problems in the growing and aging society of the 21st century. At an individual level, not all brain structures are affected with the same rate.
- Trial name
- PlasMA (NCT06822283)
- Testing
- transcranial electric stimulation
- Where
- 2 sites in Switzerland
- Volunteers
- 19 people
- Sponsor
- Friedhelm Hummel
Hypertension, Hypotension
Efficacy and Safety Evaluation of Non-invasive Temporal Interference Stimulation for Blood Pressure Regulation
The primary objective of this research is to study the efficacy and safety of temporal interference stimulation for regulating the blood pressure.
- Trial name
- NCT07239492
- Testing
- Temporal Interference
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Xuanwu Hospital, Beijing
Parkinson s Disease
The Efficacy and Safety of Temporal Interference Stimulation on Motor Symptoms of Parkinson's Disease
This study aimed to evaluate the clinical efficacy and safety of temporal interference stimulation (TIS) targeting different targets in patients with Parkinson's disease (PD), and to investigate the associated neurophysiological…
- Trial name
- NCT07572903
- Testing
- Temporal Interference Stimulation
- Where
- China
- Volunteers
- 96 people
- Sponsor
- The First Affiliated Hospital of Anhui Medical University
Major Depressive Disorder
The Efficacy and Safety of Task-state-based Temporal Interference Stimulation (TI) in the Treatment of Patients With Depression
This study intends to investigate the intervention efficacy of temporal interference stimulation (TI) on mood symptoms in depressed patients, as well as to explore the neuroimaging mechanisms of TI improvement in depressed…
- Trial name
- NCT06826469
- Testing
- Temporal Interference Stimulation
- Where
- China
- Volunteers
- 43 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Healthy Volunteers
Temporal Interference Methods for Non-invasive Deep Brain Stimulation, Study 1.3
This grant aims to develop a line of research using temporal interference (TI) electrical neurostimulation technology to understand the causal role of deep brain structures in cognition.
- Trial name
- NCT07594795
- Testing
- Temporal Interference (TI) Electrical Stimulation - dACC 20 Hz TI Active, Temporal Interference (TI) Electrical Stimulation - dACC Comparison Frequency TI Active
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Indiana University
Healthy Adult Participants, Healthy Participants
Location- and Frequency-Dependent Effects of Thalamic Temporal Interference Stimulation During Sleep
This study is to find out whether a type of non-invasive electrical brain stimulation called temporal interference transcranial electrical stimulation (TI-TES) can temporarily change brain activity during sleep, especially sleep…
- Trial name
- CAP-TI (NCT07498270)
- Testing
- Magnetic Resonance Imaging (MRI), Broad thalamic stimulation (TI-TES), Anterior thalamic stimulation (TI-TES)
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Parkinson Disease, Parkinson Disease, Secondary
Accelerated Temporal Interference Stimulation on Bilateral Subthalamic Nucleus for Parkinson's Disease and Secondary Parkinson's Syndrome
This clinical trial will evaluate the efficacy of accelerated Temporal Interference Stimulation (TIS) as a therapeutic intervention for individuals diagnosed with Parkinson's disease or secondary Parkinson's syndrome.
- Trial name
- NCT07568067
- Testing
- Temporal Interference Stimulation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Ke Dong, MD