Clinical trials: Temporal Interference Stimulation
Parkinson Disease (PD)
MRI-Guided Temporal Interference Stimulation for Parkinson's Disease
This study aims to evaluate the efficacy and safety of tTIS treatment in patients with Parkinson's disease (PD). The study will enroll eligible PD patients and randomly assign them to two groups: Group A will first receive…
- Trial name
- NCT07827456
- Testing
- Temporal Interference Stimulation (130 Hz)
- Volunteers
- 26 people
- Sponsor
- Tongji Hospital
Traumatic Brain Injury
Non-invasive Deep Brain Stimulation to Improve Spatial Navigation Abilities in Individuals Following Traumatic Brain Injury
Impairments in spatial memory and spatial navigation are commonly reported amongst patients presenting post-traumatic brain injury (TBI).
- Trial name
- NCT07271524
- Testing
- Transcranial electric stimulation
- Where
- 2 sites in Switzerland
- Volunteers
- 25 people
- Sponsor
- Friedhelm Hummel
Negative Affectivity, Non-invasive Brain Stimulation
Neural Mechanisms of Interpersonal Expectations on Negative Affect
The goal of this clinical trial is to learn whether non-invasive brain stimulation, called transcranial temporal interference stimulation (tTIS), can reduce negative affect, and how expectations shaped by care providers influence…
- Conditions
- Negative Affectivity, Non-invasive Brain Stimulation, Placebo Effect, Expectations
- Trial name
- NCT06980090
- Where
- United States
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Trustees of Dartmouth College
Bipolar Depression
Task-State-Based Temporal Interference Stimulation (TI) to Improve Depression in Patients With Bipolar Disorder
The purpose of this study is to investigate the efficacy and safety of temporal interference stimulation (TI) in improving depressive episodes of bipolar disorder, to analyze the therapeutic principle of TI in bipolar disorder…
- Trial name
- NCT06516991
- Testing
- Temporal Interference Stimulation
- Where
- China
- Volunteers
- 36 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Major Depressive Disorder (MDD
Amygdala-Targeted Transcranial Temporal Interference Stimulation for Major Depressive Disorder: A Randomized Sham-Controlled Trial of Clinical Efficacy and Neurobiological Mechanisms
This randomized, sham-controlled clinical trial aims to evaluate the efficacy and safety of amygdala-targeted transcranial temporal interference stimulation (tTIS) in adults with major depressive disorder (MDD) and to explore its…
- Trial name
- NCT07829575
- Testing
- Transcranial Temporal Interference Stimulation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University
Deglutition Disorders, Ischemic Stroke
Dentate-Targeted Temporal Interference Stimulation for Post-Stroke Dysphagia
The goal of this clinical trial is to learn whether individualized transcranial temporal interference stimulation can improve swallowing in adults with swallowing difficulties after an ischemic stroke.
- Trial name
- DENTIS-PSD (NCT07766668)
- Testing
- Active Transcranial Temporal Interference Stimulation, Standardized Task-Specific Swallowing Rehabilitation
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Zhejiang University
PARKINSON DISEASE (Disorder), Motor Symptoms
Remotely Supervised Home-based Transcranial Temporal Interference Stimulation on Motor Symptoms in Parkinson's Disease
The goal of this clinical trial is to learn if home-based temporal interference stimulation (TIS) works to improve motor symptoms in people with Parkinson's disease (PD). It will also learn about the safety of this treatment.
- Trial name
- NCT07518290
- Testing
- Home-based Transcranial Temporal Interference Stimulation (HB-TIS)
- Where
- 2 sites in China
- Volunteers
- 98 people
- Sponsor
- Shanghai University of Sport
Temporal Interference Stimulation (TIS), Parkinson's Disease
Study on the Efficacy of Temporal Interference Stimulation (TIS) for Parkinson's Disease
The primary objective of this clinical study is to evaluate the therapeutic efficacy of Temporal Interference Stimulation (TIS), a non-invasive deep brain stimulation technique, in patients with Parkinson's disease, and to…
- Trial name
- NCT07312279
- Testing
- TIS
- Volunteers
- 24 people
- Sponsor
- Zhongnan Hospital
Major Depressive Disorder
Amygdala and dLPFC MRI-TIS for Depression in Adolescents
The study utilizes a non-invasive deep brain stimulation (temporal interference, TI) technique primarily targeting the amygdala to preliminarily explore the clinical efficacy and potential mechanisms of MRI-compatible TI…
- Trial name
- NCT06452849
- Testing
- Nervio-X
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University
Major Depressive Disorder (MDD)
Temporal Interference Stimulation in Major Depressive Disorder: A Pilot Feasibility Study
This pilot feasibility study used a randomized, double-blind, within-subject crossover design to explore temporal interference (TI) stimulation in adults with major depressive disorder.
- Trial name
- NCT07888387
- Testing
- Temporal Interference Stimulation
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Ruijin Hospital
Cognitive Impairment Associated With Schizophrenia (CIAS)
TIS for Improving Cognitive Impairment Associated With Schizophrenia
This study aims to evaluate the efficacy and safety of TIS targeting the hippocampus in ameliorating cognitive impairment associated with schizophrenia (CIAS). Participants will receive TIS twice a day for 2 weeks.
- Trial name
- NCT07446478
- Testing
- temporal interference stimulation
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Central South University
Health Adults, Temporal Interference Stimulation
Safety and Feasibility of Temporal Interference Brain Stimulation for Treatment in Psychiatric Disorders
The goal of this clinical trial is to validate if temporal interference brain stimulation (TIBS) is safe in healthy volunteers aged 20 to 65.
- Conditions
- Health Adults, Temporal Interference Stimulation, Safety and Effectiveness, Crossover Study
- Trial name
- NCT07179848
- Testing
- Temporal Interference Stimulation - Treatment first
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Epilepsy
Temporally Interfering Electric Field Stimulation in the Treatment of Epilepsy
This study investigates the potential for temporally-interfering electric field stimulation (TIEFS) to treat epilepsy. In this case series within and between subjects design, the impact of TIEFS on epilepsy biomarkers was studied…
- Trial name
- EE-DES-TIEF (NCT06716866)
- Testing
- temporally-interfering electric field stimulation
- Where
- 3 sites in United States, Czechia
- Volunteers
- 100 people
- Sponsor
- University of California, Davis
Alzheimer Disease
Efficacy and Safety of Temporal Interference Stimulation on Cognitive Function in Patients With Early-Stage Alzheimer's Disease
This study aims to investigate the efficacy and safety of a novel non-invasive brain stimulation technique-Temporal Interference Stimulation (TIS)-in patients with early-stage Alzheimer's disease.
- Trial name
- NCT07543094
- Testing
- Temporal Interference Stimulation
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Ruijin Hospital
Deep Brain Stimulation, Drug Resistant Epilepsy
Evaluating Modulation Effects of Temporal Interference Using SEEG
This single-center prospective study aims to investigate the electrophysiological mechanisms of temporal interference (TI) in humans by analyzing clinical, imaging, and electrophysiological data from patients aged 14-60 with…
- Trial name
- NCT06663969
- Testing
- Temporal Interference
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Xuanwu Hospital, Beijing
Parkinson s Disease
Temporal Interference Stimulation for Motor and Non-motor Symptoms in Parkinson's Disease
This study aims to evaluate the efficacy of tTIS treatment in improving motor function in patients with Parkinson's disease (PD), as well as its effects on mood, activities of daily living, sleep, cognition, and other functional…
- Trial name
- NCT07857824
- Testing
- transcranial temporal interference stimulation (tTIS)
- Volunteers
- 50 people
- Sponsor
- Tongji Hospital
Healthy Volunteers
Temporal Interference Methods for Non-invasive Deep Brain Stimulation, Study 1.1
In its totality, this grant aims to develop a line of research using temporal interference (TI) electrical neurostimulation technology to understand the causal role of deep brain structures in cognition.
- Trial name
- NCT07215299
- Testing
- Temporal Interference (TI) Electrical Stimulation - NAcc TI Active, Temporal Interference (TI) Electrical Stimulation - NAcc No-TI Active
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Indiana University
Spinocerebellar Ataxia Type 3
Optimizing Parameters of Transcranial Temporal Interference Stimulation for Spinocerebellar Ataxia Type 3
The purpose of this research study is to identify the optimal biological dose for tTIS that targets DN in SCA3 while achieving the best possible balance between therapeutic efficacy and safety.
- Trial name
- NCT07743866
- Testing
- Transcranial Temporal Interference Stimulation (tTIS)
- Where
- China
- Volunteers
- 24 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Mild Cognitive Impairment (MCI) Amnestic, Lewy Body Disease With Mild Cognitive Impairment
Effect of Striatal Temporal Interference Stimulation on Language Processing in Neurodegenerative Diseases
The purpose of this study is to investigate the immediate effects of non-invasive temporal interference stimulation (TIS) targeting the striatum on sentence processing and brain connectivity in patients with neurodegenerative…
- Conditions
- Mild Cognitive Impairment (MCI) Amnestic, Lewy Body Disease With Mild Cognitive Impairment, Parkinson's Disease With Mild Cognitive Impairment
- Trial name
- NCT07449117
- Testing
- Active Temporal Interference Stimulation (TIS)
- Where
- Czechia
- Volunteers
- 70 people
- Sponsor
- Masaryk University
Disorders of Consciousness, Severe Brain Injury
Transcranial Temporal Interference Stimulation In Severely Brain Injured Patients With Disorders of Consciousness
The purpose of this academic lead study is to explore the effect of noninvasive neuromodulation of the CM-pf via tTIS for patients with disorders of consciousness.
- Conditions
- Disorders of Consciousness, Severe Brain Injury, Unresponsive Wakefulness Syndrome, Minimally Conscious State
- Trial name
- NCT06851156
- Testing
- tTIS
- Where
- 2 sites in China
- Volunteers
- 10 people
- Sponsor
- Xijing Hospital