Clinical trials: Temporal Interference Stimulation
Neuropathic Pain, tTIS
Effects and Mechanisms of Temporal Interference Stimulation (TIS) on Neuropathic Pain
This study employs temporal interference stimulation (tTIS) to investigate the analgesic effects of tTIS on neuropathic pain and monitor changes in neural plasticity, and explore the dynamic relationship between analgesic…
- Trial name
- TIS (NCT07735975)
- Testing
- Transcranial temporal interference stimulation
- Volunteers
- 60 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Parkinson's Disease (PD)
Subthalamic Nucleus-Targeted Transcranial Temporal Interference Stimulation for Motor and Non-Motor Symptoms in Parkinson's Disease
Transcranial temporal interference stimulation (tTIS) is a non-invasive deep brain stimulation method. This study aims to comprehensively explore the efficacy and safety of bilateral subthalamic nucleus (STN) tTIS on motor and…
- Trial name
- STN-tTIS-PD (NCT07625540)
- Testing
- real transcranial temporal interference stimulation
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Healthy Volunteers
Temporal Interference Methods for Non-invasive Deep Brain Stimulation, Study 1.2
In its totality, this grant aims to develop a line of research using temporal interference (TI) electrical neurostimulation technology to understand the causal role of deep brain structures in cognition.
- Trial name
- NCT07339072
- Testing
- Temporal Interference (TI) Electrical Stimulation - NAcc 5 Hz TI Active, Temporal Interference (TI) Electrical Stimulation - NAcc 10 Hz TI Active
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Indiana University
Temporal Lobe Epilepsy (TLE), Drug Resistant Epilepsy
Overnight TI in TLE
The goal of this clinical trial is to gauge whether overnight, non-invasive temporal interference (TI) stimulation aimed at the hippocampus can reduce abnormal brain activity linked to seizures and improve sleep in adults with…
- Conditions
- Temporal Lobe Epilepsy (TLE), Drug Resistant Epilepsy, Sleep
- Trial name
- TI-HPC-TLE (NCT07434986)
- Testing
- Non-invasive Temporal Interference (TI) Stimulation Targeting Bilateral Hippocampi
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Duke University
Alcohol Use Disorder
Transcranial Temporal Interference Stimulation Targeted of the Amygdala as an Intervention for Alcohol Use Disorder Patients
The purpose of this research is to investigate the efficacy of transcranial temporal interference stimulation (tTIS) targeting the amygdala in patients with alcohol use disorder.
- Trial name
- NCT07472673
- Testing
- tTIS on Amygdala, 10 Hz
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai Mental Health Center
Depressive Disorder, Temporal Interference Stimulation
Intervention Effect of Temporal Interference Stimulation (TIS) on Depressive Disorder
To investigate the effect of Temporal Interference Stimulation (TIS) on associative memory (AM) in patients with depressive disorder
- Trial name
- NCT07191392
- Testing
- Temporal Interference Stimulation (TIS)
- Where
- 2 sites in China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Second Hospital of Anhui Medical University
Stroke
Efficacy of Temporal Interference-based Deep Brain Stimulation Combined With Conventional Rehabilitation Training for Lower Limb Motor Dysfunction After Stroke
Stroke, as one of the most disabling neurological diseases worldwide, causes significant functional impairments in the lower limbs, severely affecting the quality of life of patients.
- Trial name
- NCT07833423
- Testing
- Transcranial Temporal Interference (TI) Stimulation, routine rehabilitation
- Volunteers
- 60 people
- Sponsor
- The Third People's Hospital of Huizhou
Major Depressive Disorder (MDD)
Temporal Interference Transcranial Alternating Current Stimulation for Major Depressive Disorder
This multi-center, double-blind study, randomized controlled trial aims to evaluate the efficacy and safety of Temporal Interference transcranial Alternating Current Stimulation (TI-tACS) in patients with major depressive…
- Trial name
- NCT07712159
- Testing
- Temporal Interference transcranial Alternating Current Stimulation (TI-tACS)
- Volunteers
- 102 people
- Sponsor
- Central South University
Schizophrenia Disorder
dACC-Targeted Temporal Interference for Negative and Cognitive Symptoms in Schizophrenia
This randomized, double-blind, sham-controlled trial aims to evaluate the efficacy and safety of dorsal anterior cingulate cortex-targeted temporal interference stimulation in individuals with schizophrenia.
- Trial name
- NCT07658898
- Testing
- Temporal Interference Stimulation
- Where
- China
- Volunteers
- 74 people
- Sponsor
- Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University
Amnestic Mild Cognitive Impairment - aMCI, AD-MCI
Temporal Interference Stimulation Treatment in Patients With Cognitive Impairment
This study aims to evaluate the efficacy and safety of temporal interference stimulation (TIS), a non-invasive neuromodulation technique, in improving cognitive function in patients with cognitive impairment.
- Conditions
- Amnestic Mild Cognitive Impairment - aMCI, AD-MCI, AD - Alzheimer's Disease, FTD
- Trial name
- TIS (NCT07643363)
- Testing
- Temporal Interference Stimulation, Targeted Cognitive Training, General Cognitive Training
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Tianjin Huanhu Hospital
Schizophrenia
Temporal Interference Stimulation (TI) for Schizophrenia (SCZ)
This study will evaluate whether temporal interference (TI) stimulation, added to usual clinical treatment, improves symptoms of schizophrenia and is safe and tolerable.
- Trial name
- TI-SCZ-Insular (NCT07887997)
- Testing
- Active transcranial temporal interference stimulation
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Anhui Medical University
Amphetamine Use Disorders
tTIS Targeted of the Striatum as an Intervention for MUD Patients
Targeted temporal interference stimulation (tTIS) of the caudate nucleus can modulate the abnormal electrophysiological activity in individuals with methamphetamine use disorder (MUD), thereby improving their impaired…
- Trial name
- NCT07479771
- Testing
- Temporal Interference Stimulation
- Where
- China
- Volunteers
- 53 people
- Sponsor
- Shanghai Mental Health Center
Parkinson's Disease
Temporal Interference Stimulation on Motor Symptoms in Parkinson's Disease
The goal of this clinical trial is to learn whether a type of brain stimulation called transcranial temporal interference stimulation (TIS) of the internal globus pallidus (GPi) can help improve movement symptoms in people with…
- Trial name
- NCT07309198
- Testing
- Transcranial Temporal Interference Stimulation (TIS)
- Where
- China
- Volunteers
- 37 people
- Sponsor
- Shanghai University of Sport
PARKINSON DIS
Comparative Study of TIS Efficacy Across Different Targets
This prospective, randomized, participant- and outcome-assessor-blinded, parallel-group exploratory trial will compare the target-dependent clinical, neuroimaging, and electrophysiological effects of temporal interference…
- Trial name
- tTIS (NCT07745673)
- Testing
- TIS-STN, TIS-GP
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Zhongnan Hospital
Schizophrenia Disorder, Cognitive Impairments
TIS for Improving Cognitive Impairment in Schizophrenia
This study aims to evaluate the efficacy, safety, and underlying neural mechanisms of TIS targeting the hippocampus in ameliorating cognitive impairment associated with schizophrenia (CIAS).
- Trial name
- NCT07647380
- Testing
- temporal interference stimulation
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Central South University
Healthy Controls
Temporal Interference Stimulation for Social Cognition
The long-term goal of this project is to evaluate whether a procedure termed transcranial interference stimulation (tIS) may be useful in the future in the treatment of severe neuropsychiatric disorders such as schizophrenia.
- Trial name
- TISSC (NCT06607432)
- Testing
- Transcranial Interference Stimulation (tIS)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Columbia University
PARKINSON DISEASE (Disorder)
TIS for Brain Network Modulation and Clinical Efficacy in Parkinson's Disease
Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor dysfunction. While deep brain stimulation (DBS) is effective, its invasive nature limits its application in early-stage patients.
- Trial name
- PD TIS (NCT07480317)
- Testing
- Temporal Interference Stimulation (130 Hz), Temporal Interference Stimulation (40 Hz)
- Where
- China
- Volunteers
- 75 people
- Sponsor
- Jiangsu Province Nanjing Brain Hospital
Temporal Interference Stimulation, Parkinson's Disease
The Efficacy and Safety of Transcranial Temporal Interference Stimulation (tTIS) Targeting the Right Globus Pallidus Internus (GPi) for Motor Symptoms in Patients With PD
To demonstrate that intervention targeting the right globus pallidus internus (GPi) using transcranial temporal interference stimulation can improve motor symptoms in patients with Parkinson's disease.
- Conditions
- Temporal Interference Stimulation, Parkinson's Disease, the Right Globus Pallidus Internus, Motor Symptoms
- Trial name
- NCT06931483
- Testing
- Transcranial temporal interference stimulation (tTIS)
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Yanghua Tian
Major Depressive Disorder (MDD)
6 Weeks Right-Amygdala TIS for Depression
The current investigation employs a directed neuromodulation technique, specifically targeting the right amygdala, to ascertain its therapeutic efficacy in managing depressive episodes.
- Trial name
- NCT07059143
- Testing
- Nervio-X
- Where
- 3 sites in China
- Volunteers
- 38 people
- Sponsor
- Ruijin Hospital
Healthy Aging, Memory Disorders in Old Age
Noninvasive Temporal Interference Stimulation: Modulating Associative Memory by Targeting Deep-brain Targets
Alzheimer's disease and its preclinical stages are characterized by progressive neurodegenerative changes in the hippocampi and default mode network resulting in dysfunctions in episodic memory and its central part the…
- Conditions
- Healthy Aging, Memory Disorders in Old Age, Mild Cognitive Impairment, Alzheimer Disease
- Trial name
- Deep-HiPs (NCT05805215)
- Testing
- Non-invasive Temporal Interference stimulation and Face-name association training task targeting the hippocampus, Non-invasive Temporal Interference stimulation and Face-name association training task targeting the Precuneus
- Where
- Czechia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Masaryk University