Clinical trials: Telomere Length
Metabolic Syndrome
Effectiveness of Weight Loss Methods on Lifespan for Metabolic Syndrome
Background. The prevalence of type 2 diabetes mellitus (T2D) in the world is constantly increasing. Treatment of T2D is complicated by arterial hypertension and obesity (metabolic syndrome - MS).
- Trial name
- NCT06410352
- Testing
- Semaglutide, Empagliflozin, Minigastric bypass, Analimentary detoxication
- Where
- Kazakhstan
- Volunteers
- 220 people
- Sponsor
- University Medical Center, Kazakhstan
Telomere Length, Exercise
Physical Exercise in Patients With First Psychotic Episode
Justification: Patients with first-episode psychosis are at increased risk of premature ageing and early mortality, associated with telomere shortening and increased inflammatory markers.
- Conditions
- Telomere Length, Exercise, First Episode Psychosis (FEP)
- Trial name
- NCT07207538
- Testing
- Other: Strength physical exercise programme, Other: Normal life
- Volunteers
- 40 people
- Sponsor
- University of Salamanca
Postoperative Cognitive Dysfunction
Correlation Between Postoperative Cognitive Dysfunction and Telomere Length in Patients With Non-cardiac Surgery
To study on the Postoperative Cognitive Dysfunction: Correlations With Leukocyte telomere length。
- Trial name
- NCT03703973
- Testing
- Neuropsychology test
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Xuzhou Medical University
Stress, Breast Cancer
Stress Management and Biological Age in Breast Cancer Patients.RCT
Intense stress has harmful effects on the body, contributing to various disorders. Breast cancer patients experience a build-up of stress due to their diagnosis and treatments.
- Conditions
- Stress, Breast Cancer, Telomere Length, Mean Leukocyte
- Trial name
- NCT05984914
- Testing
- PSAI, One day seminar
- Where
- Greece
- Volunteers
- 120 people
- Sponsor
- Maria Charalampopoulou
Sperm Preservation, Irradiated Semen
Impact of Ionizing Treatment on the Nuclear Structure of Human Spermatozoa.
Differentiated thyroid cancer is the third cause of cancer in young men of childbearing age. Its treatment by irradiation with Radioactive Iodine 131 therapy (RAT) could alter spermatogenesis and result in azoospermia and…
- Trial name
- NCT04715828
- Testing
- Cryopreserved semen, Acute and low irradiation, Long and low irradiation
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Clermont-Ferrand
Chronic Pain
Impact of Lifestyle Changes on Telomeric Activity in Patients With Chronic Pain
The current project will use the Complete Health Improvement Program (CHIP) as an intervention for patients with chronic pain. CHIP is a nationally recognized program that encourages a diet of whole plant-based foods, moderate…
- Trial name
- NCT03056417
- Testing
- The Complete Health Improvement Program
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Ohio University
Telomere Shortening, Telomere Length, Mean Leukocyte
Evaluating Efficacy and Safety of Danazol in Severe Hematologic or Pulmonary Disease Related to Telomeropathy
Constitutional mutations of genes involved in telomere repair and maintenance are responsible for "telomeropathy" (" Congenital Dyskeratosis "). Attrition of telomeres promotes cell senescence and genetic instability.
- Trial name
- ANDROTELO (NCT03710356)
- Testing
- Danazol 200 MG
- Volunteers
- 40 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Telomere Length, Mean Leukocyte
Telomere Disclosure and Impact on Psychological Distress and Health Behaviors
There is now a critical mass of data linking health to telomere length, and blood telomere length is starting to become a commercially available measure, with several companies either offering or planning to offer this measure.
- Trial name
- NCT04104386
- Testing
- Telomere Disclosure Impact
- Volunteers
- 263 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Chronic Pain
Existential Genomics: Effects of Multimodal Rehabilitation and Integrative Care on Patients With Chronic Pain
Using a comprehensive prospective clinical study design, the investigators intend to compare changes in health-related markers in patients with chronic widespread pain (CWP), undergoing one of two intervention "packages" of…
- Trial name
- ExiGence (NCT02459639)
- Testing
- Anthroposophic integrative care rehabilitation program, Conventional multi-modal care rehabilitation
- Volunteers
- 100 people
- Sponsor
- The Integrative Care Science Center
Anxiety Disorders, Social Anxiety Disorder
Brain Plasticity and Cellular Aging After Internet-delivered CBT for Social Anxiety Disorder
This study evaluates underlying psychological and biological mediators in Internet-delivered cognitive behavior therapy for adults with social anxiety disorder.
- Trial name
- UMEII (NCT02592564)
- Testing
- Internet-delivered cognitive behavior therapy
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Linkoeping University
Obstructive Sleep Apnea
Obstructive Sleep Apnea and Telomere Length
Obstructive sleep apnea (OSA) is a highly prevalent and morbid sleep disorder. Among the factors associated with its pathophysiology, the role of intermittent hypoxia stands out, contributing to the development of oxidative…
- Trial name
- NCT04872816
- Testing
- Continuous airway positive pressure
- Where
- Brazil
- Volunteers
- 46 people
- Sponsor
- Associação Fundo de Incentivo à Pesquisa
Telomere Length, Mean Leukocyte, Diet Habit
Diet Quality and LTL in NHANES
In our study, we used data from 4,758 healthy adults from the 1999-2002 National Health and Nutrition Examination Surveys to examine the associations between evidence-based diet quality indices and leukocyte telomere length.
- Trial name
- NCT03302104
- Volunteers
- 4,758 people
- Sponsor
- University of California, San Francisco
Metformin, Prediabetes
Metformin and Molecular Aging in Prediabetes
The incidence and prevalence of type 2 diabetes mellitus (T2DM) are increasing globally. The global prevalence of diabetes has nearly doubled since 1980, rising from 4.7% to 8.5% in the adult population.
- Trial name
- NCT07302932
- Testing
- Metformin treatment, Analyzed by qPCR for T/S ratio.
- Where
- India
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Diabetes Foundation, India
Fibrinogen Abnormality, Telomere Length, Mean Leukocyte
Pediatric ACEs Screening and Resiliency Study
Stressful and traumatic experiences in childhood (Adverse Childhood Events, or ACEs) have been associated with poor health outcomes that extend into adulthood.
- Conditions
- Fibrinogen Abnormality, Telomere Length, Mean Leukocyte, Atopic, Acute Infection
- Trial name
- PEARLS (NCT04182906)
- Testing
- Care Coordination, Resiliency Clinic, Usual Care
- Where
- United States
- Volunteers
- 555 people, healthy volunteers welcome
- Sponsor
- UCSF Benioff Children's Hospital Oakland
Lung Cancer
The Roles of Age, Comorbidity, and Telomere Length in Lung Cancer Treatment and Prognosis
The investigators hypothesize that the age-adjusted telomere length in lung cancer patients before chemotherapy may be correlated to comorbidity status and predict outcome.
- Trial name
- NCT01963533
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Taiwan University Hospital
Food Addiction
Differences in Length of Telomere in Food Addicted vs Non Food Addicted Persons
The purpose of this descriptive study is to examine telomere length between two groups of people, those with and those without food addiction and identify possible relationships that may play a role in food addiction, it's…
- Trial name
- NCT05649189
- Testing
- telomere length measure
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Nebraska
Aging
A Model for Healthy Aging: Moscow Centenarians (AGE-100)
This study evaluates the associations between biomarkers of ageing, comprehensive geriatric status, telomere length and progerin level, the composition of the gut microbiota, 16sRNA metagenome sequencing in Moscow centenarians.
- Trial name
- AGE-100 (NCT02876809)
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- Pirogov Russian National Research Medical University
Colonic Polyp
Study of a Screening Blood Test to Determine Patients' Potential Risk of Adenomatous or Advanced Colon Polyps (ACPs)
The aim of this study is to develop a blood test to determine which patients are at risk for pre-cancerous colon polyps (ACPs: Advanced Colon Polyps).
- Trial name
- NCT01062035
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Exercise
Body Awareness and Aerobic Exercise: Telomere Impact
Telomeres shorten with each replication cycle throughout cellular lifespan. While it is known that telomere length is age-dependent, numerous factors influencing telomere length have been identified.
- Trial name
- NCT06732934
- Testing
- exercise (Basic Body Awareness Therapy, exercise (aerobic exercise)
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Suleyman Demirel University
Aging, Stress
Fitness, Cellular Aging, and Caregiver Stress Study
The purpose of this study is to determine whether an aerobic training intervention will alter markers of immune cell aging, improve exercise capacity and blood pressure and decrease psychological distress over 24 weeks in 32…
- Conditions
- Aging, Stress, Disease Risk
- Trial name
- FAST (NCT01993082)
- Testing
- Aerobic Training Intervention
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco