Clinical trials: Tear
Laceration
A Randomized Post-market Study to Evaluate Zip Device Compared to Sutures for Laceration Repair in Pediatrics and Adults
The Zip-009 clinical investigation will enroll 26 paediatric and adult subjects requiring laceration repair and fulfilling the eligibility criteria for the clinical investigation.
- Trial name
- NCT03199456
- Testing
- Zip surgical skin closure device, Standard of Care sutures
- Where
- 2 sites in Sweden
- Volunteers
- 26 people
- Sponsor
- ZipLine Medical Inc.
Rotator Cuff Tears
Arthroscopic Rotator Cuff Repair Utilizing Mechanical Bone Debridement Versus Coblation Debridement
Randomized controlled trial comparing coblation debridement to mechanical debridement in rotator cuff repair.
- Trial name
- FLOW90 (NCT05084781)
- Testing
- Coblation Debridement (FLOW90)
- Where
- Canada
- Volunteers
- 94 people
- Sponsor
- University of Calgary
Dry Eye Syndromes, Lubricant Allergy
Safety and Tolerability of PRO-087 Versus Xyel Ofteno® and Systane Ultra®, on the Ocular Surface of Healthy Subjects
Phase I clinical study, to evaluate the safety and tolerability of the preservative-free ophthalmic solution PRO-087 versus Xyel Ofteno® and Systane Ultra®, on the ocular surface of ophthalmological and clinically healthy…
- Conditions
- Dry Eye Syndromes, Lubricant Allergy, Tear Disorder
- Trial name
- PRO-087/I (NCT03524157)
- Testing
- PRO-087, Systane Ultra, Xyel Ofteno
- Where
- Mexico
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Laboratorios Sophia S.A de C.V.
Needlestick Injuries
Blunt Needles do Not Reduce Needlestick Injuries to Doctors During Suturing After Child-Birth
The hypothesis for this study is that use of blunt tipped needles used during the repair of an episiotomy (tear in the vagina after childbirth) will result in fewer needlestick injuries to the surgeon.
- Trial name
- NCT00536289
- Testing
- Blunt needle
- Where
- United States
- Volunteers
- 438 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Acute Achilles Tendon Rupture
Popliteal Nerve Block for Acute Achilles Tendon Rupture Repair Surgery
Achilles tendon rupture is common, yet the value of popliteal nerve block for postoperative pain control during surgical repair remains uncertain.
- Trial name
- NCT06886815
- Testing
- Popliteal Nerve Block
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Women's College Hospital
Rotator Cuff Tears
Ultrasonographic and MRI Explorations of Infraspinatus Muscle in Postero-superior Rotator Cuff Tear
The project aims to evaluate the contribution of texture analysis on MRI sections, and the technical feasibility, reproducibility, and clinical relevance of quantitative ultrasound and elastography to characterize the composition…
- Trial name
- VISUMIR (NCT04223440)
- Testing
- MRI, ultrasonographic explorations
- Where
- France
- Volunteers
- 3 people
- Sponsor
- University Hospital, Tours
Non-Proliferative Diabetic Retinopathy, Proliferative Diabetic Retinopathy New Vessels on Disc
The Effect of Combination of Vitamin A, Vitamin E, Sodium Hyaluronate 0.15% Eye Drop Compared With Sodium Hyaluronate 0.1% Eye Drop to Tear Film Stability and Conjunctival Goblet Cells Density in Patient With Non-Proliferative Diabetic Retinopathy (NPDR), and Proliferative Diabetic Retinopathy (PDR)
Commonly know that one of the complications caused by Diabetes Mellitus (DM) is microangiopathy. Microangiopathy in the long term may lead to neuropathy of the corneal nerves.
- Conditions
- Non-Proliferative Diabetic Retinopathy, Proliferative Diabetic Retinopathy New Vessels on Disc, Dry Eye Syndromes
- Trial name
- NCT04000789
- Testing
- Sodium Hyaluronate, Vitamin A, Vitamin E
- Volunteers
- 96 people
- Sponsor
- Dr Cipto Mangunkusumo General Hospital
ACL Injury, ACL - Anterior Cruciate Ligament Rupture
Dynamic ACL Brace: In Vivo Kinematics
The purpose of this study is to evaluate the effect of the Össur Rebound dynamic ACL brace on knee kinematics evaluated using dynamic stereo X-ray (DSX) imaging during functional activities.
- Conditions
- ACL Injury, ACL - Anterior Cruciate Ligament Rupture, ACL, ACL - Anterior Cruciate Ligament Deficiency
- Trial name
- NCT03670550
- Testing
- Ossur Rebound ACL Brace
- Where
- United States
- Sponsor
- Steadman Philippon Research Institute
Rupture of Membranes; Premature
Urea and Creatinine Level in Vaginal Fluid as a Predicator for Length of Latency Period in Prelabour Membranes Rupture
This study aims to investigate the relation between the concentration of urea and creatinine in vaginal fluid and length of latency period in women with PROM between 32 and 35 weeks gestation.
- Trial name
- NCT03213535
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Chorioamnionitis, Intrauterine Infection
Effect of Sterile Versus Clean Gloves Intrapartum and Postpartum Infections at Term
This prospective randomized controlled study examines whether the type of glove used (sterile vs clean) for cervical examination to assess progression in labor impacts the rates of intrapartum and/or postpartum infection in…
- Conditions
- Chorioamnionitis, Intrauterine Infection, Postpartum Endometritis, Puerperal Infection
- Trial name
- NCT05603624
- Testing
- Cervical examination to assess labor
- Where
- United States
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- Eastern Virginia Medical School
Rotator Cuff Tear
Pilot Study of the Use of ULTRABRAID PLUS SUTURE in the Repair of Tears of the Rotator Cuff
The primary objective of this study is to obtain safety data on the use of the ULTRABRAID PLUS SUTURE, and to assess the preliminary effectiveness of the use of the ULTRABRAID PLUS SUTURE in comparison to the ULTRABRAID SUTURE in…
- Trial name
- NCT01767740
- Testing
- ULTRABRAID PLUS SUTURE, ULTRABRAID SUTURE
- Where
- 4 sites in Canada
- Volunteers
- 82 people
- Sponsor
- Smith & Nephew, Inc.
Clinically Isolated Syndrome, Radiologically Isolated Syndrome
Isoelectric Focusing of Tears in Children With Radiologically Isolated or Clinically Isolated Syndrome
The main gold of this study is to lead a multicentric, prospective study, to evaluate the diagnostic quality of tears in children with clinically isolated syndrome (CIS) and radiologically isolated syndrome (RIS) during a…
- Conditions
- Clinically Isolated Syndrome, Radiologically Isolated Syndrome, Multiple Sclerosis in Children
- Trial name
- OBIT (NCT03979391)
- Testing
- Tear collection and lumbar punction
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Lille Catholic University
Valvular Heart Disease, Aortic Valve Failure
NHLBI Transmural Electrosurgery LeafLet Traversal And Laceration Evaluation (TELLTALE) BASILICA-TAVR Trial
Background: Replacing a valve in the heart can save many people's lives. The procedure is called transcatheter aortic valve replacement (TAVR).
- Trial name
- NCT05666713
- Testing
- TELLTALE BASILICA procedure
- Where
- 10 sites in United States
- Volunteers
- 90 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Arthroscopic Shoulder Surgery, Rotator Cuff Tear
Randomized, Controlled Trial of Hyperosmotlar Saline for Rotator Cuff Repair Irrigation Solution
The goal of this project is to perform a randomized, double-blinded study investigating postoperative pain after arthroscopic rotator cuff using hyperosmolar saline as opposed to lactated ringer's solution (normal osmolarity) as…
- Trial name
- NCT03738735
- Testing
- Hypertonic saline
- Volunteers
- 100 people
- Sponsor
- Rothman Institute Orthopaedics
Rotator Cuff Tear
Rotator Cuff Repair Using Standard Double Row Technique With Platelet Rich Fibrin Membrane vs. Standard Double Row Technique
This study is a single-blind, randomized study evaluating the 6 month and 2 year outcomes of patients treated with arthroscopic rotator cuff repair using one of two techniques.
- Trial name
- RCRPRFM (NCT02256891)
- Testing
- PRFM, Double Row
- Where
- United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- HealthPartners Institute
Rotator Cuff Tear, Lateral Epicondylitis
Treatment of Tendon Disease Using Autologous Adipose-derived Mesenchymal Stem Cells
This study was a single-center, randomized, single-blind clinical trial. We plan to include 100 patients who met exclusion criteria of rotator cuff and lateral epicondylosis (tennis elbow) respectively by MRT or ultrasonography.
- Trial name
- NCT03279796
- Testing
- Autologous adipose-derived MSCs, Compound betamethasone
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Uterine Rupture Gravid
Uterine Rupture International Data Acquisition
Uterine rupture represents an uncommon event: it is is a life-threatening obstetric complication with high maternal and perinatal morbidity and mortality.
- Trial name
- URIDA (NCT03576950)
- Volunteers
- 100 people
- Sponsor
- Università degli Studi dell'Insubria
Perineal Tear
The Effect of Neuraxial Morphine (Duramorph) on Pain Control
With the rise of the opioid epidemic, it is important for physicians to be more mindful of the amount of narcotic prescriptions that are being written every day.
- Trial name
- NCT03926559
- Testing
- Morphine.
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Augusta University
Anterior Cruciate Ligament Injuries
Neuromuscular Rehab for ACL Reconstruction: Knee Function & Brain Plasticity
This study focuses on patients with anterior cruciate ligament (ACL) rupture and reconstruction, aiming to systematically investigate the clinical efficacy and underlying mechanisms of neuromuscular training in restoring knee…
- Trial name
- NCT07243860
- Testing
- Neuromuscular Training, Conventional Rehabilitation
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Lacerations
Suturing vs Biological Adhesive in Simple Lacerations of Hand
To assess the difference in clinical outcome between lacerations in the hand treated by sutures versus treated by tissue adhesive.
- Trial name
- sutvsglu (NCT00524888)
- Testing
- suturing laceration, bioadhesive
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Hadassah Medical Organization