Clinical trials: Tear
Neonatal Outcomes, Pregnancy Complications, Infectious
Systematic Screening of Lower Genital Tract Infections
Introduction: The investigation of systematic screening for asymptomatic genital infections in pregnant women is justified by the relevance of these conditions in determining adverse neonatal outcomes, such as prematurity, low…
- Conditions
- Neonatal Outcomes, Pregnancy Complications, Infectious, Premature Birth, Premature Rupture of Fetal Membranes
- Trial name
- NCT07592286
- Testing
- Enhanced microbiological screening, Standard prenatal care
- Volunteers
- 250 people
- Sponsor
- Universidade Federal do Pampa
Rotator Cuff Syndrome, Rotator Cuff Injury
Allograft Reconstruction of Massive Rotator Cuff Tears vs Partial Repair Alone
The investigators hypothesize that the use of an allograft adjuvant to partial repair will lead to improved shoulder outcome measure scores compared to partial repair alone in massive rotator cuff tears.
- Conditions
- Rotator Cuff Syndrome, Rotator Cuff Injury, Disorder of Rotator Cuff, Full Thickness Rotator Cuff Tear
- Trial name
- NCT01987973
- Testing
- Partial Rotator Cuff Repair, Partial Rotator Cuff Repair with Allograft Augmentation
- Where
- Canada
- Volunteers
- 29 people
- Sponsor
- Ivan Wong
Achilles Tendon Rupture
The Efficacy of Different Rehabilitation Protocols After Achilles Tendon Rupture Surgery
This study is a prospective randomized controlled clinical study. After the Achilles tendon rupture repaired , patients were randomly divided into 2 groups, and the rehabilitation protocol was traditional rehabilitation protocol…
- Trial name
- NCT04912154
- Testing
- Rehabilitation protocol
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University Third Hospital
Superior Capsular Reconstruction
Superior Capsular Reconstruction With InternalBrace Study
The aim of the study is to investigate the clinical and radiological outcomes after superior capsular reconstruction with InternalBrace (SCRIB) performed for irreparable rotator cuff tears.
- Trial name
- SCRIB (NCT05360654)
- Where
- United Kingdom
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Wrightington, Wigan and Leigh NHS Foundation Trust
Shoulder Pain
Ultrasound Guided Steroids Injection Versus PRP for Shoulder Pain Relief
Comparison between effects of ultrasound guided platelet rich plasma injection versus steroids injection for pain relief in cases of partial rotator cuff tears
- Trial name
- PRP (NCT05317624)
- Testing
- Platelet rich plasma, Methylprednisolone
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Glaucoma
Tear Interleukin Biomarkers After Glaucoma Treatment
This prospective study aims to evaluate inflammatory biomarkers in tear fluid in patients with glaucoma undergoing micropulse transscleral cyclophotocoagulation (MP-CPC), continuous-wave cyclophotocoagulation (CPC), and…
- Trial name
- TIGT (NCT07592988)
- Testing
- MicroPulse Transscleral Cyclophotocoagulation, Conventional Transscleral Cyclophotocoagulation, Antiglaucoma Surgery
- Where
- Kazakhstan
- Volunteers
- 24 people
- Sponsor
- Kazakh Eye Research Institute
Herpes Simplex
30-Day Trial of Oral Valtrex or Valtrex Plus Aspirin on Shedding of HSV DNA in Tears and Saliva of Volunteers
The purpose of this study is to determine whether oral Valtrex alone or in combination with aspirin will reduce the shedding of herpes simplex virus DNA in the tears and saliva from volunteers with no evidence of ocular herpes…
- Trial name
- NCT00587496
- Testing
- valacyclovir hydrochloride, valacyclovir plus aspirin
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)
Glaucoma, Ocular Hypertension
Safety, Tolerability and Preliminary Efficacy of Unilateral Latanoprost-loaded Punctual Plug -EXP-LP
Glaucoma is the most frequent cause of irreversible \& preventable blindness worldwide, affecting about 2% of the world's population in people over 40.
- Conditions
- Glaucoma, Ocular Hypertension, IOP
- Trial name
- EXP-LP (NCT03318146)
- Testing
- drug delivery system, XALATAN®
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Shaare Zedek Medical Center
Early Retears and Clinical Outcomes Following Surgical Repair of Massive Rotator Cuff Tears
Postoperative USG Control and Clinical Follow-up of Massive Rotator Cuff Tendon Ruptures
This prospective observational study aims to investigate the tendon integrity and clinical outcomes following surgical repair of massive rotator cuff tears.
- Trial name
- NCT07004218
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Gazi University
Rupture of Anterior Cruciate Ligament
Stability of the Knee Joint After Single and Double Bundle Anterior Cruciate Ligament Reconstruction
The purpose of this prospective study is to evaluate the influence of both bundles on the knee stability - anterior-posterior translation, internal and external rotations after the double-bundle reconstruction of Anterior…
- Trial name
- NCT01391650
- Testing
- 'biomechanic of the knee'
- Where
- Czechia
- Volunteers
- 60 people
- Sponsor
- Hospital Znojmo
Comfort, Vision and Wear Time
Masked Comparison of a New PEG Based Artificial Tear and Optive for Comfort, Vision & Wear Time in Patients Wearing Contact Lenses
The objective of this study is to evaluate the effect of a new PEG based artificial tear as compared to Optive on comfort, wear time, and vision in patients wearing contact lenses.
- Trial name
- NCT00570843
- Testing
- New PEG based artificial tear, Optive
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Bp Consulting, Inc
ACL Injury, ACL Sprain
Isoinertial Rehabilitation in Recovering Hamstring Strength Following Surgical Anterior Cruciate Ligament Reconstruction
The present experimental study aims to evaluate the effectiveness and tolerability of isoinertial strength training of the hamstrings using machines in patients with ACL-R during the intermediate post-intervention phases.
- Conditions
- ACL Injury, ACL Sprain, ACL Tear, Anterior Cruciate Ligament Rupture
- Trial name
- NCT06063915
- Testing
- Isoinertial training, Strength Training
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Università degli studi di Roma Foro Italico
Rotator Cuff Tear
InSpace™ System Over Rotator Cuff Repair in Comparison to Repair Alone.
This is a post-marketing study to further assess the safety and effectiveness of the InSpace™ in the study population in comparison to surgical RCT repair.
- Trial name
- NCT02210910
- Testing
- InSpace™ system over repair, Best Repair of torn Rotator Cuff
- Where
- Israel
- Volunteers
- 39 people
- Sponsor
- OrthoSpace Ltd.
Knee Pain Chronic, Anterior Knee Pain Syndrome
Clinical Applications of Blood Flow Restriction and Rehabilitation Outcomes
The study aims to evaluate the effect of low load resistance training combined with blood flow restriction or sham blood flow restriction in patients with anterior knee pain and rotator cuff related shoulder pain in a cross-over…
- Conditions
- Knee Pain Chronic, Anterior Knee Pain Syndrome, Patellofemoral Pain Syndrome, Rotator Cuff Impingement Syndrome
- Trial name
- NCT04989023
- Testing
- Blood flow restriction (BFR) with low load resistance training
- Where
- Qatar
- Volunteers
- 80 people
- Sponsor
- Aspetar
Meniscus Tear
Motor and Sensory Deficits Following Partial Meniscectomy
To determine changes in thigh muscle function and knee pain after a partial meniscectomy surgery and to also determine the effects of applying electrical stimulation to the knee to determine if this improves thigh muscle function…
- Trial name
- NCT02100059
- Testing
- Transcutaneous Electrical Nerve Stimulation
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Creighton University
Achilles Tendon Rupture
Two-layer Suturing of Achilles Tendon Ruptures
The purpose of the present study is to measure whether a new technique of double row suturing of a ruptured Achilles tendon will result in a normalization of the length of the Soleus part (primary outcome) and of the superficial…
- Trial name
- ATRBFH (NCT05717270)
- Testing
- Two-layered suture repair
- Where
- Denmark
- Volunteers
- 23 people
- Sponsor
- Bispebjerg Hospital
Post-partum Perineal Pain, Episiotomy
Post-partum Perineal Pain - Chirocaine®
The aim of this placebo-controlled clinical trial is to assess the effectiveness of the local infiltration of the analgesic Chirocaïne® on perineal pain after episiotomy or first-degree tear.
- Conditions
- Post-partum Perineal Pain, Episiotomy, Vaginal Tear
- Trial name
- EPISIO (NCT02905695)
- Testing
- Chirocaine
- Where
- France
- Volunteers
- 110 people
- Sponsor
- Hopital Foch
Dry Eye Disease
Study of Efficacy and Tolerability of SYSTANE Complete in Patients With Dry Eye Disease
The purpose of this study is to evaluate the clinical effectiveness and tolerability of SYSTANE® Complete in adult patients with dry eye disease.
- Trial name
- NCT03492541
- Testing
- Propylene glycol-based eye drops
- Where
- 5 sites in United States, Spain and 1 more
- Volunteers
- 134 people
- Sponsor
- Alcon Research
Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia
Epigenome-wide DNA Methylation Profiling in Aneurysmal Subarachnoid Hemorrhage and Delayed Ischemic Neurologic Deficit
The goal of this observational study is to investigate DNA methylation changes in adults with bleeding from brain aneurysm, which is called aneurysmal subarachnoid hemorrhage (aSAH), and their association with delayed ischemic…
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia, Cerebral Vasospasm After Subarachnoid Hemorrhage, Intracranial Aneurysm
- Trial name
- NCT06881329
- Where
- Poland
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Pomeranian Medical University Szczecin
Pelvic Floor Dysfunction, Perineal Laceration
Perineal Protection Device for Reducing Perineal Trauma During Vaginal Delivery in First-time Mothers: a Multicenter Randomized Controlled Trial
The goal of this clinical trial is to determine whether using a soft perineal protection device (BabySlide®) in addition to standard manual perineal support during vaginal delivery can reduce the risk of perineal trauma in…
- Conditions
- Pelvic Floor Dysfunction, Perineal Laceration, Wound Dehiscence, Anal Incontinence
- Trial name
- PeriPROTECT (NCT07862660)
- Testing
- Perineal protection device, BabySlide, Standard manual perineal support
- Where
- Sweden
- Volunteers
- 4,226 people
- Sponsor
- Region Skane