Clinical trials: Target-controlled Infusion
Elderly, Surgery
Anesthesia Maintenance With Target-controlled Infusion of Propofol and Remifentanil at Fixed Ratio
The impact of anesthesia depths on early postoperative neurocognitive complications after total intravenous anesthesia (TIVA) remains controversial.
- Conditions
- Elderly, Surgery, Depth of Anesthesia, Total Intravenous Anesthesia
- Trial name
- NCT07479719
- Testing
- Light anesthesia, Deep anesthesia
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University First Hospital
Hepatocellular Carcinoma, Chemotherapy Effect
Concurrently vs Sequentially Combined HAIC With Targeted and Immunotherapy in Potentially Resectable HCC
The goal of this clinical trial is to compare HAIC concurrently with sequentially combined with targeted and immunotherapies in terms of efficacy and safety in patients with potentially resectable intermediate and advanced HCC…
- Conditions
- Hepatocellular Carcinoma, Chemotherapy Effect, Chemotherapeutic Toxicity
- Trial name
- HAIC (NCT06041477)
- Testing
- Oxaliplatin,calcium folinic acid, levofolinic acid, 5-FU, Concurrent Lenvatinib, Concurrent PD-1 antibody
- Where
- China
- Volunteers
- 540 people
- Sponsor
- Sun Yat-sen University
Emergence Delirium, Post-Operative Cognitive Dysfunction
Post Operative Cognitive Dysfunction and Delirium After Spinal Surgery
Aim of this trial is to define if Post-Operative Cognitive Dysfunction and Delirium, detected analyzing changes between pre-operative and post-operative Neurocognitive Test, relate to concentration of effector's site…
- Trial name
- NCT03950557
- Volunteers
- 200 people
- Sponsor
- University of Padova
Diagnostic Gastroscopy
Intravenous Lidocaine to Reduce ED50 for Propofol Administered Using Target Controlled Infusion (TCI) During Gastroscopy
The goal of this prospective, interventionnal clinical trial is to assess if intravenous administration of linisol reduce the ED50 of propofol when administered using Target Controlled Infusion (TCI) during gastroscopy in healthy…
- Trial name
- NCT06143410
- Testing
- Lidocaine 2% Injectable Solution, Propofol injection, gastroscopy
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Erasme University Hospital
Flexible Bronchoscopy
Target-Controlled Infusion of Propofol for Flexible Bronchoscopy Sedation
Flexible bronchoscopy (FB) sedation requires keeping sedative level in a narrow window to prevent over or under sedation. Sedative drug titration according to subjective adjustment by individual physician may cause unsteady drug…
- Trial name
- NCT01101477
- Testing
- TCI titration by different Cet.
- Where
- Taiwan
- Volunteers
- 144 people
- Sponsor
- Chang Gung Memorial Hospital
Video-assisted Thoracoscopic Surgery (VATS), Thoracic Surgery, Video Assisted
Target-Controlled Infusion (TCI) vs Inhalational Anesthesia in Video-Assisted Thoracoscopic Surgery (VATS)
This study is designed as a prospective observational cohort to evaluate recovery after video-assisted thoracoscopic surgery (VATS).
- Conditions
- Video-assisted Thoracoscopic Surgery (VATS), Thoracic Surgery, Video Assisted, Postoperative Recovery, General Anesthesia
- Trial name
- TCI-INHALE (NCT07288099)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Istanbul University - Cerrahpasa
Anesthesia Brain Monitoring
Effects of Aminophylline Bolus on TCI (Target Controlled Infusion) Concentrations at Burst Suppression Occurence
Aminophylline is an intravenous drug commonly utilized for asthma. However, some preclinical studies and few case reports and case series have described its effects in lightining the anesthestic plan during Propofol anaesthesia…
- Trial name
- TCI (NCT06134037)
- Testing
- Aminophylline
- Where
- Italy
- Volunteers
- 32 people
- Sponsor
- University of Padova
Propofol Anesthesia in Children
Comparison of the Manually Controlled Propofol Infusion and Target Controlled Infusion in Children
Patients 1 to 8 years of age, American Society of Anesthesiologist score 1 and 2, planned for elective, one day surgery: inguinal hernia repair, hydrocele surgery, testis retention surgery, varicocele and phimosis surgery, and…
- Trial name
- NCT05081206
- Testing
- Propofol infusion via manually controlled pump., Propofol infusion via target controlled pump.
- Where
- Serbia
- Volunteers
- 61 people
- Sponsor
- University Children's Hospital
Target Controlled Infusion, Induction of Anesthesia
Slow Stepwise Propofol TCI Induction for Titration Anesthesia Maintenance
The purpose of this study is to determine if a slow stepwise propofol TCI induction with Marsh model (Ke0 0.26), allows for an accurate estimation of the effect site concentration required for maintenance of the general…
- Conditions
- Target Controlled Infusion, Induction of Anesthesia, Bispectral Index
- Trial name
- (TITINDUC) (NCT02999126)
- Testing
- Propofol, Remifentanil Hydrochloride
- Where
- Argentina
- Volunteers
- 60 people
- Sponsor
- Hospital Italiano de Buenos Aires
Anesthesia
TCI vs. Manuel TIVA in Septorhinoplasty Surgeries
Septorhinoplasty is a surgical technique that can be used to correct various nasal deformities.Total intravenous anesthesia (TIVA) is a frequently preferred method as an anesthesia technique in septorhinoplasty surgeries.It has…
- Trial name
- NCT06957470
- Testing
- Total Intravenous Anesthesia
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Bulent Ecevit University
Anesthesia
Optimal Remifentanil Concentration and Thyroidectomy
The study is aimed at determining the remifentanil effect site concentration suppressing the cough at extubation after surgical thyroidectomy, performed under remifentanil/desflurane based general anesthesia, expressed as median…
- Trial name
- ORCO (NCT03218124)
- Testing
- Remifentanil Effect site concentration
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Cagliari
Anesthesia
Comparison of TIVA by Closed Loop Anaesthesia Delivery System Versus Target Controlled Infusion Device
Total intravenous anaesthesia (TIVA) is now being adopted as a preferred technique for providing GA because of its various inherent advantages like reduced PONV incidence, improved quality of recovery post GA, anti-inflammatory…
- Trial name
- NCT04731480
- Testing
- Propofol
- Where
- 2 sites in India
- Volunteers
- 160 people
- Sponsor
- Sir Ganga Ram Hospital
Adverse Effect, Anesthesia
Airway Management During TCI vs RSI Anesthesia Induction
The aims of this observational study is to evaluate and compare feasibility of airway management during standardized TCI and RSI anesthesia induction.
- Conditions
- Adverse Effect, Anesthesia, Airway Complication of Anesthesia
- Trial name
- NCT03723109
- Testing
- Induction of anesthesia
- Where
- Sweden
- Volunteers
- 70 people
- Sponsor
- Umeå University
The Effect of BIS Closed-loop Target Control on Postoperative Operation
Effects of BIS Closed Loop Target Controlled Infusion on Perioperative Inflammatory Response and Prognosis of Elderly Patients Undergoing Laparoscopic Radical Gastrectomy for Gastric Cancer
The purpose of this study is to find the elderly patients with laparoscopic gastric cancer radical is suitable the BIS closed round target control level of anesthesia depth of sedation, can decrease the elderly laparoscopic…
- Trial name
- NCT05173909
- Testing
- BIS closed-loop target controlled infusion
- Where
- China
- Volunteers
- 73 people
- Sponsor
- Zhonghua Chen,MD
Children, Hernia, Inguinal
Comparing Inhalation and Total Intravenous Anesthesia Methods
This study compares the effects of anesthesia using target-controlled infusion (TCI) and inhalation methods on pediatric patients undergoing inguinal hernia repair.
- Trial name
- TIVA-IHA (NCT06467279)
- Testing
- Target Controlled İnfusion, Inhalation anesthetic
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- TC Erciyes University
Propofol Target-controlled Infusion, Desflurane
Effect of Desflurane v/s Propofol on the Optic Nerve Sheath Diameter
effect of propofol vs desflurane on ONSD
- Conditions
- Propofol Target-controlled Infusion, Desflurane, Optic Nerve Sheath Diameter
- Trial name
- ONSD (NCT07359508)
- Testing
- Desflurane, Propofol (Group P)
- Where
- India
- Volunteers
- 146 people
- Sponsor
- All India Institute of Medical Sciences
General Anesthesia, Elective Surgery
Therapeutic Equivalence (TE) Study of Propofol 2% MCT Fresenius (MCT=Medium-Chain Triglycerides) Compared With Diprivan® in Patients Undergoing Elective Surgery
The purpose of this study is to evaluate the therapeutic equivalence, based on pharmacodynamic parameters of Propofol 2% (20 mg/mL) MCT Fresenius and Diprivan® 20 mg/mL (AstraZeneca), administered by target controlled infusion…
- Trial name
- PropofolTE (NCT01856998)
- Testing
- Propofol, Diprivan
- Where
- France
- Volunteers
- 71 people
- Sponsor
- Fresenius Kabi
Appropriate Affect, Complication of Device Insertion
Requirements of Propofol With Target Controlled Infusions for Supraglottic Airway Devices
to evaluate and compare the effect-site concentration of propofol with the TCI system for second-generation SGA device insertion between the I-gel™, Supreme™, ProSeal™ and Laryngeal Tube Suction II™.
- Trial name
- NCT04664595
- Testing
- Propofol Fresenius
- Where
- 2 sites in Thailand
- Volunteers
- 40 people
- Sponsor
- Prince of Songkla University
Postoperative Pain
Postoperative Pain Therapy With Hydromorphone Using TCI-PCA
Treatment of postoperative pain with hydromorphone (a strong analgesic) using patient-controlled analgesia with target concentrations in blood compared to conventional patient-controlled analgesia after planed cardiac surgery
- Trial name
- TCI-PCA (NCT02035709)
- Testing
- Hydromorphone
- Where
- 2 sites in Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Brain Tumor Adult, Processed EEG
Processed EEG for Monitoring of Anesthetic Depth in Intracranial Tumor Surgery
An important feature of neurosurgical anesthesia is early postoperative recovery of consciousness with minimal residual sedation.
- Conditions
- Brain Tumor Adult, Processed EEG, Total Intravenous Anesthesia
- Trial name
- NCT06922500
- Testing
- depth of anesthesia
- Where
- Sweden
- Volunteers
- 126 people
- Sponsor
- Region Skane