Clinical trials: Target Organs Damage
Hypertension, Left Ventricular Hypertrophy
Vitamin D Therapy to Reduce Cardiac Damage Among Vulnerable Hypertensive Patients
This project seeks to reduce the disparity in hypertensive heart disease which exists for African-Americans who have poorly controlled hypertension (HTN), also known as blood pressure (BP).
- Trial name
- AdDReaCH (NCT01360476)
- Testing
- cholecalciferol (Vitamin D)
- Where
- United States
- Volunteers
- 354 people
- Sponsor
- Wayne State University
Hypertension
Salt Reduction on Blood Pressure and Cardiovascular Organ Damage
The purpose of this study is to determine the effect of a modest reduction in salt intake on blood pressure in white, black and Asian individuals with hypertension or prehypertension, and also to determine whether a modest…
- Trial name
- NCT00152074
- Testing
- Reduce salt intake
- Where
- United Kingdom
- Volunteers
- 210 people
- Sponsor
- St George's, University of London
Hypertension
Target Organ Damage and Polymorphisms Vav-2 and Vav-3 in Hypertensive Subjects
Objectives: To analyze the influence on the presence of target organ damage renal, cardiac and vascular of peripheral and central blood pressure, retinal vessels caliber, oxidative stress and polymorphisms of genes VAV-2-3 in…
- Trial name
- LOD-HTA (NCT02022618)
- Where
- Spain
- Volunteers
- 454 people
- Sponsor
- Fundacion para la Investigacion y Formacion en Ciencias de la Salud
Blood Pressure, Cardiovascular Risk Factor
Non-Invasive Aortic Ambulatory Blood Pressure Monitoring for The Detection of Target Organ Damage in The Chinese Population
This study is a sub-investigation of SAFAR study. Consecutive patients with established hypertension (treated or untreated with antihypertensive drugs) or with suspected hypertension are recruited and their 24-hour brachial and…
- Conditions
- Blood Pressure, Cardiovascular Risk Factor, Target Organ Damage, Cardiovascular Events
- Trial name
- SAFAR-China (NCT03154203)
- Testing
- No intervention in this study
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Shanghai 10th People's Hospital
Hypertension
Investigation of Dietary Nitrate Effects in Hypertension-induced Target Organ Damage
This study aims to determine whether dietary inorganic nitrate (in beetroot juice) is able to reduce overall thickening of the heart (left ventricular hypertrophy or LVH) and stiffness of the arteries when given to patients with…
- Trial name
- NITRATE-TOD (NCT03088514)
- Testing
- Beetroot juice
- Where
- United Kingdom
- Volunteers
- 149 people
- Sponsor
- Queen Mary University of London
Type 2 Diabetes Mellitus (T2DM), Chronic Kidney Disease Due to Type 2 Diabetes Mellitus
Effect of Treatment With Finerenone on Cardio-Renal Target Organ Damage in Patients With Type 2 Diabetes.
The global prevalence of diabetes is increasing substantially. Around 40 % of patients with type 2 diabetes develop chronic kidney disease.
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Chronic Kidney Disease Due to Type 2 Diabetes Mellitus, Cardiovascular Diseases
- Trial name
- FineCaRe (NCT07026539)
- Testing
- Finerenone (BAY 94-8862)
- Where
- Denmark
- Volunteers
- 80 people
- Sponsor
- University of Aarhus
Hypertension
The Chinese Early-onset Hypertension Study (CHESS)
Hypertension (HTN) is the most important cardiovascular risk factor which is responsible for 50% of cardiovascular morbidity and mortality, and also a substantial public health problem affecting approximately 1/4 of the adult…
- Trial name
- CHESS (NCT02819674)
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- China National Center for Cardiovascular Diseases
Hypertension
Sham Controlled Clinical Trial of Renal Denervation in Patients With Resistant Hypertension
The purpose of this study is to assess the efficacy of catheter-based renal denervation in reducing blood pressure in patients with resistant hypertension compared to a sham procedure.
- Trial name
- NCT02444442
- Testing
- Renal Denervation
- Where
- Australia
- Volunteers
- 105 people
- Sponsor
- Baker Heart and Diabetes Institute
Hypertension
Renal Denervation for Resistant Hypertension
This is a study investigating the effectiveness of renal denervation in lowering blood pressure in people whose blood pressure is not adequately controlled despite treatment with 3 or more blood pressure lowering drugs.
- Trial name
- RDNP-2012-01 (NCT01865240)
- Testing
- Renal Denervation
- Where
- Australia
- Volunteers
- 5 people
- Sponsor
- Baker Heart and Diabetes Institute
Hypertension, Diabetes Mellitus, Type 2
Effects of SGLT2 Inhibitor on Hemodynamic Parameters in Resistant Hypertensive Subjects
New strategies trying to achieve blood pressure control and consequently reduce cardiovascular risk in resistant hypertensive subjects are promising.
- Conditions
- Hypertension, Diabetes Mellitus, Type 2, Blood Pressure, Obesity
- Trial name
- NCT03089333
- Testing
- Dapagliflozin 10mg, Glibenclamide 5Mg Tablet
- Where
- Brazil
- Volunteers
- 16 people
- Sponsor
- University of Campinas, Brazil
Hypertension, Obesity
Bariatric Surgery, Arterial Stiffness and Target Organ Damage Study (BASTOD)
Introduction: Obesity is a major public health problem, associated with many morbidities, including metabolic and cardiovascular disease (CVD).
- Trial name
- BASTOD (NCT01494168)
- Testing
- Bariatric surgery (Roux-en-y bypass or sleeve gastrectomy)
- Where
- France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Montpellier
Hypertension
The Potential Role of Testosterone on Target Organ Damage in Postmenopausal Hypertensive Women
The incidence of CVD-related deaths is generally higher in women than men. Postmenopausal changes in estrogen/androgen ratio that induce a relative androgen excess have been proposed as important factors in the higher prevalence…
- Trial name
- NCT03451747
- Volunteers
- 322 people
- Sponsor
- LanZhou University
Target Organs Damage, Hypertensive
Evaluation of Target Organs Damage in Hypertensive Patients
Evaluation of target organs damage in hypertensive patients with no known cardiovascular (CV) or renal disease, stratified according to level of blood pressure control
- Conditions
- Target Organs Damage, Hypertensive, no Known Cardiovascular, no Known Renal Disease
- Trial name
- PreVENT-A GP (NCT01055353)
- Where
- 905 sites in France
- Volunteers
- 1,857 people
- Sponsor
- AstraZeneca
Cardiovascular Risk Factor
Prognosis in the Elderly Chinese: the Northern Shanghai Study
The Northern Shanghai Study is a prospective community-based study, which is aimed to investigate the prognostic factors, including conventional cardiovascular risk factors and asymptomatic target organ damage, for mortality and…
- Trial name
- NSS (NCT02368938)
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Shanghai 10th People's Hospital
Hypertension
Effects of Potassium Salts on Blood Pressure and Target Organ Damage
The purpose of this study is to determine the effect of potassium chloride and potassium bicarbonate on blood pressure and also to determine whether increasing potassium intake has beneficial effects on the surrogate markers of…
- Trial name
- NCT00160368
- Testing
- Potassium supplementation
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- St George's, University of London
Hypertension
Effect of Fully Blocking Type 1 Angiotensin Receptor on Target Organ Damage of Postmenopausal Hypertensive Women
This study compared the improvements of blood pressure levels, left ventricular hypertrophy, left ventricular diastolic function, vascular function and cognitive function between postmenopausal hypertensive women and age-matched…
- Trial name
- NCT03432468
- Testing
- Valsartan 1, Valsartan 80 mg
- Volunteers
- 102 people
- Sponsor
- LanZhou University
Diabetes Mellitus
Blood Pressure and Subclinical Organ Damage
Background: The purpose of this study is to analyze the relationship between central and peripheral blood pressure (clinic and ambulatory) with vascular structure and function, assessed by carotid intima-media thickness (IMT)…
- Trial name
- Vasorisk (NCT01325064)
- Where
- Spain
- Volunteers
- 500 people
- Sponsor
- Fundacion para la Investigacion y Formacion en Ciencias de la Salud
Abdominal Injuries, Wounds and Injuries
Predictors of In-Hospital Mortality in Severe Abdominal Trauma
Severe abdominal trauma is a leading cause of early death from bleeding and of later death from sepsis and organ failure. Clinicians use scoring systems to estimate the risk of dying, but most of these scores were developed and…
- Conditions
- Abdominal Injuries, Wounds and Injuries, Wounds, Nonpenetrating, Wounds, Penetrating
- Trial name
- NCT07843628
- Where
- Egypt
- Volunteers
- 430 people
- Sponsor
- Minia University
Systemic Vascular Resistance
Hemodynamic Changes and Vascular Tone Control After Bariatric Surgery
Obese patients have increased cardiovascular risk and target organ damage (TOD) as compared to people with normal weight. Weight loss reduces cardiovascular risk and TOD.
- Trial name
- NCT03115502
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Parc de Salut Mar
Hypertension
Renal Denervation for Complicated Hypertension
This is an observational proof of concept study investigating the safety and effectiveness of renal denervation to lower blood pressure in people whose blood pressure is not adequately controlled due to: intolerance to…
- Trial name
- RDNP-2012-03 (NCT01865253)
- Testing
- Renal Denervation
- Where
- Australia
- Volunteers
- 23 people
- Sponsor
- Baker Heart and Diabetes Institute