Clinical trials: Target Controlled Infusion of Propofol
Spinal (Fusion) Surgery, Total Intravenous Anesthesia
Comparison of Hemodynamic Responses During Anesthesia Induction Using Eleveld and Schnider
This randomized prospective study aims to compare the effects of two target-controlled infusion models, the Schnider and Eleveld models, on anesthetic depth and hemodynamic responses during anesthesia induction in adult patients…
- Conditions
- Spinal (Fusion) Surgery, Total Intravenous Anesthesia, Target Controlled Infusion of Propofol, Anesthesia Depth Monitoring
- Trial name
- NCT07586189
- Testing
- TCI Propofol Injection Models- Eleveld, TCI Propofol Injection Schnider
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul University
Anesthesia
Comparison of TIVA by Closed Loop Anaesthesia Delivery System Versus Target Controlled Infusion Device
Total intravenous anaesthesia (TIVA) is now being adopted as a preferred technique for providing GA because of its various inherent advantages like reduced PONV incidence, improved quality of recovery post GA, anti-inflammatory…
- Trial name
- NCT04731480
- Testing
- Propofol
- Where
- 2 sites in India
- Volunteers
- 160 people
- Sponsor
- Sir Ganga Ram Hospital
Elective Laparoscopic Surgery
Compare Pharmaceutical Economics and Efficacy of Sevoflurane With Low Fresh Gas Flow Balanced Anesthesia, Propofol Target Controlled Infusion Anesthesia and Propofol Induction Sevoflurane Maintenance Anesthesia
This study is being performed to compare the cost of anesthetic techniques with sevoflurane (low fresh gas flow balanced anesthesia) versus propofol (target controlled infusion [TCI]) versus propofol induction and sevoflurane…
- Trial name
- NCT01191476
- Testing
- Sevoflurane Inhalational Induction and Maintenance, Propofol Target Controlled Infusion for Induction and Maintenance, Propofol Target Controlled Infusion for Induction and Sevoflurane Inhalation for Maintenance
- Where
- 4 sites in China
- Volunteers
- 336 people
- Sponsor
- Abbott
Pain, Anesthesia
Effect of Low-dose Esketamine Combined With Target-controlled Infusion of Propofol for Painless Gastrointestinal Endoscopy
Purpose: 1. To determine the efficacy of low-dose esketamine in painless gastrointestinal endoscopy. 2. To determine the safety of low-dose esketamine in painless gastrointestinal endoscopy. 3.
- Trial name
- NCT04691076
- Testing
- Propofol, Esketamine, Fentanyl
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Tianjin Union Medical Center
Pain
Remifentanil Versus Propofol for TCI Sedation of Patients Undergoing Gastrointestinal Endoscopic Procedures
The purpose of this study was to compare remifentanil and propofol for sedation of patients during endoscopic gastrointestinal procedures.
- Trial name
- NCT01746641
- Testing
- Remifentanil, Propofol
- Where
- Colombia
- Volunteers
- 69 people
- Sponsor
- Fundación Universitaria de Ciencias de la Salud
Sedation
Sedation of Advanced Endoscopic Procedure
To evaluate the impacts of target-control infusion (TCI) and bispectral index (BIS) monitoring during advanced endoscopic procedure.
- Trial name
- NCT03172078
- Testing
- advanced endoscopic procedure
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Neurosurgical Patients
COMparative Performance of General Purpose Models
To compare the performance of the Eleveld models for propofol and remifentanil on neurosurgery patients admitted to intensive care with their intraoperative performance.
- Trial name
- NCT06584097
- Where
- 2 sites in Italy
- Volunteers
- 42 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Renal Transplant Recipient Patients
Comparison Between Target-controlled Infusion of Propofol and Sevoflurane as Maintenance of Anesthesia to Hemodynamic Profile of Renal Transplant Recipient
This study aimed to compare the effect of target-controlled infusion of propofol and sevoflurane as maintenance of anesthesia to intraoperative hemodynamic profile of renal transplant recipient
- Trial name
- NCT03214653
- Testing
- Propofol, Sevoflurane
- Where
- Indonesia
- Volunteers
- 23 people
- Sponsor
- Universitas Indonesia
Esketamine
Effect of Subanesthetic Dose Esketamine on Propofol-refentanil Closed-loop Targeted Controlled Infusion
The propofol-refentanil program-controlled closed-loop target-controlled infusion system based on NI guidance has been clinically verified.
- Trial name
- NCT05943028
- Testing
- Subanesthetic dose of esketamine
- Volunteers
- 48 people
- Sponsor
- bo xu
Anesthesia
The PROTECT Trial: PROpofol Titration to Enhance haemodynamiC sTability
The aim of this multicentre, single-blinded, expertise-based randomised controlled trial is evaluate whether slowly increasing the dose of the anaesthetic drug propofol based on a patient's needs leads to more stable blood…
- Trial name
- NCT06980688
- Testing
- Propofol titration, Conventional propofol induction
- Where
- 4 sites in Switzerland
- Volunteers
- 320 people
- Sponsor
- University Hospital, Basel, Switzerland
Anesthesia
Dual-loop Target Controlled Infusion for Coadministration of Propofol and Remifentanil Guided by Narcotrend Index
To investigate the application of closed target-controlled infusion(TCI) of propofol and remifentanil guided by Narcotrend index in the anterior cervical decompression and fusion with internal fixation surgery.
- Trial name
- NCT02890186
- Testing
- Narcotrend, experience
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Pharmacodynamic Interaction
Pharmacodynamic Interactions of Propofol and Dexmedetomidine on Intravenous Anesthesia
The purpose of this study is to determine pharmacodynamic interactions of propofol and dexmedetomidine,exploring the effect of dexmedetomidine on propofol unconsciousness median effective concentration (EC50).
- Trial name
- PIPDIA (NCT02777619)
- Testing
- 0.0ng/ml Dexmedetomidine, 0.4ng/ml Dexmedetomidine, 0.6ng/ml Dexmedetomidine
- Where
- China
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Monitoring Noxious Events Using EEG-Derived Pain Indices, Procedural Sedation and Analgesia
qNOX Response to Nociceptive Motor Events During Procedural Sedation
The goal of this observational study is to evaluate whether the CONOX monitor can detect pain during sedation in patients undergoing urological procedures.
- Conditions
- Monitoring Noxious Events Using EEG-Derived Pain Indices, Procedural Sedation and Analgesia, Monitored Anesthesia Care
- Trial name
- MO-NOX (NCT07413848)
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Ankara University
Bispectral Index, Transcutaneous Carbon Dioxide
Compare the Side Effects and Difference Awake Level of Three TCI Propofol Formula in TVOR Patients
This study is to find the fewer side effects formula of anesthesia for TVOR patients, to compare the BIS level during emergence and to find the correlation between BIS and transcutaneous carbon dioxide concentration.
- Conditions
- Bispectral Index, Transcutaneous Carbon Dioxide, PONV, Blood Pressure
- Trial name
- NCT00760253
- Where
- Taiwan
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Children Under General Anesthesia
Target-controlled Infusion of Propofol for Induction of Pediatric Anesthesia
The purpose of this study is to determine a effect-site concentration of propofol in children 3 to 11 years effective to make a induction of general anesthesia.
- Trial name
- NCT01411020
- Testing
- endotracheal intubation
- Where
- Chile
- Volunteers
- 60 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Strabismus, Surgery
One-stage Adjustable Strabismus Surgery Under AIVOC
The purpose of this study is to note that one-stage adjustable surgery can be enough to provide satisfactory results for the correction of strabismus in adults thanks to the use of an anesthesia type AIVOC (Target-controlled…
- Trial name
- AIVOC (NCT04261699)
- Where
- France
- Volunteers
- 159 people
- Sponsor
- Clinique Saint Jean, France
Elderly, Surgery
Anesthesia Maintenance With Target-controlled Infusion of Propofol and Remifentanil at Fixed Ratio
The impact of anesthesia depths on early postoperative neurocognitive complications after total intravenous anesthesia (TIVA) remains controversial.
- Conditions
- Elderly, Surgery, Depth of Anesthesia, Total Intravenous Anesthesia
- Trial name
- NCT07479719
- Testing
- Light anesthesia, Deep anesthesia
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University First Hospital
Target Controlled Infusion, Induction of Anesthesia
Slow Stepwise Propofol TCI Induction for Titration Anesthesia Maintenance
The purpose of this study is to determine if a slow stepwise propofol TCI induction with Marsh model (Ke0 0.26), allows for an accurate estimation of the effect site concentration required for maintenance of the general…
- Conditions
- Target Controlled Infusion, Induction of Anesthesia, Bispectral Index
- Trial name
- (TITINDUC) (NCT02999126)
- Testing
- Propofol, Remifentanil Hydrochloride
- Where
- Argentina
- Volunteers
- 60 people
- Sponsor
- Hospital Italiano de Buenos Aires
Anesthesia, General
Target-controlled Infusion of Propofol and Remifentanil During General Anaesthesia Guided by Entropy
This study compares the manual administration of propofol and remifentanil and their delivery using a combined closed-loop anesthesia system, entropy of the EEG being the controller.
- Trial name
- NCT00391885
- Testing
- Closed-loop anesthesia system
- Where
- 2 sites in France
- Volunteers
- 60 people
- Sponsor
- Hopital Foch
Propofol, Target Controlled Infusion
Propofol TCI Administered by Gastroenterologists During Endoscopy: a Randomized Double Blind Controlled Study
Many studies address safety and effectiveness of non-anesthesiologist propofol sedation (NAPS) for GI endoscopy. Target Controlled Infusion (TCI) is a sophisticated tool for providing optimal sedation regimen and avoiding under…
- Conditions
- Propofol, Target Controlled Infusion, Moderate Sedation, Gastrointestinal Endoscopy
- Trial name
- PropTCI/2012 (NCT01941888)
- Testing
- Propofol, Midazolam, Target Controlled Infusion
- Where
- 2 sites in Italy
- Volunteers
- 140 people
- Sponsor
- Ospedale San Raffaele