Clinical trials: Target Controlled Infusion of Propofol
Drug Contamination
Evaluation of Bacterial and Fungal Contamination During Propofol Continuous Infusion
The purpose of this study is to verify the existence of bacterial and/or fungal contamination during different technics of propofol with or without EDTA continuous infusion in patients undergoing general anesthesia.
- Trial name
- NCT00757458
- Testing
- EDTA without re-filling, Propofol syringe re-filling with propofol containing EDTA, Target controlled infusion of propofol without EDTA
- Where
- Brazil
- Volunteers
- 652 people
- Sponsor
- University of Sao Paulo
Delirium, Hemodynamic Instability
Target Controlled Infusion of Etomidate or Propofol for Anesthesia of Thoracoscopic Mitral Valve Replacement Surgery
For patients requiring the heart valve replacement surgery, heart function is injured in different degree.Thus, minimizing the impact of the anesthesia drug on the cardiovascular system has important clinical meanings.
- Trial name
- NCT02644980
- Testing
- Propofol, Etomidate, Bispectral Index Monitor
- Volunteers
- 110 people
- Sponsor
- Xijing Hospital
Tumor of Ear, Nose and Throat
Conditions of Diagnostic Panendoscopy of the Upper Airway Under Propofol Remifentanil General Anesthesia
The most important considerations for the general anesthesia in diagnostic panendoscopy of the upper airway is the maintenance of a patient's airway for optimal surgical exposure, adequate ventilation and sufficient depth of…
- Trial name
- ENDOTANIL (NCT02093143)
- Testing
- Remifentanil
- Where
- 2 sites in France
- Volunteers
- 256 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Anesthesia Brain Monitor, Sufentanil
Effects of Sufentanil Target Controlled Infusion on Patient State Index Values and Electroencephalographic Spectrum During Total Intravenous Anesthesia With Propofol
Sufentanil Target Controlled infusion (TCI, Gepts model) effects on Neuromonitoring during Total Intravenous Anesthesia (TIVA) with Propofol TCI (Eleveld model) has not been investigate yet.
- Conditions
- Anesthesia Brain Monitor, Sufentanil, Target Controlled Infusion
- Trial name
- NCT06388408
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Padova
Liver Transplant Recipients
Effect of TCI Propofol on Liver Transplant (TCI) Propofol on Intra-operative Usage of Vasopressors in Liver Transplant Recipients.
Both isoflurane and propofol are being used to give anaesthesia for living donor liver transplant in our institute. Propofol when compared to isoflurane has advantages like early awakening from anaesthesia, reduced nausea…
- Trial name
- NCT06418893
- Testing
- Target control infusion propofol, Inhalational isoflurane
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Anesthesia
Use of Closed-loop Anesthesia in Pediatric Patients
To compare manual administration of propofol and remifentanil and dual closed-loop using bispectral index as the control variable during pediatric anesthesia
- Trial name
- LoopPed (NCT00778505)
- Testing
- Propofol, remifentanil
- Where
- 2 sites in France
- Volunteers
- 45 people
- Sponsor
- Hopital Foch
Pain, Tachycardia
Usefulness and Predictive Capacity of ANI and SPI of the Hemodynamic Response
The primary objective of this study is to investigate the influence of a standardized noxious stimulus on the ANI, SPI and hemodynamic parameters during standard propofol and sufentanil TCI and to see if the ANI and SPI are…
- Conditions
- Pain, Tachycardia, Hypertension
- Trial name
- NCT02608775
- Testing
- Metrodoloris Medical System, Aisys® care station, Acertys
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Universitair Ziekenhuis Brussel
Anesthesia Brain Monitoring
Describe Relations Between qCON and qNOX Indicies During Propofol-Remifentanil General Anesthesia
CONOX is a neuromonitoring EEG- device for sedation (qCON) and analgesia (qNOX) monitoring during general anesthesia. It is unknown on how the indicies can differentiate themselves so aim of this study is to determine the…
- Trial name
- NCT06349681
- Where
- Italy
- Volunteers
- 14 people
- Sponsor
- University of Padova
General Anesthesia, Propofol Target-controlled Infusion
Effects of Epidural Local Anesthetics on Propofol Induction
The investigators designed a prospective, randomized, placebo-controlled study to determine whether thoracic epidural anesthesia(TEA) with different local anesthetics has different influences on the propofol dose during induction.
- Conditions
- General Anesthesia, Propofol Target-controlled Infusion, Thoracic Epidural Anesthesia
- Trial name
- NCT02000973
- Testing
- Lidocaine, Bupivacaine, Ropivacaine
- Volunteers
- 80 people
- Sponsor
- First Hospital of China Medical University
Spine Diseases
Awakening in Spine Surgery: A Comparison Between Clinical Signs and Bispectral Index
BIS is one of several equipments used to monitor depth of anesthesia.Some studies found BIS can reduce total propofol dose when being used with target controlled infusion (TCI).The objective is to compare awakening time after…
- Trial name
- NCT02174913
- Testing
- bispectral index, Target controlled infusion of propofol, Fentanyl
- Where
- Thailand
- Volunteers
- 34 people
- Sponsor
- Mahidol University
Propofol Target-controlled Infusion, Desflurane
Effect of Desflurane v/s Propofol on the Optic Nerve Sheath Diameter
effect of propofol vs desflurane on ONSD
- Conditions
- Propofol Target-controlled Infusion, Desflurane, Optic Nerve Sheath Diameter
- Trial name
- ONSD (NCT07359508)
- Testing
- Desflurane, Propofol (Group P)
- Where
- India
- Volunteers
- 146 people
- Sponsor
- All India Institute of Medical Sciences
Postoperative Delirium (POD), Postoperative Pain
Comparison of Target-Controlled and Manual Total Intravenous Anesthesia in Supratentorial Surgery
This study aims to investigate the effect of target-controlled infusion using the Eleveld pharmacokinetic model compared with manually controlled total intravenous anesthesia on the incidence of postoperative delirium in patients…
- Conditions
- Postoperative Delirium (POD), Postoperative Pain, PONV, Burst Suppression
- Trial name
- NCT07357480
- Testing
- Target Controlled Infusion, Total Intravenous Anesthesia(TIVA)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 63 people
- Sponsor
- Istanbul University - Cerrahpasa
Anesthesia, General
Automated Anesthesia During Bronchoscopy
The purpose of this study is to compare manual administration of propofol and remifentanil and dual closed-loop using bispectral index as the control variable during rigid bronchoscopy.
- Trial name
- NCT00571181
- Testing
- Closed-loop system, TCI (Infusion Toolbox)
- Where
- France
- Volunteers
- 66 people
- Sponsor
- Hopital Foch
Postoperative Cognitive Dysfunction (POCD)
Intravenous Anesthesıa and Cognıtıve Functıon ın Spınal Surgery
The aim of this study is to investigate the effect of these two different intravenous infusion techniques [manuel controlled infusion (MCI) and Target controlled Infusion( TCI)] on POCD.
- Trial name
- NCT07701187
- Testing
- Manuel controlled infusion group
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Laparoscopic Surgery, Target Controlled Infusion
Comparison of Target Controlled Infusion Anesthesia and Inhalation Anesthesia in Pediatric Laparoscopic Surgeries
Comparison of Target Controlled Infusion Anesthesia and Inhalation Anesthesia in Pediatric Laparoscopic Surgeries
- Trial name
- NCT06571682
- Testing
- Target Controlled Infusion, Inhalation anesthetic
- Volunteers
- 60 people
- Sponsor
- TC Erciyes University
Hypoxemia, Conscious Sedation
Impact of Nasal Mask Versus Nasal Cannula Oxygenation on Hypoxemia in Gastrointestinal Endoscopy: A Brain Function Monitoring (SedLine)-Guided Randomized Controlled Trial (NAMSHIC)
This randomized controlled trial compared the efficacy of a nasal mask versus a standard nasal cannula for oxygen delivery during gastrointestinal endoscopic procedures performed under target controlled propofol infusion…
- Trial name
- NAMSHIC (NCT07500779)
- Testing
- Nasal Mask Oxygenation, Nasal Cannula Oxygenation
- Where
- Turkey (Türkiye)
- Volunteers
- 600 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Anesthesia, Pediatric Anesthesia
Transition From Sevoflurane to Total Intravenous Anesthesia in Pediatric Patients
his prospective, observational, exploratory, and multicenter study aims to describe the evolution of propofol effect-site concentration administered via target-controlled infusion (TCI) based on the Eleveld model-with adjustments…
- Conditions
- Anesthesia, Pediatric Anesthesia, Total Intravenous Anesthesia
- Trial name
- TSTP (NCT07644260)
- Where
- 2 sites in Argentina
- Volunteers
- 50 people
- Sponsor
- Hospital de Clinicas José de San Martín
Obesity
Propofol Effect-Site Target Controlled Infusion in the Obese: Characterization of the Time Profile of Bispectral Index Response
The aim of this study is to characterize the Pharmacokinetic/Pharmacodynamic relationship of a single bolus dose of propofol in obese patients and to extract a time to peak effect (t-peak) from the estimated model parameters.
- Trial name
- NCT01665079
- Testing
- Propofol
- Where
- Chile
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Universidad del Desarrollo
Anesthesia, General
Manual Administration of Propofol-remifentanil Versus Dual Closed-loop Using Bispectral Index as the Control Variable
To compare manual administration of propofol and remifentanil and dual closed-loop using bispectral index as the control variable during anesthesia
- Trial name
- NCT00392158
- Testing
- Closed-loop anesthesia system
- Where
- 6 sites in France
- Volunteers
- 240 people
- Sponsor
- Hopital Foch
Propofol Anesthesia in Children
Comparison of the Manually Controlled Propofol Infusion and Target Controlled Infusion in Children
Patients 1 to 8 years of age, American Society of Anesthesiologist score 1 and 2, planned for elective, one day surgery: inguinal hernia repair, hydrocele surgery, testis retention surgery, varicocele and phimosis surgery, and…
- Trial name
- NCT05081206
- Testing
- Propofol infusion via manually controlled pump., Propofol infusion via target controlled pump.
- Where
- Serbia
- Volunteers
- 61 people
- Sponsor
- University Children's Hospital