Clinical trials: TOF
Neuromuscular Blockade
Mindray Neuromuscular Transmission Transducer
A new NMT module from Mindray (Mindray Co. Shenzhen, People's Republic of China.) claims to measure 3 directional accelerography.
- Trial name
- NMT1 (NCT02892045)
- Testing
- MMG
- Where
- 2 sites in Bosnia and Herzegovina, China
- Volunteers
- 48 people
- Sponsor
- Suez Canal University
Ventricular Septal Defect, Complete Atrioventricular Canal
Optical Tissue Identification for Myocardial Architecture
The goal of this study is to test the hypothesis that fiberoptic confocal microscopy (FCM) imaging during repair of common congenital heart defects is a useful adjunct for avoidance of conduction abnormalities.
- Conditions
- Ventricular Septal Defect, Complete Atrioventricular Canal, Tetralogy of Fallot With Pulmonary Stenosis
- Trial name
- OPTIMA (NCT04017975)
- Testing
- Fluorescite, Cellvizio 100 Series System with Confocal Miniprobes
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Aditya Kaza
Tetralogy of Fallot (TOF), Hypoplastic Left Heart Syndrome (HLHS)
3D Modalities for Medical Student Education of Congenital Heart Disease
The goal of this clinical trial is to learn if 3D-printed heart models and augmented reality can be useful modalities to teach medical students about congenital heart disease. The main questions it aims to answer are: 1.
- Trial name
- NCT07295730
- Testing
- 3D-printed heart models and augmented reality
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Time of a TOF Ratio >0,9
Minimal Optimal Dose of Sugammadex in Elective Surgery
Time of appearance of TOF Ratio >0,9 with different doses of Sugammadex
- Trial name
- NCT03515694
- Testing
- Sugammadex Injection [Bridion]
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Erasme University Hospital
Neuromuscular Blockade
Modification of Posttetanic Count (PTC) for Monitoring Deep Neuromuscular Block II
The purpose of this study is to examine the relationship between post-tetanic count (PTC) and time to first response to Train of four (TOF) stimulation during deep neuromuscular blockade induced by rocuronium.
- Trial name
- NCT00390507
- Testing
- Post-tetanic count frequency
- Where
- 2 sites in Denmark
- Volunteers
- 45 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
ARDS, TTM
TwichView-guided Atricurium Dose Adjustment Trial
The goal of this clinical trial is to learn if using a monitor that measures muscle response can lower the amount of muscle relaxant medicine needed in adults who are treated in an intensive care unit (ICU) and need a continuous…
- Conditions
- ARDS, TTM, ECMO, Neuromuscular Blockade Monitoring
- Trial name
- NCT07807046
- Testing
- EMG-based quantitative TOF-guided atracurium titration
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Fu Jen Catholic University Hospital
Neuromuscular Blockade, Anesthesia, General
Comparison of the Performances of the cTOFR and the mTOFR During Reversal of Deep Neuromuscular Blockade With Sugammadex
It is known that deep neuromuscular block improves surgical conditions, especially during laparoscopic abdominal surgery. Based on this, in the Perioperative Neuromuscular Blockade Management guide published by the ESAIC…
- Trial name
- NCT06220136
- Testing
- TOFscan monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Ankara University
General Anesthesia Monitoring
Multimodal Monitoring During General Anesthesia in ENT Surgery
This study evaluated whether using several monitoring methods together during general anesthesia could improve patient safety and help anesthesiologists adjust medication doses in adults undergoing ear, nose, and throat (ENT)…
- Trial name
- NCT07895836
- Testing
- Multimodal Anesthesia Monitoring (BIS, SPI, TOF), Standard Anesthesia Monitoring
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Barbara Verro
Congenital Disorders
MRI Assessment of RV Function: Patients With TOF or Aortic Coarctation
At Children's Healthcare of Atlanta at Egleston, it is standard of care to do a cardiac MRI on patients with the diagnosis of Tetralogy of Fallot and Aortic Coarctation to evaluate heart function.
- Trial name
- NCT00277901
- Where
- United States
- Volunteers
- 390 people
- Sponsor
- Children's Healthcare of Atlanta
Cardiac CT TOF
Role of CT in Tetralogy of Fallot Diagnosis
To evaluate the role of MSCT in diagnosis and surgical planning in tetralogy of Fallot cases.
- Trial name
- NCT07247435
- Testing
- Computed tomography
- Volunteers
- 37 people
- Sponsor
- Assiut University
Tetralogy of Fallot, Congenital Heart Disease
Tetralogy of Fallot for Life
The aim is to conduct a prospective multi-centre international inception cohort study with an enrollment goal of 3,000 TOF patients and 2 year follow-up post-repair.
- Conditions
- Tetralogy of Fallot, Congenital Heart Disease, Congenital Heart Defect
- Trial name
- TOF-LIFE (NCT02968264)
- Where
- 20 sites in United States, Australia and 10 more
- Volunteers
- 1,108 people
- Sponsor
- Population Health Research Institute
Gastric Cancer
TOF Versus SOX in Metastatic Gastric Cancer
This study was designed to compare the efficacy and safety of aclitaxel/oxaliplatin/fluorouracil (TOF) regimen and S-1/oxaliplatin (SOX) regimen for metastatic gastric cancer (GC) patients.
- Trial name
- NCT02442362
- Testing
- paclitaxel+oxaliplatin+fluorouracil, oxaliplatin+S1
- Volunteers
- 60 people
- Sponsor
- The First People's Hospital of Changzhou
Acute Lower Respiratory Tract Infection, Pneumonia
Fast Identification of Pathogen in the Setting of Pneumonia Using Multiplex PCR
With this study the investigators want to determine, if a fast identification of germs, causing infections of the lower respiratory tract, is possible through the use of Multiplex PCR technology - a method that allows on time…
- Trial name
- NCT01858974
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University of Göttingen
Pulmonary Stenosis, Pulmonary Regurgitation
Pulmonary Artery Repair With Covered Stents
The Covered Cheatham-Platinum Stent (CCPS) is being study for repair of tears that occur in the pulmonary artery during dilation (enlargement) of a conduit (passageway) connecting the right ventricle of the heart to the pulmonary…
- Conditions
- Pulmonary Stenosis, Pulmonary Regurgitation, Tetralogy of Fallot
- Trial name
- PARCS (NCT01824160)
- Testing
- Repair of RV-PA Conduit Disruption
- Where
- 38 sites in United States
- Volunteers
- 50 people
- Sponsor
- Johns Hopkins University
Tetralogy of Fallot, Implantable Defibrillator User
French National Registry of Patients With Tetralogy of Fallot and Implantable Cardioverter Defibrillator
National french registry of patients with tetralogy of Fallot and implantable cardioverter defibrillator.
- Conditions
- Tetralogy of Fallot, Implantable Defibrillator User, Congenital Heart Disease, Sudden Cardiac Death
- Trial name
- DAI-T4F (NCT03837574)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Paris Sudden Death Expertise Center
Analyse Neuromuscular Monitoring for Developing a Model to Predict TOF Ratio During Anesthesia
Predictive Modelling of the Intraoperative Train-of-Four (TOF) Ratio
Neuromuscular Blocking Agents (NMBAs) are routinely administered to patients in a multiplicity o anaesthetic settings in order to paralyze and impede (re)active muscular contraction.
- Trial name
- NCT04518761
- Testing
- Elective surgery
- Where
- 2 sites in Belgium
- Volunteers
- 200 people
- Sponsor
- Universitair Ziekenhuis Brussel
Tetralogy of Fallot
Early Re-intervention in Infants and Small Children After Correction of Tetralogy of Fallot
Tetralogy of Fallot is one of the most frequent congenital heart malformations. In many cases re-interventions, surgical or catheter-based, are necessary after the repair of tetralogy of Fallot in infancy.
- Trial name
- NCT00536432
- Where
- 14 sites in Germany
- Volunteers
- 93 people
- Sponsor
- Competence Network for Congenital Heart Defects
Muscle Relaxant, General Anesthesia
Effect of Neostigmine on the Recovery of Rocuronium: A Comparison Between Partial and TOF Ratio-Based Dose
This study aimed to evaluate the effect of Neostigmine partial dose towards neuromuscular blockade of rocuronium
- Trial name
- NCT03058263
- Testing
- Dose of Neostigmine
- Where
- Indonesia
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Muscle Relaxants
Fade Upon TOF Stimulation Induced by Succinylcholine
Muscle relaxants are medications used during surgery to facilitate surgical access. The effect of the muscle relaxant medications is measured by stimulation a motor nerve and measuring the force of the resultant muscle…
- Trial name
- NCT02425449
- Testing
- Succinylcholine
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Toledo Health Science Campus
Congenital Heart Defects, Tetralogy Of Fallot
Effects of rhBNP in Pediatrics After Corrective Repair of Tetralogy Of Fallot
The purpose of this study is to determine the effects of rhRNP on urine output and hemodynamics following corrective repair of Tetralogy Of Fallot.
- Trial name
- NCT01941576
- Testing
- recombinant human brain natriuretic peptide (rhBNP)
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine