Clinical trials: TOF
Cardiac CT TOF
Role of CT in Tetralogy of Fallot Diagnosis
To evaluate the role of MSCT in diagnosis and surgical planning in tetralogy of Fallot cases.
- Trial name
- NCT07247435
- Testing
- Computed tomography
- Volunteers
- 37 people
- Sponsor
- Assiut University
Tetralogy of Fallot, Pulmonary Insufficiency
Contrast Enhanced 3D Echocardiographic Quantification of Right Ventricular Volumes in Repaired CHD
We propose the novel integration of two echocardiographic technologies - three-dimensional echocardiography using semi-automated right ventricular analysis coupled with the administration of ultrasound enhancing agents - to…
- Trial name
- NCT05186415
- Testing
- Sulfur Hexafluoride Lipid Type A Microspheres 25 MG Injection Powder for Suspension [LUMASON]
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Nemours Children's Clinic
Ventricular Septal Defect, Complete Atrioventricular Canal
Optical Tissue Identification for Myocardial Architecture
The goal of this study is to test the hypothesis that fiberoptic confocal microscopy (FCM) imaging during repair of common congenital heart defects is a useful adjunct for avoidance of conduction abnormalities.
- Conditions
- Ventricular Septal Defect, Complete Atrioventricular Canal, Tetralogy of Fallot With Pulmonary Stenosis
- Trial name
- OPTIMA (NCT04017975)
- Testing
- Fluorescite, Cellvizio 100 Series System with Confocal Miniprobes
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Aditya Kaza
Bloodstream Infections
Clinical Impact of Rapid Identification of Positive Blood Cultures vs. Internal Laboratory Standard
In this before-after study, different new methods for bacterial species identification from positive blood cultures will be compared towards historic controls.
- Trial name
- NCT04156633
- Testing
- conventional identification method: biochemical profiling or MALDI-TOF MS, new identification method: Biofire FilmArray© BCID panel, new identification method: metagenomic WGS
- Where
- Switzerland
- Volunteers
- 800 people
- Sponsor
- University Hospital, Basel, Switzerland
Pulmonary Atresia With Ventricular Septal Defect, Tetralogy of Fallot With Pulmonary Atresia
Choice of Palliative Procedures for Pulmonary Atresia With Ventricular Septal Defect Patients
The aim is to compare effective growth true hypoplastic pulmonary arteries using Right Ventricle Outflow Tract Reconstruction by femoral allogenic vein valve conduit and systemic-to-pulmonary artery shunts (modified…
- Trial name
- NCT02861963
- Testing
- Experimental: RVOT reconstruction by femoral allogenic vein valve conduit, Systemic-to-pulmonary artery shunts
- Where
- Russia
- Volunteers
- 24 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Congenital Heart Disease, Tetralogy of Fallot
Prognostic Value of NLR, TLR, and ALC in Predicting ToF Primary Repair Outcome
Tetralogy of Fallot (ToF) were cyanotic congenital heart disease with chronic hypoxia which increases the risk of exacerbated inflammatory response in ToF primary repair.
- Conditions
- Congenital Heart Disease, Tetralogy of Fallot, Neutrophil-lymphocyte Ratio, Absolute Lymphocyte Count
- Trial name
- NCT05976204
- Testing
- ToF primary repair
- Where
- Indonesia
- Volunteers
- 501 people
- Sponsor
- National Cardiovascular Center Harapan Kita Hospital Indonesia
Neuromuscular Blockade
Validation of the TOF Cuff Monitor® Which Measures Neuromuscular Block on the Upper Arm
Neuromuscular blocking agents (NMBAs) are frequently used in anesthesia and quantitative neuromuscular monitoring is standard care.
- Trial name
- NCT03256955
- Testing
- Tof cuff, Tof Watch SX
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- Christoph Czarnetzki
Tetralogy of Fallot With Pulmonary Stenosis
Right and Left Ventricle Remodeling Predictors After Pulmonary Valve Replacement in Patients With Repaired Tetralogy of Fallot
Long term survival of patients with repaired tetralogy of Fallot is excellent (about 85% at 35 year-old). However these patients are exposed to residual pulmonary stenosis (PS) and/or pulmonary regurgitation (PR).
- Trial name
- NCT02186691
- Testing
- MRI
- Where
- France
- Volunteers
- 11 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Neuromuscular Blockade, Chronic Obstructive Pulmonary Disease
Comparison of Time to Extubation Using Sugammadex or Neostigmine
A prospective blinded randomized clinical trial to compare time to extubation using Sugammadex versus Neostigmine/glycopyrrolate as reversal agents after use of neuromuscular blockade agents in an outpatient bronchoscopy suite.
- Trial name
- NCT04606901
- Testing
- neostigmine/glycopyrrolate, sugammadex
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Temple University
Magnesium Sulfate, Pregnancy; Pre-Eclampsia
The Effect of Magnesium Use in Reversal of Neuromuscular Block With Sugammadex
Magnesium therapy used for seizure prophylaxis in patients with preeclampsia. Magnesium has been shown to prolong the effect of nondepolarizing neuromuscular blocking agents (NMBA) and neostigmine used to reverse the effect of…
- Conditions
- Magnesium Sulfate, Pregnancy; Pre-Eclampsia, Neuromuscular Blockade
- Trial name
- NCT05558969
- Testing
- pregnant women taking magnesium
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Eskisehir Osmangazi University
Renal Artery Stenosis
Renal Magnetic Resonance Angiography (MRA) Study Comparing Dotarem and Time Of Flight (TOF)
The study will evaluate the efficacy and safety of Dotarem enhanced MRA compared to TOF MRA in patients suffering from renal arterial disease.
- Trial name
- NCT00845702
- Testing
- Gadoterate meglumine (Dotarem), Time of Flight Magnetic Resonance Angiography
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Guerbet
Neuromuscular Blockade, Muscle Relaxation
Clinical Application of "Train of Four" Testing in the Intraoperative Monitoring Setting
The study examines the clinical application of TOF (train of four test) used by anesthesiologists and neurophysiologists during instrumented spine procedures, as well as certain associated parameters.
- Trial name
- NCT01932983
- Testing
- Train of four test
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- NYU Langone Health
Tetralogy of Fallot, Congenital Heart Disease
Pathophysiologic Mechanism for Arrhythmias and Impaired Aerobic Capacity in Tetralogy of Fallot and Other Congenital Heart Diseases
This study is being done to determine the mechanism(s) contributing to the onset of symptoms (i.e. shortness of breath and/or palpitations) as well as changes in heart structure in patients with congenital heart disease (CHD)
- Trial name
- PACT (NCT05122962)
- Testing
- Remote Heart Rhythm Monitoring
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Mayo Clinic
Driving Pressure, Neuromuscular Blockade Monitoring
Effect of Neuromuscular Block Depth on Driving Pressure and Postoperative Respiratory Events in Abdominal Surgeries
This randomized controlled study aims to evaluate the effects of deep versus moderate neuromuscular blockade on intraoperative driving pressure and the development of postoperative critical respiratory events in patients…
- Conditions
- Driving Pressure, Neuromuscular Blockade Monitoring, Postoperative Respiratory Complications
- Trial name
- NCT07464288
- Testing
- Rocuronium
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Tetrology of Fallot, Pulmonary Stenosis
MASA Valve Early Feasibility Study
The MASA Valve Early Feasibility Study (MVEFS) multi-site interventional clinical trial within the United States of America with each center following a common protocol.The objective of the trial is to evaluate the safety and…
- Conditions
- Tetrology of Fallot, Pulmonary Stenosis, Truncus Arteriosus, Transposition of Great Vessels
- Trial name
- MVEFS (NCT05452720)
- Testing
- Surgical Right Ventricular Outflow Tract Reconstruction
- Where
- 5 sites in United States
- Volunteers
- 10 people
- Sponsor
- PECA Labs