Clinical trials: TNF Alpha
Immune Function, Immunity
Effects of TM02® Supplementation on Immune Function in Children
This randomized, double-blind, placebo-controlled clinical study evaluated the effects of 12 weeks of TM02® supplementation on immune-related outcomes in generally healthy children aged 2 to 12 years.
- Trial name
- NCT07853573
- Testing
- TM02®
- Where
- Malaysia
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Ligno Biotech Sdn. Bhd.
Peri-implantitis
Relationship Between Metrnl Expression, IL-1β, and TNF-α in Patients With Peri-Implantitis
Peri-implantitis is an inflammatory disease affecting the tissues around dental implants and may lead to progressive bone loss and implant failure.
- Trial name
- NCT07697729
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Rheumatoid Arthritis
Evaluation of Tumour Necrosis Factor Alpha (TNFα) Blockers in Early Rheumatoid Arthritis in France
Aim: To describe 1) The use of TNF blockers in early arthritis in daily clinical practice in France 2) To evaluate symptomatic, structural efficacy, and retention rate over 5 years 3) To evaluate predictive factors for TNF…
- Trial name
- NCT02927509
- Testing
- TNF alpha blockers
- Volunteers
- 813 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Oral Lichen Planus
Efficacy of Topical Glucosamine Versus Corticosteroid in Oral Lichen Planus
Glucosamine (GlcN) is an N-deacetyl amino sugar derived from the complete hydrolysis of chitosan. It is classified as a nutraceutical and it is used mainly orally for the therapy of osteoarthritis since GlcN has immunoregulatory…
- Trial name
- NCT07114016
- Testing
- Glucosamine Hydrochloride, Triamcinolone Acetonide
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Future University in Egypt
Platinum-refractory Ovarian Carcinoma, Platinum-resistant Ovarian Cancer
Oncolytic Adenovirus Coding for TNFa and IL2 (TILT-123) With Pembrolizumab or Pembrolizumab (Phase 1a) and Pegylated Liposomal Doxorubicin (Phase 1b) as Treatment for Ovarian Cancer.
This is an open-label, phase 1/1b, dose-escalation, multicenter and multinational trial evaluating the safety of oncolytic adenovirus TILT-123 in combination with Pembrolizumab, or Pembrolizumab and Pegylated Liposomal…
- Conditions
- Platinum-refractory Ovarian Carcinoma, Platinum-resistant Ovarian Cancer, Platinum-Resistant Fallopian Tube Carcinoma, Platinum-Resistant Primary Peritoneal Carcinoma
- Trial name
- PROTA (NCT05271318)
- Testing
- TILT-123, pembrolizumab, pegylated liposomal doxorubicin
- Where
- 3 sites in United States, Finland
- Volunteers
- 29 people
- Sponsor
- TILT Biotherapeutics Ltd.
Type 1 Diabetes
Roles of T Helper 1 Cytokines in Type 1 Diabetes
The mechanism of β cell destruction in Type 1 diabetes is not exactly known, Our hyphotesis is that interferon gamma, interleukin-2 and tumor necrotizan factor alpha have impotant roles in β cell destruction.
- Trial name
- NCT02389335
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Istanbul Medeniyet University
Metabolic Syndrome
Study of TNF-Antagonism in Metabolic Syndrome
This study investigates whether blockade of TNF will result in reduced inflammatory indices in patients with the metabolic syndrome
- Trial name
- NCT00409318
- Testing
- Etanercept
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Massachusetts General Hospital
Stem Cell Transplantation
Investigating Cytokine Genes of Stem Cell Donors
This study seeks to investigate the factors that may account for the differences in the way a stem cell recipient s immune system works after a transplant.
- Trial name
- NCT00353821
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Stage II Periodontitis
Virgin Coconut Oil Versus Chlorhexidine Mouthwash in Non-Surgical Periodontal Therapy of Periodontitis Patients. A Randomized Controlled Clinical Trial With Biochemical Assessment.
This randomized controlled clinical trial will evaluate the effect of virgin coconut oil mouthwash compared with chlorhexidine mouthwash as an adjunct to non-surgical periodontal therapy in patients with stage II periodontitis.
- Trial name
- NCT07706387
- Testing
- Non-surgical periodontal therapy, Chlorhexidine mouthwash, Virgin coconut oil mouthwash
- Where
- Egypt
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Interleukines
Study of Cytokines Serum Levels in Chronic Low Back Pain
The purpose of this study is to: evaluate if there is an association between elevated levels of cytokines and chronic pain due to herniated disk disease measured cytokines levels in chronic low back pain and in healthy subjects.
- Trial name
- cytokine (NCT00991042)
- Testing
- blood collect
- Where
- Brazil
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Fibromyalgia (FM)
Chronic Fibromyalgia Pain, Lifestyle Factors, and Inflammation
The goal of this observational study is to understand how lifestyle factors (such as diet, physical activity, sleep, stress, smoking, and alcohol intake) predict changes in pain sensitivity and modulation in adults aged 18-65…
- Trial name
- BUFS (NCT07074275)
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Bournemouth University
Asthma
TNF Alpha in Refractory Asthma
The purpose of this study was to investigate whether the administration of etanercept to patients with severe asthma improved their asthma related quality of life and a measure of the degree of reactivity of the airways
- Trial name
- NCT00276029
- Testing
- Etanercept
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- University Hospitals, Leicester
Somatic Symptom Disorder (DSM-V)
Effect of Venlafaxine Versus Dosulepin in Pain Predominant Somatic Symptom Disorder
Somatic symptom disorder (SSD) is marked by persistent physical complaints, often involving pain, alongside excessive thoughts or behaviors related to health, which substantially disrupt daily functioning.
- Trial name
- NCT06803485
- Testing
- Venlafaxine, Dosulepin
- Where
- India
- Volunteers
- 84 people
- Sponsor
- All India Institute of Medical Sciences, Bhubaneswar
Uveitis, Juvenile Arthritis
Effect of Adalimumab for the Treatment of Uveitis in Juvenile Idiopathic Arthritis
The investigators propose to study the efficacy of adalimumab versus placebo (double-blind randomization on inclusion into 2 equal groups) on reduction of ocular inflammation quantified by laser flare photometry after two months…
- Trial name
- ADJUVITE (NCT01385826)
- Testing
- Anti-tumor necrosis factor alpha monoclonal antibody
- Where
- France
- Volunteers
- 34 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Peripheral Spondyloarthritis
Spondyloarthritis: Inducing Drug-free Remission by Early TNF-alpha Blockade
The SPARTACUS study will explore the therapeutic efficacy of 2 different treatment strategies for patients suffering from peripheral Spondyloarthritis (pSpA), classified according to the "Assessment in SpondyloArthritis…
- Trial name
- SPARTACUS (NCT04435288)
- Testing
- week 24, week 36, Week 48
- Where
- 6 sites in Belgium
- Volunteers
- 90 people
- Sponsor
- University Hospital, Ghent
Failure to Thrive, Infection, Bacterial
High Calorie Formula Intervention on Weight, Length Increment, Total Lymphocyte Counts, TNF-alpha and IGF-1 in Failure to Thrive Children
High calorie formula (Oral Nutrition Supplement/ONS) are products used for oral nutrition support with the aim to increase the nutritional intake. they are a nutrition treatment option children with limited intake.
- Conditions
- Failure to Thrive, Infection, Bacterial, Growth Faltering
- Trial name
- NCT05333133
- Testing
- high calorie formula (oral nutritional supplement/ONS)
- Where
- Indonesia
- Volunteers
- 80 people
- Sponsor
- Universitas Airlangga
Rheumatoid Arthritis
Anti-TNFα Use During Elective Foot and Ankle Surgery in Patients With Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a frequent inflammatory arthritis that can lead to severe joint deformity and often requires orthopaedic surgical interventions.
- Trial name
- NCT02242474
- Testing
- Anti-TNF suspended perioperatively, Anti-TNFα continued perioperatively
- Where
- Canada
- Volunteers
- 660 people
- Sponsor
- CHU de Quebec-Universite Laval
Hand Osteoarthritis
Efficacy Study of an Anti-Tumor Necrosis Factor (TNF) Alpha Agent in Patients With Hand Osteoarthritis
Digital osteoarthritis (DO) which affects the interphalangeal joints and the Metacarpophalangeal (MCP) of the thumb is a common disease, the prevalence of which increases with age (36% of the population aged over 70).
- Trial name
- DORA (NCT00597623)
- Testing
- Adalimumab (Humira®)
- Where
- France
- Volunteers
- 84 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Breast Cancer, Non-Hodgkin's Lymphoma
Trial of Mesna to Prevent Doxorubicin-induced Plasma Protein Oxidation and Tumor Necrosis Factor Alpha (TNF-α) Release
The purpose of this study is to determine whether the drug mesna is able to block a series of chemical changes that occur in the blood of patients who receive the chemotherapy medicine doxorubicin.
- Trial name
- NCT01205503
- Testing
- Mesna, Saline, Doxorubicin
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Mara Chambers
Rheumatoid Arthritis
Stopping TNF Alpha Inhibitors in Rheumatoid Arthritis
Background: Rheumatoid arthritis (RA) is often treated with drugs known as tumor necrosis factor (TNF) inhibitors, that can help decrease joint pain and swelling and can even result in RA remission.
- Trial name
- STARA (NCT01793519)
- Testing
- Etanercept, Infliximab, Adalimumab
- Where
- 2 sites in United States
- Volunteers
- 290 people
- Sponsor
- Georgetown University