Clinical trials: TIPS
Gastric Varices Bleeding, Liver Cirrhoses
Interventional Devascularization Plus HVPG-Guided Carvedilol Therapy vs TIPS
Gastric varices (GV) are present in around 20% of patients with cirrhosis. Bleeding from GV accounts for 10-20% of all variceal bleeding.
- Trial name
- NCT04198259
- Testing
- interventional devascularization, TIPS
- Volunteers
- 212 people
- Sponsor
- Air Force Military Medical University, China
Cataract
Parameters of 2 Phaco Tips Designs in Torsional Phacoemulsification
To compare the efficiency of surgical procedures using 2 phaco tip designs in torsional phacoemulsification using the bevel-down technique.
- Trial name
- NCT02089698
- Testing
- Mini-flared, Reversed tip
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hospital Oftalmologico de Brasilia
Portal Hypertension
Austrian Registry on Transjugular Intrahepatic Portosystemic Shunts
Patients with TIPS will be recruited in this prospective registry study. The clinical course will be documented and biomarkers for prediction of complicatiosn will be assessed.
- Trial name
- AUTIPS (NCT03409263)
- Testing
- Observational study
- Where
- Austria
- Volunteers
- 400 people
- Sponsor
- Thomas Reiberger
Hepatic Encephalopathy
Hepatic Encephalopathy Prevention With Polydextrose After TIPS: Pilot Study (POEME)
TIPS is a standard for the treatment of portal hypertension related complications. However, it remains at risk of HE after TIPS (around 40% the first year). Dysbiosis plays a key role in pathophysiology of HE.
- Trial name
- POEME (NCT05206487)
- Testing
- Polydextrose
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Toulouse
Portal Hypertension
Clinical Study of PTFE Covered Stent for Treating Portal Hypertension
To validate the safety and efficacy of TIPS (Transjugular Intrahepatic Portosystemic Shunt) using PTFE covered stent in the treatment of portal hypertension.
- Trial name
- NCT06117735
- Testing
- Transjugular Intrahepatic Portosystemic shunt
- Where
- 4 sites in China
- Volunteers
- 177 people
- Sponsor
- Enlight Medical Technologies (Shanghai) Co., Ltd
Patient Fall
Generalizability and Spread of an Evidenced-based Fall Prevention Toolkit: Fall TIPS
The goal of our project is to evaluate the effectiveness of the Fall TIPS program with regard to inpatient falls and fall-related injuries.
- Trial name
- NCT03499717
- Volunteers
- 37,231 people
- Sponsor
- Brigham and Women's Hospital
MASLD, Liver Cirrhosis, Alcoholic
Acquisition of Cardiac Function Parameters in MRI and Echocardiography in Patients With Ethyltoxic Liver Cirrhosis and Transjugular Intrahepatic Portosystemic Shunt (TIPSS) Placement
The aim of this clinical trial is to investigate the development of cardiac decompensation following transjugular intrahepatic portosystemic shunt (TIPSS) implantation in order to draw conclusions for future treatment methods or…
- Conditions
- MASLD, Liver Cirrhosis, Alcoholic, Cirrhosis of Liver, Heart Decompensation
- Trial name
- EVALUATION (NCT06814990)
- Testing
- Cardiac MRI, Blood samples, Echocardiography
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Stephanie Gräger
Liver Cirrhosis, Portal Hypertension
Low Molecular Weight Heparin for the Prevention of Early TIPS Dysfunction
Transjugular intrahepatic portosystemic shunt (TIPS) dysfunction is defined as a loss of decompression of the portal venous system due to occlusion or stenosis of the TIPS.
- Trial name
- NCT03171727
- Testing
- low molecular weight heparin
- Where
- China
- Volunteers
- 117 people
- Sponsor
- West China Hospital
Liver Cirrhoses
To Study the Efficacy and Safety of TIPS (Trans Intrahepatic Portosystemic Shunt) Versus Self Expanding Metallic Stent (SEMS) in the Management of Refractory Variceal Bleed in Cirrhotics.
A total of 50 patients will be enrolled and will be randomized into either Group A(TIPS) or Group B (SEMS). Primary end point of the study will be to compare efficacy of TIPS versus SEMS for survival at 6 week or Early re Bleed.
- Trial name
- NCT03827681
- Testing
- Trans Intrahepatic Portosystemic Shunt, Self Expanding Metallic Stent, Vasoactive Agent
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Portal Hypertension
Ultrasound Elastography Assessment of Spleen and Liver Stiffness Before and After Transjugular Intrahepatic Portosystemic Shunt (TIPS) Procedure
The primary purpose of this project is to determine if acute monitoring of shunt patency via ultrasound elastography measurements of splenic stiffness before and after TIPS placement results in reduced morbidity and mortality…
- Trial name
- NCT03427164
- Testing
- Transjugular Intrahepatic Portosystemic Shunt
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Kansas Medical Center
Variceal Hemorrhage, TIPS
TIPS vs. NSBB Plus Endotherapy for the Prevention of Variceal Rebleeding in NSBB Non-responders of Primary Prophylaxis
Variceal bleeding (VB) is a life-threatening complication of cirrhosis with a 6-week mortality of approximately 15%-20%. The 1-year rate of recurrent VB is approximately 60% in patients without prophylaxis treatment.
- Conditions
- Variceal Hemorrhage, TIPS, NSBB, Liver Cirrhosis
- Trial name
- NCT04207398
- Testing
- Transjugular intrahepatic portosystemic shunts, Nonselective β-blocker (NSBB)+ endoscopic band ligation (EBL)
- Volunteers
- 114 people
- Sponsor
- Air Force Military Medical University, China
Liver Cirrhosis
Embolization of Large Spontaneous Portosystemic Shunts for the Prevention of Post-TIPS Hepatic Encephalopathy
The purpose of this study is to determine whether transjugular intrahepatic portosystemic shunt (TIPS) combined with large spontaneous portosystemic shunts embolization are effective in the prevention of hepatic encephalopathy…
- Trial name
- NCT02156232
- Testing
- TIPS, SPSS embolization
- Where
- China
- Volunteers
- 56 people
- Sponsor
- Air Force Military Medical University, China
Liver Cirrhosis
Skeletal Muscle Parameters of Liver Cirrhosis in Non-invasive Imaging and Outcome
The principal aim of this study is to analyse L3-SMI (skeletal muscle index) in a cohort of patients with decompensated liver cirrhosis and TIPS (transjugular intrahepatic portosystemic shunt), and compare the prognostic power…
- Trial name
- SLIM (NCT03584204)
- Testing
- imaging
- Where
- 3 sites in Germany, Italy
- Volunteers
- 400 people
- Sponsor
- University Hospital, Bonn
Anesthesia, Catheter Blockage
The Efficacy of Continuous Femoral Nerve Catheter Orifice Configuration for Postoperative Analgesia in Knee Arthroplasty
Femoral nerve catheter for postoperative analgesia will be included in the adult patients undergoing total knee arthroplasty included in the study.
- Conditions
- Anesthesia, Catheter Blockage, Knee Arthropathy, Pain, Postoperative
- Trial name
- NCT04202250
- Testing
- CEMP (closed-ended multiport catheter) group, OESP (open-ended single port catheter) group
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Gulhane School of Medicine
Breastfeeding, Odors, Body
The Effect Of Breast Milk Sniffing And Tasting On Early Feeding Tips
The study aimed to investigate the effects of breast milk sniffing and breast milk tasting and sniffing on sucking success and early feeding cues in term newborns who were started to breastfeed for the first time.
- Conditions
- Breastfeeding, Odors, Body, Newborn; Vitality
- Trial name
- NCT06341153
- Testing
- Breast Milk Odor Stimulation, Stimulation of Breast Milk Smell and Taste
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Sibel Küçükoğlu
Macular Psudohole
Foveal Cone Outer Segment Tips Line Defect in Macular Pseudohole
Evaluation of recovery in foveal cone outer segment tips line defect and visual acuity after surgery for macular pseudohole
- Trial name
- NCT01959802
- Testing
- Vitrectomy
- Where
- Japan
- Volunteers
- 22 people
- Sponsor
- Kyorin University
Liver Cirrhosis, Transjugular Intrahepatic Portosystemic Shunt (TIPS)
Incidence and Predictors of Post-TIPS Heart Failure in Patients With Cirrhosis
The purpose of this study is to conduct a prospective trial to investigate the incidence of heart failure in cirrhosis patients undergoing transjugular intrahepatic portosystemic shunt ,and to analyze the the predictors and…
- Conditions
- Liver Cirrhosis, Transjugular Intrahepatic Portosystemic Shunt (TIPS), Heart Failure
- Trial name
- NCT05596253
- Testing
- TIPS
- Where
- China
- Volunteers
- 200 people
- Sponsor
- West China Hospital
Liver Cirrhosis, Portal Hypertension
Exploration of Systemic and Portal Hemostasis in Patients Undergoing Transjugular Intrahepatic Portosystemic Shunt Placement
Portal vein thrombosis is defined as non-tumoural obstruction of the portal vein or one of its branches. Its incidence is 0.7 to 2.7 per 100,000 patient-years in the general population, and 4.6 per 100 patient-years in patients…
- Trial name
- PORTHEMOST (NCT07439939)
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cirrhosis
Comparison of Covered and Bare Stent in TIPS
Investigators aim to compare the efficacy of 8 mm Fluency covered stent and bare stent in transjugular intrahepatic portosystemic shunt (TIPS) for the treatment of cirrhotic portal hypertension.
- Trial name
- NCT02540382
- Testing
- covered stent, bare stent
- Where
- China
- Volunteers
- 258 people, healthy volunteers welcome
- Sponsor
- Beijing Shijitan Hospital, Capital Medical University
Liver Cirrhoses, Portal Hypertension Related to Cirrhosis
Optimizing Portal Hypertension With TIPS and Interval Metabolic Surgery for Advanced Liver Disease
Cirrhosis is a form of advanced liver disease that can lead to serious complications, especially when combined with severe obesity.
- Conditions
- Liver Cirrhoses, Portal Hypertension Related to Cirrhosis, Severe Obesity, TIPS
- Trial name
- OPTIMAL (NCT07058155)
- Testing
- Transjugular Intrahepatic Portosystemic Shunt (TIPS), Sleeve Gastrectomy, Anti-Obesity Pharmacotherapy (Class Effect)
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- The Cleveland Clinic