Clinical trials: THC
To Determine Bioequivalence Under Fasting Conditions
Bioavailability Study of Dronabinol Capsules 10 mg Under Fasting Conditions
The purpose of this study is to compare the rate and extent of absorption of Dronabinol 10 mg capsules verses Marinol.
- Trial name
- NCT01380457
- Testing
- Dronabinol, Marinol
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Par Pharmaceutical, Inc.
Healthy
Pharmacokinetics of SP-104
This open-label, 3-period, 3-treatment, randomized study will characterize the pharmacokinetics and safety and tolerability of SP-104 under fasting and fed conditions as compared to the pharmacokinetics of Naltrexone…
- Trial name
- NCT05002946
- Testing
- SP-104, Naltrexone Hydrochloride 50Mg Oral Tablet
- Where
- New Zealand
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Scilex Pharmaceuticals, Inc.
Post-Traumatic Stress Disorder
Cannabinoid Control of Fear Extinction Neural Circuits in Post-traumatic Stress Disorder
The goal of this study is to look at how a type of drug called cannabinoids are related to the processing of fear signals, the experience of emotions and fear, and the pattern of activity in the brain that is involved in these…
- Trial name
- NCT02069366
- Testing
- Dronabinol
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Wayne State University
HIV Infections, Healthy
In Vivo Study of THC-induced Immune-genome Changes at Single Cell Solution in HIV-infected Humans
In this study, the investigators hypothesize that THC alters the immunogenome in a cell type-specific fashion and alters cytokine production via epigenetic regulatory mechanisms and that these alterations differ between…
- Trial name
- NCT04920539
- Testing
- Active Delta-9-THC
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Yale University
Cannabis, Dependence
Effects of Sativex(Registered Trademark) and Oral THC on Attention, Affect, Working Memory, Reversal Learning, Physiology and Brain Activation
Background: The therapeutic modalities of cannabis have received more research attention recently with the discovery of its ability to stimulate appetite and to provide pain and nausea relief in patients with AIDS, cancer, and…
- Conditions
- Cannabis, Dependence, Cannabis Abuse, Pharmacokinetics
- Trial name
- NCT01037608
- Testing
- Sativex(Registered Trademark), THC
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Healthy
Testing the Interactive Effects of Delta-9-Tetrahydrocannabinol and Pregnenolone
The overall purpose of this study is to examine the effect of pregnenolone (PREG) on the acute psychosis-like and cognitive effects of Delta-9-tetrahydrocannabinol (THC).
- Trial name
- THC-Preg (NCT02576912)
- Testing
- Active Delta-9-THC, Active Pregnenolone
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Yale University
Marijuana Smoking
Effects of Dronabinol (Oral THC) on Cannabis Use
Study participants received dronabinol (0, 120mg/day and 240mg/day) for 12 consecutive days in a randomized order. During each dronabinol maintenance period they were able to self-administer active or placebo cannabis using…
- Trial name
- NCT01394185
- Testing
- Dronabinol 120mg/day, Dronabinol 240mg/day
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Impairment, Cognitive, Impairment of Attention
High Confusion: Cannabis & Driving
This study is being done to assess the feasibility of administrating Δ9-THC and Δ8-THC isolates and simultaneously adopting several data harmonization measures to generate uniquely translatable data.
- Conditions
- Impairment, Cognitive, Impairment of Attention, Impairment, Psychomotor
- Trial name
- NCT06236815
- Testing
- Delta-9-THC, Delta-8-THC
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Alcohol Drinking, Marijuana Smoking
Motivation and Skills for Delta-9-tetrahydrocannabinol/Ethanol (THC/ETOH+) Teens in Jail
This study will focus on treating substance abusing incarcerated teens using individually administered Motivational Interviewing (MI) followed by group Cognitive Behavior Therapy (CBT).
- Trial name
- SMART (NCT00506753)
- Testing
- MI/CBT, RT/SU
- Where
- United States
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- University of Rhode Island
None Volunteer
An Investigation of Mechanisms That Underly Paranoia in Behaviour and Brain That Can Inform Clinical Diagnoses That Include Paranoid Symptoms.
The study team is studying how delta-9-tetrahydrocannabinol (THC) - the component of cannabis that is responsible for "getting people feeling high" - influences how people think about the behaviour of others and a variety of…
- Trial name
- NCT07878130
- Testing
- Low-dose THC administration via IV, High-Dose THC administration via IV, Saline administration via IV
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- King's College London
Cancer, Cancer (With or Without Metastasis)
Assessing Claims of Cannabis as an Anti-cancer Agent (CATA)
The purpose of the study is to find out how cannabis may help control cancer growth by reviewing medical records of patients who report cannabis helped treat their cancer.
- Trial name
- CATA (NCT07107607)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- HealthPartners Institute
Marijuana Abuse
Responses to Marijuana-Related Cues Versus Neutral Cues in Adults Taking Tetrahydrocannabinol (THC) - 2
The majority of past research on marijuana treatment has targeted the alleviation of withdrawal symptoms. Minimal focus has been placed on how altering craving effects may play a role in treating marijuana addiction.
- Trial name
- NCT00218504
- Testing
- Tetrahydrocannabinol
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Intoxication Alcohol, Intoxication THC
Using Imaging to Assess Effects of THC on Brain Activity
This study will assess effects of tetrahydrocannabinol (THC) and THC + alcohol in marijuana users on prefrontal brain activity, using functional near-infrared spectroscopy (fNIRS) during resting state and during memory task…
- Conditions
- Intoxication Alcohol, Intoxication THC, Intoxication Combined Alcohol THC
- Trial name
- fNIRS (NCT03655717)
- Testing
- Dronabinol, Ethanol
- Where
- United States
- Volunteers
- 316 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Healthy, Cannabis
A Study Investigating the Bioavailability of CBD and THC in an Emulsion Product in a Healthy Population
The objective of this study is to investigate the bioavailability of Cannabidiol (CBD) and Tetrahydrocannabinol (THC) in an emulsion product against a comparator product.
- Trial name
- NCT04601207
- Testing
- Cannabis Preparation
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- New Age Ventures LLC
Sleep, THC
Tetrahydrocannabinol (THC) and Sleep
The investigators will test the effects of 10-60mg dronabinol (oral THC) on sleep in non-frequent and frequent cannabis users.
- Conditions
- Sleep, THC, Marijuana, Cannabis
- Trial name
- NCT03560934
- Testing
- Dronabinol
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Respiratory Depression, Cannabis Use
Influence of Δ9-tetrahydrocannabinol (THC) on Oxycodone Induced Ventilatory Depression in Healthy Volunteers
Rationale: Opioid misuse and abuse are common problems in the Western world. The rate of unintentional drug overdose is rapidly increasing, not only in the Unites States but also in the Netherlands.
- Conditions
- Respiratory Depression, Cannabis Use, Opioid Use
- Trial name
- COXY (NCT05235503)
- Testing
- Medicinal cannabis in combination with oxycodon
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Healthy
Evaluation of the Pharmacokinetics of Prana P1 Capsules
This is a single dose clinical trial to assess the Pharmacokinetics of two (2) dosages; 10 mg and 20mg of THC: THCa of Prana P1 bionutrients in healthy volunteers.
- Trial name
- NCT03744091
- Testing
- P1
- Where
- Jamaica
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- The University of The West Indies
Schizophrenia, Dual Diagnosis
Cannabis and Schizophrenia: Self-Medication and Agonist Treatment
The first aim of this study is to determine whether a brain reward center (BRC) deficiency in patients with schizophrenia (SCZ) and cannabis use disorder (CUD) will be normalized when patients are given cannabis or dronabinol.
- Conditions
- Schizophrenia, Dual Diagnosis, Schizoaffective Disorder, Psychotic Disorder
- Trial name
- NCT00946348
- Testing
- Dronabinol, Cannabis
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Pain, Tolerance, Oral vs Vaporized THC
PK/PD of Oral and Vaporized Delta-9-Tetrahydrocannabinol (THC) in Older Adults
The overarching goal of this double-blind, placebo-controlled, crossover study is to characterize the pharmacokinetic (PK) and pharmacodynamic (PD) effects of the main analgesic and psychoactive constituent of cannabis, delta-9…
- Conditions
- Pain, Tolerance, Oral vs Vaporized THC, Abuse Liability
- Trial name
- NCT05906511
- Testing
- Dronabinol 5 MG, Dronabinol 10 MG, 2mg Purified THC in an ethanolic solution
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Yale University
Pain
Cannabinoid Modulation of Pain
The purpose of this study is to test the effects of cannabinoids on pain response using a variety of human experimental pain models.
- Trial name
- NCT01595620
- Testing
- Thermal, Electrical, Capsaicin
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Yale University