Clinical trials: TBI-Traumatic Brain Injury
Brain Injuries
CDP-Choline and Working Memory After TBI: A Neuroimaging Study
The purpose of this study is to determine whether an investigational drug, called "CDP-Choline", improves memory in people with traumatic brain injury (TBI).
- Trial name
- NCT00727246
- Testing
- CDP-Choline
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Patricia M. Arenth
Traumatic Brain Injury, Post-Traumatic Stress Disorder
Multimodal Neurodiagnostic Imaging of Traumatic Brain Injury and Post-Traumatic Stress Disorder
The purpose of this study is to determine whether the brains of persons with and without traumatic brain injury differ in a meaningful way when advanced technology images of the brain are taken using three newer technologies that…
- Trial name
- SANIC (NCT01075035)
- Where
- United States
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- St. Louis University
Mild Traumatic Brain Injury, Post-Concussive Symptoms
Consistency of Automated Neuropsychological Assessment Metrics (ANAM) Performance in Those With Deployment Acquired Mild Traumatic Brain Injury (TBI)
The purpose of this project is to explore the degree to which performance consistency on neuropsychological measures varies in a sample of Operation Iraqi Freedom (OIF)/Operation Enduring Freedom (OEF) Veterans with a history of…
- Trial name
- ANAM (NCT01334528)
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- VA Eastern Colorado Health Care System
Traumatic Brain Injury
In-Field Detection of Intracranial Pressure
This is a research study to develop a noninvasive test using ultrasound to determine when urgent, life-saving treatment is needed for those with severe traumatic brain injuries.
- Trial name
- NCT04515212
- Testing
- Optic Nerve Ultrasounds
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Duke University
Traumatic Brain Injury (TBI), Chronic Traumatic Encephalopathy (CTE)
The Effects of Fish Oil Supplementation on the Brain Health of Collegiate Football Athletes
Determine if the daily docosahexaenoic acid (DHA)/eicosapentaenoic acid (EPA) supplement will reduce serum levels of biomarkers of sub-concussion injuries over a course of American football season among collegiate football…
- Trial name
- NCT04796207
- Testing
- Fish Oil (DPA+EPA 2:1 ratio) Capsules, High Oleic Safflower Oil Capsules
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Brain Injury, Chronic, Brain Injuries, Traumatic
Traumatic Brain Injury and the Gut Microbiome
The purpose of the study is to determine whether administration of a prebiotic, inulin, can improve the symptom complex associated with traumatic brain injury and whether inulin administration can alter the bacteria that live in…
- Trial name
- NCT04949607
- Testing
- Inulin fructooligosaccharide
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Centre for Neuro Skills
Concussion, Brain, Mild Traumatic Brain Injury
The Effects of Environmental Distractions on SCAT6 Outcomes
The purpose of this study is to assess the effects of visual and auditory distractions on SCAT5 scores. The study is designed to identify the effects of about 80 participants completing the SCAT5 in college-aged athletes.
- Trial name
- NCT05886400
- Testing
- SCAT6, Visual/ Auditory Distraction
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Indiana University
Traumatic Brain Injury
Noninvasive Modulation of Motivational Brain Regions in Healthy Volunteers
21 healthy control participants will be recruited. On Day 1 they will complete reward-guided decision making tasks and questionnaires followed by a functional magnetic resonance imaging (fMRI) scan.
- Trial name
- NCT04972786
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Mild Traumatic Brain Injury
Imaging [18F]PI-2620 and [18F]Florbetaben in Military Service Members With Blast Related Mild Traumatic Brain Injury
The main objective of this interdisciplinary study is to develop an understanding of the molecular imaging features of blast-related mild traumatic brain injury (mTBI) in military personnel, while helping to establish assessment…
- Trial name
- NCT05337774
- Testing
- [18F]PI-2620
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Life Molecular Imaging SA.
Concussion
EEG Diagnostic for Repetitive Sub-concussive Head Impacts
The purpose of this study is to develop a diagnostic algorithm to help with the detection, diagnosis, and monitoring of sub-concussive head impacts.
- Trial name
- NCT05562544
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Mild Traumatic Brain Injury
Functional MRI Study of Attention in Normal Controls and Traumatic Brain Injured Patients
The purpose of this study will be to assess the attentional ability of patients with mild to moderate traumatic brain injury (TBI) using the functional Magnetic Resonance Imaging (fMRI) technique.
- Trial name
- NCT00580918
- Testing
- functional magnetic resonance imaging fMRI
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, Irvine
Traumatic Brain Injury
Assessment of Noninvasive Neuromodulation in a Group of Traumatic Brain Injured Patients and Healthy Volunteers
Background: Severe traumatic brain injury, particularly diffuse axonal injury (DAI), often leads to lasting neurological issues.
- Trial name
- NCT07373366
- Testing
- Subjects in the intervention group receive low-frequency radioelectric therapy
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
MTBI - Mild Traumatic Brain Injury, Concussion, Mild
Evaluation of Helmet Technology and Head Impact Exposure
The purpose of the study is to monitor longitudinal changes in brain structure and function between the preseason and postseason, in a population of football playing athletes grouped by helmet make and model.
- Trial name
- NCT03883451
- Testing
- Helmet Model
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Concussion, Brain, Musculoskeletal Pain
The Impact of Eye and Body Training on the Injury Rate of Concussions in Female Soccer Players
The research project aims to find out how special training influences the frequency and severity of injuries among female footballers in the top Swiss league.
- Trial name
- NCT06473883
- Testing
- Training recommendation
- Volunteers
- 209 people, healthy volunteers welcome
- Sponsor
- BrainCare Medical Group
Traumatic Brain Injury
Growth Hormone and Insulin Growth Factor 1 Deficiencies in Children/Adolescents Following Traumatic Brain Injury: The Impact on Growth and Neuropsychological Development
The purpose of this study is to look at the relationship between growth hormones, and recovery from a TBI - traumatic brain injury. It is believed that a TBI may interfere with the body's ability to produce growth hormones.
- Trial name
- NCT00929045
- Testing
- Growth Hormone Replacement
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Craniocerebral Trauma, Traumatic Brain Injury
Effect of Passive Gait Training on the Cortical Activity in Patients With Severe Traumatic Brain Injury.
The aim of this study is to determine whether passive gait training increases arousal, demonstrated as changes in EEG (electroencephalogram) activity.
- Conditions
- Craniocerebral Trauma, Traumatic Brain Injury, "Rehabilitation"
- Trial name
- NCT00430703
- Testing
- body weight support treadmill training
- Where
- Denmark
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Brain Concussion
The s100β Levels in Patients With Mild Brain Injury.
Mild traumatic brain injury (TBI) accounts for the majority of TBI. At present, whether TBI has traumatic intracranial lession is mainly diagnosed by computed tomography (CT), while only 5% of mild TBI has positive CT results.
- Trial name
- NCT06131242
- Testing
- It is an observational study
- Volunteers
- 494 people, healthy volunteers welcome
- Sponsor
- Sumei Lu
Children, Only, Traumatic Brain Injury
Neurophysiological Measurements Using the NeuroCatch™ Platform in Pediatric Concussion
EEG signals have been collected and studied since the early 1990's as a way of assessing brain function at a gross level. As early as the 1930's a derivative of the raw EEG signal - event-related potentials (ERPs) - have been…
- Conditions
- Children, Only, Traumatic Brain Injury, Concussion, Mild, Pediatric ALL
- Trial name
- NCT03889483
- Testing
- NeuroCatch™ Platform
- Where
- Canada
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Dr. Michael Esser
Traumatic Brain Injury
Hemp-Derived Botanical Dietary Supplementation During Recovery From Brain Injury
The objective of the proposed research is to evaluate adult subjects currently taking phytocannabinoid Hemp-derived botanical supplements (HDS) during recovery from traumatic brain injury.
- Trial name
- NCT03826368
- Testing
- Hemp-derived botanical dietary supplement
- Volunteers
- healthy volunteers welcome
- Sponsor
- Real Time Diagnostics Ventures INC
Traumatic Brain Injury
Aerobic Exercise After Traumatic Brain Injury
The purpose of this study is to examine the effects of individualized aerobic exercise regimen on recovery after traumatic brain injury (TBI).Investigators will determine if exercise facilitates recovery by facilitating…
- Trial name
- AER-TBI1 (NCT05786729)
- Testing
- Aerobic Exercise (AER), Rehabilitation
- Where
- United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Centre for Neuro Skills