Clinical trials: T1D
Hypoglycemia, Diabetes Mellitus, Type 1
The Late Effects of Ethanol Intake on the Glucose Response to Subcutaneous Glucagon in Type 1 Diabetes
Objective: Because many people with type 1 diabetes drink ethanol and because glucagon is used to treat mild hypoglycaemia, it is essential to determine whether ethanol will impair the effectiveness of glucagon to increase…
- Trial name
- ALCO1 (NCT02881060)
- Testing
- Alcohol
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- Hvidovre University Hospital
Diabetes Mellitus, Diabetes Mellitus, Type 1
Efficacy and Safety of Android Artificial Pancreas System in Adult Patients With Type 1 Diabetes Mellitus in China
This is a 26-week randomized, free-living, open-label, two-arm, two-phase, crossover trial. Participants will receive two interventions at different phases, including the Android artificial pancreas system(AndroidAPS-rt-CGM) and…
- Conditions
- Diabetes Mellitus, Diabetes Mellitus, Type 1, Glucose Metabolism Disorders, Metabolic Disease
- Trial name
- NCT05726461
- Testing
- AndroidAPS-rt-CGM;, sensor augmented pump(SAP);
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Type 1 Diabetes, Diabetic Ketoacidosis
Study to Explore the Effect of Dapagliflozin and Stress in Adolescent and Adult Subjects With Type 1 Diabetes (T1D)
Type 1 Diabetes is characterized by an absolute lack of insulin caused by autoimmune ß-cell destruction. Looking for different therapeutic approaches, beyond the administration of Insulin SGLT-Inhibitors (SGLT=sodium-glucose…
- Trial name
- Dapa-Stress (NCT04234867)
- Testing
- Dapagliflozin, Stress
- Where
- Germany
- Volunteers
- 2 people
- Sponsor
- Kinderkrankenhaus auf der Bult
Diabetes Mellitus, Type 1
AT278 and NovoRapid® in Glucose Clamp Study
A phase 1, randomised, single-centre, double-blind, single-dose, two period balanced cross over study in a glucose clamp setting.
- Trial name
- NCT04660305
- Testing
- AT278, NovoRapid
- Where
- Austria
- Volunteers
- 38 people
- Sponsor
- Arecor Limited
Type 1 Diabetes Mellitus
Telecare in Type 1 Diabetes (T1D) Patients Treated by Insulin Pump
The purpose of this study is to determine whether Telecare can be used for efficient management of adults with Type 1 Diabetes Mellitus using insulin pump, in lieu of frequent clinic visits.
- Trial name
- NCT01887431
- Testing
- Telecare, Conventional therapy
- Where
- Israel
- Volunteers
- 66 people
- Sponsor
- Assuta Hospital Systems
Type 1 Diabetes Mellitus
Difficulties and Obstacles to the Integration in Community of Children With Type 1 Diabetes Before Primary School.
The incidence of type 1 diabetes is increasing worldwide and in France, including among young children. Type 1 diabetes has consequences for integration in community, especially on the management of hypoglycemia and…
- Trial name
- DIABECO (NCT03980353)
- Testing
- Questionnaires
- Where
- France
- Volunteers
- 146 people
- Sponsor
- Hospices Civils de Lyon
Diabetes Mellitus, Type 1
The Loop Observational Study
An observational study to collect data on the efficacy, safety, usability, and quality of life/psychosocial effects of the Loop DIY automated insulin delivery system.
- Trial name
- LOS (NCT03838900)
- Testing
- Loop
- Where
- United States
- Volunteers
- 1,212 people
- Sponsor
- Jaeb Center for Health Research
Diabetes Mellitus, Type 1
Optimizing Metabolic Control in Type 1 Diabetes - The Automatic Bolus Calculator Flash Study
This study aims to compare the effect of flash glucose monitoring (FGM) with traditional self-monitoring of blood glucose (SMBG) with or without carbohydrate counting and automated bolus calculation, in patients with type 1…
- Trial name
- NCT03682237
- Testing
- Carbohydrate counting, automated bolus calculation, Flash glucose monitoring (FGM)
- Where
- Denmark
- Volunteers
- 184 people
- Sponsor
- Steno Diabetes Center Copenhagen
Type 1 Diabetes
Overnight Type 1 Diabetes Control Under MD-Logic Closed Loop System at the Patient's Home
This is a randomized prospective single blind trial to evaluate blood glucose control overnight under closed-loop insulin delivery with MD-Logic Artificial Pancreas (MDLAP) system in patients with type 1 diabetes, being conducted…
- Trial name
- NCT01726829
- Testing
- MD-Logic Artificial Pancreas (MDLAP) system, sensor augmented pump therapy
- Where
- 3 sites in Germany, Israel and 1 more
- Volunteers
- 75 people
- Sponsor
- Rabin Medical Center
Type 1 Diabetes
Use of Continuous Glucose Monitoring Devices Among People Living With Type 1 Diabetes in Kenya.
Diabetes mellitus (diabetes) is a chronic condition that represents a major public health and clinical concern. Self-monitoring of blood glucose (SMBG) is a critical part of the care of individuals with diabetes.
- Trial name
- ACCEDE (NCT05944731)
- Testing
- Continuous glucose monitor
- Where
- Kenya
- Volunteers
- 246 people, healthy volunteers welcome
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland
Diabetes, Diabetes Mellitus, Type 1
Safety and Efficacy of Insulin Aspart in Children With Type 1 Diabetes
This trial is conducted in Europe. The aim of this trial is to evaluate safety and efficacy in children with type 1 diabetes.
- Trial name
- NCT01467141
- Testing
- insulin aspart, human insulin, isophane human insulin
- Where
- 6 sites in Germany
- Volunteers
- 26 people
- Sponsor
- Novo Nordisk A/S
Type 1 Diabetes
Profiling of Original Cellular and Humoral Biomarkers of Type 1 Diabetes
The "Lymphoscreen" study aims to characterize precisely (phenotypes/cytokines/functions) CD8+ T cell responses in type 1 Diabetes to identify biomarkers of the disease.
- Trial name
- Lymphoscreen (NCT01042301)
- Testing
- Blood samplings
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Type 1 Diabetes, Diabetes Mellitus, Type 1
Weekly Subcutaneous Semaglutide as Adjunct to Closed-loop Therapy in Type 1 Diabetes Care
A closed-loop insulin system, also referred to as the "artificial pancreas" (AP), is made up of an insulin pump, a continuous glucose monitor, and an application communicating between the two to adjust insulin administration…
- Trial name
- SEMA-AP (NCT05205928)
- Testing
- Outpatient therapy: 11 weeks of drug therapy with usual treatment + 4 weeks of closed-loop therapy
- Where
- Canada
- Volunteers
- 28 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Type 1 Diabetes Mellitus, Dyslipidemia
Treatment Effects of Atorvastatin on Hemostasis and Skin Microcirculation in Patients With Type 1 Diabetes
Patients with type 1 diabetes are at increased risk of vascular complications both in the micro- and macrocirculation. Hyperglycemia plays a major role in the development of these vascular complications, but other factors such…
- Trial name
- NCT01497912
- Testing
- Atorvastatin
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Karolinska Institutet
Type 1 Diabetes, Vitamin D Deficiency/Insufficiency
The Effects of Vitamin D on Glycemic Control and Proinflammatory Markers in Adolescents With T1DM
The investigators are conducting a prospective cross-over study to evaluate the effects of vitamin D supplementation on diabetes control and the pro-inflammatory markers involved in microvascular complications in adolescents with…
- Trial name
- NCT01697228
- Testing
- Vitamin D
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Children's Hospital Los Angeles
Type1diabetes
HIT on Hypoglycemic Risk in Type 1 Diabetes (T1D)
There is clear evidence that regular exercise improves wellbeing and reduces the risk of diabetes related complications in people with type 1 diabetes. However, many people with type 1 diabetes do not exercise regularly.
- Trial name
- NCT03598400
- Testing
- high intensity interval training, moderate intensity continous training
- Where
- United Kingdom
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Liverpool John Moores University
Type 1 Diabetes
Dual-Hormone Closed-Loop Glucose Control in Adolescents With Type 1 Diabetes
Objective: To assess the efficacy and safety of an insulin-glucagon dual-hormone (DH) closed-loop system compared with an insulin-only single-hormone (SH) closed-loop system in adolescent with type 1 diabetes.
- Trial name
- DHCL2021 (NCT04949867)
- Testing
- Glucagon, Closed-loop System
- Where
- 2 sites in Denmark
- Volunteers
- 11 people
- Sponsor
- Steno Diabetes Center Copenhagen
Diabetes Mellitus
The Effects of GIP and GLP-2 on the Secretion of Glucagon in Patients With Type 1 Diabetes
The purpose of this study is to determine whether Glucose-dependent Insulinotropic Polypeptide (GIP) or Glucagon Like Peptide 2 (GLP-2) has an affect on the secretion of Glucagon from the pancreas in patients with type 1 diabetes…
- Trial name
- NCT00732602
- Testing
- GIP-infusion, Sodium-chloride, GLP-2 infusion
- Where
- Denmark
- Volunteers
- 8 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Diabetes Mellitus, Coronary Heart Disease
Long-term Mortality in Diabetics Undergoing Major Surgery
Patients with CAD and diabetes mellitus have a better prognosis than patients with CAD and no diabetes mellitus. In acute coronary syndrome patients with an insulin therapy had a better survival than patients with oral…
- Conditions
- Diabetes Mellitus, Coronary Heart Disease, Major Non-cardiac Surgery
- Trial name
- NCT00286572
- Where
- Switzerland
- Volunteers
- 380 people
- Sponsor
- University Hospital, Basel, Switzerland
Type 1 Diabetes
Efficacy of Glycemic Improvement Project (GLITTER Study) in Type 1 Diabetes-GLITTER Study 2
The GLITTER Study 2 is a cluster randomized trial that will evaluate the impact of comprehensive and intensive management, comprising a team, technology, education, and peer resources, on metabolic control and psychological…
- Trial name
- NCT07097818
- Testing
- T1D team, structured education, peer support , and diabetes technologies, Routine Management
- Where
- 10 sites in China
- Volunteers
- 400 people
- Sponsor
- Second Xiangya Hospital of Central South University