Clinical trials: Systemic Right Ventricle
Complex Congenital Heart Disease
National Registry of Adult Heart Failure Patients With Complex Congenital Heart Disease: Systemic Right Ventricle and Single Ventricle Treated With Sacubitril/Valsartan
Heart failure in adults with congenital heart disease is a major cause of morbidity and mortality. Patients with systemic right ventricle (SRV) and single ventricle (SV) are particularly at risk1, 2, 3.
- Trial name
- ISACC (NCT06149806)
- Testing
- Sacubitril / Valsartan Oral Tablet [Entresto]
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Grenoble
Transposition of Great Arteries
Cardiovascular Magnetic Resonance in Adults With SysTemic Right Ventricle (STAR)
The main aim of the study is to explore HFs in SRV, comparing their magnitude and direction with that of subpulmonary RV and systemic LV.
- Trial name
- STAR (NCT05690854)
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
Sepsis and Septic Shock
The Prognostic Impact of Right Ventricular Systolic Dysfunction on the Survival of Patients With Sepsis and Septic Shock
This study sought to evaluate the association of right ventricular systolic dysfunction and 28-day in-hospital mortality in patients with sepsis and septic shock.
- Trial name
- NCT06193109
- Where
- Thailand
- Volunteers
- 200 people
- Sponsor
- Burapha University
Right Heart Failure, Unspecified, Critical Illness
Echocardiographic Evaluation of RV Injury in the ICU
The adequate characterization of RV injury is currently unknown. The hypothesis is that the best characterization of RV injury is the one with the most significant impact on the response to fluids and on the outcome.
- Conditions
- Right Heart Failure, Unspecified, Critical Illness, ARDS, Human, Septic Shock
- Trial name
- RECHOicu (NCT05525936)
- Testing
- Echocardiography and central venous pressure
- Volunteers
- 440 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sudden Cardiac Death, Congenital Heart Disease
Sudden Cardiac Death in Systemic Right Ventricle
In complete transposition of the great arteries (TGA) with previous atrial switch repair, and congenitally corrected transposition of the great arteries (ccTGA), the morphological right ventricle and its tricuspid valve continue…
- Conditions
- Sudden Cardiac Death, Congenital Heart Disease, Transposition of Great Vessels
- Trial name
- STARSII (NCT03833843)
- Testing
- imaging
- Where
- France
- Volunteers
- 1,240 people
- Sponsor
- European Georges Pompidou Hospital
Septic Shock
Right Ventricular Dysfunction in Septic Shock Patients in ICU
Assesment of right ventricular dysfunction in septic shock patients in intensive care unit.
- Trial name
- Septicshock (NCT05193682)
- Volunteers
- 25 people
- Sponsor
- Shimaa Hammad Ahmed
Septic Shock
Comparison of Cardiac Index Measurement Using Right Ventricular Pressure Curve Analysis and Thermodilution Via a Swan-Ganz IQ™ Catheter.
The pulmonary artery catheter (Swan-Ganz) is a standard tool in intensive care for measuring and monitoring cardiac index by thermodilution.
- Trial name
- MICAP (NCT07628023)
- Testing
- Swan-Ganz
- Where
- 2 sites in France
- Volunteers
- 43 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pulmonary Embolism, Pulmonary Hypertension
Peripheral Systemic Thrombolysis Versus Catheter Directed Thrombolysis for Submassive PE
To determine whether peripheral low dose systemic thrombolysis (PLST) is non-inferior to catheter directed acoustic pulse thrombolysis (ACDT) in improving RV function and reducing pulmonary artery pressures in submassive…
- Conditions
- Pulmonary Embolism, Pulmonary Hypertension, Thromboembolism, Right Ventricular Dysfunction
- Trial name
- NCT03581877
- Testing
- Alteplase, EKOS
- Where
- 2 sites in United States
- Volunteers
- 31 people
- Sponsor
- Northwell Health
Systemic Right Ventricle, Heart Failure
ARNI Versus plAcebo in Patients With Congenital sYStemic Right Ventricle Heart Failure
This study is a prospective monocentric, randomized, double-blind, placebo-controlled, crossover clinical trial to assess the efficacy of Sacubitril/Valsartan over placebo in improving exercise capacity and neurohormonal…
- Trial name
- PARACYS-RV (NCT05117736)
- Testing
- Sacubitril / Valsartan Oral Tablet
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Montreal Heart Institute