Clinical trials: Syphilis Infection
HIV Infections, Sexually Transmitted Diseases
Integrating Enhanced HIV PrEP Into a STI Clinic in Lilongwe
This is a prospective cohort study evaluating acceptability, feasibility, and effectiveness of integrating HIV pre-exposure prophylaxis (PrEP) into a sexually transmitted infection (STI) clinic alongside assisted partner…
- Conditions
- HIV Infections, Sexually Transmitted Diseases, Blood-Borne Infections, Communicable Disease
- Trial name
- NCT05307991
- Testing
- PrEP, STI testing, Assisted partner notification
- Where
- Malawi
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Treponema Pallidum, Treponema Pallidum Infection
This Study Evaluates the ALPCO Syphilis-T and Syphilis-NT CLIA Kits for Detecting Syphilis Antibodies in Serum and Plasma. Samples From At-risk, HIV-positive, Pregnant, and Healthy Individuals Will Assess Assay Performance Versus Established Comparator Tests.
This study will evaluate the clinical performance of two investigational diagnostic kits developed by ALPCO: the Syphilis-T CLIA Kit and the Syphilis-NT CLIA Kit.
- Conditions
- Treponema Pallidum, Treponema Pallidum Infection, Syphilis Infection, Serum
- Trial name
- NCT07089836
- Testing
- ALPCO Syphilis-T, ALPCO Syphilis-NT CLIA Kits
- Where
- 6 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- American Laboratory Products Company
Syphilis, Early Syphilis
Cefixime for Alternative Syphilis Treatment
The goal of the study is to evaluate the efficacy of oral cefixime as an alternative treatment for syphilis infection. One hundred adult patients (≥18 years old) with syphilis infection (positive Treponema Pallidum Particle…
- Trial name
- NCT03660488
- Testing
- Cefixime 400 milligram Oral Capsule [Suprax], Benzathine Penicillin G
- Where
- 10 sites in United States
- Volunteers
- 58 people
- Sponsor
- University of California, Los Angeles
Syphilis
Video Tool to Promote Knowledge of Syphilis as Facilitator of HIV Transmission
During the winter of 2007, the Syphilis Advisory Group and Bureau of STD Control of the NYC Department of Health funded the Emergency Department of Jacobi Medical Center to further evaluate the effectiveness of the Syphilis and…
- Trial name
- NCT00553111
- Testing
- educational video
- Where
- 2 sites in United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Jacobi Medical Center
Syphilis
Investigational Study to Evaluate the DPP® Syphilis Screen & Confirm Antibody Point-of-care Test (POCT) to Diagnose Infectious Syphilis
The goal of this observational study is to evaluate the sensitivity, specificity, and utility of the DPP® Syphilis Screen \& Confirm antibody point-of-care test (POCT) to diagnose infectious syphilis in participants attending the…
- Trial name
- NCT06927843
- Testing
- point of care test
- Where
- Canada
- Volunteers
- 312 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
HIV, Syphilis
Peer Delivered HIV/Syphilis Self-Testing With Assisted Partner Notification Services
Background and rationale Men who engage in sexual relations with other men (MSM) are disproportionately affected by HIV and other sexually transmitted infections (STI), such as syphilis.
- Trial name
- PEER (NCT06791928)
- Testing
- Peer distribution of self testking kits
- Where
- Uganda
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Makerere University
HIV Infections, Syphilis
Impact of COVID-19 on Provision and Uptake of Prevention of Mother-to-child Transmission of HIV Services in Zimbabwe
The COVID-19 pandemic and response are likely to lead to severe unintended consequences for the prevention of mother-to-child transmission (PMTCT) of HIV and syphilis.
- Trial name
- NCT04782739
- Testing
- None - Descriptive study
- Where
- 2 sites in Zimbabwe
- Volunteers
- 30 people
- Sponsor
- University of Zimbabwe
Syphilis, COVID - 19
Impact of Covid-19 on Syphilis
Sexually transmitted infections (STIs) represent a significant challenge to global public health. Although many of these infections are treatable, failure to diagnose and delayed treatment can lead to serious complications…
- Conditions
- Syphilis, COVID - 19, HIV (Human Immunodeficiency Virus), Retrospective Studies
- Trial name
- SIPAND (NCT07150871)
- Testing
- Patients diagnosed with syphilis
- Where
- Italy
- Volunteers
- 240 people
- Sponsor
- Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria
HIV Infections
Surveillance and Medical Help for HIV-infected Intravenous Drug Users in and Out of Prison
It is difficult to detect the intestinal protozoal infections among the HIV-infected persons or travelers diarrhea by using the traditional microscopy or staining methods.
- Trial name
- NCT00739258
- Where
- Taiwan
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Serologic Response of Syphilis, Early Syphilis
Comparisons of Serologic Response of Early Syphilis
Syphilis and HIV are prone to occur concomitantly and the two diseases share several modes of acquisition and risk factors such as men who have sex with men (MSM), sexual workers, intravenous drug users, previous history of…
- Conditions
- Serologic Response of Syphilis, Early Syphilis, High Risk Behavior
- Trial name
- NCT01944358
- Where
- 2 sites in Taiwan
- Volunteers
- 1,128 people
- Sponsor
- National Taiwan University Hospital
Sexually Transmitted Diseases
A Trial to Compare Antibacterial vs. Placebo Mouthwash to Reduce the Incidence of Sexually Transmitted Infections (STIs) in Men Who Have Sex With Men (MSM) Taking HIV Pre-Exposure Prophylaxis (PrEP)
The study involves a randomized placebo controlled trial that aims to assess if a mouthwash (Listerine cool mint, LCM) is able to reduce the cumulative incidence of gonorrhoea (Ng), chlamydia (Ct) and syphilis in men who have sex…
- Trial name
- PReGo (NCT03881007)
- Testing
- Mouthwash with LCM
- Where
- Belgium
- Volunteers
- 343 people, healthy volunteers welcome
- Sponsor
- Institute of Tropical Medicine, Belgium
Syphilis
One Dose Versus Three Weekly Doses of Benzathine Penicillin G for Patients With Early Syphilis
The purpose of this study is to observe the serological response to 1 or 3 weekly doses of benzathine penicillin G in patients with early syphilis.
- Trial name
- NCT02857959
- Testing
- Benzathine Penicillin G
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Jun Li
Syphilis Infection
Syphilis Treatment of Partners Trial
2.1 Primary Study Hypothesis In sub-Saharan Africa, between 2.5-17% of pregnant women are infected with syphilis [1]. It is estimated that 53-82% of women with untreated syphilis had adverse outcomes compared to only 10-21% of…
- Trial name
- STOP (NCT02262390)
- Testing
- Partner Notification Reminders
- Where
- Uganda
- Volunteers
- 1,752 people
- Sponsor
- Makerere University
HIV, Syphilis
Dual Rapid HIV & Syphilis Tests in Zambia
The purpose of this study is to provide evidence on the performance and operational characteristics of commercially available dual HIV/syphilis Rapid Diagnostic Tests (RDTs) in Zambia for their introduction into antenatal care…
- Trial name
- NCT02445846
- Testing
- dual HIV/syphilis rapid diagnostics tests
- Where
- Zambia
- Volunteers
- 3,010 people
- Sponsor
- University of North Carolina, Chapel Hill
HPV Infection, HIV Infection
Human Papillomavirus Infection and Knowledge and Attitudes About HPV Vaccines Among Men Who Have Sex With Men (MSM)
This is a observational study aims to assess anal and genital human papillomavirus (HPV) infection status among men who have sex with men (MSM) in China, and their knowledge and attitude about HPV vaccine.
- Conditions
- HPV Infection, HIV Infection, Syphilis
- Trial name
- NCT01300689
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences
Sexually Transmitted Diseases, Syphilis
Doxi-Rio: Study on the Use of Doxycycline to Prevent Sexually Transmitted Infections in Rio de Janeiro
The goal of this clinical trial is to learn if doxycycline post-exposure prophylaxis (doxy-PEP) can help prevent bacterial sexually transmitted infections (STIs) among sexual and gender minorities in Rio de Janeiro, Brazil…
- Conditions
- Sexually Transmitted Diseases, Syphilis, Gonorrhea, Chlamydia Infections
- Trial name
- NCT07500415
- Testing
- Doxycycline
- Where
- Brazil
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Oswaldo Cruz Foundation
Pregnancy
Study of Ceftriaxone and Benzathine Penicillin G During Pregnancy
IMPAACT 2044 is a study to characterize the pharmacokinetics (PK) and safety of ceftriaxone and benzathine penicillin G during pregnancy.
- Trial name
- NCT07207876
- Testing
- Ceftriaxon, Benzathine penicillin G
- Where
- 9 sites in United States, Puerto Rico
- Volunteers
- 110 people
- Sponsor
- International Maternal Pediatric Adolescent AIDS Clinical Trials Group
Chagas Disease, Syphilis
Implementation Strategy of Bio-molecular Techniques for Early Diagnose of Congenital Syphilis and Chagas Diseases
Chagas disease and syphilis are considered a mayor public health problem worldwide. Both pathologies affect socio-economic vulnerable population and they are both transmitted congenitally, causing an alarming increasing number of…
- Trial name
- NCT04084379
- Where
- Argentina
- Volunteers
- 560 people
- Sponsor
- Hospital de Niños R. Gutierrez de Buenos Aires
Syphilis, Human Immunodeficiency Virus
Cefixime Clinical Trial
This study aims to evaluate the efficacy of cefixime compared to benzathine penicillin G in the treatment of syphilis.
- Trial name
- NCT04958122
- Testing
- Cefixime 400mg, benzathine penicillin
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- University of Southern California
Syphilis Infection, Syphilis
Study to Evaluate Diagnostic Sensitivity and Specificity of iStatis Syphilis Ab Test at the Point- Of-Care Sites
This study is a prospective cross-sectional study in which surgically non-invasive sample- taking is done only for the purpose of the study.
- Trial name
- NCT06365606
- Testing
- iStatis Syphilis Ab Test
- Where
- South Africa
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- bioLytical Laboratories