Clinical trials: Syphilis
Opioid Use Disorder, HIV Infections
Combination Primary Care and Prevention Services for Women Who Inject Drugs and Exchange Sex in Seattle, Washington
The investigators will implement a non-randomized observational clinical trial that will include a pop-up clinic for women who inject drugs (WWID) near venues for exchange sex and drug use in north Seattle.
- Conditions
- Opioid Use Disorder, HIV Infections, Chlamydia, Gonorrhea
- Trial name
- NCT06187064
- Testing
- Mobile Van Clinic
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Washington
Syphilis
Lumbar Puncture and Syphilis Outcome
Treponema pallidum, the bacterium that causes syphilis, invades the central nervous system in about 40% of patients with syphilis. This happens early after infection.
- Trial name
- NCT02031146
- Testing
- Lumbar puncture
- Where
- United States
- Volunteers
- 231 people
- Sponsor
- University of Washington
HIV Infections, Sexually Transmitted Diseases, Viral
mLab App Plus: A Randomized Controlled Trial of a Mobile Health (mHealth) Intervention
Men who have sex with men (MSM), especially young men who have sex with men (YMSM), and transgender women (TGW) have some of the highest rates of HIV and syphilis diagnoses in the United States.
- Conditions
- HIV Infections, Sexually Transmitted Diseases, Viral, Syphilis
- Trial name
- NCT06059443
- Testing
- mLab App Plus
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Columbia University
Early Syphilis
Treatment Responses of Early Syphilis to Ceftriaxone Plus Doxycycline
In a prospective study investigating the prevalence of sexually transmitted infections (STIs) among at-risk people living with HIV (PLWH), the prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae was 24.7% and 12.1%…
- Trial name
- NCT05980871
- Testing
- Doxycycline, Ceftriaxone, benzathine penicillin G
- Where
- Taiwan
- Volunteers
- 109 people
- Sponsor
- National Taiwan University Hospital
Syphilis
Syphilis Self-testing to Expand Test Uptake Among Men Who Have Sex With Men (SST)
Syphilis infection is a major global health problem, leading to substantial morbidity among key populations in low- and middle-income countries (LMICs).
- Trial name
- NCT04480749
- Testing
- Access to Facility based Syphilis Testing, Syphilis Self-Test
- Where
- Zimbabwe
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
HIV Infections, Syphilis
Ending the HIV Epidemic Through Point-of-Care Technologies (EHPOC)
This study proposes to investigate the performance of existing and new technologies for HIV diagnosis, one of the key strategies for Ending the HIV Epidemic in the U.S.
- Trial name
- EHPOC (NCT04793750)
- Testing
- Cepheid GeneXpert HIV-1 Qual POC HIV VL test, DPP HIV-Syphilis test system, OraQuick
- Where
- 3 sites in United States
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Syphilis
Phase 4 Comparative Trial of Benzathine Penicillin G for Treatment of Early Syphilis in Subjects With or Without HIV Infection
This is a phase 4, randomized, open-label, multicenter trial to evaluate the efficacy of a single injected dose of Benzathine Penicillin G (BPG) 2.4 MU (Arm 1) compared to three successive weekly injected doses of BPG 2.4 MU (Arm…
- Trial name
- NCT03637660
- Testing
- Benzathine Penicillin
- Where
- 10 sites in United States
- Volunteers
- 249 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Human Immunodeficiency Virus, Risk Reduction
Building Mobile HIV Prevention and Mental Health Support in Low-resource Settings
The purpose of this research study is to provide help and support for mental health and human immunodeficiency virus (HIV) risk reduction among Romanian gay and bisexual men.
- Conditions
- Human Immunodeficiency Virus, Risk Reduction, Alcohol Abuse, Depression, Anxiety
- Trial name
- NCT03912753
- Testing
- Comunică, Education Attention Control
- Where
- Romania
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Columbia University
Gonorrhea, Chlamydia
Evaluation of Doxycycline Post-exposure Prophylaxis to Reduce Sexually Transmitted Infections in PrEP Users and HIV-infected Men Who Have Sex With Men
The purpose of this study is to understand if taking an antibiotic called doxycycline by mouth as soon as possible after sexual contact without a condom can reduce the risk of sexually transmitted infections (STIs), including…
- Conditions
- Gonorrhea, Chlamydia, Syphilis
- Trial name
- NCT03980223
- Testing
- Doxycycline Hyclate Delayed-Release 200 mg
- Where
- 3 sites in United States
- Volunteers
- 641 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Syphilis, Early Syphilis
Cefixime for Alternative Syphilis Treatment
The goal of the study is to evaluate the efficacy of oral cefixime as an alternative treatment for syphilis infection. One hundred adult patients (≥18 years old) with syphilis infection (positive Treponema Pallidum Particle…
- Trial name
- NCT03660488
- Testing
- Cefixime 400 milligram Oral Capsule [Suprax], Benzathine Penicillin G
- Where
- 10 sites in United States
- Volunteers
- 58 people
- Sponsor
- University of California, Los Angeles
Syphilis, HIV Infections
Spotting Syphilis: A Dual Point-of-Care Syphilis Screening Initiative in a Low-Resource Healthcare Setting
The purpose of this study is to determine if a strategy utilizing the Chembio HIV/syphilis rapid point-of-care (POC) test for diagnosis of HIV and syphilis in pregnant women attending prenatal clinics in Guatemala will increase…
- Trial name
- NCT07498153
- Testing
- Chembio HIV/Syphilis rapid POC test
- Where
- United States
- Volunteers
- 153 people
- Sponsor
- The University of Texas Health Science Center, Houston
Sexually Transmitted Diseases, Gonorrhea
Zenyth: Motivational Interviewing-based Telehealth Intervention for Bacterial Sexually Transmitted Infection Screening
In the United States (US), gay and bisexual men living with human immunodeficiency virus (HIV) bear a heavy burden of bacterial sexually transmitted infections (STIs) such as gonorrhea, chlamydia, and syphilis.
- Conditions
- Sexually Transmitted Diseases, Gonorrhea, Chlamydia, Syphilis
- Trial name
- NCT06100250
- Testing
- Motivational interviewing and specimen self-collection
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Michigan
Syphilis
Syphilis Response to Higher Penicillin Dosage: The 2.4 Versus 7.2 Study
Syphilis remains a significant health problem worldwide, with an estimated 10.6 million new cases per year. Due to shared transmission route and risk factors, co-infection with syphilis and Human Immunodeficiency Virus (HIV) is…
- Trial name
- NCT02611765
- Testing
- Benzathine penicillin G intramuscular 7.2 million units, Benzathine penicillin G intramuscular 2.4 million units
- Volunteers
- 64 people
- Sponsor
- Baylor College of Medicine
Sexually Transmitted Diseases
A Trial to Compare Antibacterial vs. Placebo Mouthwash to Reduce the Incidence of Sexually Transmitted Infections (STIs) in Men Who Have Sex With Men (MSM) Taking HIV Pre-Exposure Prophylaxis (PrEP)
The study involves a randomized placebo controlled trial that aims to assess if a mouthwash (Listerine cool mint, LCM) is able to reduce the cumulative incidence of gonorrhoea (Ng), chlamydia (Ct) and syphilis in men who have sex…
- Trial name
- PReGo (NCT03881007)
- Testing
- Mouthwash with LCM
- Where
- Belgium
- Volunteers
- 343 people, healthy volunteers welcome
- Sponsor
- Institute of Tropical Medicine, Belgium
HIV Infections, HIV/AIDS
Doxycycline PEP for Prevention of Sexually Transmitted Infections Among Kenyan Women Using HIV PrEP
This is a randomized clinical trial of doxycycline post-exposure prophylaxis (dPEP) to reduce bacterial STIs among Kenyan women taking pre-exposure prophylaxis (PrEP).
- Conditions
- HIV Infections, HIV/AIDS, Neisseria Gonorrheae Infection, Chlamydia Trachomatis Infection
- Trial name
- dPEP-KE (NCT04050540)
- Testing
- Doxycycline
- Where
- Kenya
- Volunteers
- 449 people, healthy volunteers welcome
- Sponsor
- University of Washington